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  1. Article ; Online: Lp(a)-Associated Oxidized Phospholipids in Healthy Black and White Participants in Relation to apo(a) Size, Age, and Family Structure.

    Berglund, Lars / Kim, Kyoungmi / Zhang, Wei / Prakash, Nishant / Truax, Kevin / Anuurad, Erdembileg / Enkhmaa, Byambaa

    Journal of the American Heart Association

    2021  Volume 10, Issue 17, Page(s) e020158

    Abstract: Background Lp(a) (lipoprotein(a)) is the major lipoprotein carrier of oxidized phospholipids (OxPL) and this function mediates Lp(a) atherogenicity. However, the relationship between OxPL, Lp(a), and genetic and biological characteristics remains poorly ... ...

    Abstract Background Lp(a) (lipoprotein(a)) is the major lipoprotein carrier of oxidized phospholipids (OxPL) and this function mediates Lp(a) atherogenicity. However, the relationship between OxPL, Lp(a), and genetic and biological characteristics remains poorly understood. We assessed the relationship between Lp(a)-bound OxPL, apolipoprotein(a) (apo(a)) size, age, and family structure in 2 racial groups. Methods and Results Healthy Black and White families were recruited from the general population (age: 6-74 years, n=267). OxPL and Lp(a) levels were assayed enzymatically; apo(a) isoform,
    MeSH term(s) Adolescent ; Adult ; Aged ; Apoprotein(a)/genetics ; Blacks/genetics ; Child ; Humans ; Lipoprotein(a)/genetics ; Middle Aged ; Oxidation-Reduction ; Phospholipids ; Whites/genetics ; Young Adult
    Chemical Substances Lipoprotein(a) ; Phospholipids ; Apoprotein(a) (EC 3.4.21.-)
    Language English
    Publishing date 2021-08-25
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.020158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PCSK9 in African Americans and Caucasians in Relation to Lp(a) Level, Apo(a) Size and Heritability.

    Enkhmaa, Byambaa / Kim, Kyoungmi / Zhang, Wei / Prakash, Nishant / Truax, Kevin / Anuurad, Erdembileg / Berglund, Lars

    Journal of the Endocrine Society

    2020  Volume 4, Issue 7, Page(s) bvaa073

    Abstract: Context: Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces lipoprotein(a) [Lp(a)] levels, but the association of PCSK9 with Lp(a) level and its major determinant, apolipoprotein(a) [apo(a)] size, is not fully understood.: ... ...

    Abstract Context: Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces lipoprotein(a) [Lp(a)] levels, but the association of PCSK9 with Lp(a) level and its major determinant, apolipoprotein(a) [apo(a)] size, is not fully understood.
    Objective: To assess the relationship between PCSK9, Lp(a) level, apo(a) size, age, and ethnicity/race.
    Design: Cross-sectional.
    Setting: General population.
    Participants: Healthy African Americans and Caucasians (n = 267); age range: 6 to 74 years.
    Interventions: None.
    Main outcome measures: PCSK9 levels, apo(a) isoform and
    Results: Plasma PCSK9 levels were significantly higher in African Americans vs Caucasians, in females vs males, and in adults vs children. PCSK9 levels were not associated with total plasma Lp(a) levels either in all participants or in ethnicity-specific analyses. However, PCSK9 levels were significantly positively associated with isoform-specific Lp(a) levels carried by the larger apo(a) size in all participants (
    Conclusions: Among African Americans, but not Caucasians, PCSK9 levels were associated with isoform-specific Lp(a) levels carried on larger, but not smaller, apo(a) sizes. The findings illustrate a diverging relationship of PCSK9 with isoform-specific Lp(a) levels across ethnicity.
    Language English
    Publishing date 2020-06-11
    Publishing country United States
    Document type Journal Article
    ISSN 2472-1972
    ISSN (online) 2472-1972
    DOI 10.1210/jendso/bvaa073
    Database MEDical Literature Analysis and Retrieval System OnLINE

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