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  1. Article ; Online: Intravenous fosfomycin for the treatment of patients with central nervous system infections: evaluation of the published evidence.

    Tsegka, Katerina G / Voulgaris, Georgios L / Kyriakidou, Margarita / Falagas, Matthew E

    Expert review of anti-infective therapy

    2020  Volume 18, Issue 7, Page(s) 657–668

    Abstract: Introduction: Central nervous system (CNS) infections have considerable morbidity and mortality. Fosfomycin is a broad spectrum bactericidal antibiotic with favorable pharmacokinetic properties and low toxicity, satisfactory penetration in the ... ...

    Abstract Introduction: Central nervous system (CNS) infections have considerable morbidity and mortality. Fosfomycin is a broad spectrum bactericidal antibiotic with favorable pharmacokinetic properties and low toxicity, satisfactory penetration in the cerebrospinal fluid and is authorized for the treatment of bacterial meningitis.
    Areas covered: The objective of this analysis was to evaluate the available data regarding the effectiveness and safety of intravenous fosfomycin for the treatment of CNS infections. Thirty-two relevant publications were identified. Data from 224 patients who received intravenous fosfomycin as treatment for CNS infections were evaluated. Overall, 93.8% of patients were cured from the infection.
    Expert opinion: The evaluation of the published evidence suggests that fosfomycin may be beneficial in the treatment of patients with CNS infections.
    MeSH term(s) Administration, Intravenous ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/pharmacokinetics ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; Central Nervous System Infections/drug therapy ; Central Nervous System Infections/microbiology ; Dose-Response Relationship, Drug ; Drug Resistance, Multiple, Bacterial ; Fosfomycin/administration & dosage ; Fosfomycin/adverse effects ; Fosfomycin/pharmacokinetics ; Humans ; Meningitis, Bacterial/drug therapy ; Meningitis, Bacterial/microbiology ; Treatment Outcome
    Chemical Substances Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE)
    Language English
    Publishing date 2020-05-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2020.1754193
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Intravenous fosfomycin for the treatment of patients with bone and joint infections: a review.

    Tsegka, Katerina G / Voulgaris, Georgios L / Kyriakidou, Margarita / Kapaskelis, Anastasios / Falagas, Matthew E

    Expert review of anti-infective therapy

    2021  Volume 20, Issue 1, Page(s) 33–43

    Abstract: Introduction: Fosfomycin is a wide spectrum bactericidal antibiotic with a unique mode of action, low toxicity, and good penetration in tissues with deep-seated infections, including bone and joint infections.: Areas covered: Data were extracted from ...

    Abstract Introduction: Fosfomycin is a wide spectrum bactericidal antibiotic with a unique mode of action, low toxicity, and good penetration in tissues with deep-seated infections, including bone and joint infections.
    Areas covered: Data were extracted from 19 published articles. Three hundred and sixty-five patients, with broad age range, received intravenous fosfomycin for the treatment of bone and joint infections (including arthritis, acute and chronic osteomyelitis, discitis, periprosthetic joint infection). Fosfomycin was given as part of a combination antimicrobial therapy in the majority of patients (93.7%). The dosage of fosfomycin ranged from 4 g/day (in one case) to 24 g/day. The dosage of fosfomycin, in some cases, mostly pediatric, was calculated based on body weight, ranging from 50 mg/kg/day to 250 mg/kg/day. The duration of fosfomycin treatment ranged from a couple of days up to 3 months. The most common isolated pathogen was
    Expert opinion: The available data suggests that intravenous fosfomycin may be beneficial for the treatment of patients with bone and joint infections, especially when used as part of a combination antibiotic regimen.
    MeSH term(s) Administration, Intravenous ; Anti-Bacterial Agents/adverse effects ; Arthritis, Infectious/drug therapy ; Child ; Fosfomycin ; Humans ; Staphylococcal Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Fosfomycin (2N81MY12TE)
    Language English
    Publishing date 2021-07-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2021.1932463
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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