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  1. AU="Tsang, Stephen H"
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  1. Book ; Online ; E-Book: CRISPR genome surgery in stem cells and disease tissues

    Tsang, Stephen H.

    2022  

    Title variant Genome surgery in stem cells and disease tissues
    Author's details edited by Stephen H. Tsang
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (ix, 126 Seiten), Illustrationen, Diagramme
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021203454
    ISBN 978-0-12-817877-5 ; 9780128178768 ; 0-12-817877-9 ; 0128178760
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Retinitis pigmentosa

    Tsang, Stephen H. / Quinn, Peter M. J.

    (Methods in molecular biology ; 2560 ; Springer protocols)

    2023  

    Author's details edited by Stephen H. Tsang, Peter M.J. Quinn
    Series title Methods in molecular biology ; 2560
    Springer protocols
    Collection
    Keywords Retinitis pigmentosa
    Subject code 617.735
    Language English
    Size xvii, 404 Seiten, Illustrationen, 26 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT021691030
    ISBN 978-1-0716-2650-4 ; 9781071626511 ; 1-0716-2650-7 ; 1071626515
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2560- not available for loan Lesesaal EG

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  3. Book: Atlas on inherited retinal diseases

    Tsang, Stephen H. / Sharma, Tarun

    Stephen H. Tsang, Tarun Sharma editors

    (Advances in experimental medicine and biology ; 1085)

    2019  

    Series title Advances in experimental medicine and biology ; 1085
    Collection
    Keywords exon sequencing ; genetic eye disorder ; genome testing ; inherited retinal disease ; molecular genetics
    Subject code 610
    Language English
    Size xix, 274 Seiten, Illustrationen, 27.9 cm x 21 cm
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019862718
    ISBN 978-3-319-95045-7 ; 3-319-95045-2 ; 9783319950464 ; 3319950460
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1085- not available for loan Zeitschriften-Lesesaal

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  4. Book ; Online ; E-Book: Precision medicine, CRISPR, and genome engineering

    Tsang, Stephen H.

    moving from Association to Biology and Therapeutics

    (Advances in experimental medicine and biology ; 1016)

    2017  

    Author's details Stephen H. Tsang editor ; foreword by George M. Church
    Series title Advances in experimental medicine and biology ; 1016
    Collection
    Keywords Life sciences ; Human genetics ; Ophthalmology ; Agriculture ; Stem cells ; Regenerative medicine ; Tissue engineering
    Subject code 612.028 ; 571.538
    Language English
    Size 1 Online-Ressource (ix, 178 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019555083
    ISBN 978-3-319-63904-8 ; 9783319639031 ; 3-319-63904-8 ; 331963903X
    DOI 10.1007/978-3-319-63904-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  5. Book: Stem cell biology and regenerative medicine in ophthalmology

    Tsang, Stephen H.

    (Stem cell biology and regenerative medicine)

    2013  

    Author's details Stephen H. Tsang ed
    Series title Stem cell biology and regenerative medicine
    Keywords Ophthalmology ; Stem cells ; Regenerative medicine
    Language English
    Size XVI, 186 S. : Ill., graph. Darst., 24 cm
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017511308
    ISBN 978-1-4614-5492-2 ; 1-4614-5492-1 ; 9781461454939 ; 146145493X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 4779 order for loan Magazin

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  6. Article ; Online: Bypassing pre-existing antibodies extends the applicability of AAV-based retinal therapies.

    Hu, Hannah F / Tsang, Stephen H

    Molecular therapy : the journal of the American Society of Gene Therapy

    2023  Volume 31, Issue 12, Page(s) 3363

    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2023.11.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Gene therapy and therapeutic editing with outer or inner retina animal models.

    Baehr, Wolfgang / Tsang, Stephen H

    Vision research

    2023  Volume 213, Page(s) 108316

    MeSH term(s) Animals ; Retina ; Models, Animal ; Genetic Therapy
    Language English
    Publishing date 2023-09-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 200427-6
    ISSN 1878-5646 ; 0042-6989
    ISSN (online) 1878-5646
    ISSN 0042-6989
    DOI 10.1016/j.visres.2023.108316
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 521: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book: Precision medicine, CRISPR, and genome engineering

    Church, George M. / Tsang, Stephen H.

    moving from association to biology and therapeutics

    (Advances in experimental medicine and biology ; 1016 ; Biomedicine)

    2017  

    Author's details Stephen H. Tsang (editor) ; foreword by George M. Church
    Series title Advances in experimental medicine and biology ; 1016
    Biomedicine
    Collection
    Keywords Life sciences ; Human genetics ; Ophthalmology ; Agriculture ; Stem cells ; Regenerative medicine ; Tissue engineering
    Subject code 612.028 ; 571.538
    Language English
    Size ix, 178 Seiten, Illustrationen, Diagramme
    Publisher Springer
    Publishing place Cham, Switzerland
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT019524953
    ISBN 978-3-319-63903-1 ; 9783319639048 ; 3-319-63903-X ; 3319639048
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 3192 -1016- not available for loan Zeitschriften-Lesesaal

    Order via subito

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  9. Article ; Online: A New Preclinical Model of Retinitis Pigmentosa Due to

    Jentzsch, Michelle Carmen / Tsang, Stephen H / Koch, Susanne Friederike

    Ophthalmology science

    2023  Volume 3, Issue 4, Page(s) 100332

    Abstract: Purpose: Retinitis pigmentosa (RP) is the most common cause of inherited blindness, with onset occurring as early as 4 years of age in certain rare but severe forms caused by mutations in the gamma subunit of phosphodiesterase 6 (PDE6). Studies in ... ...

    Abstract Purpose: Retinitis pigmentosa (RP) is the most common cause of inherited blindness, with onset occurring as early as 4 years of age in certain rare but severe forms caused by mutations in the gamma subunit of phosphodiesterase 6 (PDE6). Studies in humans and mice have shown that RP pathology begins with progressive photoreceptor death, which then drives changes in downstream neurons, neighboring retinal pigment epithelium (RPE), and vasculature. Here, we present the first detailed analysis of RP disease progression in
    Design: Experimental study of an RP mouse model.
    Subjects: We studied
    Methods: Photoreceptor degeneration and retinal remodeling were analyzed in retinal sections by immunofluorescence. Retinal blood vessel degradation was analyzed in flat-mounted retinas immunolabeled for isolectin GS-IB4. Protein expression was measured by immunoblot. Acellular capillaries were assessed in trypsin-digested and hematoxylin-eosin-stained retinas at postnatal day (P) 44. Retinal pigment epithelium cells were delineated in flat-mounted RPE-choroid-sclera by immunolabeling for the cell-adhesion protein β-catenin.
    Main outcome measures: Immunofluorescence and morphometry (quantitative analysis of outer nuclear layer, dendrite area, vessel area, acellular vessels, RPE cell size, number of nuclei per RPE cell, RPE cell eccentricity, and RPE cell solidity).
    Results: This novel RP model exhibits early onset and rapid rod degeneration, with the vast majority gone by P16. This pathology leads to retinal remodeling, including changes of inner retinal neurons, early activation of glia cells, degradation of retinal vasculature, and structural abnormalities of the RPE.
    Conclusions: The pathology in our
    Financial disclosures: Proprietary or commercial disclosure may be found after the references.
    Language English
    Publishing date 2023-05-16
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-9145
    ISSN (online) 2666-9145
    DOI 10.1016/j.xops.2023.100332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Primary versus Secondary Elevations in Fundus Autofluorescence.

    Parmann, Rait / Tsang, Stephen H / Sparrow, Janet R

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: The method of quantitative fundus autofluorescence (qAF) can be used to assess the levels of bisretinoids in retinal pigment epithelium (RPE) cells so as to aid the interpretation and management of a variety of retinal conditions. In this review, we ... ...

    Abstract The method of quantitative fundus autofluorescence (qAF) can be used to assess the levels of bisretinoids in retinal pigment epithelium (RPE) cells so as to aid the interpretation and management of a variety of retinal conditions. In this review, we focused on seven retinal diseases to highlight the possible pathways to increased fundus autofluorescence.
    MeSH term(s) Humans ; Fundus Oculi ; Photoreceptor Cells/metabolism ; Retinal Degeneration/metabolism ; Scotoma/metabolism ; White Dot Syndromes/metabolism ; Fluorescein Angiography ; Tomography, Optical Coherence ; Retinal Pigment Epithelium/metabolism ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Alcohol Oxidoreductases/metabolism
    Chemical Substances ABCA4 protein, human ; ATP-Binding Cassette Transporters ; RDH12 protein, human (EC 1.1.1.105) ; Alcohol Oxidoreductases (EC 1.1.-)
    Language English
    Publishing date 2023-08-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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