Article ; Online: Effect of Exercise on β-Endorphin and Its Receptors in Myasthenia Gravis Patients.
2023 Volume 60, Issue 6, Page(s) 3010–3019
Abstract: This is a prospective observational study evaluating the change in β-endorphin (BE) and its receptors following exercise in patients with myasthenia gravis (MG) and their association with clinical improvement. Fifteen patients with mild to moderate MG, ... ...
| Abstract | This is a prospective observational study evaluating the change in β-endorphin (BE) and its receptors following exercise in patients with myasthenia gravis (MG) and their association with clinical improvement. Fifteen patients with mild to moderate MG, aged 16-70 years, who were able to do 6-Minute Walk Test (6-MWT) and had MG Quality of Life-15 (MGQoL-15) ≤ 45 without any contraindication for exercise were included. The patients walked 30 min daily for 3 months. The primary outcome at 3 months was > 50% improvement in MGQoL-15 from the baseline, and the secondary outcomes were MG Activities of Daily Living (MGADL), Hospital Anxiety and Depression Scale (HADS), number of steps, and distance covered on 6-MWT and adverse events. Plasma BE level, μ-opioid receptor (MOR), and δ-opioid receptor (DOR) were measured on admission and at 1 and 3 months. Twelve age- and gender-matched healthy controls who were not on regular exercise were included for comparison of BE, MOR, and DOR levels. Plasma BE level (P = 0.007) and DOR expression (P = 0.001) were lower in MG patients compared to the healthy controls. After 3 months of exercise, 6 patients improved. Plasma BE, MOR, and DOR levels increased in the first and decreased in the third month. MGQoL-15 (P < 0.001), HADS (P < 0.0001), number of steps (P < 0.007), distance (P = 0.030), and MGADL (P < 0.001) significantly improved compared to baseline. At 3 months, MGQoL-15 was associated with HADS score (P = 0.001), reduced depression (P = 0.013), MGADL (P = 0.035), and distance travelled on the 6-WMW test (P = 0.050). The improvement in depression was associated with higher BE level. |
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| MeSH term(s) | Humans ; beta-Endorphin ; Quality of Life ; Activities of Daily Living ; Receptors, Opioid, mu/metabolism ; Myasthenia Gravis ; Exercise |
| Chemical Substances | beta-Endorphin (60617-12-1) ; Receptors, Opioid, mu |
| Language | English |
| Publishing date | 2023-02-13 |
| Publishing country | United States |
| Document type | Observational Study ; Journal Article |
| ZDB-ID | 645020-9 |
| ISSN | 1559-1182 ; 0893-7648 |
| ISSN (online) | 1559-1182 |
| ISSN | 0893-7648 |
| DOI | 10.1007/s12035-023-03247-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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