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  1. Article: Vernacular healing landscapes in Australian aged-care gardens

    Tsai, Mimi

    Landscape research. 2022 Apr. 3, v. 47, no. 3

    2022  

    Abstract: Designing for people’s health and well-being is one important purpose for landscape design in healthcare environments. The concept of therapeutic landscapes has been applied widely in various healthcare settings. This research extends the concept of ... ...

    Abstract Designing for people’s health and well-being is one important purpose for landscape design in healthcare environments. The concept of therapeutic landscapes has been applied widely in various healthcare settings. This research extends the concept of therapeutic landscapes in ordinary everyday context and explores the role of gardens in Australian aged-care facilities. Fieldwork shows aged-care residents reclaim the outdoor environment by actively shaping the landscape to create special meanings and embed memories in characterising their current living space. Findings suggest broadening the current understandings of therapeutic landscapes to incorporate residents’ vernacular healing landscapes. This paper addresses a gap in existing literature and introduces the importance of vernacular healing landscapes in aged-care facilities for its holistic reflection of older people’s landscape experiences and connection with residents' memories, which positively contributes to their health and wellbeing. It argues for future design to value and incorporate residents' vernacular healing landscapes in aged-care gardens.
    Keywords health services ; landscapes ; landscaping ; people ; research ; therapeutics
    Language English
    Dates of publication 2022-0403
    Size p. 400-413.
    Publishing place Routledge
    Document type Article
    ZDB-ID 2020719-0
    ISSN 0142-6397 ; 1469-9710 ; 0142-6397
    ISSN (online) 0142-6397 ; 1469-9710
    ISSN 0142-6397
    DOI 10.1080/01426397.2022.2039602
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Warning signs for suicide attempts in psychiatric inpatients: Patient and informant perspectives.

    Tsai, Michelle / Klonsky, E David

    General hospital psychiatry

    2023  Volume 85, Page(s) 207–212

    Abstract: Objective: Warning signs can help prevent suicide attempts and death. It is important to develop an evidence base for warning signs that considers both self-perspectives (i.e., those at risk for suicide) and informant-perspectives (i.e., those who ... ...

    Abstract Objective: Warning signs can help prevent suicide attempts and death. It is important to develop an evidence base for warning signs that considers both self-perspectives (i.e., those at risk for suicide) and informant-perspectives (i.e., those who observe individuals at risk for suicide).
    Methods: A questionnaire assessing a diverse set of 80 potential warning signs ("present in the minutes, hours, or days before the suicide attempts") was developed based on literature searches, lived experience consultations, and the American Association of Suicidology (AAS) expert consensus list. This questionnaire was administered to two samples: psychiatric inpatients who had attempted suicide (n = 476), and informants identified as friends, family, or caretakers of patients (n = 120).
    Results: Hopelessness, anxiousness, and unbearable pain were each endorsed as warning signs by >80% of inpatients and informants. Warning signs were similar across patient and informant perspectives, and across sociodemographic and clinical characteristics. Some AAS warning signs were endorsed by few patients and informants (risky behaviors, alcohol or drug use, seeking revenge) and may warrant re-evaluation.
    Conclusions: Findings are consistent with models of suicide risk emphasizing pain, hopelessness, and anxiousness. Existing lists of warning signs may benefit from revision as the evidence base continues to develop.
    MeSH term(s) Humans ; Suicide, Attempted ; Inpatients ; Anxiety ; Pain ; Risk Factors
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392299-6
    ISSN 1873-7714 ; 0163-8343
    ISSN (online) 1873-7714
    ISSN 0163-8343
    DOI 10.1016/j.genhosppsych.2023.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Choline degradation in

    Parekh, Trusha / Tsai, Marcus / Spiro, Stephen

    Journal of bacteriology

    2024  Volume 206, Issue 4, Page(s) e0008124

    Abstract: Paracoccus ... ...

    Abstract Paracoccus denitrificans
    MeSH term(s) Betaine/metabolism ; Sarcosine/metabolism ; Paracoccus denitrificans/genetics ; Paracoccus denitrificans/metabolism ; Methanol ; Choline/metabolism ; Glycine ; Formaldehyde ; Formates ; Methylamines
    Chemical Substances Betaine (3SCV180C9W) ; Sarcosine (Z711V88R5F) ; Methanol (Y4S76JWI15) ; Choline (N91BDP6H0X) ; Glycine (TE7660XO1C) ; Formaldehyde (1HG84L3525) ; Formates ; Methylamines
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00081-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Is Industry- Versus Government-Sponsored Research a Zero-Sum Game?

    Kain, Zeev N / Tsai, Mitchel / Browne, James

    Anesthesia and analgesia

    2023  Volume 136, Issue 6, Page(s) 1052–1054

    MeSH term(s) Industry ; Government ; Drug Industry
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80032-6
    ISSN 1526-7598 ; 0003-2999
    ISSN (online) 1526-7598
    ISSN 0003-2999
    DOI 10.1213/ANE.0000000000006407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is Industry- Versus Government-Sponsored Research a Zero-Sum Game?

    Kain, Zeev N / Tsai, Mitchel / Browne, James

    The Journal of arthroplasty

    2023  Volume 38, Issue 6, Page(s) 984–985

    MeSH term(s) Humans ; Industry ; Government ; Drug Industry
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2023.02.017
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  6. Article ; Online: Effects of Intra-Base Pair Proton Transfer on Dissociation and Singlet Oxygenation of 9-Methyl-8-Oxoguanine-1-Methyl-Cytosine Base-Pair Radical Cations.

    Moe, May Myat / Tsai, Midas / Liu, Jianbo

    Chemphyschem : a European journal of chemical physics and physical chemistry

    2023  Volume 24, Issue 23, Page(s) e202300511

    Abstract: 8-Oxoguanosine is the most common oxidatively generated base damage and pairs with complementary cytidine within duplex DNA. The 8-oxoguanosine-cytidine lesion, if not recognized and removed, not only leads to G-to-T transversion mutations but renders ... ...

    Abstract 8-Oxoguanosine is the most common oxidatively generated base damage and pairs with complementary cytidine within duplex DNA. The 8-oxoguanosine-cytidine lesion, if not recognized and removed, not only leads to G-to-T transversion mutations but renders the base pair being more vulnerable to the ionizing radiation and singlet oxygen (
    MeSH term(s) Protons ; Base Pairing ; Cytosine/chemistry ; Cations ; Cytidine
    Chemical Substances Protons ; 8-hydroxyguanine (5614-64-2) ; Cytosine (8J337D1HZY) ; Cations ; Cytidine (5CSZ8459RP)
    Language English
    Publishing date 2023-10-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2025223-7
    ISSN 1439-7641 ; 1439-4235
    ISSN (online) 1439-7641
    ISSN 1439-4235
    DOI 10.1002/cphc.202300511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Positive Outcome Bias in the Influential Otolaryngology Clinical Trial Literature.

    Yang, Hong-Ho / Tsai, Matthew / Mukdad, Laith / St John, Maie

    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

    2023  Volume 170, Issue 3, Page(s) 812–820

    Abstract: Objective: To assess for the presence of positive outcome bias in the otolaryngology clinical trial literature. Specifically, we investigate the prevalence of clinical trials with positive findings (CTP) and clinical trials with negative findings (CTN), ...

    Abstract Objective: To assess for the presence of positive outcome bias in the otolaryngology clinical trial literature. Specifically, we investigate the prevalence of clinical trials with positive findings (CTP) and clinical trials with negative findings (CTN), as well as their quality of evidence and subsequent impact.
    Study design: Retrospective analysis.
    Setting: Clinical Trials in the Influential Otolaryngology Literature.
    Methods: We reviewed all clinical trials published in 4 major otolaryngology journals between 2000 and 2020. We constructed several multivariable regression models to investigate the relationship of finding direction with randomization status and citation count. Subsequently, we incorporated an interaction term between year and the primary covariate of each model to assess the temporal trajectory of these relationships. All models accounted for sample size, journal, subspecialty, and the affiliated program prestige.
    Results: Of the 1367 trials analyzed, 1143 (84%) were CTPs, a rate that persisted throughout the study period (aOR 1.00, 95% CI 0.98-1.03). CTPs were significantly less likely to be randomized compared to CTNs (aOR 0.25, 0.17-0.37), a relationship that persisted over time (aOR 1.05, 0.99-1.03). CTPs received significantly more citations compared to CTNs (aIRR 1.41, 1.25-1.60), a disparity that also persisted over time (aIRR 0.99, 0.97-1.01).
    Conclusion: The otolaryngology clinical trial literature has been heavily dominated by positive findings. CTPs were more frequently cited and published even with a lower level of evidence compared to CTNs. This bias may influence the objectivity of evidence used to guide clinical practice and warrants attention when reviewing findings and changing practices.
    MeSH term(s) Humans ; Retrospective Studies ; Otolaryngology ; Publication Bias ; Publications ; Bias
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 392085-9
    ISSN 1097-6817 ; 0161-6439 ; 0194-5998
    ISSN (online) 1097-6817
    ISSN 0161-6439 ; 0194-5998
    DOI 10.1002/ohn.562
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  8. Article ; Online: Recently matched students are effective residency application teachers.

    Brach, Richard / Tzeng, Allison / Yousef, Hakeem / Tsai, Matthew / Greenberger, Emily

    Medical education

    2023  Volume 57, Issue 5, Page(s) 481–482

    MeSH term(s) Humans ; Internship and Residency ; Students
    Language English
    Publishing date 2023-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.15043
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  9. Article ; Online: KIT as a master regulator of the mast cell lineage.

    Tsai, Mindy / Valent, Peter / Galli, Stephen J

    The Journal of allergy and clinical immunology

    2022  Volume 149, Issue 6, Page(s) 1845–1854

    Abstract: The discovery in 1987/1988 and 1990 of the cell surface receptor KIT and its ligand, stem cell factor (SCF), was a critical achievement in efforts to understand the development and function of multiple distinct cell lineages. These include hematopoietic ... ...

    Abstract The discovery in 1987/1988 and 1990 of the cell surface receptor KIT and its ligand, stem cell factor (SCF), was a critical achievement in efforts to understand the development and function of multiple distinct cell lineages. These include hematopoietic progenitors, melanocytes, germ cells, and mast cells, which all are significantly affected by loss-of-function mutations of KIT or SCF. Such mutations also influence the development and/or function of additional cells, including those in parts of the central nervous system and the interstitial cells of Cajal (which control gut motility). Many other cells can express KIT constitutively or during immune responses, including dendritic cells, eosinophils, type 2 innate lymphoid cells, and taste cells. Yet the biological importance of KIT in many of these cell types largely remains to be determined. We here review the history of work investigating mice with mutations affecting the white spotting locus (which encodes KIT) or the steel locus (which encodes SCF), focusing especially on the influence of such mutations on mast cells. We also briefly review efforts to target the KIT/SCF pathway with anti-SCF or anti-Kit antibodies in mouse models of allergic disorders, parasite immunity, or fibrosis in which mast cells are thought to play significant roles.
    MeSH term(s) Animals ; Cell Lineage ; Humans ; Immunity, Innate ; Lymphocytes/cytology ; Lymphocytes/immunology ; Lymphocytes/metabolism ; Mast Cells/metabolism ; Mice ; Proto-Oncogene Proteins c-kit/genetics ; Proto-Oncogene Proteins c-kit/metabolism ; Stem Cell Factor/genetics ; Stem Cell Factor/metabolism
    Chemical Substances Stem Cell Factor ; Proto-Oncogene Proteins c-kit (EC 2.7.10.1)
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.04.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Anesthesiologist Staffing Ratio and Surgical Outcome.

    Dutton, Richard P / Tsai, Mitchell / Hudson, Mark

    JAMA surgery

    2022  Volume 158, Issue 5, Page(s) 557–558

    MeSH term(s) Humans ; Anesthesiologists ; Treatment Outcome ; Workforce ; Personnel Staffing and Scheduling
    Language English
    Publishing date 2022-12-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2022.6603
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