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  1. Article ; Online: Testosterone replacement therapy: For whom, when and how?

    Tsametis, Christos P / Isidori, Andrea M

    Metabolism: clinical and experimental

    2018  Volume 86, Page(s) 69–78

    Abstract: The finding of low circulating testosterone level in men is relatively frequent. The symptoms of hypogonadism are very frequent in the aging men. However, the diagnosis of hypogonadism is often neglected and the opportunity to replace low testosterone in ...

    Abstract The finding of low circulating testosterone level in men is relatively frequent. The symptoms of hypogonadism are very frequent in the aging men. However, the diagnosis of hypogonadism is often neglected and the opportunity to replace low testosterone in older men is highly debated. The aim of this narrative review is to summarize the steps necessary to formulate a proper diagnosis and to guide toward an individualized treatment. While universally recognized the need to treat the young adults with known causes of pituitary or testicular failure, there are controversies on the cost-benefit of treating testosterone deficiency in older men. Discrepancies among the several available guidelines do not help to clarify the scenario, however, the recent larger clinical trials have shed some light on the fact that testosterone treatment carries some benefit, that is not free from risks. We provide an updated review of the diagnostic hallmarks, the several treatment modalities, with their advantages and disadvantages, and how to individualize and monitor treatment in order to maximize the benefits and minimize the risks. The treatment of male hypogonadism can no longer be downgraded and must become part of the cultural baggage of the endocrinologist.
    MeSH term(s) Age Factors ; Diagnostic Techniques, Endocrine ; Drug Administration Schedule ; Early Diagnosis ; Hormone Replacement Therapy/methods ; Humans ; Hypogonadism/diagnosis ; Hypogonadism/drug therapy ; Hypogonadism/epidemiology ; Male ; Patient Selection ; Testosterone/deficiency ; Testosterone/therapeutic use ; Time Factors ; Time-to-Treatment
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2018-03-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 80230-x
    ISSN 1532-8600 ; 0026-0495
    ISSN (online) 1532-8600
    ISSN 0026-0495
    DOI 10.1016/j.metabol.2018.03.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.316: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Measuring testosterone in women and men.

    Kanakis, George A / Tsametis, Christos P / Goulis, Dimitrios G

    Maturitas

    2019  Volume 125, Page(s) 41–44

    Abstract: Measurement of serum testosterone (T) level is of utmost importance for the evaluation of hypogonadism in men and androgen excess in women. Despite the advances in steroid hormone assessment, substantial variability exists regarding measurement of T ... ...

    Abstract Measurement of serum testosterone (T) level is of utmost importance for the evaluation of hypogonadism in men and androgen excess in women. Despite the advances in steroid hormone assessment, substantial variability exists regarding measurement of T concentrations. Several factors affect T measurement in men, including circadian rhythms, intra-individual daily variability and transient stressors, while T concentrations in women vary mainly according to the phase of the menstrual cycle. Most of the available immunoassays lack the required accuracy when dealing with T concentrations at the lower end of the normal range for men and across the entire range for females. Consequently, there is no universally accepted lower T threshold for healthy adult men and most immunoassays fail to detect states of mild androgen excess in women. Mass spectrometry is considered the gold-standard method for T measurement; however, due to its complexity and cost, it has not been widely adopted. To increase accuracy, T in men should be measured with a fasting morning sample and repeated if the level is found to be low; in women, measurement must be performed at the follicular phase of the cycle. In both cases, borderline results may be clarified by the assessment of free testosterone (fT). Since most fT assays are unreliable, calculated surrogates should be used instead. Collaborative efforts have been undertaken, with rigorous internal and external quality controls and the establishment of reference methods, to harmonise the commercial assays.
    MeSH term(s) Adult ; Biological Assay ; Cholesterol/analysis ; Female ; Follicular Phase/blood ; Humans ; Hypogonadism/blood ; Immunoassay ; Male ; Mass Spectrometry ; Menstrual Cycle ; Reference Values ; Reproducibility of Results ; Sex Factors ; Testosterone/blood ; Young Adult
    Chemical Substances Testosterone (3XMK78S47O) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2019-04-03
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 80460-5
    ISSN 1873-4111 ; 0378-5122
    ISSN (online) 1873-4111
    ISSN 0378-5122
    DOI 10.1016/j.maturitas.2019.04.203
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1432: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 575: Show issues

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