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Article ; Online: Sudden Cardiac Death in Athletes.

Tsang, Darren C / Link, Mark S

2021 Volume 48, Issue 4

MeSH term(s)	Athletes ; Death, Sudden, Cardiac/etiology ; Humans
Language	English
Publishing date	2021-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	604761-0
ISSN	1526-6702 ; 0730-2347
ISSN (online)	1526-6702
ISSN	0730-2347
DOI	10.14503/THIJ-20-7513
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Zs.A 1452: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Seronegative immune-mediated necrotising myopathy complicated by fulminant myocarditis resulting in cardiogenic shock and cardiac arrest.

Tsang, Darren / Malladi, Chaitanya Lakshmidhar / Patel, Komal / Bajaj, Puneet

BMJ case reports

2022 Volume 15, Issue 4

Abstract: A woman in her late 30s recently diagnosed with viral myopericarditis presented with 1 month of worsening fatigue, diffuse myalgias and chest pain radiating to her back. While undergoing work-up for chest wall myositis, she rapidly decompensated, ... ...

Abstract	A woman in her late 30s recently diagnosed with viral myopericarditis presented with 1 month of worsening fatigue, diffuse myalgias and chest pain radiating to her back. While undergoing work-up for chest wall myositis, she rapidly decompensated, developing heart failure and acute hypoxaemic respiratory failure. Her clinical course was complicated by cardiac arrest and severe cardiogenic shock requiring intra-aortic balloon pump support.
MeSH term(s)	Female ; Heart Arrest/complications ; Heart Arrest/therapy ; Humans ; Intra-Aortic Balloon Pumping/adverse effects ; Myocarditis/complications ; Myocarditis/diagnosis ; Myositis/complications ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy
Language	English
Publishing date	2022-04-04
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2021-248535
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Article ; Online: Sleeping prone with a left ventricular assist device: Dream or reality?

Tsang, Darren C / Kellner, Melissa / Thomas, Melanie / Araj, Faris G

Heart & lung : the journal of critical care

2022 Volume 56, Page(s) 57–61

Abstract: Background: Among many other factors, restrictions on sleeping positions decrease quality of life after durable left ventricular assist device implantation. Specifically, device manufacturers and clinicians typically advise against sleeping in the prone ...

Abstract	Background: Among many other factors, restrictions on sleeping positions decrease quality of life after durable left ventricular assist device implantation. Specifically, device manufacturers and clinicians typically advise against sleeping in the prone position owing to concerns for driveline disruption, exit site infection, and hemodynamic compromise. Yet, no data exist to inform these recommendations and to the best of our knowledge no studies have examined sleep position in people with left ventricular assist devices. We report the first case of a person with a left ventricular assist device who slept prone, every night, for over one year. Case: This is a 38-year-old man with a HeartWare™ left ventricular assist device who had previously not disclosed that he was sleeping in the prone position for the 16 months following device implantation. The patient did not suffer any episodes of device-related malfunction, infection, neurologic insult, or hemodynamic compromise. We performed a non-invasive assessment in both supine and prone positions to better understand the hemodynamic effects of the prone position. Conclusion: In select recipients of left ventricular assist devices, sleeping in the prone position may be safely tolerated.
MeSH term(s)	Male ; Humans ; Adult ; Heart-Assist Devices ; Quality of Life ; Heart Failure/therapy ; Hemodynamics ; Sleep
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	193129-5
ISSN	1527-3288 ; 0147-9563
ISSN (online)	1527-3288
ISSN	0147-9563
DOI	10.1016/j.hrtlng.2022.06.016
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Article ; Online: Cardiac sarcoidosis masquerading as ventricular tachycardia storm: a challenging diagnosis.

Aitken, William / Tsang, Darren / Chaparro, Sandra / Kir, Devika

BMJ case reports

2021 Volume 14, Issue 2

Abstract: A 67-year-old African-American woman with remote history of complete heart block (s/p pacemaker 3 years ago) and recent onset of ventricular tachycardia (VT) (s/p VT ablation and cardiac resynchronisation therapy defibrillator upgrade 3 months ago) ... ...

Abstract	A 67-year-old African-American woman with remote history of complete heart block (s/p pacemaker 3 years ago) and recent onset of ventricular tachycardia (VT) (s/p VT ablation and cardiac resynchronisation therapy defibrillator upgrade 3 months ago) presented to the hospital with VT storm. Workup showed newly reduced left ventricular ejection fraction with global hypokinesis (20%) and restrictive physiology. Positive technetium pyrophosphate scan was suspicious for TTR amyloid while serological workup revealed a monoclonal gammopathy. Cardiac MRI was contraindicated given remote brain aneurysm clip. Given clinical suspicion for cardiac sarcoidosis and divergent non-invasive workup, endomyocardial biopsy was performed which showed non-necrotising granulomas consistent with cardiac sarcoidosis. She was started on steroids with clinical improvement. Cardiac sarcoidosis is a challenging clinical diagnosis, particularly in patients without extracardiac manifestations. This case highlights the importance of a detailed and thorough workup of non-ischaemic cardiomyopathy and being cognizant of infiltrative disease as it can change patient management and outcomes.
MeSH term(s)	Aged ; Biopsy ; Cardiomyopathies/diagnosis ; Cardiomyopathies/drug therapy ; Cardiomyopathies/pathology ; Diagnosis, Differential ; Electrocardiography ; Female ; Humans ; Sarcoidosis/diagnosis ; Sarcoidosis/drug therapy ; Sarcoidosis/pathology ; Steroids/therapeutic use ; Tachycardia, Ventricular/diagnosis
Chemical Substances	Steroids
Language	English
Publishing date	2021-02-09
Publishing country	England
Document type	Case Reports ; Journal Article ; Video-Audio Media
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2020-237530
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Article: A case of symmetrical peripheral gangrene associated with transvenous lead extraction.

Tsang, Darren C / Carrillo, Roger G

HeartRhythm case reports

2017 Volume 3, Issue 9, Page(s) 436–439

Language	English
Publishing date	2017-07-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2834871-0
ISSN	2214-0271
ISSN	2214-0271
DOI	10.1016/j.hrcr.2017.07.001
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Article ; Online: Self-Perceived Hearing Status Creates an Unrealized Barrier to Hearing Healthcare Utilization.

Angara, Prashant / Tsang, Darren C / Hoffer, Michael E / Snapp, Hillary A

The Laryngoscope

2020 Volume 131, Issue 1, Page(s) E289–E295

Abstract: Objective: To examine sociodemographic and audiometric factors associated with hearing aid (HA) uptake in adults with hearing loss (HL), and to investigate the role of self-perceived hearing status on pursuit of hearing treatment. The relationship ... ...

Abstract	Objective: To examine sociodemographic and audiometric factors associated with hearing aid (HA) uptake in adults with hearing loss (HL), and to investigate the role of self-perceived hearing status on pursuit of hearing treatment. The relationship between self-perceived hearing status and HA adoption has not been reported in a nationally representative sample of United States (US) adults. Study design: Cross-sectional analysis of nationwide household health survey. Methods: Audiometric and questionnaire data from the 2005 to 2012 National Health and Nutrition Examination Survey cycles were used to examine trends in untreated HL and HA adoption in US adults. Adjusted odds ratios for HA adoption were calculated for individuals with measured HL. Results: Of 5230 respondents, 26.1% had measurable HL, of which only 16.0% correctly self-identified their hearing status, and only 17.7% used an HA. Age, higher education, severe hearing impairments, and recent hearing evaluations, were positively associated with HA adoption. Conclusion: Hearing loss is a global public health concern placing significant economic burden on both the individual and society. Self-reported hearing status is not a reliable indicator for HL, and measured HL is not correlated with increased rates of treatment. Recent hearing evaluation is positively associated with increased rates of treatment. Routine hearing assessment will help to better identify those with HL and improve access to hearing treatment. Level of evidence: III Laryngoscope, 131:E289-E295, 2021.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Audiometry, Pure-Tone ; Cross-Sectional Studies ; Female ; Hearing Aids/statistics & numerical data ; Hearing Loss/epidemiology ; Hearing Loss/therapy ; Humans ; Male ; Middle Aged ; Nutrition Surveys ; Patient Acceptance of Health Care/statistics & numerical data ; Self Report ; United States/epidemiology
Language	English
Publishing date	2020-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.28604
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Ul II Zs.82: Show issues

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Article ; Online: Symptomatic Aortic Valve Mass - Cardiac Work-Up Challenges and Role of Computed Tomography Angiography: A Case Report.

Reis, Victor S / Tsang, Darren C / Williams, Donald B / Carrillo, Roger G

Brazilian journal of cardiovascular surgery

2019 Volume 34, Issue 4, Page(s) 499–502

Abstract: Cardiac papillary fibroelastoma are rare, benign cardiac tumors that may lead to lethal complications from embolization or valvular dysfunction if left untreated. When working up symptomatic tumors with concomitant angina, traditional diagnostic studies ... ...

Abstract	Cardiac papillary fibroelastoma are rare, benign cardiac tumors that may lead to lethal complications from embolization or valvular dysfunction if left untreated. When working up symptomatic tumors with concomitant angina, traditional diagnostic studies such as cardiac catheterization may predispose the patient to embolic complications if the mass is located in the path of the catheter. Newer, non-invasive diagnostic testing, such as cardiac magnetic resonance imaging or dynamic computed tomography angiography, may be considered in lieu of invasive approaches to avoid potentially devastating complications. We herein present a case report of a 77-year-old female with a symptomatic aortic valve tumor and describe our diagnostic strategy and management.
MeSH term(s)	Aged ; Aortic Valve/diagnostic imaging ; Computed Tomography Angiography/methods ; Female ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/pathology ; Heart Neoplasms/surgery ; Heart Valve Diseases/diagnostic imaging ; Heart Valve Diseases/surgery ; Humans
Language	English
Publishing date	2019-08-27
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2031026-2
ISSN	1678-9741 ; 0102-7638
ISSN (online)	1678-9741
ISSN	0102-7638
DOI	10.21470/1678-9741-2018-0151
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Article ; Online: Effect of Prior Sternotomy on Outcomes in Transvenous Lead Extraction.

Tsang, Darren C / Perez, Adryan A / Boyle, Thomas A / Carrillo, Roger G

Circulation. Arrhythmia and electrophysiology

2019 Volume 12, Issue 9, Page(s) e007278

Abstract: Background: A history of open-heart surgery has been a heavily debated topic in transvenous lead extraction. This study evaluates the impact of prior sternotomy on transvenous lead extraction outcomes.: Methods: Data for all patients undergoing ... ...

Abstract	Background: A history of open-heart surgery has been a heavily debated topic in transvenous lead extraction. This study evaluates the impact of prior sternotomy on transvenous lead extraction outcomes. Methods: Data for all patients undergoing transvenous lead extraction at a tertiary referral center were prospectively gathered from 2004 to 2017. Relevant clinical information was compared between patients with a history of sternotomy before transvenous lead extraction and those without. After considering baseline differences, multivariate regression, and propensity-matched analysis were performed. Outcome variables included major and minor complication rates, clinical success, and in-hospital mortality as defined by the 2017 Heart Rhythm Society consensus statement. Results: Of 1480 patients in the study period, 455 had a prior sternotomy. When compared with patients with no prior sternotomy, those with prior sternotomy were more likely to be older, male, and present with more comorbidities and leads targeted for extraction. No statistical differences were identified in major and minor complication rates ( Conclusions: In a large, single-center series, no differences in clinical or procedural outcomes were elucidated between patients with a history of sternotomy and those without. Patients with sternotomies before lead extraction who experienced vascular or cardiac perforations clinically presented with hemothoraces rather than pericardial effusions.
MeSH term(s)	Aged ; Defibrillators, Implantable/adverse effects ; Device Removal/methods ; Endovascular Procedures/methods ; Equipment Failure ; Female ; Follow-Up Studies ; Humans ; Jugular Veins ; Male ; Prospective Studies ; Sternotomy
Language	English
Publishing date	2019-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.119.007278
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Article ; Online: Endovascular Occlusion Balloon for Treatment of Superior Vena Cava Tears During Transvenous Lead Extraction: A Multiyear Analysis and an Update to Best Practice Protocol.

Azarrafiy, Ryan / Tsang, Darren C / Wilkoff, Bruce L / Carrillo, Roger G

Circulation. Arrhythmia and electrophysiology

2019 Volume 12, Issue 8, Page(s) e007266

Abstract: Background: Superior vena cava (SVC) tears are one of the most lethal complications in transvenous lead extraction. An endovascular balloon can occlude the SVC in the event of a laceration, preventing blood loss and offering a more controlled surgical ... ...

Abstract	Background: Superior vena cava (SVC) tears are one of the most lethal complications in transvenous lead extraction. An endovascular balloon can occlude the SVC in the event of a laceration, preventing blood loss and offering a more controlled surgical field for repair. An early study demonstrated that proper use of this device is associated with reduced mortality. Thereafter, high-volume extractors at the Eleventh Annual Lead Management Symposium developed a best practice protocol for the endovascular balloon. Methods: We collected data on adverse events in lead extraction from July 1, 2016, to July 31, 2018. Data were prospectively collected from both a US Food and Drug Administration-maintained database and physician reports of adverse events as they occurred. We gathered case details directly from extracting physicians. Confirmed SVC tears were analyzed for patient demographics, case details, and index hospitalization mortality. Results: From July 1, 2016, to July 31, 2018, 116 confirmed SVC events were identified, of which 44.0% involved proper balloon use and 56.0% involved no use or improper use. When an endovascular balloon was properly used, 45 of 51 patients (88.2%) survived in comparison to 37 of 65 patients (56.9%) when a balloon was not used or improperly used (P=0.0002). Furthermore, multivariate regression modeling found that proper balloon deployment was an independent, negative predictor of in-hospital mortality for patients who experienced an SVC laceration (odds ratio, 0.13; 95% CI, 0.04-0.40; P<0.001). Conclusions: From July 1, 2016, through July 31, 2018, patients undergoing lead extraction were more likely to survive SVC tears when treatment included an endovascular balloon.
MeSH term(s)	Balloon Occlusion/methods ; Device Removal/adverse effects ; Electrodes, Implanted/adverse effects ; Endovascular Procedures/methods ; Female ; Follow-Up Studies ; Humans ; Intraoperative Complications ; Male ; Middle Aged ; Phlebography ; Retrospective Studies ; Treatment Outcome ; Vascular System Injuries/diagnosis ; Vascular System Injuries/etiology ; Vascular System Injuries/surgery ; Vena Cava, Superior/diagnostic imaging ; Vena Cava, Superior/injuries ; Vena Cava, Superior/surgery
Language	English
Publishing date	2019-08-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.119.007266
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Article ; Online: Evaluation of positive patch test reactions using optical coherence tomography: A pilot study.

Rajabi-Estarabadi, Ali / Tsang, Darren C / Nouri, Keyvan / Tosti, Antonella

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

2019 Volume 25, Issue 5, Page(s) 625–630

Abstract: Introduction: Patch testing is the gold standard for evaluating allergic contact dermatitis (ACD), yet current interpretation methods are limited by their subjectivity and possible variability between observers. Optical coherence tomography (OCT) ... ...

Abstract	Introduction: Patch testing is the gold standard for evaluating allergic contact dermatitis (ACD), yet current interpretation methods are limited by their subjectivity and possible variability between observers. Optical coherence tomography (OCT) imaging enables noninvasive in vivo skin visualization and holds promise as an objective method of patch test interpretation. Objective: To evaluate the micromorphological changes of patch test reactions and identify objective, quantitative OCT markers that correlate with clinically graded patch test reactions. Results: A total of 25 patch test reactions (7 grade-0, 4 grade-1+, 14 grade-2+) from 7 patients underwent OCT evaluation. Increased epidermal thickness and density was qualitatively observed in grade 1+ and grade 2+ allergic reactions while well-demarcated, signal-free cavities were observed in all grade 2+ reactions. Attenuation coefficients significantly increased across the three reaction grades (2.58 ± 0.092, 2.96 ± 0.121, 3.05 ± 0.065; P < 0.01). Cutaneous blood flow at 0.35 mm monotonically increased with reaction grade severity and blood measurements significantly differed across the three reaction grades (0.053 ± 0.011 mm/s, 0.078 ± 0.015 mm/s, and 0.121 ± 0.008 mm/s; P < 0.01). Conclusions and relevance: Attenuation coefficient and cutaneous blood flow at 0.35 mm correlate with clinically graded patch test reactions and hold promise as objective, quantitative markers. OCT may help dermatologists differentiate clinical scoring of allergic reactions in patch test and thereby improve their diagnostic accuracy and interpretation of patch test reactions.
MeSH term(s)	Analysis of Variance ; Blood Flow Velocity/physiology ; Dermatitis, Allergic Contact/diagnosis ; Dermatitis, Allergic Contact/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Patch Tests/methods ; Pilot Projects ; Tomography, Optical Coherence
Language	English
Publishing date	2019-03-19
Publishing country	England
Document type	Evaluation Study ; Journal Article
ZDB-ID	1229160-2
ISSN	1600-0846 ; 0909-752X ; 1397-1344
ISSN (online)	1600-0846
ISSN	0909-752X ; 1397-1344
DOI	10.1111/srt.12695
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