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  1. AU="Trujillo Hernández, Angélica"
  2. AU="Song, MinGyu"
  3. AU="Liu, Qigong"
  4. AU="Darlene Dela Cruz"
  5. AU="Gorog, Diana A"
  6. AU="Fan, Yuan"
  7. AU="Cho, Yong Sang"
  8. AU="Silveira, Amanda Bortolini"
  9. AU="Carugati, Manuela"
  10. AU="Jurriaans, Suzanne"
  11. AU="Tsai, Kelvin K"
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  13. AU=Mojet Barbara Louise AU=Mojet Barbara Louise
  14. AU=Alessandri-Haber Nicole AU=Alessandri-Haber Nicole
  15. AU="Alan White"
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  18. AU="Barrejón, Myriam"
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  20. AU="Agnarelli, Alessandro"
  21. AU="Rill, Nathaniel O"
  22. AU="Sarah Lyon-Caen"
  23. AU="Endharti, Agustina Tri"
  24. AU="Baez-Noyer, Nelson"
  25. AU="Kucherlapati, Raju S."
  26. AU="Loyaux, Romain"
  27. AU="Yaxin Long"
  28. AU="Vlasenkova, Ramilia"
  29. AU="Taheri, Fateme"
  30. AU="Berman, Robert F"
  31. AU="Resnick, Cory M"
  32. AU=Freeman Gordon J AU=Freeman Gordon J
  33. AU="Fangru Zhou"

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  1. Artikel ; Online: Characterization of sperm motility and testosterone secretion in the

    Muñoz de la Torre, Luz Patricia / Trujillo Hernández, Angélica / Eguibar, José Ramón / Cortés, Carmen / Morales-Ledesma, Leticia

    Animal reproduction

    2023  Band 20, Heft 3, Seite(n) e20220102

    Abstract: Presently, demyelinating diseases have been reported to affect the reproductive life of patients who suffer from them, but the progression of the alterations is unknown, especially in men. To better understand these effects, it is necessary to perform ... ...

    Abstract Presently, demyelinating diseases have been reported to affect the reproductive life of patients who suffer from them, but the progression of the alterations is unknown, especially in men. To better understand these effects, it is necessary to perform studies in animal models, such as the male
    Sprache Englisch
    Erscheinungsdatum 2023-10-30
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 2227229-X
    ISSN 1984-3143 ; 1984-3143
    ISSN (online) 1984-3143
    ISSN 1984-3143
    DOI 10.1590/1984-3143-AR2022-0102
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  2. Artikel: Administration of a VIP-antagonist in vivo modifies ovarian hormone secretion in a rat model with polycystic ovary syndrome

    Morales-Ledesma, Leticia / Trujillo Hernández, Angélica / Ramírez, María Isabel / Rosas, Gabriela / Linares, Rosa

    Life sciences. 2021 Jan. 15, v. 265

    2021  

    Abstract: In the cyclic rat in estrus, the vasoactive intestinal peptide (VIP) has an impact on ovarian function, which depends on the endocrine status of the animal. In this work, we aimed to clarify the participation of VIP in the pathophysiological condition of ...

    Abstract In the cyclic rat in estrus, the vasoactive intestinal peptide (VIP) has an impact on ovarian function, which depends on the endocrine status of the animal. In this work, we aimed to clarify the participation of VIP in the pathophysiological condition of polycystic ovary syndrome (PCOS) using a model of PCOS induced by estradiol valerate (EV-PCOS) in rats.In the cyclic rat in estrus and in the EV-PCOS model, we analyzed the acute effects of blocking VIP receptors with the use of an antagonist (Ant-VIP) injected into the left or right ovarian bursa on the steroidogenic response and ovarian catecholamine levels.In the cyclic animal in estrus, the treatment with Ant-VIP in the left ovarian bursa resulted in a reduction in testosterone serum levels and in ovarian levels of dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC), without changes in 4-hydroxy-3-methoxyphenyl (MHPG) and norepinephrine (NE). When the treatment was applied on the right side, only MHPG levels increased.In the EV-PCOS model, the treatment with Ant-VIP in the left ovarian bursa increased testosterone, estradiol, MHPG, and NE levels. When the treatment was performed on the right side, progesterone levels decreased and estradiol increased, without changes in ovarian catecholamines.The binding of VIP to its receptors differentially regulates steroidogenesis in the cyclic animal in estrus and in the EV-PCOS model. The blocking of VIP signaling produces changes in ovarian catecholamines.
    Schlagwörter animal models ; animal ovaries ; antagonists ; blood serum ; dopamine ; estradiol ; estrus ; hormone secretion ; norepinephrine ; polycystic ovary syndrome ; progesterone ; rats ; steroidogenesis ; testosterone ; vasoactive intestinal peptide
    Sprache Englisch
    Erscheinungsverlauf 2021-0115
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2020.118792
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 73/732: Hefte anzeigen

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  3. Artikel ; Online: Obese female Zucker rats (fa/fa) exhibit dendritic retraction in neurons in the ventromedial hypothalamic nucleus.

    Bravo Durán, Dolores Adriana / Barreda Guzmán, Selina Jocelyn / Trujillo Hernández, Angélica / Silva Gómez, Adriana Berenice

    Journal of chemical neuroanatomy

    2021  Band 113, Seite(n) 101919

    Abstract: The ventromedial hypothalamic nucleus (VMH) is located in the tuberal region of the hypothalamus and is traditionally considered the satiety center. In obese Zucker rats, which express a mutation in the leptin receptor gene and exhibit obesity from the ... ...

    Abstract The ventromedial hypothalamic nucleus (VMH) is located in the tuberal region of the hypothalamus and is traditionally considered the satiety center. In obese Zucker rats, which express a mutation in the leptin receptor gene and exhibit obesity from the first weeks of life, the morphology of VMH neurons is unknown. In the present study, we found that the dendritic length of VMH neurons in obese Zucker rats was significantly shorter than that in Long Evans rats. This finding allows us to suggest that obese Zucker rats exhibit both neuronal metabolic alterations related to leptin and a reduction in the flow of information within the neuronal circuits in which the VMH nucleus participates to regulate foraging.
    Mesh-Begriff(e) Animals ; Cell Shape/physiology ; Dendrites/pathology ; Neurons/pathology ; Obesity/pathology ; Rats ; Rats, Zucker ; Ventromedial Hypothalamic Nucleus/pathology
    Sprache Englisch
    Erscheinungsdatum 2021-01-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 639443-7
    ISSN 1873-6300 ; 0891-0618
    ISSN (online) 1873-6300
    ISSN 0891-0618
    DOI 10.1016/j.jchemneu.2021.101919
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2363: Hefte anzeigen Standort:
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  4. Artikel ; Online: Sex-specific hypothalamic expression of kisspeptin, gonadotropin releasing hormone, and kisspeptin receptor in progressive demyelination model.

    Muñoz de la Torre, Luz Patricia / Trujillo Hernández, Angélica / Eguibar, Jose R / Cortés, Carmen / Morales-Ledesma, Leticia

    Journal of chemical neuroanatomy

    2022  Band 123, Seite(n) 102120

    Abstract: Demyelinating diseases, such as multiple sclerosis, decrease the quality of life of patients and can affect reproduction. Assisted reproductive therapies are available, which although effective, aggravate motor symptoms. For this reason, it is important ... ...

    Abstract Demyelinating diseases, such as multiple sclerosis, decrease the quality of life of patients and can affect reproduction. Assisted reproductive therapies are available, which although effective, aggravate motor symptoms. For this reason, it is important to determine how the control of the hypothalamus-pituitary-gonadal axis is affected in order to develop better strategies for these patients. One way to determine this is using animal models such as the taiep rat, which shows progressive demyelination of the central nervous system, and was used in the present study to characterize the expression of gonadotrophin-releasing hormone (GnRH), Kisspeptin, and kisspeptin receptor (Kiss1R) and luteinizing hormone (LH) secretion. The expression of kisspeptin, GnRH, and Kiss1R was determined at the hypothalamic level by immunofluorescence and serum LH levels were determined by ELISA. The expression of kisspeptin at the hypothalamic level showed sexual dimorphism, where there was an increase in males and a decrease in females during oestrus. There was no change in the expression of GnRH or kisspeptin receptor, regardless of sex. However, a decrease in serum LH concentration was observed in both sexes. The taiep rat showed changes in the expression of kisspeptin at the hypothalamic level. These changes are different from those reported in the literature with the use of animals with experimental allergic encephalomyelitis, this is because both animal models represent different degrees of progression of multiple sclerosis. Our results suggest that the effects on the hypothalamus-pituitary-gonadal axis depend on the differences between the demyelinating processes, their progression, and even individual factors, and it is thus important that fertility treatments are individualized to maximize therapeutic effects.
    Mesh-Begriff(e) Animals ; Demyelinating Diseases/metabolism ; Demyelinating Diseases/pathology ; Female ; Gonadotropin-Releasing Hormone/biosynthesis ; Gonadotropin-Releasing Hormone/metabolism ; Hypothalamus/metabolism ; Kisspeptins/biosynthesis ; Luteinizing Hormone/blood ; Male ; Multiple Sclerosis/metabolism ; Multiple Sclerosis/pathology ; Quality of Life ; Rats ; Receptors, Kisspeptin-1/biosynthesis
    Chemische Substanzen Kiss1r protein, mouse ; Kisspeptins ; Receptors, Kisspeptin-1 ; Gonadotropin-Releasing Hormone (33515-09-2) ; Luteinizing Hormone (9002-67-9)
    Sprache Englisch
    Erscheinungsdatum 2022-06-16
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639443-7
    ISSN 1873-6300 ; 0891-0618
    ISSN (online) 1873-6300
    ISSN 0891-0618
    DOI 10.1016/j.jchemneu.2022.102120
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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2363: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Artikel ; Online: Administration of a VIP-antagonist in vivo modifies ovarian hormone secretion in a rat model with polycystic ovary syndrome.

    Morales-Ledesma, Leticia / Trujillo Hernández, Angélica / Ramírez, María Isabel / Rosas, Gabriela / Linares, Rosa

    Life sciences

    2020  Band 265, Seite(n) 118792

    Abstract: Aims: In the cyclic rat in estrus, the vasoactive intestinal peptide (VIP) has an impact on ovarian function, which depends on the endocrine status of the animal. In this work, we aimed to clarify the participation of VIP in the pathophysiological ... ...

    Abstract Aims: In the cyclic rat in estrus, the vasoactive intestinal peptide (VIP) has an impact on ovarian function, which depends on the endocrine status of the animal. In this work, we aimed to clarify the participation of VIP in the pathophysiological condition of polycystic ovary syndrome (PCOS) using a model of PCOS induced by estradiol valerate (EV-PCOS) in rats.
    Main methods: In the cyclic rat in estrus and in the EV-PCOS model, we analyzed the acute effects of blocking VIP receptors with the use of an antagonist (Ant-VIP) injected into the left or right ovarian bursa on the steroidogenic response and ovarian catecholamine levels.
    Key findings: In the cyclic animal in estrus, the treatment with Ant-VIP in the left ovarian bursa resulted in a reduction in testosterone serum levels and in ovarian levels of dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC), without changes in 4-hydroxy-3-methoxyphenyl (MHPG) and norepinephrine (NE). When the treatment was applied on the right side, only MHPG levels increased. In the EV-PCOS model, the treatment with Ant-VIP in the left ovarian bursa increased testosterone, estradiol, MHPG, and NE levels. When the treatment was performed on the right side, progesterone levels decreased and estradiol increased, without changes in ovarian catecholamines.
    Significance: The binding of VIP to its receptors differentially regulates steroidogenesis in the cyclic animal in estrus and in the EV-PCOS model. The blocking of VIP signaling produces changes in ovarian catecholamines.
    Mesh-Begriff(e) Animals ; Catecholamines/metabolism ; Disease Models, Animal ; Estradiol/metabolism ; Estradiol/toxicity ; Female ; Ovary/drug effects ; Ovary/metabolism ; Polycystic Ovary Syndrome/chemically induced ; Polycystic Ovary Syndrome/drug therapy ; Polycystic Ovary Syndrome/metabolism ; Rats ; Receptors, Vasoactive Intestinal Peptide/antagonists & inhibitors ; Receptors, Vasoactive Intestinal Peptide/metabolism ; Testosterone/metabolism ; Vasoactive Intestinal Peptide/antagonists & inhibitors ; Vasoactive Intestinal Peptide/metabolism
    Chemische Substanzen Catecholamines ; Receptors, Vasoactive Intestinal Peptide ; Vasoactive Intestinal Peptide (37221-79-7) ; Testosterone (3XMK78S47O) ; Estradiol (4TI98Z838E)
    Sprache Englisch
    Erscheinungsdatum 2020-11-18
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2020.118792
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    Verfügbar in ZB MED Köln/Königswinter

    Uc I Zs.368: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  6. Artikel ; Online: Unilateral section of the superior ovarian nerve induces first ovulation in the Zucker fatty (fa/fa) rat.

    Puga Y Colmenares, María Concepción / Trujillo Hernández, Angélica / Morales-Ledesma, Leticia

    General and comparative endocrinology

    2020  Band 300, Seite(n) 113636

    Abstract: Hyperactivity in the sympathetic nervous system has been shown to be related to the development of ovarian pathologies. In addition, obesity has been found to be associated with multiple reproductive anomalies and is considered a chronic stress condition ...

    Abstract Hyperactivity in the sympathetic nervous system has been shown to be related to the development of ovarian pathologies. In addition, obesity has been found to be associated with multiple reproductive anomalies and is considered a chronic stress condition of low intensity with changes in the peripheral sympathetic activity. Therefore, in the present study, we aimed to evaluate if the information reaching the ovaries through the superior ovarian nerve (SON) modifies the ovarian function of Zucker fatty rats. We performed a unilateral section of the SON at 32 days of age and autopsies were carried out on the day of the first vaginal estrus. The results showed that fatty animals do not ovulate on the day of the first vaginal estrus and exhibit an increase in catecholaminergic fibers and the presence of precystic structures in the ovaries, without changes in the onset of puberty or in the secretion of ovarian and hypophyseal hormones. We also found that the section of the right SON resulted in ovulation on the day of the first vaginal estrus, which was accompanied by a decrease in ovarian noradrenaline content. The section of the left SON caused a delay in puberty without changes in the rest of the parameters. These results provide functional evidence that the peripheral sympathetic innervation participates in the regulation of ovarian functions in an animal model of genetic obesity.
    Mesh-Begriff(e) Animals ; Catecholamines/metabolism ; Female ; Nerve Tissue/physiology ; Ovary/anatomy & histology ; Ovary/innervation ; Ovulation/physiology ; Rats, Zucker ; Sexual Maturation/physiology ; Rats
    Chemische Substanzen Catecholamines
    Sprache Englisch
    Erscheinungsdatum 2020-10-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1851-x
    ISSN 1095-6840 ; 0016-6480
    ISSN (online) 1095-6840
    ISSN 0016-6480
    DOI 10.1016/j.ygcen.2020.113636
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 164: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Artikel ; Online: Polycystic ovary syndrome induced by exposure to testosterone propionate and effects of sympathectomy on the persistence of the syndrome.

    Morales-Ledesma, Leticia / Díaz Ramos, Juan Antonio / Trujillo Hernández, Angélica

    Reproductive biology and endocrinology : RB&E

    2017  Band 15, Heft 1, Seite(n) 50

    Mesh-Begriff(e) Animals ; Animals, Newborn ; Estradiol/blood ; Estrous Cycle/drug effects ; Female ; Ovary/innervation ; Ovary/pathology ; Ovary/physiopathology ; Polycystic Ovary Syndrome/blood ; Polycystic Ovary Syndrome/chemically induced ; Polycystic Ovary Syndrome/physiopathology ; Progesterone/blood ; Rats ; Sympathectomy/methods ; Testosterone Propionate/administration & dosage ; Testosterone Propionate/toxicity ; Time Factors
    Chemische Substanzen Progesterone (4G7DS2Q64Y) ; Estradiol (4TI98Z838E) ; Testosterone Propionate (WI93Z9138A)
    Sprache Englisch
    Erscheinungsdatum 2017-07-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 1477-7827
    ISSN (online) 1477-7827
    DOI 10.1186/s12958-017-0267-0
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  8. Artikel: Yawning and Penile Erection Frequencies Are Resilient to Maternal Care Manipulation in the High-Yawning Subline of Sprague-Dawley Rats.

    Dorantes-Nieto, Ángeles / Cortes, Carmen / Ugarte, Araceli / Trujillo Hernández, Angélica / Carrasco, Ángeles / Cepeda-Freyre, Héctor Alejandro / Eguibar, Jose R

    Frontiers in behavioral neuroscience

    2020  Band 14, Seite(n) 20

    Abstract: Yawning is a stereotyped behavioral pattern characterized by wide opening of the mouth associated with deep inspiration followed by short expiration. All vertebrate species yawn, but with low frequencies. We obtained two sublines of Sprague-Dawley (SD) ... ...

    Abstract Yawning is a stereotyped behavioral pattern characterized by wide opening of the mouth associated with deep inspiration followed by short expiration. All vertebrate species yawn, but with low frequencies. We obtained two sublines of Sprague-Dawley (SD) rats by a strict inbreeding process: one with a high-yawning frequency (HY) of 20 yawns/h, which is one order of magnitude higher with respect to the low-yawning frequency (LY) subline, with 2 yawns/h. Outbred SD rats had a yawning frequency of 1 yawn/h. HY dams had a different organization of maternal care with respect to that displayed by LY and SD dams because HY dams constructed lower quality nests and had more re-retrieving and atypical retrieving. The aim of this study was to analyze the changes in maternal care using in- and cross-fostering between the sublines and SD dams and to measure spontaneous and dopaminergic-induced yawning, penile erections, grooming and scratching bouts. We also measured the expression of dopamine D
    Sprache Englisch
    Erscheinungsdatum 2020-03-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2452960-6
    ISSN 1662-5153
    ISSN 1662-5153
    DOI 10.3389/fnbeh.2020.00020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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