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Article ; Online: A Montessori-based approach to treat behavioral and psychological symptoms in dementia.

Tschanz, JoAnn T / Hammond, Alexandra G

2020 Volume 32, Issue 3, Page(s) 303–306

MeSH term(s)	Caregivers ; Cross-Over Studies ; Dementia/therapy ; Humans ; Nursing Homes
Language	English
Publishing date	2020-03-19
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	1038825-4
ISSN	1741-203X ; 1041-6102
ISSN (online)	1741-203X
ISSN	1041-6102
DOI	10.1017/S1041610220000149
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Article ; Online: Scheltens ratings, clinical white matter hyperintensities and executive functioning in the Cache County Memory Study.

Farrer, Thomas J / Bigler, Erin D / Tsui-Caldwell, Yoko H W / Abildskov, Tracy J / Tschanz, JoAnn T / Welsh-Bohmer, Kathleen A

Applied neuropsychology. Adult

2023 , Page(s) 1–7

Abstract: Objective: Examine the association between neuropsychologically assessed executive function and clinically identifiable white matter burden from magnetic resonance imaging, using a visual rating system (Scheltens Rating System) applied to the Cache ... ...

Abstract	Objective: Examine the association between neuropsychologically assessed executive function and clinically identifiable white matter burden from magnetic resonance imaging, using a visual rating system (Scheltens Rating System) applied to the Cache County Memory Study (CCMS) archival database. Method: We used the Scheltens Ratings Scale to quantify white matter lesion burden in the CCMS sample and used this metric as a predictor of executive function. The sample included 60 individuals with dementia and 13 healthy controls. Results: Higher Scheltens ratings were associated with poorer task performance on an Executive Function composite score of common neuropsychological tests. This association held true for both controls and dementing cases. Conclusions: The current findings support extensive prior literature demonstrating the association between brain vascular health determined by white matter burden and clinical outcomes based on neuropsychological assessment of cognitive performance.
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2673736-X
ISSN	2327-9109 ; 2327-9095
ISSN (online)	2327-9109
ISSN	2327-9095
DOI	10.1080/23279095.2023.2287140
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Article ; Online: Malnutrition and neuropsychiatric symptoms in dementia: the Cache County Dementia Progression Study.

Kauzor, Kaitlyn / Drewel, Mikaela / Gonzalez, Hector / Rattinger, Gail B / Hammond, Alexandra G / Wengreen, Heidi / Lyketsos, Constantine G / Tschanz, JoAnn T

International psychogeriatrics

2023 Volume 35, Issue 11, Page(s) 653–663

Abstract: Objectives: Among people with dementia, poor nutritional status has been associated with worse cognitive and functional decline, but few studies have examined its association with neuropsychiatric symptoms (NPS). We examined this topic in a population- ... ...

Abstract	Objectives: Among people with dementia, poor nutritional status has been associated with worse cognitive and functional decline, but few studies have examined its association with neuropsychiatric symptoms (NPS). We examined this topic in a population-based sample of persons with dementia. Design: Longitudinal, observational cohort study. Setting: Community. Participants: Two hundred ninety-two persons with dementia (71.9% Alzheimer's disease, 56.2% women) were followed up to 6 years. Measurements: We used a modified Mini-Nutritional Assessment (mMNA) and the Neuropsychiatric Inventory (NPI) to evaluate nutritional status and NPS, respectively. Individual linear mixed effects models examined the associations between time-varying mMNA total score or clinical categories (malnourishment, risk for malnourishment, or well-nourished) and NPI total score (excluding appetite domain) or NPI individual domain or cluster (e.g. psychosis) scores. Covariates tested were dementia onset age, type, and duration, medical comorbidities, sex, apolipoprotein E (APOE) genotype, and education. Results: Compared to the well-nourished, those at risk for malnourishment and those malnourished had higher total NPI scores [ Conclusions: Worse nutritional status is associated with more severe NPS. Dietary or behavioral interventions to prevent malnutrition may be beneficial for persons with dementia.
MeSH term(s)	Humans ; Female ; Male ; Dementia/psychology ; Alzheimer Disease/psychology ; Longitudinal Studies ; Cohort Studies ; Malnutrition/epidemiology ; Neuropsychological Tests
Language	English
Publishing date	2023-05-29
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1038825-4
ISSN	1741-203X ; 1041-6102
ISSN (online)	1741-203X
ISSN	1041-6102
DOI	10.1017/S1041610223000467
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Zs.A 2621: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer's Disease: A Population Database Analysis.

Valentine, David / Teerlink, Craig C / Farnham, James M / Rowe, Kerry / Kaddas, Heydon / Tschanz, JoAnn / Kauwe, John S K / Cannon-Albright, Lisa A

International journal of environmental research and public health

2022 Volume 19, Issue 24

Abstract: 1) Importance: Alzheimer's disease (AD) is complex and only partially understood. Analyzing the relationship between other more treatable or preventable diseases and AD may help in the prevention and the eventual development of treatments for AD. Risk ... ...

Abstract	(1) Importance: Alzheimer's disease (AD) is complex and only partially understood. Analyzing the relationship between other more treatable or preventable diseases and AD may help in the prevention and the eventual development of treatments for AD. Risk estimation in a high-risk population, rather than a population already affected with AD, may reduce some bias in risk estimates. (2) Objective: To examine the rates of various comorbidities and cancers in individuals at high-risk for AD, but without a clinical diagnosis, relative to individuals from the same population with normal AD risk. (3) Design, Setting, and Participants: We conducted a study using data from the Utah Population Database (UPDB). The UPDB contains linked data from the Utah Cancer Registry, Utah death certificates, the Intermountain Health patient population, and the University of Utah Health patient population. Subjects were selected based on the availability of ancestral data, linked health information, and self-reported biometrics. (4) Results: In total, 75,877 participants who were estimated to be at high risk for AD based on family history, but who did not have an active AD diagnosis, were analyzed. A lower incidence of diabetes (RR = 0.95, 95% CI [0.92,0.97],
MeSH term(s)	Humans ; Alzheimer Disease/epidemiology ; Neoplasms/epidemiology ; Comorbidity ; Incidence ; Risk Factors
Language	English
Publishing date	2022-12-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192416419
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Article ; Online: How good are medical and death records for identifying dementia?

Schliep, Karen C / Ju, Shinyoung / Foster, Norman L / Smith, Ken R / Varner, Michael W / Østbye, Truls / Tschanz, JoAnn T

Alzheimer's & dementia : the journal of the Alzheimer's Association

2021 Volume 18, Issue 10, Page(s) 1812–1823

Abstract: Introduction: Retrospective studies using administrative data may be an efficient way to assess risk factors for dementia if diagnostic accuracy is known.: Methods: Within-individual clinical diagnoses of Alzheimer's disease (AD) and all-cause ... ...

Abstract	Introduction: Retrospective studies using administrative data may be an efficient way to assess risk factors for dementia if diagnostic accuracy is known. Methods: Within-individual clinical diagnoses of Alzheimer's disease (AD) and all-cause dementia in ambulatory (outpatient) surgery, inpatient, Medicare administrative records and death certificates were compared with research diagnoses among participants of Cache County Study on Memory, Health, and Aging (CCSMHA) (1995-2008, N = 5092). Results: Combining all sources of clinical health data increased sensitivity for identifying all-cause dementia (71%) and AD (48%), while maintaining relatively high specificity (81% and 93%, respectively). Medicare claims had the highest sensitivity for case identification (57% and 40%, respectively). Discussion: Administrative health data may provide a less accurate method than a research evaluation for identifying individuals with dementing disease, but accuracy is improved by combining health data sources. Assessing all-cause dementia versus a specific cause of dementia such as AD will result in increased sensitivity, but at a cost to specificity.
MeSH term(s)	Humans ; Aged ; United States ; Dementia/diagnosis ; Retrospective Studies ; Death Certificates ; Medicare ; Alzheimer Disease/diagnosis ; Sensitivity and Specificity
Language	English
Publishing date	2021-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.12526
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Zs.A 6316: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 540: Show issues

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Article ; Online: Neuropsychiatric symptoms in severe dementia: Associations with specific cognitive domains the Cache County Dementia Progression Study.

Rozum, William J / Cooley, Bryce / Vernon, Elizabeth / Matyi, Joshua / Tschanz, JoAnn T

International journal of geriatric psychiatry

2019 Volume 34, Issue 7, Page(s) 1087–1094

Abstract: Objectives: To examine the prevalence of neuropsychiatric symptoms (NPS) and cognitive correlates in severe dementia.: Methods: A population-based sample of 56 individuals with severe dementia (85.7% Alzheimer's type; 67.9% female) were assessed with ...

Abstract	Objectives: To examine the prevalence of neuropsychiatric symptoms (NPS) and cognitive correlates in severe dementia. Methods: A population-based sample of 56 individuals with severe dementia (85.7% Alzheimer's type; 67.9% female) were assessed with the Severe Cognitive Impairment Profile (SCIP) and the Neuropsychiatric Inventory (NPI). Descriptive statistics displayed the frequency of NPS and bivariate and multiple regression analyses examined the associations between cognitive domains on the SCIP and NPS total, domain, and cluster scores. Results: NPS were common in severe dementia with 98% of the sample exhibiting at least one symptom. Most common were delusions, apathy, agitation/aggression, and aberrant motor behavior, affecting 50% or more of participants. SCIP comportment was significantly associated with NPI total score and apathy (r = -.350 and -.292, respectively). All SCIP domains except for arithmetic, visuospatial, comportment, and motor behavior were significantly associated with agitation/aggression (r = -.285 to -.350). These associations remained in individual multiple regression models. Conclusion: In severe dementia, impairment in specific cognitive domains was associated with more severe NPS. Environmental manipulations to reduce processing demands in persons with severe dementia may be a useful strategy to target agitation and aggressive behaviors.
MeSH term(s)	Aged ; Aged, 80 and over ; Anxiety/epidemiology ; Apathy ; Cognitive Dysfunction/psychology ; Delusions/epidemiology ; Dementia/psychology ; Disease Progression ; Female ; Humans ; Male ; Mental Disorders/epidemiology ; Neuropsychological Tests ; Prevalence ; Regression Analysis ; Utah/epidemiology
Language	English
Publishing date	2019-04-25
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.5112
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Article ; Online: Lifetime estrogen exposure and cognition in late life: the Cache County Study.

Matyi, Joshua M / Rattinger, Gail B / Schwartz, Sarah / Buhusi, Mona / Tschanz, JoAnn T

Menopause (New York, N.Y.)

2019 Volume 26, Issue 12, Page(s) 1366–1374

Abstract: Objective: Prevalence of Alzheimer's disease (AD) is higher for women, possibly influenced by sex-dependent effects of the estrogen. We examined the association between estrogen and cognitive decline in over 2,000 older adult women in a 12-year ... ...

Abstract	Objective: Prevalence of Alzheimer's disease (AD) is higher for women, possibly influenced by sex-dependent effects of the estrogen. We examined the association between estrogen and cognitive decline in over 2,000 older adult women in a 12-year population-based study in Cache County, Utah. Methods: The baseline sample included 2,114 women (mean age = 74.94 y, SD = 6.71) who were dementia-free at baseline and completed a women's health questionnaire, asking questions regarding reproductive history and hormone therapy (HT). Endogenous estrogen exposure (EEE) was calculated taking the reproductive window (age at menarche to age at menopause), adjusted for pregnancy and breastfeeding. HT variables included duration of use, HT type (unopposed; opposed), and time of HT initiation. A modified version of the Mini-Mental State Examination (3MS) was administered at four triennial waves to assess cognitive status. Linear mixed-effects models examined the relationship between estrogen exposure and 3MS score over time. Results: EEE was positively associated with cognitive status (β = 0.03, P = 0.054). In addition, longer duration of HT use was positively associated with cognitive status (β = 0.02, P = 0.046) and interacted with age; older women had greater benefit compared with younger women. The timing of HT initiation was significantly associated with 3MS (β = 0.55, P = 0.048), with higher scores for women who initiated HT within 5 years of menopause compared with those initiating HT 6-or-more years later. Conclusions: Our results suggest that longer EEE and HT use, especially in older women, are associated with higher cognitive status in late life.
MeSH term(s)	Aged ; Aged, 80 and over ; Cognition/drug effects ; Cognitive Dysfunction/classification ; Cognitive Dysfunction/epidemiology ; Estrogen Replacement Therapy/statistics & numerical data ; Estrogens/pharmacology ; Female ; Health Surveys ; Humans ; Longitudinal Studies ; Postmenopause ; Time Factors ; Utah/epidemiology
Chemical Substances	Estrogens
Language	English
Publishing date	2019-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1205262-0
ISSN	1530-0374 ; 1072-3714
ISSN (online)	1530-0374
ISSN	1072-3714
DOI	10.1097/GME.0000000000001405
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Article: Hypertensive disorders of pregnancy and subsequent risk of Alzheimer's disease and other dementias.

Schliep, Karen C / Shaaban, C Elizabeth / Meeks, Huong / Fraser, Alison / Smith, Ken R / Majersik, Jennifer J / Foster, Norman L / Wactawski-Wende, Jean / Østbye, Truls / Tschanz, JoAnn / Padbury, James F / Sharma, Surrendra / Zhang, Yue / Facelli, Julio C / Abdelrahman, C Samir / Theilen, Lauren / Varner, Michael W

Alzheimer's & dementia (Amsterdam, Netherlands)

2023 Volume 15, Issue 2, Page(s) e12443

Abstract: Introduction: Women with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later-life dementia has not been fully explored.: Methods: Using the Utah Population Database, we ...

Abstract	Introduction: Women with hypertensive disorders of pregnancy (HDP) have an increased risk of cardiovascular disease. Whether HDP is also associated with later-life dementia has not been fully explored. Methods: Using the Utah Population Database, we performed an 80-year retrospective cohort study of 59,668 parous women. Results: Women with, versus without, HDP, had a 1.37 higher risk of all-cause dementia (95% confidence interval [CI]: 1.26, 1.50) after adjustment for maternal age at index birth, birth year, and parity. HDP was associated with a 1.64 higher risk of vascular dementia (95% CI: 1.19, 2.26) and 1.49 higher risk of other dementia (95% CI: 1.34, 1.65) but not Alzheimer's disease dementia (adjusted hazard ratio = 1.04; 95% CI: 0.87, 1.24). Gestational hypertension and preeclampsia/eclampsia showed similar increased dementia risk. Nine mid-life cardiometabolic and mental health conditions explained 61% of HDP's effect on subsequent dementia risk. Discussion: Improved HDP and mid-life care could reduce the risk of dementia.
Language	English
Publishing date	2023-05-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2832898-X
ISSN	2352-8729
ISSN	2352-8729
DOI	10.1002/dad2.12443
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Article: Modelling mobile-based technology adoption among people with dementia.

Chaurasia, Priyanka / McClean, Sally / Nugent, Chris D / Cleland, Ian / Zhang, Shuai / Donnelly, Mark P / Scotney, Bryan W / Sanders, Chelsea / Smith, Ken / Norton, Maria C / Tschanz, JoAnn

Personal and ubiquitous computing

2021 Volume 26, Issue 2, Page(s) 365–384

Abstract: The work described in this paper builds upon our previous research on adoption modelling and aims to identify the best subset of features that could offer a better understanding of technology adoption. The current work is based on the analysis and fusion ...

Abstract	The work described in this paper builds upon our previous research on adoption modelling and aims to identify the best subset of features that could offer a better understanding of technology adoption. The current work is based on the analysis and fusion of two datasets that provide detailed information on background, psychosocial, and medical history of the subjects. In the process of modelling adoption, feature selection is carried out followed by empirical analysis to identify the best classification models. With a more detailed set of features including psychosocial and medical history information, the developed adoption model, using
Language	English
Publishing date	2021-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1480656-3
ISSN	1617-4917 ; 1433-3066 ; 1617-4909 ; 0949-2054
ISSN (online)	1617-4917 ; 1433-3066
ISSN	1617-4909 ; 0949-2054
DOI	10.1007/s00779-021-01572-x
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Article ; Online: Neuropsychiatric Symptoms as Risk Factors for Cognitive Decline in Clinically Normal Older Adults: The Cache County Study.

Burhanullah, Muhammad Haroon / Tschanz, JoAnn T / Peters, Matthew E / Leoutsakos, Jeannie-Marie / Matyi, Joshua / Lyketsos, Constantine G / Nowrangi, Milap A / Rosenberg, Paul B

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

2019 Volume 28, Issue 1, Page(s) 64–71

Abstract: Introduction: There has been considerable progress in identifying early cognitive and biomarker predictors of Alzheimer's disease (AD). Neuropsychiatric symptoms (NPS) are common in AD and appear to predict progression after the onset of mild cognitive ... ...

Abstract	Introduction: There has been considerable progress in identifying early cognitive and biomarker predictors of Alzheimer's disease (AD). Neuropsychiatric symptoms (NPS) are common in AD and appear to predict progression after the onset of mild cognitive impairment or dementia. Objectives: The objective of the study is to examine the relationship between NPS in clinically normal older adults and subsequent cognitive decline in a population-based sample. Methods: The Cache County Study on Memory in Aging consists of a population-based sample of 5,092 older adults. We identified 470 clinically normal adults who were followed for an average period of 5.73 years. NPS were evaluated at the baseline clinical assessment using the Neuropsychiatric Inventory (NPI). NPI domain scores were quantified as the product of frequency X severity in individual NPI domains, and then summed for the NPI-Total. Neuropsychological measures were collected at baseline and at each subsequent follow-up wave. Linear mixed-effects models assessed the association of NPI-Total, NPI-Depression, and NPI-Anxiety scores (obtained at baseline) on longitudinal change in neuropsychological performance, controlling for age, sex, and education. Results: Baseline NPI-Total score was associated with a more rapid rate of decline in word list memory, praxis recall, and animal fluency. Baseline NPI-Depression was not associated with later decline on any of the cognitive tests, while baseline NPI-Anxiety was associated with decline in Symbol Digit Modality. Conclusion: In conclusion, among clinically normal older adults derived from this population-based study, total burden of NPS was associated with longitudinal cognitive decline. These results add to the evidence that NPS are risk factors for or clinical indicators of preclinical dementia syndrome. Our study was an exploratory study and we did not control for multiple comparisons.
MeSH term(s)	Aged ; Aged, 80 and over ; Aging/physiology ; Alzheimer Disease/epidemiology ; Alzheimer Disease/physiopathology ; Anxiety/epidemiology ; Anxiety/physiopathology ; Behavioral Symptoms/epidemiology ; Behavioral Symptoms/physiopathology ; Case-Control Studies ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/physiopathology ; Dementia/epidemiology ; Dementia/physiopathology ; Depression/epidemiology ; Depression/physiopathology ; Female ; Humans ; Longitudinal Studies ; Male ; Neuropsychological Tests ; Psychiatric Status Rating Scales ; Risk Factors ; Utah/epidemiology
Language	English
Publishing date	2019-05-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1278145-9
ISSN	1545-7214 ; 1064-7481
ISSN (online)	1545-7214
ISSN	1064-7481
DOI	10.1016/j.jagp.2019.03.023
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