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Article ; Online: Platycodi radix aqueous extract salvages doxorubicin-induced senescence by mitochondrial reactive oxygen species reduction in umbilical cord matrix stem cells.

Lee, Pei-Ying / Sitorus, Maria Angelina / Kuo, Chia-Hua / Tsai, Bruce Chi-Kang / Kuo, Wei-Wen / Lin, Kuan-Ho / Lu, Shang-Yeh / Lin, Yueh-Min / Ho, Tsung-Jung / Huang, Chih-Yang

Environmental toxicology

2024

Abstract: Platycodi radix is a widely used herbal medicine that contains numerous phytochemicals beneficial to health. The health and biological benefits of P. radix have been found across various diseases. The utilization of umbilical cord stromal stem cells, ... ...

Abstract	Platycodi radix is a widely used herbal medicine that contains numerous phytochemicals beneficial to health. The health and biological benefits of P. radix have been found across various diseases. The utilization of umbilical cord stromal stem cells, derived from Wharton's jelly of the human umbilical cord, has emerged as a promising approach for treating degenerative diseases. Nevertheless, growing evidence indicates that the function of stem cells declines with age, thereby limiting their regenerative capacity. The primary objective in this study is to investigate the beneficial effects of P. radix in senescent stem cells. We conducted experiments to showcase that diminished levels of Lamin B1 and Sox-2, along with an elevation in p21, which serve as indicative markers for the senescent stem cells. Our findings revealed the loss of Lamin B1 and Sox-2, coupled with an increase in p21, in umbilical cord stromal stem cells subjected to a low-dose (0.1 μM) doxorubicin (Dox) stimulation. However, P. radix restored the Dox-damage in the umbilical cord stromal stem cells. P. radix reversed the senescent conditions when the umbilical cord stromal stem cells exposed to Dox-induced reactive oxygen species (ROS) and mitochondrial membrane potential are significantly changed. In Dox-challenged aged umbilical cord stromal stem cells, P. radix reduced senescence, increased longevity, prevented mitochondrial dysfunction and ROS and protected against senescence-associated apoptosis. This study suggests that P. radix might be as a therapeutic and rescue agent for the aging effect in stem cells. Inhibition of cell death, mitochondrial dysfunction and aging-associated ROS with P. radix provides additional insights into the underlying molecular mechanisms.
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24240
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Article: Novel chromium (III)-based compound for inhibition of oxaliplatin-resistant colorectal cancer progression.

Chen, Ming-Cheng / Devi, Hema Sri / Pien, Hsueh-Fa / Wen, Shina Fong-Mei / Sheu, Jenn-Line / Tsai, Bruce Chi-Kang / Huang, Chih-Yang / Lin, Yu-Jung

American journal of cancer research

2024 Volume 14, Issue 3, Page(s) 979–995

Abstract: Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality worldwide. The current standard of care includes systemic chemotherapy with cytotoxic agents, offering palliative relief for severe CRC cases and serving as the primary ... ...

Abstract	Colorectal cancer (CRC) ranks as the third leading cause of cancer-related mortality worldwide. The current standard of care includes systemic chemotherapy with cytotoxic agents, offering palliative relief for severe CRC cases and serving as the primary therapy for metastatic recurrence. However, the development of chemoresistance poses a substantial obstacle in the realm of chemotherapy. This study delved into the potential of a novel chromium (III)-based compound, hexaacetotetraaquadihydroxochromium (III) diiron (III) nitrate, for CRC treatment. The therapeutic promise of this innovative chromium (III)-based compound was explored by utilizing LoVo colon cancer cells and an
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2589522-9
ISSN	2156-6976
ISSN	2156-6976
DOI	10.62347/XTRT2780
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Article ; Online: Ligustrazine improves the compensative effect of Akt survival signaling to protect liver Kupffer cells in trauma-hemorrhagic shock rats.

Chen, Ray-Jade / Chen, Ming-Cheng / Tsai, Bruce Chi-Kang / Roy, Rakesh / Chang, Yi-Ru / Wang, Tso-Fu / Kuo, Wei-Wen / Kuo, Chia-Hua / Yao, Chun-Hsu / Li, Chi-Cheng / Huang, Chih-Yang

Chemical biology & drug design

2023 Volume 102, Issue 6, Page(s) 1399–1408

Abstract: Trauma-hemorrhagic shock (THS) is a medical emergency that is encountered by physicians in the emergency department. Chuan Xiong is a traditional Chinese medicine and ligustrazine is a natural compound from it. Ligustrazine improves coronary blood flow ... ...

Abstract	Trauma-hemorrhagic shock (THS) is a medical emergency that is encountered by physicians in the emergency department. Chuan Xiong is a traditional Chinese medicine and ligustrazine is a natural compound from it. Ligustrazine improves coronary blood flow and reduces cardiac ischemia in animals through Ca
MeSH term(s)	Rats ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Shock, Hemorrhagic/drug therapy ; Kupffer Cells/metabolism ; Liver/metabolism ; Inflammation/drug therapy
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; tetramethylpyrazine (V80F4IA5XG)
Language	English
Publishing date	2023-08-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2216600-2
ISSN	1747-0285 ; 1747-0277
ISSN (online)	1747-0285
ISSN	1747-0277
DOI	10.1111/cbdd.14327
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Article ; Online: Cardiac-specific overexpression of insulin-like growth factor II receptor-α interferes with the regulation of calcium homeostasis in the heart under hyperglycemic conditions.

Lu, Shang-Yeh / Tsai, Bruce Chi-Kang / Van Thao, Dao / Lai, Chin-Hu / Chen, Michael Yu-Chih / Kuo, Wei-Wen / Kuo, Chia-Hua / Lin, Kuan-Ho / Hsieh, Dennis Jine-Yuan / Huang, Chih-Yang

Molecular biology reports

2023 Volume 50, Issue 5, Page(s) 4329–4338

Abstract: Background: Diabetic cardiomyopathy is a progressive disease caused by inexplicit mechanisms, and a novel factor, insulin-like growth factor II receptor-α (IGF-IIRα), may contribute to aggravating its pathogenesis. We hypothesized that IGF-IIRα could ... ...

Abstract	Background: Diabetic cardiomyopathy is a progressive disease caused by inexplicit mechanisms, and a novel factor, insulin-like growth factor II receptor-α (IGF-IIRα), may contribute to aggravating its pathogenesis. We hypothesized that IGF-IIRα could intensify diabetic heart injury. Methods and results: To demonstrate the potential role of IGF-IIRα in the diabetic heart, we used (SD-TG [IGF-IIRα]) transgenic rat model with cardiac-specific overexpression of IGF-IIRα, along with H9c2 cells, to study the effects of IGF-IIRα in the heart under hyperglycemic conditions. IGF-IIRα was found to remodel calcium homeostasis and intracellular Ca Conclusions: Our study reveals the novel role of IGF-IIRα in regulating cardiac intracellular Ca
MeSH term(s)	Rats ; Animals ; Calcium/metabolism ; Insulin-Like Growth Factor II ; Diabetic Cardiomyopathies ; Heart ; Calcium-Binding Proteins/metabolism ; Rats, Transgenic ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/genetics ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/pharmacology ; Homeostasis ; Myocytes, Cardiac/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Insulin-Like Growth Factor II (67763-97-7) ; Calcium-Binding Proteins ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8)
Language	English
Publishing date	2023-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08327-2
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Zs.A 1140: Show issues

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Article ; Online: Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage.

Hsieh, Dennis Jine-Yuan / Tsai, Bruce Chi-Kang / Barik, Parthasarathi / Shibu, Marthandam Asokan / Kuo, Chia-Hua / Kuo, Wei-Wen / Lin, Pi-Yu / Shih, Cheng-Yen / Lin, Shinn-Zong / Ho, Tsung-Jung / Huang, Chih-Yang

Aging

2023 Volume 15, Issue 17, Page(s) 9167–9181

Abstract: Pathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a ... ...

Abstract	Pathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a promising approach for protection against doxorubicin (Dox)-induced cardiac hypertrophy. Herein, we investigated whether human adipose-derived stem cells (hADSCs) preconditioned with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin-induced cardiac damage. The effect of JS on hADSC viability and migration capacity was determined via MTT and migration assays, respectively. Co-culture of hADSC or JS-preconditioned hADSCs with H9c2 cells was analyzed with immunoblot, flow cytometry, TUNEL staining, LC3B staining, F-actin staining, and MitoSOX staining. The
MeSH term(s)	Humans ; Animals ; Rats ; Rats, Sprague-Dawley ; Heart ; Stem Cells ; Doxorubicin/toxicity ; Cardiomegaly
Chemical Substances	Doxorubicin (80168379AG)
Language	English
Publishing date	2023-09-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205026
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Article: Development and evaluation of a novel chromium III-based compound for potential inhibition of emerging SARS-CoV-2 variants.

Lin, Yu-Jung / Sundhar, Navaneethan / Devi, Hema Sri / Pien, Hsueh-Fa / Wen, Shina Fong-Mei / Sheu, Jenn-Line / Tsai, Bruce Chi-Kang / Huang, Chih-Yang

Heliyon

2023 Volume 9, Issue 9, Page(s) e20011

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused 403 million cases of coronavirus disease (COVID-19) and resulted in more than 5.7 million deaths worldwide. Extensive research has identified several potential drug treatments for ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused 403 million cases of coronavirus disease (COVID-19) and resulted in more than 5.7 million deaths worldwide. Extensive research has identified several potential drug treatments for COVID-19. However, the development of new compounds or therapies is necessary to prevent the emergence of drug resistance in SARS-CoV-2. In this study, a novel compound based on hexaacetotetraaquadihydroxochromium(III)diiron(III) nitrate, which contains small amounts of chromium (III), was synthesised and evaluated for its effectiveness against multiple variants of COVID-19 using both
Language	English
Publishing date	2023-09-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e20011
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Article ; Online: Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways.

Ju, Da-Tong / Huang, Rwei-Fen S / Tsai, Bruce Chi-Kang / Su, Yi-Chen / Chiu, Ping-Ling / Chang, Yung-Ming / Padma, V Vijaya / Ho, Tsung-Jung / Yao, Chun-Hsu / Kuo, Wei-Wen / Huang, Chih-Yang

Neurotoxicity research

2023 Volume 41, Issue 6, Page(s) 648–659

Abstract: Patients with Alzheimer's disease have increased risk of developing heart disease, which therefore highlights the need for strategies aiming at reducing Alzheimer's disease-related cardiovascular disease. Folic acid and folinic acid are beneficial to the ...

Abstract	Patients with Alzheimer's disease have increased risk of developing heart disease, which therefore highlights the need for strategies aiming at reducing Alzheimer's disease-related cardiovascular disease. Folic acid and folinic acid are beneficial to the heart. We aimed to investigate the benefits of folic acid and folinic acid in heart of patients with late-stage Alzheimer's disease. Twelve 16-month-old mice of triple-transgenic late-stage Alzheimer's disease were divided into three groups: Alzheimer's disease group, Alzheimer's disease + folic acid group, and Alzheimer's disease + folinic acid group. The mice were administered 12 mg/kg folic acid or folinic acid once daily via oral gavage for 3 months. In the folic acid and folinic acid treatment groups, the intercellular space was reduced, compared with the Alzheimer's disease group. TUNEL assay and western blot images showed that the number of apoptotic cells and the apoptosis-related protein expression were higher in the Alzheimer's disease group than in other two treated groups. Folic acid and folinic acid induced the IGF1R/PI3K/AKT and SIRT1/ AMPK pathways in the hearts of mice with Alzheimer's disease. Our results showed that folic acid and folinic acid treatment increased survival and SIRT1 expression to reduce apoptotic proteins in the heart. The aging mice treated with folinic acid had more IGF1R and SIRT1/AMPK axes to limit myocardial cell apoptosis. In conclusion, folic acid and folinic acid promote cardiac cell survival and prevent apoptosis to inhibit heart damage in aging mice with triple-transgenic late-stage Alzheimer's disease. In particular, folinic acid provides a better curative effect than folic acid.
MeSH term(s)	Humans ; Mice ; Animals ; Folic Acid/pharmacology ; Folic Acid/therapeutic use ; Leucovorin/pharmacology ; Leucovorin/therapeutic use ; AMP-Activated Protein Kinases ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Mice, Transgenic ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Sirtuin 1 ; Aging ; Receptor, IGF Type 1
Chemical Substances	Folic Acid (935E97BOY8) ; Leucovorin (Q573I9DVLP) ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Sirtuin 1 (EC 3.5.1.-) ; SIRT1 protein, human (EC 3.5.1.-) ; IGF1R protein, human ; Receptor, IGF Type 1 (EC 2.7.10.1)
Language	English
Publishing date	2023-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2036826-4
ISSN	1476-3524 ; 1029-8428
ISSN (online)	1476-3524
ISSN	1029-8428
DOI	10.1007/s12640-023-00666-z
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Zs.A 5749: Show issues

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Article ; Online: Diosgenin Attenuates Myocardial Cell Apoptosis Triggered by Oxidative Stress through Estrogen Receptor to Activate the PI3K/Akt and ERK Axes.

Chen, Michael Yu-Chih / Tsai, Bruce Chi-Kang / Kuo, Wei-Wen / Kuo, Chia-Hua / Lin, Yueh-Min / Hsieh, Dennis Jine-Yuan / Pai, Pei-Ying / Liao, Shih-Chieh / Huang, Shang-En / Lee, Shin-Da / Huang, Chih-Yang

The American journal of Chinese medicine

2023 Volume 51, Issue 5, Page(s) 1211–1232

Abstract: Cardiovascular diseases in post-menopausal women are on a rise. Oxidative stress is the main contributing factor to the etiology and pathogenesis of cardiovascular diseases. Diosgenin, a member of steroidal sapogenin, is structurally similar to estrogen ... ...

Abstract	Cardiovascular diseases in post-menopausal women are on a rise. Oxidative stress is the main contributing factor to the etiology and pathogenesis of cardiovascular diseases. Diosgenin, a member of steroidal sapogenin, is structurally similar to estrogen and has been shown to have antioxidant effects. Therefore, we aimed to investigate the effects of diosgenin in preventing oxidation-induced cardiomyocyte apoptosis and assessed its potential as a substitute substance for estrogen in post-menopausal women. Apoptotic pathways and mitochondrial membrane potential were measured in H9c2 cardiomyoblast cells and neonatal cardiomyocytes treated with diosgenin for 1[Formula: see text]h prior to hydrogen peroxide (H
MeSH term(s)	Infant, Newborn ; Female ; Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Estrogen/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Hydrogen Peroxide/toxicity ; Diosgenin/pharmacology ; Cardiovascular Diseases ; Oxidative Stress ; Apoptosis ; Estrogens/metabolism ; Estrogens/pharmacology ; Myocytes, Cardiac/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, Estrogen ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Hydrogen Peroxide (BBX060AN9V) ; Diosgenin (K49P2K8WLX) ; Estrogens
Language	English
Publishing date	2023-06-17
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	193085-0
ISSN	1793-6853 ; 0090-2942 ; 0192-415X
ISSN (online)	1793-6853
ISSN	0090-2942 ; 0192-415X
DOI	10.1142/S0192415X23500556
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Zs.A 1110: Show issues

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Article ; Online: Ohwia caudata aqueous extract attenuates doxorubicin-induced mitochondrial dysfunction in Wharton's jelly-derived mesenchymal stem cells.

Lee, Pei-Ying / Tsai, Bruce Chi-Kang / Sitorus, Maria Angelina / Lin, Pi-Yu / Lin, Shinn-Zong / Shih, Cheng-Yen / Lu, Shang-Yeh / Lin, Yueh-Min / Ho, Tsung-Jung / Huang, Chih-Yang

Environmental toxicology

2023 Volume 38, Issue 10, Page(s) 2450–2461

Abstract: Mitochondrial dysfunction has been linked to many diseases, including organ degeneration and cancer. Wharton's jelly-derived mesenchymal stem cells provide a valuable source for stem cell-based therapy and represent an emerging therapeutic approach for ... ...

Abstract	Mitochondrial dysfunction has been linked to many diseases, including organ degeneration and cancer. Wharton's jelly-derived mesenchymal stem cells provide a valuable source for stem cell-based therapy and represent an emerging therapeutic approach for tissue regeneration. This study focused on screening the senomorphic properties of Ohwia caudata aqueous extract as an emerging strategy for preventing or treating mitochondrial dysfunction in stem cells. Wharton's jelly-derived mesenchymal stem cells were incubated with 0.1 μM doxorubicin, for 24 h to induce mitochondrial dysfunction. Next, the cells were treated with a series concentration of Ohwia caudata aqueous extract (25, 50, 100, and 200 μg/mL) for another 24 h. In addition, an untreated control group and a doxorubicin-induced mitochondrial dysfunction positive control group were maintained under the same conditions. Our data showed that Ohwia caudata aqueous extract markedly suppressed doxorubicin-induced mitochondrial dysfunction by increasing Tid1 and Tom20 expression, decreased reactive oxygen species production, and maintained mitochondrial membrane potential to promote mitochondrial stability. Ohwia caudata aqueous extract retained the stemness of Wharton's jelly-derived mesenchymal stem cells and reduced the apoptotic rate. These results indicate that Ohwia caudata aqueous extract protects Wharton's jelly-derived mesenchymal stem cells against doxorubicin-induced mitochondrial dysfunction and can potentially prevent mitochondrial dysfunction in other cells. This study provides new directions for the medical application of Ohwia caudata.
MeSH term(s)	Animals ; Wharton Jelly/metabolism ; Mesenchymal Stem Cells/metabolism ; Doxorubicin/toxicity ; Cells, Cultured ; Mitochondria/metabolism ; Urodela ; Cell Differentiation
Chemical Substances	Doxorubicin (80168379AG)
Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.23880
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Article ; Online: Anethole mitigates H

Huang, Tai-Lung / Chang, Yu-Chun / Tsai, Bruce Chi-Kang / Chen, Tung-Sheng / Kao, Shih-Wen / Tsai, Yung-Yun / Lin, Shinn-Zong / Yao, Chun-Hsu / Lin, Kuan-Ho / Kuo, Wei-Wen / Huang, Chih-Yang

Environmental toxicology

2023 Volume 39, Issue 2, Page(s) 965–978

Abstract: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting approximately 1% of the global population, with a higher prevalence in women than in men. Chronic inflammation and oxidative stress play pivotal roles in the pathogenesis of RA. ... ...

Abstract	Rheumatoid arthritis (RA) is an autoimmune inflammatory disease affecting approximately 1% of the global population, with a higher prevalence in women than in men. Chronic inflammation and oxidative stress play pivotal roles in the pathogenesis of RA. Anethole, a prominent compound derived from fennel (Foeniculum vulgare), possesses a spectrum of therapeutic properties, including anti-arthritic, anti-inflammatory, antioxidant, and tumor-suppressive effects. However, its specific impact on RA remains underexplored. This study sought to uncover the potential therapeutic value of anethole in treating RA by employing an H
MeSH term(s)	Male ; Humans ; Female ; Synoviocytes/metabolism ; Aquaporin 1 ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Inflammation/pathology ; Arthritis, Rheumatoid/metabolism ; Fibroblasts/metabolism ; Cells, Cultured ; Cell Proliferation
Chemical Substances	anethole (Q3JEK5DO4K) ; Aquaporin 1 (146410-94-8) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11)
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1463449-1
ISSN	1522-7278 ; 1520-4081
ISSN (online)	1522-7278
ISSN	1520-4081
DOI	10.1002/tox.24023
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