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  1. Article ; Online: The importance of nutritional status in heart failure.

    Trullàs, J C

    Revista clinica espanola

    2018  Volume 218, Issue 2, Page(s) 68–69

    Title translation La importancia del estado nutricional en la insuficiencia cardiaca.
    Language Spanish
    Publishing date 2018-02-15
    Publishing country Spain
    Document type Editorial
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rce.2018.01.002
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  2. Article ; Online: Acute mountain sickness. Is its prevalence overestimated?

    Soteras, Í / Ayala, M / Subirats, E / Trullàs, J C / Jiménez-Fàbrega, X

    Revista clinica espanola

    2022  

    Language English
    Publishing date 2022-05-13
    Publishing country Spain
    Document type Letter
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rceng.2022.02.005
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  3. Article ; Online: Prognostic impact of metformin in patients with type 2 diabetes mellitus and acute heart failure: Combined analysis of the EAHFE and RICA registries.

    Povar-Echeverría, M / Méndez-Bailón, M / Martín-Sánchez, F J / Montero-Pérez-Barquero, M / Trullàs, J C / Miró, Ò

    Revista clinica espanola

    2023  Volume 223, Issue 9, Page(s) 542–551

    Abstract: Introduction: Patients with diabetes mellitus (DM) and heart failure (HF) have a worse prognosis despite therapeutic advances in both diseases. Sodium-glucose co-transporter type 2 and GLP-1 receptor agonists have shown cardiovascular benefits and they ... ...

    Abstract Introduction: Patients with diabetes mellitus (DM) and heart failure (HF) have a worse prognosis despite therapeutic advances in both diseases. Sodium-glucose co-transporter type 2 and GLP-1 receptor agonists have shown cardiovascular benefits and they have been positioned as the first step in the treatment of DM in patients with HF or high cardiovascular risk. However, in the pivotal trials the majority of patients receive concomitant treatment with metformin. Randomized clinical trials have not yet been developed to assess the prognostic impact of metformin at the cardiovascular level. Our objective has been centered in analyzing whether patients with DM and acute HF who receive treatment with metformin at the time of discharge may have a better prognosis at one year of follow-up.
    Methods: Prospective cohort trial using the combined analysis of the two main Spanish HF registries, the EAHFE Registry (Epidemiology of Acute Heart Failure in Emergency Departments) and the RICA (National Registry of Patients with Heart Failure).
    Results: 33% (1453) of a total of 4403 patients with DM type 2 received treatment with metformin. This group presents significantly lower mortality after one year of treatment (22 versus 32%; Log Rank test P < 0.001). In the adjusted analysis of mortality, patients receiving treatment with metformin have lower mortality at one year of follow-up regardless of the rest of the variables (RR 0,814; 95%IC 0,712-0,930; P < 0.01).
    Conclusions: Patients with DM type 2 and acute HF who receive metformin have a better prognosis after one year of follow-up, so we believe that this drug should continue to be a fundamental pillar in the treatment of these patients.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Metformin/therapeutic use ; Prognosis ; Prospective Studies ; Heart Failure ; Registries ; Hypoglycemic Agents/therapeutic use
    Chemical Substances Metformin (9100L32L2N) ; Hypoglycemic Agents
    Language English
    Publishing date 2023-09-17
    Publishing country Spain
    Document type Journal Article
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rceng.2023.09.007
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  4. Article ; Online: Pseudofeocromocitoma (o cuando no encontramos el feocromocitoma).

    Trullàs, J C

    Revista clinica espanola

    2012  Volume 212, Issue 11, Page(s) e89–91

    Title translation Pseudopheochromocytoma (or when we do not find pheocromocytoma).
    MeSH term(s) Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/diagnosis ; Diagnosis, Differential ; Female ; Humans ; Hypertension/etiology ; Middle Aged ; Pheochromocytoma/complications ; Pheochromocytoma/diagnosis
    Language Spanish
    Publishing date 2012-12
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 123597-7
    ISSN 1578-1860 ; 0014-2565 ; 0014-2565
    ISSN (online) 1578-1860 ; 0014-2565
    ISSN 0014-2565
    DOI 10.1016/j.rce.2012.08.004
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 197: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Sex differences in clinical characteristics and outcomes in the CLOROTIC (combining loop with thiazide diuretics for decompensated heart failure) trial.

    Conde-Martel, A / Trullàs, J C / Morales-Rull, J L / Casado, J / Carrera-Izquierdo, M / Sánchez-Marteles, M / Llácer, P / Salamanca-Bautista, P / Manzano, L / Formiga, F

    Revista clinica espanola

    2024  Volume 224, Issue 2, Page(s) 67–76

    Abstract: Aims: The addition of hydrochlorothiazide (HCTZ) to furosemide improved the diuretic response in patients with acute heart failure (AHF) in the CLOROTIC trial. Our aim was to evaluate if there were differences in clinical characteristics and outcomes ... ...

    Abstract Aims: The addition of hydrochlorothiazide (HCTZ) to furosemide improved the diuretic response in patients with acute heart failure (AHF) in the CLOROTIC trial. Our aim was to evaluate if there were differences in clinical characteristics and outcomes according to sex.
    Methods: This is a post-hoc analysis of the CLOROTIC trial, including 230 patients with AHF randomized to receive HCTZ or placebo in addition to an intravenous furosemide regimen. The primary and secondary outcomes included changes in weight and patient-reported dyspnoea 72 and 96 h after randomization, metrics of diuretic response and mortality/rehospitalizations at 30 and 90 days. The influence of sex on primary, secondary and safety outcomes was evaluated.
    Results: One hundred and eleven (48%) women were included in the study. Women were older and had higher values of left ventricular ejection fraction. Men had more ischemic cardiomyopathy and chronic obstructive pulmonary disease and higher values of natriuretic peptides. The addition of HCTZ to furosemide was associated to a greatest weight loss at 72/96 h, better metrics of diuretic response and higher 24-h diuresis compared to placebo without significant differences according to sex (all p-values for interaction were not significant). Worsening renal function occurred more frequently in women (OR [95%CI]: 8.68 [3.41-24.63]) than men (OR [95%CI]: 2.5 [0.99-4.87]), p = 0.027. There were no differences in mortality or rehospitalizations at 30/90 days.
    Conclusion: Adding HCTZ to intravenous furosemide is an effective strategy to improve diuretic response in AHF with no difference according to sex, but worsening renal function was more frequent in women.
    Clinical trial registration: Clinicaltrials.gov: NCT01647932; EudraCT Number: 2013-001852-36.
    MeSH term(s) Female ; Humans ; Male ; Furosemide/therapeutic use ; Sodium Chloride Symporter Inhibitors/therapeutic use ; Stroke Volume ; Sex Characteristics ; Ventricular Function, Left ; Heart Failure/drug therapy ; Diuretics/therapeutic use ; Hydrochlorothiazide/therapeutic use
    Chemical Substances Furosemide (7LXU5N7ZO5) ; Sodium Chloride Symporter Inhibitors ; Diuretics ; Hydrochlorothiazide (0J48LPH2TH)
    Language English
    Publishing date 2024-01-11
    Publishing country Spain
    Document type Randomized Controlled Trial ; Journal Article
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rceng.2023.11.003
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  6. Article ; Online: COVID-19 en trabajadores sanitarios del Hospital comarcal de Olot (Girona).

    Trullàs, J C / Vilardell, I / Blasco, M / Heredia, J

    Revista clinica espanola

    2020  Volume 220, Issue 8, Page(s) 529–531

    Title translation COVID-19 in health workers from the Olot Regional Hospital (Girona).
    Language Spanish
    Publishing date 2020-07-17
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 123597-7
    ISSN 1578-1860 ; 0014-2565 ; 0014-2565
    ISSN (online) 1578-1860 ; 0014-2565
    ISSN 0014-2565
    DOI 10.1016/j.rce.2020.07.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: COVID-19 in health workers from the Olot Regional Hospital (Girona).

    Trullàs, J C / Vilardell, I / Blasco, M / Heredia, J

    Revista clinica espanola

    2020  Volume 220, Issue 8, Page(s) 529–531

    Title translation COVID-19 en trabajadores sanitarios del Hospital comarcal de Olot (Girona).
    Keywords covid19
    Language Spanish
    Publishing date 2020-07-17
    Publishing country Spain
    Document type Letter
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rce.2020.07.002
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  8. Article ; Online: Initiation, maintenance and withdrawal of disease-modifying treatment during an acute heart failure decompensation.

    Trullàs, J C / Formiga, F / Casado, J / González-Franco, A

    Revista clinica espanola

    2019  Volume 219, Issue 8, Page(s) 464–466

    Title translation Inicio, mantenimiento y retirada del tratamiento modificador de la enfermedad durante una descompensación por insuficiencia cardiaca aguda.
    Language Spanish
    Publishing date 2019-06-29
    Publishing country Spain
    Document type Letter
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rce.2019.05.009
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  9. Article ; Online: Replay to «About European guidelines for heart failure 2016».

    Trullàs, J C / González-Franco, Á

    Revista clinica espanola

    2017  Volume 218, Issue 3, Page(s) 157–158

    Title translation Réplica a «Acerca de las guías europeas de insuficiencia cardiaca de 2016».
    Language Spanish
    Publishing date 2017-12-15
    Publishing country Spain
    Document type Letter
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rce.2017.11.004
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  10. Article ; Online: Major developments in the 2016 european guidelines for heart failure.

    Trullàs, J C / González-Franco, Á

    Revista clinica espanola

    2017  Volume 217, Issue 7, Page(s) 405–409

    Abstract: The European Society of Cardiology has recently published new guidelines on the diagnosis and treatment of acute and chronic heart failure (HF). This article aims to review these recommendations and their level of scientific evidence and to present the ... ...

    Title translation Principales novedades de las guías europeas de insuficiencia cardiaca del 2016.
    Abstract The European Society of Cardiology has recently published new guidelines on the diagnosis and treatment of acute and chronic heart failure (HF). This article aims to review these recommendations and their level of scientific evidence and to present the most innovative aspects. The most significant deviations from the 2012 edition are: 1) the introduction of the concept of HF with midrange LVEF (40-49%); 2) a new diagnostic algorithm for chronic HF, initially considering the clinical probability; 3) recommendations on preventing or delaying the apparition of HF; 4) indications for the use of the new sacubitril-valsartan compound, the first angiotensin receptor blocker and neprilysin inhibitor; 5) modification of indications for cardiac resynchronisation therapy; and 6) a new algorithm for a combined diagnostic and treatment strategy for acute HF based on the presence or absence of congestion and hypoperfusion.
    Language Spanish
    Publishing date 2017-03-18
    Publishing country Spain
    Document type Journal Article
    ISSN 2254-8874
    ISSN (online) 2254-8874
    DOI 10.1016/j.rce.2017.01.010
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