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  1. Article: Reinforcing Photoprotection for Skin of Color: A Narrative Review.

    Tsai, Jerry / Chien, Anna L

    Dermatology and therapy

    2023  Volume 13, Issue 9, Page(s) 1935–1958

    Abstract: Skin of color (SOC) is characterized by increased tendency for tanning and decreased likelihood of sunburns due to the attenuation of sunlight by epidermal melanin. Although this contributes to the decreased incidence of skin cancer among SOC populations, ...

    Abstract Skin of color (SOC) is characterized by increased tendency for tanning and decreased likelihood of sunburns due to the attenuation of sunlight by epidermal melanin. Although this contributes to the decreased incidence of skin cancer among SOC populations, individuals with SOC remain susceptible to various health consequences associated with sun exposure, including non-melanoma skin cancer, photoaging, pigmentary disorders, and photodermatoses - many of which not only present differently, but also disproportionately affect SOC. Prior epidemiological studies have found lower prevalence of sun protection behaviors among individuals with SOC, particularly in sunscreen use, signifying an unmet area for improvement in the prevention of sun-induced dermatologic conditions in these populations. The objective of this narrative review was to summarize the biology and health consequences of sun exposure in SOC, as well as cognitive and behavioral factors that affect the practice of photoprotection behaviors in SOC populations. We also review prior interventions that have been used to enhance photoprotection knowledge and behaviors among individuals with SOC, either in racially and ethnically diverse communities or within specific SOC populations.
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2680284-3
    ISSN 2190-9172 ; 2193-8210
    ISSN (online) 2190-9172
    ISSN 2193-8210
    DOI 10.1007/s13555-023-00982-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Photoprotection for Skin of Color.

    Tsai, Jerry / Chien, Anna L

    American journal of clinical dermatology

    2022  Volume 23, Issue 2, Page(s) 195–205

    Abstract: Photoprotection behaviors can mitigate skin damage caused by ultraviolet radiation, and common methods include seeking shade, avoiding sun exposure during peak daylight hours, wearing sun-protective clothing, applying sunscreen, and using sunglasses. ... ...

    Abstract Photoprotection behaviors can mitigate skin damage caused by ultraviolet radiation, and common methods include seeking shade, avoiding sun exposure during peak daylight hours, wearing sun-protective clothing, applying sunscreen, and using sunglasses. While the role of sun protection in preventing sunburns, photoaging, and skin cancer is well established in fair-skinned populations, individuals with skin of color (SOC) are presumed to suffer fewer negative effects from solar radiation. Thus, the importance of photoprotection in this population is understudied and may be underestimated. In SOC populations, sun exposure is known to cause pigmentary disorders, photoaging, and basal cell carcinoma (BCC), highlighting the potential benefits of photoprotection. Although SOC populations tend to practice photoprotection by seeking shade and wearing sun-protective clothing, survey and interview-based studies have consistently found relatively low use of sunscreen among these populations. Common motivators for photoprotection in individuals with SOC include preventing sunburn and pigmentation, with the prevention of skin cancer being a less important reason. As a skin cancer risk behavior, indoor tanning is relatively rare in SOC populations, but its use may increase with acculturation to US norms. While more studies are necessary to clarify whether photoprotection behaviors may decrease skin cancer-related mortality in SOC populations, regular dermatologic care and counseling on photoprotection remain essential in patients with SOC for overall skin health.
    MeSH term(s) Humans ; Skin/radiation effects ; Skin Pigmentation ; Sunburn/epidemiology ; Sunburn/prevention & control ; Sunscreening Agents/therapeutic use ; Ultraviolet Rays/adverse effects
    Chemical Substances Sunscreening Agents
    Language English
    Publishing date 2022-01-19
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1502476-3
    ISSN 1179-1888 ; 1175-0561
    ISSN (online) 1179-1888
    ISSN 1175-0561
    DOI 10.1007/s40257-021-00670-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Increased susceptibility to sunburn with hydrochlorothiazide is influenced by race/ethnicity, sex, and treatment duration: Results from the National Health and Nutrition Examination Survey, 2009-2018.

    Tsai, Jerry / Chien, Anna L

    Journal of the American Academy of Dermatology

    2021  Volume 86, Issue 5, Page(s) 1145–1148

    MeSH term(s) Ethnicity ; Humans ; Hydrochlorothiazide/therapeutic use ; Nutrition Surveys ; Sunburn/drug therapy ; Sunburn/epidemiology ; United States/epidemiology
    Chemical Substances Hydrochlorothiazide (0J48LPH2TH)
    Language English
    Publishing date 2021-05-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.04.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Topical Metronidazole Versus Ivermectin for Low-density Demodex Rosacea: A Rater-blinded, Randomized, Split-face Trial.

    Yeh, Marvin Chia-Han / Tsai, Jerry / Huang, Yu Chen / Wang, Hsiao-Han

    Acta dermato-venereologica

    2022  Volume 102, Page(s) adv00811

    MeSH term(s) Animals ; Humans ; Ivermectin/adverse effects ; Metronidazole/adverse effects ; Mites ; Rosacea/diagnosis ; Rosacea/drug therapy
    Chemical Substances Ivermectin (70288-86-7) ; Metronidazole (140QMO216E)
    Language English
    Publishing date 2022-11-07
    Publishing country Sweden
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v102.4391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Understanding and Harnessing Epithelial‒Mesenchymal Interactions in the Development of Palmoplantar Identity.

    Tsai, Jerry / Rostom, Mary / Garza, Luis A

    The Journal of investigative dermatology

    2021  Volume 142, Issue 2, Page(s) 282–284

    Abstract: Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte‒fibroblast interactions, with keratin ... ...

    Abstract Palmoplantar skin has several unique characteristics such as increased thickness, high resilience, hypopigmentation, and lack of hair follicles. The establishment of palmoplantar identity occurs through keratinocyte‒fibroblast interactions, with keratin 9 expression and Wnt signaling playing key roles. Understanding how palmoplantar features develop may help efforts to reproduce them at both palmoplantar and nonpalmoplantar body sites.
    MeSH term(s) Animals ; Fibroblasts/metabolism ; Foot ; Hand ; Humans ; Keratin-9/metabolism ; Keratinocytes/metabolism ; Mice ; Models, Animal ; Skin/cytology ; Skin/growth & development ; Skin/metabolism ; Skin Pigmentation ; Wnt Signaling Pathway
    Chemical Substances Keratin-9
    Language English
    Publishing date 2021-08-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2021.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Characterizing the consensus residue specificity and surface of BCL-2 binding to BH3 ligands using the Knob-Socket model.

    Yi, Jennifer / Kellner, Vivian / Joo, Hyun / Chien, Nathaniel / Patel, Shivarni / Chaban, Zaina / Tsai, Jerry

    PloS one

    2023  Volume 18, Issue 2, Page(s) e0281463

    Abstract: Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are apoptotic pathway regulators. Upregulation of pro-survival BCL-2 proteins or downregulation of cell death effectors BAX and BAK interferes with the ... ...

    Abstract Cancer cells bypass cell death by changing the expression of the BCL-2 family of proteins, which are apoptotic pathway regulators. Upregulation of pro-survival BCL-2 proteins or downregulation of cell death effectors BAX and BAK interferes with the initiation of the intrinsic apoptotic pathway. In normal cells, apoptosis can occur through pro-apoptotic BH3-only proteins interacting and inhibiting pro-survival BCL-2 proteins. When cancer cells over-express pro-survival BCL-2 proteins, a potential remedy is the sequestration of these pro-survival proteins through a class of anti-cancer drugs called BH3 mimetics that bind in the hydrophobic groove of pro-survival BCL-2 proteins. To improve the design of these BH3 mimetics, the packing interface between BH3 domain ligands and pro-survival BCL-2 proteins was analyzed using the Knob-Socket model to identify the amino acid residues responsible for interaction affinity and specificity. A Knob-Socket analysis organizes all the residues in a binding interface into simple 4 residue units: 3-residue sockets defining surfaces on a protein that pack a 4th residue knob from the other protein. In this way, the position and composition of the knobs packing into sockets across the BH3/BCL-2 interface can be classified. A Knob-Socket analysis of 19 BCL-2 protein and BH3 helix co-crystals reveal multiple conserved binding patterns across protein paralogs. Conserved knob residues such as a Gly, Leu, Ala and Glu most likely define binding specificity in the BH3/BCL-2 interface, whereas other residues such as Asp, Asn, and Val are important for forming surface sockets that bind these knobs. These findings can be used to inform the design of BH3 mimetics that are specific to pro-survival BCL-2 proteins for cancer therapeutics.
    MeSH term(s) Proto-Oncogene Proteins/metabolism ; Consensus ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Apoptosis Regulatory Proteins/chemistry ; Apoptosis
    Chemical Substances Proto-Oncogene Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Apoptosis Regulatory Proteins
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0281463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Efficacy of Acupuncture for Treatment of Atopic Eczema and Chronic Eczema: A Systematic Review and Meta-analysis.

    Jwo, Jhen-Yu / Chiou, Katie / Tsai, Jerry / Huang, Yu-Chen / Lin, Chia-Yu

    Acta dermato-venereologica

    2022  Volume 102, Page(s) adv00791

    MeSH term(s) Acupuncture Therapy ; Dermatitis, Atopic/diagnosis ; Dermatitis, Atopic/therapy ; Eczema/diagnosis ; Eczema/therapy ; Humans
    Language English
    Publishing date 2022-10-11
    Publishing country Sweden
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/actadv.v102.4380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Hip Ganglion Cyst Causing Femoral Nerve Dysesthesia.

    Chen, Wen-Ling / Tsai, Jerry Ch

    American journal of physical medicine & rehabilitation

    2017  Volume 96, Issue 12, Page(s) e227

    MeSH term(s) Female ; Femoral Nerve ; Ganglion Cysts/etiology ; Hip Joint/innervation ; Humans ; Joint Diseases/etiology ; Middle Aged ; Paresthesia/complications
    Language English
    Publishing date 2017-03-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 219390-5
    ISSN 1537-7385 ; 0002-9491 ; 0894-9115
    ISSN (online) 1537-7385
    ISSN 0002-9491 ; 0894-9115
    DOI 10.1097/PHM.0000000000000737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Rare disasters and the term structure of interest rates

    Tsai, Jerry

    (Department of Economics discussion paper series / University of Oxford ; 665)

    2013  

    Author's details Jerry Tsai
    Series title Department of Economics discussion paper series / University of Oxford ; 665
    Language English
    Size Online-Ressource (71 S.), graph. Darst.
    Publisher Univ. of Oxford, Dep. of Economics
    Publishing place Oxford
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  10. Article ; Online: A Rational Approach for Creating Peptides Mimicking Antibody Binding.

    Sachdeva, Sameer / Joo, Hyun / Tsai, Jerry / Jasti, Bhaskara / Li, Xiaoling

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 997

    Abstract: This study reports a novel method to design peptides that mimic antibody binding. Using the Knob-Socket model for protein-protein interaction, the interaction surface between Cetuximab and EGFR was mapped. EGFR binding peptides were designed based on ... ...

    Abstract This study reports a novel method to design peptides that mimic antibody binding. Using the Knob-Socket model for protein-protein interaction, the interaction surface between Cetuximab and EGFR was mapped. EGFR binding peptides were designed based on geometry and the probability of the mapped knob-sockets pairs. Designed peptides were synthesized and then characterized for binding specificity, affinity, cytotoxicity of drug-peptide conjugate and inhibition of phosphorylation. In cell culture studies, designed peptides specifically bind and internalize to EGFR overexpressing cells with three to four-fold higher uptake compared to control cells that do not overexpress EGFR. The designed peptide, Pep11, bound to EGFR with K
    MeSH term(s) Amino Acid Motifs ; Antibodies, Monoclonal/metabolism ; Cell Death ; Cell Line, Tumor ; Cell Survival ; Drug Delivery Systems ; Drug Design ; ErbB Receptors/metabolism ; HEK293 Cells ; Humans ; Kinetics ; Molecular Docking Simulation ; Peptides/chemistry ; Peptides/metabolism ; Phosphorylation ; Protein Binding ; Protein Structure, Secondary ; Surface Plasmon Resonance
    Chemical Substances Antibodies, Monoclonal ; Peptides ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2019-01-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-018-37201-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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