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  1. Article ; Online: Towards a better understanding of the use of additives in tattoos.

    Milanesi, Nicola / Gigli, Ugo / Tronconi, Greta / Grimaldi, Gianluca / Gola, Massimo

    Italian journal of dermatology and venereology

    2022  Volume 157, Issue 1, Page(s) 69–71

    Abstract: Background: Tattooing is a popular practice worldwide, this practice is not free from complications and the last few decades have seen the raising occurrence of complications and adverse reactions.: Methods: The aim of this study is to evaluate which ...

    Abstract Background: Tattooing is a popular practice worldwide, this practice is not free from complications and the last few decades have seen the raising occurrence of complications and adverse reactions.
    Methods: The aim of this study is to evaluate which substances are commonly used as additives among a group of tattoo artists working in Florence, to understand if mixing of colors and dilution of inks can be considered a potential source of infection or hypersensitivity reaction. A questionnaire containing a list of substances suspected to be added during the process of tattooing, was administered in presence of an investigator.
    Results: Forty-one licensed tattoo artists participated in the study. The cosmetic most frequently used as additive, resulted a rinse on cosmetic (36%) followed by distilled water (34%) and hamamelis lotion (17%).
    Conclusions: Our study provides new insights about the procedure of ink dilution and mixing of colors, shedding light on the possible risks related to the use of non-sterile products. The results of our study suggest that mixing of colors and ink dilution can be consider a potential source of infection and hypersensitivity reactions. Additional actions are necessary to strengthen and protect public health.
    MeSH term(s) Ink ; Tattooing/adverse effects
    Language English
    Publishing date 2022-02-17
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.21.06948-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sulfur 17% ointment for topical treatment of scabies in children: old but gold.

    Baffa, Maria E / Filippeschi, Cesare / Tronconi, Greta / Diociaiuti, Andrea / El Hachem, May / Oranges, Teresa

    International journal of dermatology

    2023  Volume 63, Issue 1, Page(s) e19–e20

    MeSH term(s) Child ; Humans ; Scabies/drug therapy ; Ointments ; Sulfur/therapeutic use ; Ivermectin ; Administration, Topical
    Chemical Substances Ointments ; Sulfur (70FD1KFU70) ; Ivermectin (70288-86-7)
    Language English
    Publishing date 2023-11-10
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.16898
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dupilumab treatment of trichothiodystrophy in a child.

    Magnaterra, Elisabetta / Giovannini, Mattia / Filippeschi, Cesare / Pedaci, Fausto Andrea / Tronconi, Greta / Callea, Michele / Ricci, Silvia / Mori, Francesca / Parpagnoli, Maria / Oranges, Teresa

    Pediatric dermatology

    2024  

    Abstract: Trichothiodystrophy (TTD) is a rare congenital disorder caused by genetic mutations, leading to hair and skin abnormalities. We report successful treatment of a TTD case using dupilumab, a monoclonal antibody targeting IL-4Rα. The patient, a 7-year-old ... ...

    Abstract Trichothiodystrophy (TTD) is a rare congenital disorder caused by genetic mutations, leading to hair and skin abnormalities. We report successful treatment of a TTD case using dupilumab, a monoclonal antibody targeting IL-4Rα. The patient, a 7-year-old boy, exhibited significant improvement in skin and hair conditions, suggesting the potential of dupilumab as a therapeutic option for TTD. Further research is needed to elucidate its mechanism and efficacy in TTD treatment.
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Case Reports
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15612
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  4. Article ; Online: Impact of dupilumab discontinuation in a patient with atopic prurigo.

    Milanesi, Nicola / Tronconi, Greta / Gola, Massimo / Flori, Maria Laura / Russo, Filomena

    Italian journal of dermatology and venereology

    2020  Volume 156, Issue 3, Page(s) 406

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Dermatitis, Atopic/drug therapy ; Humans ; Prurigo/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2020-10-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.20.06714-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of dupilumab on sleep disturbances in adult patients with severe atopic dermatitis.

    Milanesi, Nicola / Gola, Massimo / Cartocci, Alessandra / Tronconi, Greta / Bruzziches, Francesco / Flori, Maria L / Rubegni, Pietro / Russo, Filomena

    Italian journal of dermatology and venereology

    2021  Volume 157, Issue 2, Page(s) 142–145

    Abstract: Background: Sleep disturbances are common in patients with atopic dermatitis (AD). Considering their relevant burden on health, routine screening of sleep disturbances seems to be very useful in AD adults' management. However, few studies have evaluated ...

    Abstract Background: Sleep disturbances are common in patients with atopic dermatitis (AD). Considering their relevant burden on health, routine screening of sleep disturbances seems to be very useful in AD adults' management. However, few studies have evaluated the association between sleep disturbances and AD in adults, and real-life data are lacking. The aim of this study was to assess the effect of treatment with dupilumab on sleep disturbances in adult patients with severe atopic dermatitis.
    Methods: This is a retrospective, multicenter study including patients (age ≥18 y) with severe atopic dermatitis treated with dupilumab for at least 8 months from January 2019 to January 2020. Patients were evaluated three times: at treatment initiation (T0), at 4 (T4) and 8 months (T8) from the start of treatment. At each visit disease activity was assessed by severity score (Eczema Area and Severity Index [EASI]), patient-reported outcomes (Pruritus Numerical Rating Scale [NRS], Dermatology Life Quality Index [DLQI], and Pittsburgh Sleep Quality Index [PSQI]). Kolmogorov-Smirnov Test was performed to evaluate the normality distribution, Bartlett's Test for homoscedasticity. Since the assumptions were met, ANOVA for repeated measures was performed to evaluate the mean difference of PSQI, EASI, DLQI and pruritus NRS between baseline, the 4
    Results: A total of 36 patients (15 females and 21 males) with a mean age of 42.5±14.3 (range 20-67) were included in the study. The mean score for PSQI at TO was 9.0±3.6. At week 16 (T4) the mean score for PSQI was 4.92±2.99 and at week 32 (T8), the mean score for PSQI was 4.3±3.0. EASI, NRS pruritus and DLQI significantly improved during follow-up (P<0.001) whereas PSQI improved significantly at 16 weeks (T4); however, no significant further improvement was observed at 32 weeks. Of the 31 patients (86%) with baseline PSQI≥5, 17 (54%) experienced sleep quality improvement during treatment. Overall, we observed a total of 22 patients (61.1%) having a PSQI<5 at 32 weeks.
    Conclusions: Our data show effectiveness of dupilumab in improving sleep disturbances in adult patients with severe AD. However, further studies are required to understand if PSQI could serve as useful evaluating tool.
    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized ; Dermatitis, Atopic/complications ; Female ; Humans ; Infant ; Male ; Middle Aged ; Pruritus/drug therapy ; Retrospective Studies ; Sleep ; Sleep Wake Disorders/drug therapy ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2021-07-20
    Publishing country Italy
    Document type Journal Article ; Multicenter Study
    ZDB-ID 3065415-4
    ISSN 2784-8450
    ISSN (online) 2784-8450
    DOI 10.23736/S2784-8671.21.07072-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 119: Show issues Location:
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  6. Article ; Online: SB5 adalimumab biosimilar in the treatment of psoriasis and psoriatic arthritis.

    Di Cesare, Antonella / Tronconi, Greta / Fastame, Thais M / Rosi, Elia / Pescitelli, Leonardo / Ricceri, Federica / Prignano, Francesca

    Dermatologic therapy

    2020  Volume 33, Issue 3, Page(s) e13435

    MeSH term(s) Adalimumab/adverse effects ; Antirheumatic Agents/adverse effects ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Biosimilar Pharmaceuticals/adverse effects ; Humans ; Psoriasis/diagnosis ; Psoriasis/drug therapy
    Chemical Substances Antirheumatic Agents ; Biosimilar Pharmaceuticals ; Adalimumab (FYS6T7F842)
    Language English
    Publishing date 2020-05-11
    Publishing country United States
    Document type Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13435
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    Zs.A 5181: Show issues Location:
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  7. Article ; Online: Dupilumab in Elderly Patients With Severe Atopic Dermatitis.

    Russo, Filomena / Milanesi, Nicola / Cartocci, Alessandra / Bruzziches, Francesco / Tronconi, Greta / Lazzeri, Laura / D'erme, Angelo Massimiliano / Bagnoni, Giovanni / Gola, Massimo / Cinotti, Elisa / Rubegni, Pietro / Flori, Maria Laura

    Dermatitis : contact, atopic, occupational, drug

    2020  Volume 32, Issue 1S, Page(s) S24–S27

    Abstract: Background: Atopic dermatitis (AD) in the elderly has been poorly investigated, although its incidence is gradually increasing mainly in industrialized countries. Age-specific factors in older patients must be considered when selecting treatment options. ...

    Abstract Background: Atopic dermatitis (AD) in the elderly has been poorly investigated, although its incidence is gradually increasing mainly in industrialized countries. Age-specific factors in older patients must be considered when selecting treatment options.
    Objectives: To evaluate the efficacy and tolerability of dupilumab in treating elderly patients with severe AD.
    Methods: This was a retrospective, multicenter study involving 26 elderly patients (age, ≥65 years) with severe AD who were treated with dupilumab for at least 16 weeks. Absolute and percentage frequencies were used to evaluate qualitative variables and mean and SD for quantitative ones. For Eczema Area and Severity Index (EASI), Pruritus Numeric Rating Scale (NRS), and Dermatology Life Quality Index (DLQI), the median was also calculated. Wilcoxon test was used to evaluate the variations in EASI, Pruritus NRS, and DLQI observed between the 2 examinations.
    Results: After 4 months of therapy, the majority of patients showed a significant improvement in EASI (64.4%), Pruritus NRS (58.2%), and DLQI (44.9%). Only 11% of patients reported mild or moderate conjunctivitis.
    Conclusions: To the best of our knowledge, this is the first study concerning the use of dupilumab in the elderly with severe AD. Our data show the effectiveness of dupilumab in this particular population with a lower percentage of conjunctivitis than observed in studies on adults and also excellent control of itching. Only larger, controlled case studies will be able to clarify whether the dosage or frequency of administration of dupilumab in these patients should be different from the protocol used for adults.
    MeSH term(s) Adult ; Age Factors ; Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/drug therapy ; Humans ; Male ; Quality of Life ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Antibodies, Monoclonal, Humanized ; dupilumab (420K487FSG)
    Language English
    Publishing date 2020-12-21
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1097/DER.0000000000000686
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