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Article ; Online: Effects of carnosic acid on mitochondrial biogenesis and insulin sensitivity in 3T3-L1 adipocytes are through induction of PGC-1α and ubiquitination of PARIS by parkin

Lin, Chia-Yuan / Cheng, Yun-Hsin / Lai, Chiao-Ni / Tsai, Chia-Wen

Journal of Functional Foods. 2023, p.105717-

2023 , Page(s) 105717–

Abstract: The PGC-1α plays a vital role in regulating mitochondrial biogenesis and insulin sensitivity. This study investigated the role of PGC-1α in preventing the effects of carnosic acid (CA) against TNF-α-suppressed mitochondrial biogenesis and insulin ... ...

Abstract	The PGC-1α plays a vital role in regulating mitochondrial biogenesis and insulin sensitivity. This study investigated the role of PGC-1α in preventing the effects of carnosic acid (CA) against TNF-α-suppressed mitochondrial biogenesis and insulin signaling. Exposure of 3T3-L1 adipocytes to TNF-α decreased the proteins of PGC-1α and nuclear respiratory factor 1 (NRF1). However, pretreatment with CA improved this change. Additionally, CA led to increases in parkin protein and decreases in PARIS protein. Using immunoprecipitation assay, the protein interaction between PARIS and ubiquitin was increased and that between PARIS and parkin was decreased after CA treatment. Parkin siRNA blocked the effects of CA on PARIS, PGC-1α, and NRF1 proteins. PGC-1α siRNA abolished the capacity of CA to reverse the TNF-α-inhibited insulin signaling and membrane GLUT4 protein translocation. Therefore, CA attenuates the TNF-α induced impairment of mitochondrial biogenesis and glucose uptake through activation of PGC-1α via ubiquitination of PARIS by parkin.
Keywords	adipocytes ; biogenesis ; glucose ; insulin ; insulin resistance ; mitochondria ; precipitin tests ; protein transport ; ubiquitin ; ubiquitination ; CA ; DMEM ; DM ; DMSO ; GAPDH ; GLUT4 ; IP ; IRS ; IRS-1 ; NTC ; PARIS ; PGC-1α ; NRF1/2 ; siRNA ; TFAM ; TNF-α ; Carnosic acid ; Parkin ; 3T3-L1 adipocytes
Language	English
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	2511964-3
ISSN	1756-4646
ISSN	1756-4646
DOI	10.1016/j.jff.2023.105717
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: PINK1/parkin-mediated mitophagy pathway is related to neuroprotection by carnosic acid in SH-SY5Y cells.

Lin, Chia-Yuan / Tsai, Chia-Wen

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2019 Volume 125, Page(s) 430–437

Abstract: Impairment in mitophagy contributes to the pathology of Parkinson's disease. This study investigated whether Phosphatase and tensin homologue (PTEN)-induced kinase 1 (PINK1)/parkin-mediated mitophagy is linked to the protective effect of carnosic acid ( ... ...

Abstract	Impairment in mitophagy contributes to the pathology of Parkinson's disease. This study investigated whether Phosphatase and tensin homologue (PTEN)-induced kinase 1 (PINK1)/parkin-mediated mitophagy is linked to the protective effect of carnosic acid (CA) from rosemary. Treatment of SH-SY5Y cells with 6-hydroxydopamine (6-OHDA) disrupted the mitochondrial membrane potential, inhibited voltage-dependent anion channel 1 (VDAC1) protein, and induced cytosolic cytochrome c, but CA pretreatment reversed these findings. By immunofluorescence, CA pretreatment was shown to increase the co-localization of red fluorescence (parkin) and MitoTracker green FM fluorescence (mitochondria), indicating that CA promoted the translocation of parkin into mitochondria. Immunoprecipitation with VDAC1 antibody showed that 6-OHDA treatment decreased the interaction of ubiquitinated protein with VDAC1. However, CA pretreatment reversed this reduction in the interaction of ubiquitinated protein with VDAC1. Silencing of PINK1 and parkin by use of small interfering RNA (siRNA) attenuated the ability of CA to reverse 6-OHDA-inhibited autophagic vacuoles. Moreover, in PINK1 siRNA-transfected cells, CA no longer reversed these actions of 6-OHDA on the inhibition of mitophagy-related proteins (PINK1, parkin, VDAC1, and LC3-II) and anti-apoptotic Bcl-2 protein, as well as the induction of apoptotic-related proteins, and nuclear condensation. In conclusion, CA appears to counteract the neurotoxicity of 6-OHDA by activating PINK1/parkin-mediated mitophagy.
MeSH term(s)	Cell Line, Tumor ; Cytochromes c/metabolism ; Diterpenes, Abietane/pharmacology ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Mitochondria/drug effects ; Mitochondrial Degradation/drug effects ; Mitochondrial Diseases/chemically induced ; Mitochondrial Diseases/prevention & control ; Neuroprotective Agents/pharmacology ; Oxidopamine ; Protein Kinases/genetics ; Protein Kinases/metabolism ; RNA, Small Interfering/genetics ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Voltage-Dependent Anion Channel 1/metabolism
Chemical Substances	Diterpenes, Abietane ; Neuroprotective Agents ; RNA, Small Interfering ; VDAC1 protein, human ; Oxidopamine (8HW4YBZ748) ; Cytochromes c (9007-43-6) ; Voltage-Dependent Anion Channel 1 (EC 1.6.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; parkin protein (EC 2.3.2.27) ; Protein Kinases (EC 2.7.-) ; PTEN-induced putative kinase (EC 2.7.11.1) ; salvin (LI791SXT24)
Language	English
Publishing date	2019-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2019.01.027
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Article ; Online: Genetic susceptibility to prostate cancer in Taiwan: A genome-wide association study.

Bau, Da-Tian / Tsai, Chia-Wen / Chang, Wen-Shin / Yang, Jai-Sing / Liu, Ting-Yuan / Lu, Hsing-Fang / Wang, Yu-Wen / Tsai, Fuu-Jen

Molecular carcinogenesis

2024 Volume 63, Issue 4, Page(s) 617–628

Abstract: We conducted the first genome-wide association study (GWAS) of prostate cancer (PCa) in Taiwan with 1844 cases and 80,709 controls. Thirteen independent single-nucleotide polymorphisms (SNPs) reached genome-wide significance (p < 5 × ... ...

Abstract	We conducted the first genome-wide association study (GWAS) of prostate cancer (PCa) in Taiwan with 1844 cases and 80,709 controls. Thirteen independent single-nucleotide polymorphisms (SNPs) reached genome-wide significance (p < 5 × 10
MeSH term(s)	Male ; Humans ; Genome-Wide Association Study ; Genotype ; RNA, Long Noncoding/genetics ; Taiwan/epidemiology ; Genetic Predisposition to Disease ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/genetics ; Genetic Risk Score ; Polymorphism, Single Nucleotide ; Microfilament Proteins
Chemical Substances	RNA, Long Noncoding ; CORO2B protein, human ; Microfilament Proteins
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1004029-8
ISSN	1098-2744 ; 0899-1987
ISSN (online)	1098-2744
ISSN	0899-1987
DOI	10.1002/mc.23676
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Article ; Online: Therapeutic Potential and Mechanisms of Novel Simple O-Substituted Isoflavones against Cerebral Ischemia Reperfusion.

Yang, Shu-Er / Lien, Jin-Cherng / Tsai, Chia-Wen / Wu, Chi-Rei

International journal of molecular sciences

2022 Volume 23, Issue 18

Abstract: Isoflavones have been widely studied and have attracted extensive attention in fields ranging from chemotaxonomy and plant physiology to human nutrition and medicine. Isoflavones are often divided into three subgroups: simple O-substituted derivatives, ... ...

Abstract	Isoflavones have been widely studied and have attracted extensive attention in fields ranging from chemotaxonomy and plant physiology to human nutrition and medicine. Isoflavones are often divided into three subgroups: simple O-substituted derivatives, prenylated derivatives, and glycosides. Simple O-substituted isoflavones and their glycosides, such as daidzein (daidzin), genistein (genistin), glycitein (glycitin), biochanin A (astroside), and formononetin (ononin), are the most common ingredients in legumes and are considered as phytoestrogens for daily dietary hormone replacement therapy due to their structural similarity to 17-β-estradiol. On the basis of the known estrogen-like potency, these above isoflavones possess multiple pharmacological activities such as antioxidant, anti-inflammatory, anticancer, anti-angiogenetic, hepatoprotective, antidiabetic, antilipidemic, anti-osteoporotic, and neuroprotective activities. However, there are very few review studies on the protective effects of these novel isoflavones and their related compounds in cerebral ischemia reperfusion. This review primarily focuses on the biosynthesis, metabolism, and neuroprotective mechanism of these aforementioned novel isoflavones in cerebral ischemia reperfusion. From these published works in in vitro and in vivo studies, simple O-substituted isoflavones could serve as promising therapeutic compounds for the prevention and treatment of cerebral ischemia reperfusion via their estrogenic receptor properties and neuron-modulatory, antioxidant, anti-inflammatory, and anti-apoptotic effects. The detailed mechanism of the protective effects of simple O-substituted isoflavones against cerebral ischemia reperfusion might be related to the PI3K/AKT/ERK/mTOR or GSK-3β pathway, eNOS/Keap1/Nrf-2/HO-1 pathway, TLRs/TIRAP/MyD88/NFκ-B pathway, and Bcl-2-regulated anti-apoptotic pathway. However, clinical trials are needed to verify their potential on cerebral ischemia reperfusion because past studies were conducted with rodents and prophylactic administration.
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Brain Ischemia/drug therapy ; Estradiol ; Estrogens ; Genistein/pharmacology ; Glycogen Synthase Kinase 3 beta/metabolism ; Humans ; Hypoglycemic Agents ; Isoflavones/metabolism ; Isoflavones/pharmacology ; Isoflavones/therapeutic use ; Kelch-Like ECH-Associated Protein 1/metabolism ; Myeloid Differentiation Factor 88/metabolism ; NF-E2-Related Factor 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phytoestrogens/pharmacology ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Reperfusion ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants ; Estrogens ; Hypoglycemic Agents ; Isoflavones ; Kelch-Like ECH-Associated Protein 1 ; Myeloid Differentiation Factor 88 ; NF-E2-Related Factor 2 ; Phytoestrogens ; Proto-Oncogene Proteins c-bcl-2 ; Estradiol (4TI98Z838E) ; Genistein (DH2M523P0H) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms231810394
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Article ; Online: Carnosic acid protects SH-SY5Y cells against 6-hydroxydopamine-induced cell death through upregulation of parkin pathway.

Lin, Chia-Yuan / Tsai, Chia-Wen / Tsai, Chia-Wen

Neuropharmacology

2016 Volume 110, Issue Pt A, Page(s) 109–117

Abstract: Parkin is a Parkinson's disease (PD)-linked gene that plays an important role in the ubiquitin-proteasome system (UPS). This study explored whether carnosic acid (CA) from rosemary protects against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity via ... ...

Abstract	Parkin is a Parkinson's disease (PD)-linked gene that plays an important role in the ubiquitin-proteasome system (UPS). This study explored whether carnosic acid (CA) from rosemary protects against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity via upregulation of parkin in vivo and in vitro. We found that the reduction in proteasomal activity by 6-OHDA was attenuated in SH-SY5Y cells pretreated with 1 μM CA. Immunoblots showed that CA reversed the induction of ubiquitinated protein and the reduction of PTEN-induced putative kinase 1 (PINK1) and parkin protein in 6-OHDA-treated SH-SY5Y cells and rats. Moreover, in a transgenic OW13 Caenorhabditis elegans model of PD that expresses human α-synuclein in muscle cells, CA reduced α-synuclein accumulation in a dose-dependent manner. In cells pretreated with the proteasome inhibitor MG132, CA no longer reversed the 6-OHDA-mediated induction of cleavage of caspase 3 and poly(ADP)-ribose polymerase and no longer reversed the suppression of proteasome activity. When parkin expression was silenced by use of small interfering RNA, the ability of CA to inhibit apoptosis and induce proteasomal activity was significantly reduced. The reduction in 6-OHDA-induced neurotoxicity by CA was associated with the induction of parkin, which in turn upregulated the UPS and then decreased cell death.
MeSH term(s)	Animals ; Animals, Genetically Modified ; Antioxidants/pharmacology ; Caenorhabditis elegans ; Cell Death/drug effects ; Cell Death/physiology ; Cell Line, Tumor ; Cytoprotection/drug effects ; Cytoprotection/physiology ; Diterpenes, Abietane/pharmacology ; Humans ; Male ; Oxidopamine/toxicity ; Rats ; Rats, Wistar ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Ubiquitin-Protein Ligases/biosynthesis ; Up-Regulation/drug effects ; Up-Regulation/physiology ; alpha-Synuclein/biosynthesis
Chemical Substances	Antioxidants ; Diterpenes, Abietane ; alpha-Synuclein ; Oxidopamine (8HW4YBZ748) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; parkin protein (EC 2.3.2.27) ; salvin (LI791SXT24)
Language	English
Publishing date	2016-11
Publishing country	England
Document type	Journal Article
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2016.04.017
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Article ; Online: A Genome-Wide Association Study Identified Novel Genetic Susceptibility Loci for Oral Cancer in Taiwan.

Bau, Da-Tian / Liu, Ting-Yuan / Tsai, Chia-Wen / Chang, Wen-Shin / Gu, Jian / Yang, Jai-Sing / Shih, Liang-Chun / Tsai, Fuu-Jen

International journal of molecular sciences

2023 Volume 24, Issue 3

Abstract: Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is mostly an environmentally induced cancer, genetic factors also play an important role in its etiology. Genome-wide association studies (GWAS) have identified nine ... ...

Abstract	Taiwan has the highest incidence rate of oral cancer in the world. Although oral cancer is mostly an environmentally induced cancer, genetic factors also play an important role in its etiology. Genome-wide association studies (GWAS) have identified nine susceptibility regions for oral cancers in populations of European descent. In this study, we performed the first GWAS of oral cancer in Taiwan with 1529 cases and 44,572 controls. We confirmed two previously reported loci on the 6p21.33 (HLA-B) and 6p21.32 (HLA-DQ gene cluster) loci, highlighting the importance of the human leukocyte antigen and, hence, the immunologic mechanisms in oral carcinogenesis. The TERT-CLMPT1L locus on 5p15.33, the 4q23 ADH1B locus, and the LAMC3 locus on 9q34.12 were also consistent in the Taiwanese. We found two new independent loci on 6p21.32, rs401775 in SKIV2L gene and rs9267798 in TNXB gene. We also found two suggestive novel Taiwanese-specific loci near the TPRS1 gene on 8q23.3 and in the TMED3 gene on 15q25.1. This study identified both common and unique oral cancer susceptibility loci in the Taiwanese as compared to populations of European descent and shed significant light on the etiology of oral cancer in Taiwan.
MeSH term(s)	Humans ; Genome-Wide Association Study ; Genetic Predisposition to Disease ; Taiwan ; Mouth Neoplasms/genetics ; Genetic Loci ; Histocompatibility Antigens Class I ; Polymorphism, Single Nucleotide ; Case-Control Studies ; Laminin ; Vesicular Transport Proteins
Chemical Substances	Histocompatibility Antigens Class I ; LAMC3 protein, human ; Laminin ; TMED3 protein, human ; Vesicular Transport Proteins
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24032789
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Article ; Online: Interaction of a Novel Alternatively Spliced Variant of

Fu, Ru-Huei / Hong, Syuan-Yu / Tsai, Chia-Wen / Liu, Shih-Ping / Chiu, Shao-Chih / Wu, Meng-Zhen / Shyu, Woei-Cherng / Lin, Shinn-Zong

Cells

2023 Volume 12, Issue 6

Abstract: Glioblastoma (GBM) is a primary brain tumor of unknown etiology. It is extremely aggressive, incurable and has a short average survival time for patients. Therefore, understanding the precise molecular mechanisms of this diseases is essential to ... ...

Abstract	Glioblastoma (GBM) is a primary brain tumor of unknown etiology. It is extremely aggressive, incurable and has a short average survival time for patients. Therefore, understanding the precise molecular mechanisms of this diseases is essential to establish effective treatments. In this study, we cloned and sequenced a splice variant of the hydroxysteroid 11-β dehydrogenase 1 like gene (
MeSH term(s)	Animals ; Humans ; Mice ; 11-beta-Hydroxysteroid Dehydrogenase Type 1/drug effects ; 11-beta-Hydroxysteroid Dehydrogenase Type 1/genetics ; 11-beta-Hydroxysteroid Dehydrogenase Type 1/metabolism ; Brain Neoplasms/drug therapy ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Carcinogenesis/genetics ; Cevanes/pharmacology ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Protein Isoforms/drug effects ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Ubiquitin-Protein Ligases/drug effects ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	11-beta-Hydroxysteroid Dehydrogenase Type 1 (EC 1.1.1.146) ; Cevanes ; HSD11B1 protein, human (EC 1.1.1.146) ; parkin protein (EC 2.3.2.27) ; peiminine (JKN43410XZ) ; Protein Isoforms ; Ubiquitin-Protein Ligases (EC 2.3.2.27)
Language	English
Publishing date	2023-03-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12060894
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Article: Metformin induces autophagy of cisplatin-resistant human gastric cancer cells in addition to apoptosis.

Fang, Chih-Wun / Yang, Jai-Sing / Chiang, Jo-Hua / Shieh, Po-Chuen / Tsai, Fuu-Jen / Tsai, Chia-Wen / Chang, Wen-Shin

BioMedicine

2023 Volume 13, Issue 2, Page(s) 14–23

Abstract: Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies have shown that metformin can act alone or in synergy with other anticancer agents to achieve anti-cancer efficacies on various types of tumors. However, the role of ...

Abstract	Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies have shown that metformin can act alone or in synergy with other anticancer agents to achieve anti-cancer efficacies on various types of tumors. However, the role of metformin in either inducing autophagy and cisplatin-resistance of human gastric cancer (GC) cells has never been examined. The study has established a cisplatin-resistant GC cell line and investigated the effects of metformin on inducing autophagy on it. The results demonstrated that treatment with metformin can concentration-dependently suppress the cell viability and cell confluence of cisplatin-resistant GC cells, while having no effects on human primary stomach epithelial cells (HPSEC). For the first time, we found that metformin can significantly increase the acidic vesicular organelles (AVO) level and decrease the acridine orange (AO) level spontaneously in the cisplatin-resistant GC cells. Thus, we further checked the other markers, Atg5, Atg12 and LC3-II, which showed that metformin indeed induced autophagy in the cisplatin-resistant GC cells. In addition, treatment of 3-Methyladenine (3-MA) can significantly rescue the metformin-induced autophagy. At the same time, metformin can induce the alterations of apoptosis-associated signal molecules, such as caspase-3 and caspase-7 activities. Overall, the pilot study provided evidence for metformin induced autophagy in addition to apoptosis, making it as an effective anticancer drug for the therapy of cisplatin-resistant GC. Killing the cisplatin-resistant GC cells with non-toxic metformin
Language	English
Publishing date	2023-06-01
Publishing country	China (Republic : 1949- )
Document type	Journal Article
ZDB-ID	2648006-2
ISSN	2211-8039 ; 2211-8020
ISSN (online)	2211-8039
ISSN	2211-8020
DOI	10.37796/2211-8039.1408
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Article ; Online: Novel genetic variants in long non-coding RNA MEG3 are associated with the risk of asthma.

Chiu, Kuo-Liang / Chang, Wen-Shin / Tsai, Chia-Wen / Mong, Mei-Chin / Hsia, Te-Chun / Bau, Da-Tian

PeerJ

2023 Volume 11, Page(s) e14760

Abstract: Background: Asthma is the most common chronic inflammatory airway disease worldwide. Asthma is a complex disease whose exact etiologic mechanisms remain elusive; however, it is increasingly evident that genetic factors play essential roles in the ... ...

Abstract	Background: Asthma is the most common chronic inflammatory airway disease worldwide. Asthma is a complex disease whose exact etiologic mechanisms remain elusive; however, it is increasingly evident that genetic factors play essential roles in the development of asthma. The purpose of this study is to identify novel genetic susceptibility loci for asthma in Taiwanese. We selected a well-studied long non-coding RNA (lncRNA), Methods: We genotyped four single nucleotide polymorphisms (SNPs) in Results: The variant AG and AA genotypes of Conclusion: MEG3
MeSH term(s)	Humans ; Asthma/genetics ; Genetic Predisposition to Disease ; Genotype ; Polymorphism, Single Nucleotide ; RNA, Long Noncoding/genetics
Chemical Substances	RNA, Long Noncoding ; MEG3 non-coding RNA, human
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.14760
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Article: Impacts of

Wang, Bo-Ren / Chang, Wen-Shin / Liao, Cheng-Hsi / Wang, Yun-Chi / Gu, Jian / Bau, Da-Tian / Tsai, Chia-Wen

Biomedicines

2023 Volume 11, Issue 5

Abstract: The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) ... ...

Abstract	The aim of this study was to investigate the association between single-nucleotide polymorphisms (SNPs) in
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11051396
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