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  1. Article ; Online: Complex genetics of Alport and Goodpasture syndromes.

    Tryggvason, Karl

    Nature reviews. Nephrology

    2021  Volume 17, Issue 10, Page(s) 635–636

    MeSH term(s) Anti-Glomerular Basement Membrane Disease/genetics ; Humans ; Mutation ; Nephritis, Hereditary/genetics
    Language English
    Publishing date 2021-10-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-021-00451-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Molecular Pathology and Genetics of Alport Syndrome

    Tryggvason, K.

    (Contributions to Nephrology ; Vol.117)

    1996  

    Series title Contributions to Nephrology ; Vol.117
    Keywords Genetics ; Nephrology ; Pathology ; Epidemiology ; Internal Medicine ; Molecular Biology ; Pediatrics ; Surgery ; Transplantation ; Urology
    Language English
    Size 1 Online-Ressource (VIII + 200 S.)
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    HBZ-ID HT019542640
    ISBN 978-3-318-03381-6 ; 3-318-03381-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Chemically defined and xenogeneic-free culture method for human epidermal keratinocytes on laminin-based matrices.

    Tjin, Monica Suryana / Chua, Alvin Wen Choong / Tryggvason, Karl

    Nature protocols

    2020  Volume 15, Issue 2, Page(s) 694–711

    Abstract: The basal keratinocyte progenitor cells in cultured epithelial autografts (CEAs) regenerate human epidermis after transplantation, a curative therapy for severe burns and, recently, diseases with epidermal loss, such as junctional epidermolysis bullosa ( ... ...

    Abstract The basal keratinocyte progenitor cells in cultured epithelial autografts (CEAs) regenerate human epidermis after transplantation, a curative therapy for severe burns and, recently, diseases with epidermal loss, such as junctional epidermolysis bullosa (EB). Although a culturing technique for skin keratinocytes was developed four decades ago, the xenogeneic nature of that conventional CEA culture system restricts its use to the treatment of critical and life-threatening cases, such as severe burns on >30% of total body surface area and EB. In the present protocol, we describe how to implement a defined, xeno-free culture system that supports long-term ex vivo expansion of functional human epidermal keratinocytes. Skin-specific basement membrane proteins called laminins play important roles in the maintenance of phenotypic integrity and in supporting the survival of keratinocytes that are adhered to them. This fully human keratinocyte culture system is 'regulatory friendly' and increases the potential of epithelial cellular therapy, which can be expanded to treat less severe burns and other skin defects, such as chronic diabetic wounds. It takes between 7 and 14 d to obtain an initial culture. Conservatively, a secondary culture from the primary culture can be expanded up to 20-fold within 4-5 d once cells reach confluency.
    MeSH term(s) 3T3 Cells ; Animals ; Basement Membrane/metabolism ; Cell Culture Techniques/methods ; Epidermis/metabolism ; Feeder Cells/cytology ; Humans ; Keratinocytes/cytology ; Keratinocytes/metabolism ; Laminin/metabolism ; Mice
    Chemical Substances Laminin
    Language English
    Publishing date 2020-01-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/s41596-019-0270-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Nephrin: role in normal kidney and in disease.

    Tryggvason, K

    Advances in nephrology from the Necker Hospital

    2001  Volume 31, Page(s) 221–234

    MeSH term(s) Humans ; Kidney/physiology ; Kidney/physiopathology ; Kidney Diseases/genetics ; Kidney Diseases/physiopathology ; Membrane Proteins ; Proteins/genetics ; Proteins/metabolism
    Chemical Substances Membrane Proteins ; Proteins ; nephrin
    Language English
    Publishing date 2001
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 121702-1
    ISSN 0084-5957
    ISSN 0084-5957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm.

    Tryggvason, K

    Journal of the American Society of Nephrology : JASN

    1999  Volume 10, Issue 11, Page(s) 2440–2445

    MeSH term(s) Animals ; Humans ; Kidney Glomerulus/physiology ; Membrane Proteins ; Nephrotic Syndrome/congenital ; Nephrotic Syndrome/genetics ; Proteins/chemistry ; Proteins/genetics ; Proteins/physiology ; Ultrafiltration
    Chemical Substances Membrane Proteins ; Proteins ; nephrin
    Language English
    Publishing date 1999-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.V10112440
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  6. Article: Mutations in type IV collagen genes and Alport phenotypes.

    Tryggvason, K

    Contributions to nephrology

    1996  Volume 117, Page(s) 154–171

    MeSH term(s) Amino Acid Sequence ; Animals ; Basement Membrane/metabolism ; Basement Membrane/ultrastructure ; Collagen/genetics ; Collagen/metabolism ; Humans ; Kidney Glomerulus/metabolism ; Kidney Glomerulus/ultrastructure ; Microscopy, Electron ; Molecular Sequence Data ; Mutation/genetics ; Nephritis, Hereditary/genetics ; Nephritis, Hereditary/metabolism ; Nephritis, Hereditary/pathology ; Phenotype
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 1996
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 0302-5144
    ISSN 0302-5144
    DOI 10.1159/000424812
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article ; Online: Skin mesenchymal niches maintain and protect AML-initiating stem cells.

    Sandhow, Lakshmi / Cai, Huan / Leonard, Elory / Xiao, Pingnan / Tomaipitinca, Luana / Månsson, Alma / Kondo, Makoto / Sun, Xiaoyan / Johansson, Anne-Sofie / Tryggvason, Karl / Kasper, Maria / Järås, Marcus / Qian, Hong

    The Journal of experimental medicine

    2023  Volume 220, Issue 10

    Abstract: Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report ... ...

    Abstract Leukemia cutis or leukemic cell infiltration in skin is one of the common extramedullary manifestations of acute myeloid leukemia (AML) and signifies a poorer prognosis. However, its pathogenesis and maintenance remain understudied. Here, we report massive AML cell infiltration in the skin in a transplantation-induced MLL-AF9 AML mouse model. These AML cells could regenerate AML after transplantation. Prospective niche characterization revealed that skin harbored mesenchymal progenitor cells (MPCs) with a similar phenotype as BM mesenchymal stem cells. These skin MPCs protected AML-initiating stem cells (LSCs) from chemotherapy in vitro partially via mitochondrial transfer. Furthermore, Lama4 deletion in skin MPCs promoted AML LSC proliferation and chemoresistance. Importantly, more chemoresistant AML LSCs appeared to be retained in Lama4-/- mouse skin after cytarabine treatment. Our study reveals the characteristics and previously unrecognized roles of skin mesenchymal niches in maintaining and protecting AML LSCs during chemotherapy, meriting future exploration of their impact on AML relapse.
    MeSH term(s) Animals ; Mice ; Prospective Studies ; Stem Cells ; Skin ; Leukemia, Myeloid, Acute ; Mesenchymal Stem Cells
    Language English
    Publishing date 2023-07-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20220953
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  8. Article: Molecular properties and diseases of collagens.

    Tryggvason, K

    Kidney international. Supplement

    1995  Volume 49, Page(s) S24–8

    MeSH term(s) Basement Membrane/metabolism ; Collagen/chemistry ; Collagen/genetics ; Collagen/metabolism ; Collagen/physiology ; Collagen Diseases ; Genes ; Humans
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 1995-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 193442-9
    ISSN 2157-1716 ; 0098-6577 ; 2157-1724
    ISSN (online) 2157-1716
    ISSN 0098-6577 ; 2157-1724
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  9. Article: The laminin family.

    Tryggvason, K

    Current opinion in cell biology

    1993  Volume 5, Issue 5, Page(s) 877–882

    Abstract: During the preceding year significant progress has been made in our understanding of laminin structure and expression. Highlights include the identification of new subunit chains and molecular isoforms as well as new information on tissue-specific gene ... ...

    Abstract During the preceding year significant progress has been made in our understanding of laminin structure and expression. Highlights include the identification of new subunit chains and molecular isoforms as well as new information on tissue-specific gene expression, laminin self-assembly and interactions with other matrix components.
    MeSH term(s) Animals ; Basement Membrane/physiology ; Genetic Variation ; Humans ; Laminin/chemistry ; Laminin/metabolism ; Laminin/physiology ; Models, Structural
    Chemical Substances Laminin
    Language English
    Publishing date 1993-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/0955-0674(93)90038-r
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  10. Article: Biochemistry and genetic diseases of glomerular basement membrane.

    Tryggvason, K

    Seminars in nephrology

    1993  Volume 13, Issue 5, Page(s) 447–456

    MeSH term(s) Basement Membrane ; Humans ; Kidney Glomerulus ; Nephritis, Hereditary ; Nephrotic Syndrome/congenital ; Research/trends
    Language English
    Publishing date 1993-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
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