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  1. Article: Post-transplantation primary central nervous system lymphoma in a patient with systemic lupus erythematosus and prolonged use of immunosuppressant.

    Tse, Teresa P K / Chan, Allan N L / Chan, Tony K T / Po, Y C

    Hong Kong medical journal = Xianggang yi xue za zhi

    2014  Volume 20, Issue 6, Page(s) 541–544

    Abstract: Post-transplantation primary central nervous system lymphoma is an uncommon and fatal post-transplant lymphoproliferative disorder. Such lymphomas have been described in only a few case series in the literature. The incidence of this condition is rising ... ...

    Abstract Post-transplantation primary central nervous system lymphoma is an uncommon and fatal post-transplant lymphoproliferative disorder. Such lymphomas have been described in only a few case series in the literature. The incidence of this condition is rising with improved survival after organ transplantation. A case of post-transplantation primary central nervous system lymphoma in a young Chinese woman with systemic lupus erythematosus is described here. She presented with right-sided weakness and memory loss after tooth extraction 2 weeks before admission. Contrast computed tomography of the brain demonstrated a contrast rim-enhancing lesion over the left frontal lobe. With a history of recent dental procedure, long-term immunosuppressive therapy and computed tomography findings, cerebral abscess was highly suspected. Emergency operation was performed. Histopathology showed post-transplantation primary central nervous system lymphoma, with cells positive for B-cell marker CD20. Immunosuppressant was stopped and she was treated with radiotherapy and rituximab (anti-CD20 monoclonal antibody). She remained disease-free at 16 months. Post-transplantation primary central nervous system lymphoma is rare with variable presentation and radiological features. We believe rituximab may have a role in the treatment of such lymphomas.
    MeSH term(s) Adult ; Brain Neoplasms/surgery ; Diagnosis, Differential ; Female ; Frontal Lobe ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/adverse effects ; Kidney Transplantation ; Lupus Erythematosus, Systemic/drug therapy ; Lymphoma/surgery ; Postoperative Complications/surgery
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2014-12
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    DOI 10.12809/hkmj134095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Determining a cut-off residual tumor volume threshold for patients with newly diagnosed glioblastoma treated with temozolomide chemoradiotherapy: A multicenter cohort study.

    Woo, Peter Y M / Ho, Jason M K / Tse, Teresa P K / Lam, Sandy W / Mak, Calvin H K / Chan, Danny T M / Lee, Michael W Y / Wong, Sui-To / Chan, Kwong-Yau / Poon, Wai-Sang

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

    2019  Volume 63, Page(s) 134–141

    Abstract: Standard-of-care treatment of glioblastomas involves maximal safe resection and adjuvant temozolomide chemo-radiotherapy. Although extent of resection (EOR) is a well-known surgical predictor for overall survival most lesions cannot be completely ... ...

    Abstract Standard-of-care treatment of glioblastomas involves maximal safe resection and adjuvant temozolomide chemo-radiotherapy. Although extent of resection (EOR) is a well-known surgical predictor for overall survival most lesions cannot be completely resected. We hypothesize that in the event of incomplete resection, residual tumor volume (RTV) may be a more significant predictor than EOR. This was a multicenter retrospective review of 147 adult glioblastoma patients (mean age 53 years) that underwent standard treatment. Semiautomatic magnetic resonance imaging segmentation was performed for pre- and postoperative scans for volumetric analysis. Cox proportional hazards regression and Kaplan-Meier survival analyses were performed for prognostic factors including: age, Karnofsky performance score (KPS), O(6)-methylguanine methyltransferase (MGMT) promoter methylation status, EOR and RTV. EOR and RTV cut-off values for improved OS were determined and internally validated by receiver operator characteristic (ROC) analysis for 12-month overall survival. Half of the tumors had MGMT promoter methylation (77, 52%). The median tumor volume, EOR and RTV were 43.20 cc, 93.5%, and 3.80 cc respectively. Gross total resection was achieved in 52 patients (35%). Cox proportional hazards regression, ROC and maximum Youden index analyses for RTV and EOR showed that a cut-off value of <3.50 cc (HR 0.69; 95% CI 0.48-0.98) and ≥84% (HR 0.64; 95% CI 0.43-0.96) respectively conferred an overall survival advantage. Independent overall survival predictors were MGMT promoter methylation (adjusted HR 0.35; 95% CI 0.23-0.55) and a RTV of <3.50 cc (adjusted HR 0.53; 95% CI 0.29-0.95), but not EOR for incompletely resected glioblastomas.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Brain Neoplasms/pathology ; Brain Neoplasms/therapy ; Chemoradiotherapy, Adjuvant ; Cohort Studies ; Female ; Glioblastoma/diagnostic imaging ; Glioblastoma/genetics ; Glioblastoma/pathology ; Glioblastoma/therapy ; Humans ; Kaplan-Meier Estimate ; Karnofsky Performance Status ; Magnetic Resonance Imaging ; Middle Aged ; Neoplasm, Residual/diagnosis ; Neoplasm, Residual/pathology ; Retrospective Studies ; Temozolomide/therapeutic use ; Tumor Burden ; Young Adult
    Chemical Substances Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2019-01-31
    Publishing country Scotland
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1193674-5
    ISSN 1532-2653 ; 0967-5868
    ISSN (online) 1532-2653
    ISSN 0967-5868
    DOI 10.1016/j.jocn.2019.01.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Patterns of care and survival of Chinese glioblastoma patients in the temozolomide era: a Hong Kong population-level analysis over a 14-year period.

    Woo, Peter Y M / Yau, Stephen / Lam, Tai-Chung / Pu, Jenny K S / Li, Lai-Fung / Lui, Louisa C Y / Chan, Danny T M / Loong, Herbert H F / Lee, Michael W Y / Yeung, Rebecca / Kwok, Carol C H / Au, Siu-Kie / Tan, Tze-Ching / Kan, Amanda N C / Chan, Tony K T / Mak, Calvin H K / Mak, Henry K F / Ho, Jason M K / Cheung, Ka-Man /
    Tse, Teresa P K / Lau, Sarah S N / Chow, Joyce S W / El-Helali, Aya / Ng, Ho-Keung / Poon, Wai-Sang

    Neuro-oncology practice

    2022  Volume 10, Issue 1, Page(s) 50–61

    Abstract: Background: The aim of this study is to address the paucity of epidemiological data regarding the characteristics, treatment patterns and survival outcomes of Chinese glioblastoma patients.: Methods: This was a population-level study of Hong Kong ... ...

    Abstract Background: The aim of this study is to address the paucity of epidemiological data regarding the characteristics, treatment patterns and survival outcomes of Chinese glioblastoma patients.
    Methods: This was a population-level study of Hong Kong adult (
    Results: One thousand and ten patients with a median follow-up of 10.0 months were reviewed. The ASIR of glioblastoma was 1.0 per 100 000 population with no significant change during the study period. The mean age was 57
    Conclusions: The incidence of glioblastoma in the Chinese general population is low. We charted the development of neuro-oncological care of glioblastoma patients in Hong Kong during the temozolomide era. Although there was an increased adoption of temozolomide chemoradiotherapy, a corresponding improvement in survival was not observed.
    Language English
    Publishing date 2022-09-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2768945-1
    ISSN 2054-2585 ; 2054-2577
    ISSN (online) 2054-2585
    ISSN 2054-2577
    DOI 10.1093/nop/npac069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Computed tomography interobserver agreement in the assessment of aneurysmal subarachnoid hemorrhage and predictors for clinical outcome.

    Woo, Peter Y M / Tse, Teresa P K / Chan, Robert S K / Leung, Lianne N Y / Liu, Stephanie K K / Leung, Andrew Y T / Wong, Hoi-Tung / Chan, Kwong-Yau

    Journal of neurointerventional surgery

    2017  Volume 9, Issue 11, Page(s) 1118–1124

    Abstract: Background: The severity of aneurysmal subarachnoid hemorrhage (SAH) is often assessed by the clinical state of the patient on presentation, but radiological evaluation of the extent of hemorrhage has rarely been examined in the literature. Several CT ... ...

    Abstract Background: The severity of aneurysmal subarachnoid hemorrhage (SAH) is often assessed by the clinical state of the patient on presentation, but radiological evaluation of the extent of hemorrhage has rarely been examined in the literature. Several CT scan based grading systems exist yet only a few studies have investigated interobserver agreement. We evaluated five radiological grading systems and assessed their clinical value for early prognostication.
    Methodology: This was a retrospective study of patients diagnosed with aneurysmal SAH with a CT scan performed within 72 hours of symptom onset. Four independent observers, blinded to patient outcome, evaluated each scan using the five grading systems. A separate assessor determined 6 month outcome from clinical records. The primary outcome was interobserver agreement for each grading system using the Fleiss κ statistic. The secondary endpoint was the 6 month modified Rankin Scale score, with poor outcome defined as a score of 4-6.
    Results: 165 patients with a mean age of 59 years were assessed. Interobserver agreement for the Fisher, modified Fisher, Claassen, Barrow Neurological Institute, and Hijdra grading systems were as follows: k=0.53 (moderate), k=0.42 (moderate), k=0.38 (mild), k=0.20 (poor), and k=0.66 (good), respectively. The only independent clinical risk factor for poor outcome was a World Federation of Neurological Surgeons (WFNS) grade of 4 or 5 (adjusted OR 6.55; p<0.05). After adjusting for confounders, Fisher grade 4 (adjusted OR 17.84), modified Fisher grade 4 (adjusted OR 5.65), and Hijdra grade 3 (adjusted OR 3.34) were associated with poor outcome. Receiver operator characteristic analysis revealed that the Hijdra grading system (area under the curve=0.76) was more predictive of outcome compared with the Fisher and modified Fisher systems. A Hijdra cut-off score of 22 was associated with poor outcome (adjusted OR 5.92).
    Conclusions: The Hijdra grading system had the best interobserver agreement and was a better independent early predictor for 6 month clinical outcome than the other systems. A Hijdra score ≥22 was associated with poor outcome.
    Language English
    Publishing date 2017-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/neurintsurg-2016-012576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6845: Show issues Location:
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  5. Article: Airway inflammatory and spirometric measurements in obese children.

    Chow, Joyce S W / Leung, Amelia S M / Li, Wincy W S / Tse, Teresa P K / Sy, H Y / Leung, T F

    Hong Kong medical journal = Xianggang yi xue za zhi

    2009  Volume 15, Issue 5, Page(s) 346–352

    Abstract: Objectives: To investigate the association between obesity and airway inflammation and spirometric parameters in local children.: Design: Cross-sectional and observational study.: Setting: Paediatric clinics of a university-affiliated teaching ... ...

    Abstract Objectives: To investigate the association between obesity and airway inflammation and spirometric parameters in local children.
    Design: Cross-sectional and observational study.
    Setting: Paediatric clinics of a university-affiliated teaching hospital in Hong Kong.
    Patients: Chinese subjects aged 6 to 18 years were recruited from the paediatric clinics. Obesity was defined as being 120% or more of the median weight-for-height.
    Main outcome measures: Airway inflammation assessed by exhaled nitric oxide concentration; lung function evaluated by measuring forced expiratory flow in 1-second and forced vital capacity using spirometry; and peak expiratory flow rate measured by using a mini-Wright peak flow meter.
    Results: Fifty-five subjects were recruited into four groups as follows: 13 non-obese controls, 16 obese non-asthmatics, 15 non-obese asthmatics, and 11 obese asthmatics. The median (interquartile range) exhaled nitric oxide concentrations of these groups were 17.6 (14.4-20.9), 33.3 (26.1-75.4), 65.7 (32.0-110.0) and 49.2 (41.1-82.6) parts per billion, respectively (P=0.001 for trend). Post-hoc analysis revealed higher exhaled nitric oxide concentration in the latter three groups (obese and/or asthmatic subjects) than controls (P< or =0.002). Exhaled nitric oxide concentration did not differ among obese non-asthmatics, non-obese asthmatics, and obese asthmatics (P>0.1 for all). In non-asthmatics, exhaled nitric oxide concentration correlated positively with age (P=0.048), weight-for-height z-score (P=0.001), and forced vital capacity (P=0.009). Weight-for-height z-score correlated positively with forced vital capacity (P=0.041), but inversely with the forced expiratory flow in 1-second/forced vital capacity ratio (P=0.049). Such correlations were not observed in asthmatic children.
    Conclusion: Increased airway inflammation as revealed by exhaled nitric oxide concentration was found in obese non-asthmatic children. Weight-for-height z-score as an indicator of childhood obesity correlated with exhaled nitric oxide concentration and spirometric parameters in children without asthma. Nonetheless, concomitant obesity does not influence exhaled nitric oxide concentration in asthmatic children. Further studies are needed to identify the pathophysiologic mechanisms for such associations.
    MeSH term(s) Adolescent ; Asthma/complications ; Asthma/physiopathology ; Breath Tests/methods ; Child ; Cross-Sectional Studies ; Forced Expiratory Volume ; Hong Kong ; Hospitals, University ; Humans ; In Vitro Techniques ; Inflammation/diagnosis ; Inflammation/etiology ; Inflammation/physiopathology ; Male ; Nitric Oxide/analysis ; Obesity/complications ; Peak Expiratory Flow Rate ; Spirometry ; Vital Capacity
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2009-10
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1239255-8
    ISSN 1024-2708
    ISSN 1024-2708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4347: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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