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Article: Using Cu as a Spacer to Fabricate and Control the Porosity of Titanium Zirconium Based Bulk Metallic Glass Foams for Orthopedic Implant Applications.

Wong, Pei-Chun / Song, Sin-Mao / Tsai, Pei-Hua / Maqnun, Muhammad Jauharul / Wang, Wei-Ru / Wu, Jia-Lin / Jang, Shian-Ching Jason

Materials (Basel, Switzerland)

2022 Volume 15, Issue 5

Abstract: In this study, a porous titanium zirconium (TiZr)-based bulk metallic foam was successfully fabricated using the Cu spacer by employing the hot press method. TiZr-based bulk metallic foams with porosities ranging from 0% to 50% were fabricated and ... ...

Abstract	In this study, a porous titanium zirconium (TiZr)-based bulk metallic foam was successfully fabricated using the Cu spacer by employing the hot press method. TiZr-based bulk metallic foams with porosities ranging from 0% to 50% were fabricated and analyzed. The results indicate that thermal conductivity increased with the addition of Cu spacer; the increased thermal conductivity reduced the holding time in the hot press method. Moreover, the compressive strength decreased from 1261 to 76 MPa when the porosity of the TiZr-based bulk metallic foam increased to 50%, and the compressive strength was predictable. In addition, the foam demonstrated favorable biocompatibility in cell viability, cell migration capacity, and calcium deposition tests. Moreover, the pore size of the porous TiZr-based bulk metallic foam was around 120 µm. In conclusion, TiZr-based bulk metallic foam has favorable biocompatibility, mechanical property controllability, and porous structure for bone ingrowth and subsequent enhanced osteointegration. This porous TiZr-based bulk metallic foam has great potential as an orthopedic implant to enhance bone healing and decrease healing time.
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15051887
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Functional Analysis of a Fibronectin Binding Protein of Streptococcus parasanguinis FW213

Chen, Yi-Ywan M / Lu, Pei-Shan / Tsai, Pei-Hua / Chiu, Cheng-Hsun

Current microbiology. 2020 Nov., v. 77, no. 11

2020

Abstract: Streptococcus parasanguinis is a primary colonizer of dental plaque and an opportunistic pathogen for subacute endocarditis. A putative fibronectin binding protein (Spaf_1409) that lacks both an N-terminal signal peptide and a C-terminal cell wall- ... ...

Abstract	Streptococcus parasanguinis is a primary colonizer of dental plaque and an opportunistic pathogen for subacute endocarditis. A putative fibronectin binding protein (Spaf_1409) that lacks both an N-terminal signal peptide and a C-terminal cell wall-anchoring motif was identified from the S. parasanguinis FW213 genome. Spaf_1409 was abundantly present in the cytoplasm and also was found in the cell wall preparation and culture supernatant. By using an isogenic mutant strain, MPH4, Spaf_1409 was found to mediate the binding of S. parasanguinis FW213 to fibronectin. Inactivation of Spaf_1409 did not significantly alter the mass of static biofilm, but reduced the resistance of S. parasanguinis against the shearing force in a flow cell biofilm system, resulting in scattered biofilm. The mortality in Galleria mellonella larvae infected with MPH4 was higher than in those infected with wild-type S. parasanguinis. However, fewer viable bacterial cells were recovered from larvae infected with MPH4, compared to those infected with wild-type S. parasanguinis, up to 42 h post infection, suggesting that the infection by MPH4, but not the growth, was responsible for the elevated mortality. The phagocytic analysis using flow cytometry indicated that Spaf_1409 participates in the recognition of S. parasanguinis FW213 by RAW264.7 macrophages, suggesting that inactivation of Spaf_1409 intensified the immune responses in larvae, leading to larval death. Taken together, the data indicate that Spaf_1409 plays different roles in the development of dental biofilm and in systemic infections.
Keywords	Galleria mellonella ; Streptococcus parasanguinis ; biofilm ; cell walls ; cytoplasm ; death ; dental plaque ; endocarditis ; fibronectins ; flow cytometry ; genome ; macrophages ; mortality ; mutants ; opportunistic pathogens ; signal peptide
Language	English
Dates of publication	2020-11
Size	p. 3430-3440.
Publishing place	Springer US
Document type	Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-020-02152-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Functional Analysis of a Fibronectin Binding Protein of Streptococcus parasanguinis FW213.

Chen, Yi-Ywan M / Lu, Pei-Shan / Tsai, Pei-Hua / Chiu, Cheng-Hsun

Current microbiology

2020 Volume 77, Issue 11, Page(s) 3430–3440

Abstract	Streptococcus parasanguinis is a primary colonizer of dental plaque and an opportunistic pathogen for subacute endocarditis. A putative fibronectin binding protein (Spaf_1409) that lacks both an N-terminal signal peptide and a C-terminal cell wall-anchoring motif was identified from the S. parasanguinis FW213 genome. Spaf_1409 was abundantly present in the cytoplasm and also was found in the cell wall preparation and culture supernatant. By using an isogenic mutant strain, MPH4, Spaf_1409 was found to mediate the binding of S. parasanguinis FW213 to fibronectin. Inactivation of Spaf_1409 did not significantly alter the mass of static biofilm, but reduced the resistance of S. parasanguinis against the shearing force in a flow cell biofilm system, resulting in scattered biofilm. The mortality in Galleria mellonella larvae infected with MPH4 was higher than in those infected with wild-type S. parasanguinis. However, fewer viable bacterial cells were recovered from larvae infected with MPH4, compared to those infected with wild-type S. parasanguinis, up to 42 h post infection, suggesting that the infection by MPH4, but not the growth, was responsible for the elevated mortality. The phagocytic analysis using flow cytometry indicated that Spaf_1409 participates in the recognition of S. parasanguinis FW213 by RAW264.7 macrophages, suggesting that inactivation of Spaf_1409 intensified the immune responses in larvae, leading to larval death. Taken together, the data indicate that Spaf_1409 plays different roles in the development of dental biofilm and in systemic infections.
MeSH term(s)	Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Carrier Proteins ; Fibronectins ; Fimbriae Proteins/metabolism ; Streptococcus/metabolism
Chemical Substances	Bacterial Proteins ; Carrier Proteins ; Fibronectins ; Fimbriae Proteins (147680-16-8)
Language	English
Publishing date	2020-08-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-020-02152-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development and Fabrication of Biocompatible Ti-Based Bulk Metallic Glass Matrix Composites for Additive Manufacturing.

Chen, Po-Sung / Tsai, Pei-Hua / Li, Tsung-Hsiung / Jang, Jason Shian-Ching / Huang, Jacob Chih-Ching / Lin, Che-Hsin / Pan, Cheng-Tang / Lin, Hsuan-Kai

Materials (Basel, Switzerland)

2023 Volume 16, Issue 17

Abstract: Ti-based metallic glasses have a high potential for implant applications. The feasibility of a new biocompatible Ti-based bulk metallic glass composite for selective laser melting (SLM) had been examined. Therefore, it is necessary to design a high-glass- ...

Abstract	Ti-based metallic glasses have a high potential for implant applications. The feasibility of a new biocompatible Ti-based bulk metallic glass composite for selective laser melting (SLM) had been examined. Therefore, it is necessary to design a high-glass-forming-ability Ti-based metallic glass (∆T
Language	English
Publishing date	2023-08-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16175935
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Remarkable Enhanced Mechanical Properties of TiAlCrNbV Medium-Entropy Alloy with Zr Additions.

Chen, Po-Sung / Shiu, Sheng-Jia / Tsai, Pei-Hua / Liao, Yu-Chin / Jang, Jason Shian-Ching / Wu, Hsin-Jay / Chang, Shou-Yi / Chen, Chih-Yen / Tsao, I-Yu

Materials (Basel, Switzerland)

2022 Volume 15, Issue 18

Abstract: Most medium entropy alloys (MEAs) exhibit excellent mechanical properties, but their applications are limited because of their high density. This study explores a series of lightweight nonequiatomic Ti65(AlCrNbV)35-xZrx (x = 3, 5, 7, and 10) MEAs with a ... ...

Abstract	Most medium entropy alloys (MEAs) exhibit excellent mechanical properties, but their applications are limited because of their high density. This study explores a series of lightweight nonequiatomic Ti65(AlCrNbV)35-xZrx (x = 3, 5, 7, and 10) MEAs with a low density, high strength, and high ductility. To achieve solid solution strengthening, Zr with a large atomic radius was used. In addition, various thermomechanical treatment parameters were adopted to further improve the MEAs’ mechanical properties. The density of the MEAs was revealed to be approximately 5 g/cm3, indicating that they were lightweight. Through an X-ray diffraction analysis, the MEAs were revealed to have a single body-centered cubic structure not only in the as-cast state but also after thermomechanical treatment. In terms of mechanical properties, all the as-cast MEAs with Zr additions achieved excellent performance (>1000 MPa tensile yield strength and 20% tensile ductility). In addition, hot rolling effectively eliminated the defects of the MEAs; under a given yield strength, hot-rolled MEAs exhibited superior ductility relative to non-hot-rolled MEAs. Overall, the Ti65(AlCrNbV)28Zr7 MEAs exhibited an optimum combination of mechanical properties (yield strength > 1200 MPa, plastic strain > 15%) after undergoing hot rolling 50%, cold rolling 70%, and rapid annealing for 30 to 50 s (at a temperature of approximately 850 °C) with a heating rate of 15 K/s. With their extremely high specific yield strength (264 MPa·g/cm3) and high ductility (22%), the Ti65(AlCrNbV)28Zr7 MEAs demonstrate considerable potential for energy and transportation applications.
Language	English
Publishing date	2022-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15186324
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Relationship between the Surface Roughness of Biodegradable Mg-Based Bulk Metallic Glass and the Osteogenetic Ability of MG63 Osteoblast-Like Cells.

Wong, Pei-Chun / Song, Sin-Mao / Tsai, Pei-Hua / Nien, Yi-Yuan / Jang, Jason Shian-Ching / Cheng, Cheng-Kung / Chen, Chih-Hwa

Materials (Basel, Switzerland)

2020 Volume 13, Issue 5

Abstract: Mg-based bulk metallic glass materials have been investigated for their large potential for application in orthopedic implants due to their biocompatibility, low degradation rate, and osteogenetic ability. As an orthopedic implant, initial cell adhesion ... ...

Abstract	Mg-based bulk metallic glass materials have been investigated for their large potential for application in orthopedic implants due to their biocompatibility, low degradation rate, and osteogenetic ability. As an orthopedic implant, initial cell adhesion has been a critical issue for subsequent osteogenesis and bone formation because the first contact between cells and the implant occurs upon the implants surface. Here, we aimed to create Mg-based bulk metallic glass samples with three different surface roughness attributes in order to understand the degradation behavior of Mg-based bulk metallic glass and the adhesion ability and osteogenetic ability of the contact cells. It was found that the degradation behavior of Mg
Language	English
Publishing date	2020-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13051188
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A bi-phase core-shell structure of Mg-based bulk metallic glass for application in orthopedic fixation implants.

Song, Sin-Mao / Wong, Pei-Chun / Chiang, Chih-Wei / Tsai, Pei-Hua / Jang, J S C / Chen, Chih-Hwa

Materials science & engineering. C, Materials for biological applications

2020 Volume 111, Page(s) 110783

Abstract: Mg-based bulk metallic glass (BMG) and its composites have been promising candidates for orthopedic fixation implants because of their biocompatibility, low degradation rate, and osteogenic potential. However, the amorphous state is affected by the ... ...

Abstract	Mg-based bulk metallic glass (BMG) and its composites have been promising candidates for orthopedic fixation implants because of their biocompatibility, low degradation rate, and osteogenic potential. However, the amorphous state is affected by the cooling rate during the casting process. Solid, unstable structures combined with amorphous and crystalline structures are generated when an insufficient cooling rate is used. Here, we aimed to design and synthesize a novel core-shell structure comprising an amorphous shell and a crystalline core in order to overcome the material size limit imposed by the cooling rate effects. Our results show that the core-shell structure of Mg-based BMG does have a lower degradation rate and can maintain a more amorphous structure after six weeks of degradation. Moreover, the biocompatibility and osteogenic effects were similar between the core-shell and solid structures of Mg-based BMG. In conclusion, the core-shell structure of Mg-based BMG exhibits a lower degradation rate while still enhancing osteogenic potential in vitro. This core-shell structure of Mg-based BMG overcomes the cooling rate effects and provides a new structure for manufacturing Mg-based BMG.
MeSH term(s)	Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Cell Line ; Cell Survival/drug effects ; Compressive Strength ; Glass/chemistry ; Humans ; Magnesium/chemistry ; Orthopedic Fixation Devices ; Osteogenesis/drug effects ; Phase Transition ; Surface Properties ; Temperature ; Zirconium/chemistry
Chemical Substances	Biocompatible Materials ; Zirconium (C6V6S92N3C) ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2020-02-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2012160-X
ISSN	1873-0191 ; 0928-4931
ISSN (online)	1873-0191
ISSN	0928-4931
DOI	10.1016/j.msec.2020.110783
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Development of Novel Lightweight Al-Rich Quinary Medium-Entropy Alloys with High Strength and Ductility.

Chen, Po-Sung / Liao, Yu-Chin / Lin, Yen-Ting / Tsai, Pei-Hua / Jang, Jason S C / Hsieh, Ker-Chang / Chen, Chih-Yen / Huang, Jacob C / Wu, Hsin-Jay / Tsao, I-Yu

Materials (Basel, Switzerland)

2021 Volume 14, Issue 15

Abstract: Most high-entropy alloys and medium-entropy alloys (MEAs) possess outstanding mechanical properties. In this study, a series of lightweight nonequiatomic ... ...

Abstract	Most high-entropy alloys and medium-entropy alloys (MEAs) possess outstanding mechanical properties. In this study, a series of lightweight nonequiatomic Al
Language	English
Publishing date	2021-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14154223
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Biocompatibility and Osteogenic Capacity of Mg-Zn-Ca Bulk Metallic Glass for Rabbit Tendon-Bone Interference Fixation.

Wong, Chin-Chean / Wong, Pei-Chun / Tsai, Pei-Hua / Jang, Jason Shian-Ching / Cheng, Cheng-Kung / Chen, Hsiang-Ho / Chen, Chih-Hwa

International journal of molecular sciences

2019 Volume 20, Issue 9

Abstract: Mg-based alloys have great potential for development into fixation implants because of their highly biocompatible and biodegradable metallic properties. In this study, we sought to determine the biocompatibility of ... ...

Abstract	Mg-based alloys have great potential for development into fixation implants because of their highly biocompatible and biodegradable metallic properties. In this study, we sought to determine the biocompatibility of Mg
MeSH term(s)	Animals ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Biomarkers ; Bone and Bones/diagnostic imaging ; Bone and Bones/metabolism ; Calcium/chemistry ; Cell Movement ; Cell Survival/drug effects ; Extracellular Matrix/metabolism ; Glass/chemistry ; Imaging, Three-Dimensional ; Magnesium/chemistry ; Materials Testing ; Metal Nanoparticles/chemistry ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteogenesis/drug effects ; Rabbits ; Tendons ; X-Ray Microtomography ; Zinc/chemistry
Chemical Substances	Biocompatible Materials ; Biomarkers ; Magnesium (I38ZP9992A) ; Zinc (J41CSQ7QDS) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2019-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20092191
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Open-Cell Tizr-Based Bulk Metallic Glass Scaffolds with Excellent Biocompatibility and Suitable Mechanical Properties for Biomedical Application.

Nguyen, Van Tai / Wong, Xavier Pei-Chun / Song, Sin-Mao / Tsai, Pei-Hua / Jang, Jason Shian-Ching / Tsao, I-Yu / Lin, Che-Hsin / Nguyen, Van Cuong

Journal of functional biomaterials

2020 Volume 11, Issue 2

Abstract: A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology ...

Abstract	A series of biocompatible high-porosity (up to 72.4%) TiZr-based porous bulk metallic glass (BMG) scaffolds were successfully fabricated by hot pressing a mixture of toxic element-free TiZr-based BMG powder and an Al particle space holder. The morphology of the fabricated scaffolds was similar to that of human bones, with pore sizes ranging from 75 to 250 μm. X-ray diffraction patterns and transmission electron microscopy images indicated that the amorphous structure of the TiZr-based BMG scaffolds remained in the amorphous state after hot pressing. Noncytotoxicity and extracellular calcium deposition of the TiZr-based BMG scaffolds at porosities of 32.8%, 48.8%, and 64.0% were examined by using the direct contact method. The results showed that the BMG scaffolds possess high cell viability and extracellular calcium deposition with average cell survival and deposition rates of approximately 170.1% and 130.9%, respectively. In addition, the resulting TiZr-based BMG scaffolds exhibited a considerable reduction in Young's moduli from 56.4 to 2.3 GPa, compressive strength from 979 to 19 MPa, and bending strength from 157 MPa to 49 MPa when the porosity was gradually increased from 2.0% to 72.4%. Based on the aforementioned specific characteristics, TiZr-based BMG scaffolds can be considered as potential candidates for biomedical applications in the human body.
Language	English
Publishing date	2020-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2648525-4
ISSN	2079-4983
ISSN	2079-4983
DOI	10.3390/jfb11020028
Database	MEDical Literature Analysis and Retrieval System OnLINE

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