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  1. Article ; Online: Palliative and End-of-Life Care in Hematologic Malignancies: Progress and Opportunities.

    Tsang, Mazie / LeBlanc, Thomas W

    JCO oncology practice

    2024  , Page(s) OP2400081

    Abstract: JCOOP_ASCO editorial on unique needs of end-of-life care for different blood cancers discusses: #pallheme improves QOL but less utilized in cancers. Contextualize Weisse et al study. More #pallheme research needed for lymphoma and myeloma in era of cell ...

    Abstract @JCOOP_ASCO editorial on unique needs of end-of-life care for different blood cancers discusses: #pallheme improves QOL but less utilized in cancers. Contextualize Weisse et al study. More #pallheme research needed for lymphoma and myeloma in era of cell therapy.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.24.00081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7198: Show issues Location:
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  2. Article ; Online: Geriatric Assessments in Older Adults With Cancer.

    Diaz, Fernando C / Velazquez, Ana I / Tsang, Mazie

    JAMA oncology

    2023  Volume 9, Issue 11, Page(s) 1592

    MeSH term(s) Humans ; Aged ; Geriatric Assessment ; Neoplasms/therapy ; Medical Oncology
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2023.3329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Perspectives on geriatric oncology research presented at the 2023 American Society of Hematology Annual Meeting: Young International Society of Geriatric Oncology report.

    Abdallah, Maya / Akhtar, Othman Salim / Major, Ajay / Mian, Hira / Tsang, Mazie / Torka, Pallawi

    Journal of geriatric oncology

    2024  , Page(s) 101762

    Language English
    Publishing date 2024-04-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2024.101762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Decision-making about clinical trial options among older patients with metastatic cancer who have exhausted standard therapies.

    Tsang, Mazie / DeBoer, Rebecca J / Garrett, Sarah B / Dohan, Daniel

    Journal of geriatric oncology

    2022  Volume 13, Issue 5, Page(s) 594–599

    Abstract: Objectives: Older adults under-enroll in early phase cancer clinical trials. There are limited data on their trial experiences, which hampers our ability to understand potential reasons and responses to under-enrollment. We aimed to explore older adults' ...

    Abstract Objectives: Older adults under-enroll in early phase cancer clinical trials. There are limited data on their trial experiences, which hampers our ability to understand potential reasons and responses to under-enrollment. We aimed to explore older adults' experiences and deliberations with phase 1 trials.
    Materials and methods: We analyzed 101 in-depth interviews with 39 adults (average 2.6 interviews per participant) about their experiences with phase 1 trials. All respondents were ≥ 65 years and had advanced cancer. Interviews lasted 60-90 min and were audio-recorded, transcribed, and analyzed to identify respondents' understanding of clinical research, perceptions of early phase trials, and experiences with enrollment.
    Results: Clinical trial participation was an interactive process that unfolded over time. Older adults relied on ongoing guidance and discussion with their oncologist to navigate the process. Respondents were generally interested in life-prolonging therapies, including enrollment in early phase clinical trials, but did not necessarily state this explicitly to their oncologist. While respondents did not mention age as a limitation to trials participation, participants age > 70 were less enthusiastic about participation and more often discussed their quality of life and weighed benefits of trial participation in the context of their remaining months of life.
    Conclusion: Early phase clinical trial enrollment is complex, and older adults rely on their oncologist to navigate this process. Acknowledging this complexity through shared decision-making may ensure that older adults have appropriate opportunities to enroll in early phase clinical trials and guard against inappropriate under-enrollment.
    MeSH term(s) Aged ; Clinical Trials as Topic ; Humans ; Neoplasms/drug therapy ; Patient Selection ; Quality of Life ; Standard of Care
    Language English
    Publishing date 2022-02-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2022.01.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Primary central nervous system lymphoma in older adults and the rationale for maintenance strategies: a narrative review.

    Tsang, Mazie / Rubenstein, James L / Pulczynski, Elisa Jacobsen

    Annals of lymphoma

    2021  Volume 5

    Abstract: Objective: To provide a summary and analysis of the evidence for various agents applied as maintenance therapy and highlight ongoing trials or trials in development that evaluate the efficacy of maintenance therapy strategies in older patients with ... ...

    Abstract Objective: To provide a summary and analysis of the evidence for various agents applied as maintenance therapy and highlight ongoing trials or trials in development that evaluate the efficacy of maintenance therapy strategies in older patients with primary central nervous system lymphoma (PCNSL).
    Background: PCNSL are rare neoplasms that can have an aggressive course with short-lived remissions when compared to systemic diffuse large B-cell lymphoma (DLBCL). There is currently a paucity of evidence on treatment in older adults with PCNSL, who may be unfit to tolerate effective therapies for PCNSL. Those who can tolerate these therapies and survive PCNSL are at increased risk from developing treatment-related toxicity, functional decline, and debilitating neurotoxicity. While there is no clearly defined role for maintenance therapy after treatment of systemic DLBCL, it should be considered in PCNSL because central nervous system (CNS) recurrence often has a devastating and irreversible impact on neurologic function. Therefore, at least theoretically, use of effective maintenance therapy in older adults with PCNSL, either in lieu of consolidation or after consolidation therapy, may be better tolerated and help delay tumor progression, resulting in an improved overall global neurologic function and quality of life.
    Methods: We systematically searched MEDLINE (via PubMed) for all studies of drug treatments for maintenance therapy in PCNSL and also relied on expert opinion. We provide a summary and analysis of the evidence for various maintenance therapy agents, including methotrexate, rituximab, lenalidomide, temozolomide, ibrutinib, and procarbazine. We also highlight ongoing trials or trials in development that evaluate the efficacy of maintenance therapy in PCNSL.
    Conclusions: Prospective clinical studies focusing on PCNSL patients who are not candidates for intensive post-induction therapy are scarce. To date, there are no studies that clarify whether maintenance therapy can be used in lieu of consolidation therapy with autologous stem cell transplant or radiation. Prospective studies may provide critical data regarding the identification of optimal agents, whether consolidation therapy could be replaced by maintenance therapy, and the overall role of maintenance therapy as a means to potentially improve survival and preserve quality of life and function in a vulnerable, older patient population.
    Language English
    Publishing date 2021-09-30
    Publishing country China
    Document type Journal Article
    DOI 10.21037/aol-20-43
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The importance of empathy--as I have studied and experienced it.

    Tsang, Mazie

    Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health

    2013  Volume 72, Issue 9 Suppl 4, Page(s) 79–80

    MeSH term(s) Communication ; Education, Medical ; Empathy ; Humans ; Male ; Middle Aged ; Physician-Patient Relations
    Language English
    Publishing date 2013-08-19
    Publishing country United States
    Document type Journal Article ; Personal Narrative
    ZDB-ID 2653459-9
    ISSN 2165-8242 ; 2165-8218
    ISSN (online) 2165-8242
    ISSN 2165-8218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 305: Show issues Location:
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  7. Article ; Online: Where the Sidewalk Ends: Parenting as a Trainee during COVID-19.

    Tsang, Mazie / Banerjee, Rahul / Quiroga, Dionisia / Idossa, Dame / Schoenbeck, Kelly L

    Cancer investigation

    2023  Volume 41, Issue 6, Page(s) 559–567

    Abstract: Physicians who are also parents have faced significant difficulties during the COVID-19 pandemic. However, most studies of the physician-parent workforce have focused on the experiences of attending physicians. In this commentary, we highlight the ways ... ...

    Abstract Physicians who are also parents have faced significant difficulties during the COVID-19 pandemic. However, most studies of the physician-parent workforce have focused on the experiences of attending physicians. In this commentary, we highlight the ways that trainee parents have uniquely experienced three major stressors during the pandemic: (1) childcare challenges, (2) scheduling difficulties, and (3) career uncertainties. We discuss potential solutions to mitigate these challenges for the future hematology/oncology workforce. As the pandemic continues, we hope that these steps can improve the ability of trainee parents to care both for their patients and their families.
    MeSH term(s) Humans ; COVID-19 ; Parenting ; Pandemics ; Physicians
    Language English
    Publishing date 2023-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 604942-4
    ISSN 1532-4192 ; 0735-7907
    ISSN (online) 1532-4192
    ISSN 0735-7907
    DOI 10.1080/07357907.2023.2219747
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    Zs.A 1862: Show issues Location:
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  8. Article ; Online: "Celebrating Resilience": A review of abstracts on functional resilience at the International Society of Geriatric Oncology 2022 annual meeting.

    Tsang, Mazie / Dong, JiaXi / DuMontier, Clark / Neuendorff, Nina Rosa / Presley, Carolyn J

    Journal of geriatric oncology

    2023  Volume 14, Issue 7, Page(s) 101587

    MeSH term(s) Humans ; Aged ; Neoplasms ; Medical Oncology ; Hematology
    Language English
    Publishing date 2023-07-15
    Publishing country Netherlands
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2023.101587
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  9. Article ; Online: On point in primary CNS lymphoma.

    Tsang, Mazie / Cleveland, Joseph / Rubenstein, James L

    Hematological oncology

    2020  Volume 38, Issue 5, Page(s) 640–647

    Abstract: Primary CNS lymphoma (PCNSL) is an aggressive brain tumor that represents a significant challenge both to elucidate its biological pathogenesis as well as to develop definitive precision medicines with minimal collateral toxicity. We highlight the key ... ...

    Abstract Primary CNS lymphoma (PCNSL) is an aggressive brain tumor that represents a significant challenge both to elucidate its biological pathogenesis as well as to develop definitive precision medicines with minimal collateral toxicity. We highlight the key issues in diagnosis and treatment and focus on emerging technologies, current options among consolidation strategies, and biological agents. We anticipate that further development of molecular diagnostics and molecular imaging approaches that elucidate minimal residual disease in brain parenchyma, leptomeninges, intraocular compartments and even bone marrow will greatly impact the delivery and timing of cytotoxic and biological therapies. Implementation of these approaches is likely essential to clarify ongoing discrepancies in the interpretation of clinical trial results that currently are based on relatively unrefined definitions of response. While the results of early phase investigations involving ibrutinib and the IMiD agents, lenalidomide, pomalidomide, as well as avadomide, strongly support the hypothesis that the B-cell receptor (BCR) pathway, involving MYD88 and CD79B and NF-kB activation, is critical to the pathogenesis of PCNSL, much work is needed to elucidate mechanisms of resistance. Similarly, development of strategies to overcome immunosuppressive mechanisms that are upregulated in the tumor microenvironment is a high priority. Finally, ongoing evidence supports the hypothesis that the blood-brain barrier represents a significant impediment to efficient brain tumor penetration of novel therapeutic agents and innovative strategies of drug delivery remain essential to further improve outcomes.
    MeSH term(s) Animals ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/etiology ; Central Nervous System Neoplasms/therapy ; Combined Modality Therapy/adverse effects ; Combined Modality Therapy/methods ; Disease Management ; Disease Susceptibility ; Humans ; Lymphoma/diagnosis ; Lymphoma/etiology ; Lymphoma/therapy ; Molecular Diagnostic Techniques ; Multimodal Imaging/methods ; Symptom Assessment ; Treatment Outcome ; Tumor Microenvironment
    Language English
    Publishing date 2020-07-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.2761
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1816: Show issues Location:
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  10. Article ; Online: The epidemiology of preexisting geriatric and palliative conditions in older adults with poor prognosis cancers.

    Tsang, Mazie / Gan, Siqi / Boscardin, W John / Wong, Melisa L / Walter, Louise C / Smith, Alexander K

    Journal of the American Geriatrics Society

    2022  Volume 70, Issue 12, Page(s) 3402–3412

    Abstract: Background: Older patients with poor prognosis cancers have complex needs that can benefit from geriatrics and palliative care principles. Because they are not routinely assessed, the prevalence of preexisting geriatric and palliative conditions in this ...

    Abstract Background: Older patients with poor prognosis cancers have complex needs that can benefit from geriatrics and palliative care principles. Because they are not routinely assessed, the prevalence of preexisting geriatric and palliative conditions in this population is unknown.
    Methods: We used the nationally representative Health and Retirement Study (HRS) linked with Medicare claims (1998-2016) to identify adults aged ≥65 years diagnosed with poor prognosis cancers (cancers with a median survival ≤1 year). Using the HRS interview before the first Medicare cancer claim, we used survey-weighted descriptive statistics and modified Poisson regression analysis to examine the prevalence of the following clinically significant conditions: functional impairment, difficulty with mobility, falls and injurious falls, social support, cognition, advance care planning, use of pain or sleep medications, and presence of pain or breathlessness.
    Results: Of 2105 participants (mean age 76, 53% women, 34% lung cancer, 21% gastrointestinal cancer), the median survival was 9.6 months. Approximately 65% had difficulty climbing stairs (95% CI 63%-67%), 49% had no advance directive (95% CI 45%-54%), 35% lived alone (95% CI 33%-37%), 36% fell in the last 2 years (95% CI 34%-38%), and 32% rated their memory as poor (95% CI 29%-34%). After adjusting for gender, cancer type, and HRS survey time before the first Medicare claim for a poor prognosis cancer, functional impairment and falls were highest among adults aged 85+. Adults aged 65-74 years were less likely to have an advance directive. After adjusting for age, cancer type, and HRS survey time, women had a higher rate of pain and physical impairment. In exploratory analyses, race and socioeconomic status predicted difficulty with mobility and instrumental activities of daily living, living alone, and advance directive completion.
    Conclusions: Due to a high prevalence across multiple domains, all older adults with poor prognosis cancers should be assessed for geriatric and palliative care conditions.
    MeSH term(s) Aged ; Humans ; Female ; United States/epidemiology ; Male ; Activities of Daily Living ; Geriatric Assessment ; Medicare ; Neoplasms/epidemiology ; Neoplasms/therapy ; Pain/epidemiology ; Prognosis
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18039
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    Ud II Zs.168: Show issues Location:
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