Article ; Online: Cholesterol twists the transmembrane Di-Gly region of amyloid-precursor protein.
PNAS nexus
2023 Volume 2, Issue 5, Page(s) pgad162
Abstract: Nearly 95% of Alzheimer's disease (AD) occurs sporadically without genetic linkage. Aging, hypertension, high cholesterol content, and diabetes are known nongenomic risk factors of AD. Aggregation of Aβ peptides is an initial event of AD pathogenesis. Aβ ...
| Abstract | Nearly 95% of Alzheimer's disease (AD) occurs sporadically without genetic linkage. Aging, hypertension, high cholesterol content, and diabetes are known nongenomic risk factors of AD. Aggregation of Aβ peptides is an initial event of AD pathogenesis. Aβ peptides are catabolic products of a type I membrane protein called amyloid precursor protein (APP). Aβ40 is the major product, whereas the 2-residue-longer version, Aβ42, induces amyloid plaque formation in the AD brain. Since cholesterol content is one risk factor for sporadic AD, we aimed to explore whether cholesterol in the membrane affects the structure of the APP transmembrane region, thereby modulating the γ-secretase cutting behavior. Here, we synthesized several peptides containing the APP transmembrane region (sequence 693-726, corresponding to the Aβ |
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| Language | English |
| Publishing date | 2023-05-17 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2752-6542 |
| ISSN (online) | 2752-6542 |
| DOI | 10.1093/pnasnexus/pgad162 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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