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  1. Article: O'Brien's actinic granuloma in association with prolonged doxycycline phototoxicity.

    Lim, Davin S / Triscott, Joe

    The Australasian journal of dermatology

    2003  Volume 44, Issue 1, Page(s) 67–70

    Abstract: O'Brien's actinic granuloma is clinically characterized by annular papules and plaques on sun-exposed areas of skin. These lesions often occur insidiously on a background of severe solar elastosis; however, an acute variant following sunburn has been ... ...

    Abstract O'Brien's actinic granuloma is clinically characterized by annular papules and plaques on sun-exposed areas of skin. These lesions often occur insidiously on a background of severe solar elastosis; however, an acute variant following sunburn has been reported in the literature. We present two cases of acute actinic granuloma precipitated by episodes of sunburn occurring on a background of prolonged doxycycline phototoxicity. Biopsies from both patients showed a histiocytic infiltrate with multinucleate giant cells engulfing elastotic material, with a reduction of elastin towards the centre of the papule. Marked resolution of the lesions was noted after 8 weeks of treatment with betamethasone dipropionate 0.05% ointment in optimized vehicle together with adequate photoprotection in the form of broad-spectrum sunscreens.
    MeSH term(s) Administration, Cutaneous ; Adult ; Antimalarials/adverse effects ; Betamethasone/administration & dosage ; Betamethasone/analogs & derivatives ; Diagnosis, Differential ; Doxycycline/adverse effects ; Granuloma/diagnosis ; Granuloma/drug therapy ; Granuloma/etiology ; Granuloma/pathology ; Humans ; Malaria/drug therapy ; Male ; Neck ; Skin Diseases/diagnosis ; Skin Diseases/drug therapy ; Skin Diseases/etiology ; Skin Diseases/pathology ; Sunlight/adverse effects
    Chemical Substances Antimalarials ; betamethasone-17,21-dipropionate (826Y60901U) ; Betamethasone (9842X06Q6M) ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2003-01-22
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1046/j.1440-0960.2003.00641.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Factors Related to Nevus-Associated Cutaneous Melanoma: A Case-Case Study.

    Pandeya, Nirmala / Kvaskoff, Marina / Olsen, Catherine M / Green, Adèle C / Perry, Susan / Baxter, Catherine / Davis, Marcia B / Mortimore, Rohan / Westacott, Lorraine / Wood, Dominic / Triscott, Joe / Williamson, Richard / Whiteman, David C

    The Journal of investigative dermatology

    2018  Volume 138, Issue 8, Page(s) 1816–1824

    Abstract: A proportion of cutaneous melanomas display neval remnants on histologic examination. Converging lines of epidemiologic and molecular evidence suggest that melanomas arising from nevus precursors differ from melanomas arising de novo. In a large, ... ...

    Abstract A proportion of cutaneous melanomas display neval remnants on histologic examination. Converging lines of epidemiologic and molecular evidence suggest that melanomas arising from nevus precursors differ from melanomas arising de novo. In a large, population-based study comprising 636 cutaneous melanomas subjected to dermatopathology review, we explored the molecular, host, and environmental factors associated with the presence of neval remnants. We found that nevus-associated melanomas were significantly associated with younger age at presentation, non-brown eye color, trunk site, thickness of less than 0.5 mm, and BRAF
    MeSH term(s) Adult ; Age Factors ; Aged ; Disease Progression ; Eye Color ; Female ; Humans ; Male ; Melanoma/genetics ; Melanoma/pathology ; Middle Aged ; Mutation ; Nevus, Pigmented/genetics ; Nevus, Pigmented/pathology ; Odds Ratio ; Prospective Studies ; Proto-Oncogene Proteins B-raf/genetics ; Risk Factors ; Skin/pathology ; Skin/radiation effects ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Sunlight/adverse effects
    Chemical Substances BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
    Language English
    Publishing date 2018-03-07
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2017.12.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Histologic and Phenotypic Factors and MC1R Status Associated with BRAF(V600E), BRAF(V600K), and NRAS Mutations in a Community-Based Sample of 414 Cutaneous Melanomas.

    Hacker, Elke / Olsen, Catherine M / Kvaskoff, Marina / Pandeya, Nirmala / Yeo, Abrey / Green, Adèle C / Williamson, Richard M / Triscott, Joe / Wood, Dominic / Mortimore, Rohan / Hayward, Nicholas K / Whiteman, David C

    The Journal of investigative dermatology

    2016  Volume 136, Issue 4, Page(s) 829–837

    Abstract: Cutaneous melanomas arise through causal pathways involving interplay between exposure to UV radiation and host factors, resulting in characteristic patterns of driver mutations in BRAF, NRAS, and other genes. To gain clearer insights into the factors ... ...

    Abstract Cutaneous melanomas arise through causal pathways involving interplay between exposure to UV radiation and host factors, resulting in characteristic patterns of driver mutations in BRAF, NRAS, and other genes. To gain clearer insights into the factors contributing to somatic mutation genotypes in melanoma, we collected clinical and epidemiologic data, performed skin examinations, and collected saliva and tumor samples from a community-based series of 414 patients aged 18 to 79, newly diagnosed with cutaneous melanoma. We assessed constitutional DNA for nine common polymorphisms in melanocortin-1 receptor gene (MC1R). Tumor DNA was assessed for somatic mutations in 25 different genes. We observed mutually exclusive mutations in BRAF(V600E) (26%), BRAF(V600K) (8%), BRAF(other) (5%), and NRAS (9%). Compared to patients with BRAF wild-type melanomas, those with BRAF(V600E) mutants were significantly younger, had more nevi but fewer actinic keratoses, were more likely to report a family history of melanoma, and had tumors that were more likely to harbor neval remnants. BRAF(V600K) mutations were also associated with high nevus counts. Both BRAF(V600K) and NRAS mutants were associated with older age but not with high sun exposure. We also found no association between MC1R status and any somatic mutations in this community sample of cutaneous melanomas, contrary to earlier reports.
    MeSH term(s) Adolescent ; Adult ; Aged ; DNA, Neoplasm/genetics ; Family Health ; Female ; Genes, ras ; Genotype ; Humans ; Keratosis, Actinic/genetics ; Male ; Melanoma/metabolism ; Middle Aged ; Mutation ; Odds Ratio ; Phenotype ; Proto-Oncogene Proteins B-raf/genetics ; Receptor, Melanocortin, Type 1/metabolism ; Skin Neoplasms/metabolism ; Sunlight/adverse effects ; Surveys and Questionnaires ; Young Adult ; ras Proteins/genetics ; Melanoma, Cutaneous Malignant
    Chemical Substances DNA, Neoplasm ; Receptor, Melanocortin, Type 1 ; BRAF protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; ras Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2016-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2015.12.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Hand, foot and mouth disease in an immunocompromised adult treated with aciclovir.

    Faulkner, Catherine F / Godbolt, Amanda M / DeAmbrosis, Brian / Triscott, Joe

    The Australasian journal of dermatology

    2003  Volume 44, Issue 3, Page(s) 203–206

    Abstract: A 27-year-old man, immunosuppressed from recent chemotherapy for metastatic Ewing's sarcoma, presented with a 1-week history of a painful, pruritic, papulovesicular eruption on the hands and feet. A diagnosis of hand, foot and mouth disease was made ... ...

    Abstract A 27-year-old man, immunosuppressed from recent chemotherapy for metastatic Ewing's sarcoma, presented with a 1-week history of a painful, pruritic, papulovesicular eruption on the hands and feet. A diagnosis of hand, foot and mouth disease was made based on histology, detection of Enterovirus ribonucleic acid by polymerase chain reaction on a swab from a vesicle, and a four-fold increase in Enterovirus antibody levels. At no stage however, were there lesions in the mouth. Another unusual feature in this case was a prolonged course, presumably as a result of immunosuppression. After 3 1/2 weeks he was commenced on oral aciclovir 200 mg five times daily, with subsequent resolution of all lesions within 5 days. There may be a role for systemic aciclovir in some patients with hand, foot and mouth disease.
    MeSH term(s) Acyclovir/therapeutic use ; Adult ; Antiviral Agents/therapeutic use ; Diagnosis, Differential ; Enterovirus/isolation & purification ; Enterovirus Infections/complications ; Enterovirus Infections/diagnosis ; Enterovirus Infections/drug therapy ; Hand, Foot and Mouth Disease/complications ; Hand, Foot and Mouth Disease/diagnosis ; Hand, Foot and Mouth Disease/drug therapy ; Humans ; Immunocompromised Host ; Male ; Sarcoma, Ewing/complications ; Sarcoma, Ewing/therapy ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2003-07-04
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 138052-7
    ISSN 1440-0960 ; 0004-8380
    ISSN (online) 1440-0960
    ISSN 0004-8380
    DOI 10.1046/j.1440-0960.2003.00679.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Solar elastosis and cutaneous melanoma: a site-specific analysis.

    Kvaskoff, Marina / Pandeya, Nirmala / Green, Adèle C / Perry, Susan / Baxter, Catherine / Davis, Marcia B / Mortimore, Rohan / Westacott, Lorraine / Wood, Dominic / Triscott, Joe / Williamson, Richard / Whiteman, David C

    International journal of cancer

    2014  Volume 136, Issue 12, Page(s) 2900–2911

    Abstract: Cutaneous melanomas are postulated to arise through at least two causal pathways, namely the "chronic sun exposure" and "nevus" pathways. While chronic sun exposure probably causes many head/neck melanomas, its role at other sites is unclear. In a ... ...

    Abstract Cutaneous melanomas are postulated to arise through at least two causal pathways, namely the "chronic sun exposure" and "nevus" pathways. While chronic sun exposure probably causes many head/neck melanomas, its role at other sites is unclear. In a population-based, case-case comparison study conducted in Brisbane, Australia, we determined the prevalence and epidemiologic correlates of chronic solar damage in skin adjacent to invasive, incident melanomas on the trunk (n = 418) or head/neck (n = 92) among patients aged 18-79 in 2007-2010. Participants self-reported information about environmental and phenotypic factors, and a dermatologist counted nevi and actinic keratoses. Dermatopathologists assessed solar elastosis adjacent to each melanoma using a four-point scale (nil, mild, moderate, marked), and noted the presence or absence of adjacent neval remnants. We measured associations between various factors and solar elastosis using polytomous logistic regression. Marked or moderate solar elastosis was observed in 10% and 27%, respectively, of trunk melanomas, and 60% and 17%, respectively, of head/neck melanomas. At both sites, marked elastosis was positively associated with age (p(trend)  < 0.0001) and inversely associated with neval remnants (p(trend)  < 0.001). For trunk melanomas, marked elastosis was associated with highest quartiles of total sun exposure [odds-ratio (OR) = 5.47, 95% confidence interval (CI) = 1.08-27.60] and facial freckling (OR = 2.98, 95% CI = 1.17-7.56), and inversely associated with deeply tanning skin (OR = 0.29, 95% CI = 0.08-1.11) and high nevus counts (OR = 0.08, 95% CI = 0.01-0.66). Mostly similar associations were observed with moderate solar elastosis. About one in three trunk melanomas in Queensland have evidence of moderate-to-marked sun damage, and they differ in risk associations from those without.
    MeSH term(s) Adolescent ; Adult ; Aged ; Australia/epidemiology ; Dermatology/methods ; Face ; Female ; Humans ; Logistic Models ; Male ; Melanoma/diagnosis ; Melanoma/epidemiology ; Middle Aged ; Neck ; Nevus/diagnosis ; Nevus/epidemiology ; Nevus, Pigmented/diagnosis ; Nevus, Pigmented/epidemiology ; Severity of Illness Index ; Skin/pathology ; Skin/radiation effects ; Skin Diseases/diagnosis ; Skin Diseases/epidemiology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/epidemiology ; Sunlight ; Young Adult ; Melanoma, Cutaneous Malignant
    Language English
    Publishing date 2014-11-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218257-9
    ISSN 1097-0215 ; 0020-7136
    ISSN (online) 1097-0215
    ISSN 0020-7136
    DOI 10.1002/ijc.29335
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    Zs.A 478: Show issues Location:
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  6. Article ; Online: Site-specific determinants of cutaneous melanoma: a case-case comparison of patients with tumors arising on the head or trunk.

    Kvaskoff, Marina / Pandeya, Nirmala / Green, Adèle C / Perry, Susan / Baxter, Catherine / Davis, Marcia B / Mortimore, Rohan / Westacott, Lorraine / Wood, Dominic / Triscott, Joe / Williamson, Richard / Whiteman, David C

    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

    2013  Volume 22, Issue 12, Page(s) 2222–2231

    Abstract: Background: Cutaneous melanomas have been hypothesized to arise through different pathways according to phenotype, body site, and sun exposure. To further test this hypothesis, we explored associations between phenotype and melanoma at different sites ... ...

    Abstract Background: Cutaneous melanomas have been hypothesized to arise through different pathways according to phenotype, body site, and sun exposure. To further test this hypothesis, we explored associations between phenotype and melanoma at different sites using a case-case comparative approach.
    Methods: Melanoma patients (n = 762) aged 18 to 79 years and diagnosed from 2007 to 2010 were ascertained from pathology laboratories in Brisbane, Australia. Patients reported phenotypic information and a dermatologist counted melanocytic nevi and solar keratoses. We compared data for patients with trunk melanoma (n = 541, the reference group), head/neck melanoma (n = 122), or lentigo maligna melanoma (LMM) of the head/neck (n = 69). ORs and 95% confidence intervals were calculated using classical or polytomous logistic regression models.
    Results: Compared with trunk melanoma patients, those with head/neck melanoma were significantly less likely to have high nevus counts (≥135: OR = 0.27; Ptrend = 0.0004). Associations between category of nevus count and LMM head/neck were weaker and significantly different (≥135: OR = 1.09; Ptrend = 0.69; Phomogeneity = 0.02). Patients with head/neck melanoma were more likely than those with truncal melanoma to have high solar keratosis counts (≥7: OR = 1.78, Ptrend = 0.04). Again, associations with LMM head/neck were weaker, albeit not significantly different (≥7: OR = 1.61; Ptrend = 0.42; Phomogeneity = 0.86).
    Conclusion: Trunk melanomas are more strongly associated with nevus counts than head/neck melanomas, but are less strongly associated with number of solar keratoses, a marker of chronic sun exposure.
    Impact: These findings underscore the notion that melanomas on the trunk typically arise through a causal pathway associated with nevus propensity, whereas melanomas on the head/neck arise through a pathway associated with cumulative sun exposure.
    MeSH term(s) Adolescent ; Adult ; Aged ; Australia/epidemiology ; Female ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/pathology ; Humans ; Male ; Melanoma/epidemiology ; Melanoma/pathology ; Middle Aged ; Skin Neoplasms/epidemiology ; Skin Neoplasms/pathology ; Surveys and Questionnaires ; Young Adult ; Melanoma, Cutaneous Malignant
    Language English
    Publishing date 2013-10-01
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1153420-5
    ISSN 1538-7755 ; 1055-9965
    ISSN (online) 1538-7755
    ISSN 1055-9965
    DOI 10.1158/1055-9965.EPI-13-0475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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