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Article: Effect of Chemotherapy on the Gut Microbiome of Breast Cancer Patients During the First Year of Treatment.

Wu, Anna H / Vigen, Cheryl / Tseng, Chiuchen / Garcia, Agustin A / Spicer, Darcy

2022 Volume 14, Page(s) 433–451

Abstract: Introduction: There is accumulating information of the effects of chemotherapy and weight changes on the gut microbiome of breast cancer patients.: Methods: In this 1-year follow-up study, we investigated gut microbiome of 33 breast cancer patients ... ...

Abstract	Introduction: There is accumulating information of the effects of chemotherapy and weight changes on the gut microbiome of breast cancer patients. Methods: In this 1-year follow-up study, we investigated gut microbiome of 33 breast cancer patients who donated fecal samples at baseline and after completion of treatment. We compared alpha diversity and mean taxa abundance at baseline and absolute taxa abundance changes (final-baseline) by treatment (16 neoadjuvant [neoADJ], 13 adjuvant [ADJ], 4 no chemotherapy [noC]) and specific chemotherapy agent using Wilcoxon rank sum and negative binomial mixed model (NBMM) analysis. Results: All four gut alpha diversity measures changed in association with chemotherapy treatment; they increased in the neoADJ (+16.4% OTU Conclusion: Results from this pilot longitudinal study support an effect of chemotherapy, particularly neoADJ on the gut microbiome of breast cancer patients even after adjustment for weight changes. Further investigations are needed to confirm these findings in larger studies and with longer follow-up and to assess the impact of these microbiome changes on patient outcome.
Language	English
Publishing date	2022-12-09
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520722-2
ISSN	1179-1314
ISSN	1179-1314
DOI	10.2147/BCTT.S305486
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Article ; Online: Association of Endocrine Disrupting Chemicals With the Metabolic Syndrome Among Women in the Multiethnic Cohort Study.

Ihenacho, Ugonna / Guillermo, Cherie / Wilkens, Lynne R / Franke, Adrian A / Tseng, Chiuchen / Li, Yuqing / Sangaramoorthy, Meera / Derouen, Mindy C / Haiman, Christopher A / Stram, Daniel O / Le Marchand, Loïc / Cheng, Iona / Wu, Anna H

Journal of the Endocrine Society

2023 Volume 7, Issue 12, Page(s) bvad136

Abstract: Metabolic syndrome (MetS) is associated with a high risk of cardiovascular disease, a leading cause of death among women. MetS is a diagnosis of at least 3 of the following: high blood pressure, high fasting glucose, high triglycerides, high waist ... ...

Abstract	Metabolic syndrome (MetS) is associated with a high risk of cardiovascular disease, a leading cause of death among women. MetS is a diagnosis of at least 3 of the following: high blood pressure, high fasting glucose, high triglycerides, high waist circumference, and low high-density lipoprotein cholesterol. Epidemiological studies suggest that endocrine disrupting chemical (EDC) exposure is positively associated with individual components of MetS, but evidence of an association between EDCs and MetS remains inconsistent. In a cross-sectional analysis within the Multiethnic Cohort Study, we evaluated the association between 4 classes of urinary EDCs (bisphenol A [BPA], triclosan, parabens, and phthalates) and MetS among 1728 women. Multivariable logistic regression was used to estimate odds ratios and 95% CI for the association between tertiles of each EDC and MetS adjusting for age, body mass index (BMI), racial and ethnic group, and breast cancer status. Stratified analyses by race and ethnicity and BMI were conducted. MetS was identified in 519 (30.0%) women. We did not detect statistically significant associations of MetS with BPA, triclosan, or phthalate metabolite excretion. MetS was inversely associated with total parabens (
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvad136
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Article ; Online: Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study.

Bookstein, Arthur / Po, Justine / Tseng, Chiuchen / Larson, Timothy V / Yang, Juan / Park, Sung-Shim L / Wu, Jun / Shariff-Marco, Salma / Inamdar, Pushkar P / Ihenacho, Ugonna / Setiawan, Veronica Wendy / DeRouen, Mindy C / Le Marchand, Loïc / Stram, Daniel O / Samet, Jonathan / Ritz, Beate / Fruin, Scott / Wu, Anna H / Cheng, Iona

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2024

Abstract: Background: Ultrafine particles (UFPs) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study ... ...

Abstract	Background: Ultrafine particles (UFPs) are unregulated air pollutants abundant in aviation exhaust. Emerging evidence suggests that UFPs may impact lung health due to their high surface area-to-mass ratio and deep penetration into airways. This study aimed to assess long-term exposure to airport-related UFPs and lung cancer incidence in a multiethnic population in Los Angeles County. Methods: Within the California Multiethnic Cohort, we examined the association between long-term exposure to airport-related UFPs and lung cancer incidence. Multivariable Cox proportional hazards regression models were used to estimate the effect of UFP exposure on lung cancer incidence. Subgroup analyses by demographics, histology and smoking status were conducted. Results: Airport-related UFP exposure was not associated with lung cancer risk [per one IGR HR = 1.01, 95% CI: 0.97-1.05] overall and across race/ethnicity. A suggestive positive association was observed between a one IQR increase in UFP exposure and lung squamous cell carcinoma (SCC) risk [HR = 1.08, 95% CI: 1.00-1.17] with a Phet for histology=0.05. Positive associations were observed in 5-year lag analysis for SCC [HR = 1.12, CI: 1.02-1.22] and large cell carcinoma risk [HR = 1.23, CI: 1.01-1.49] with a [Phet for histology = 0.01]. Conclusions: This large prospective cohort analysis suggests a potential association between airport-related UFP exposure and specific lung histologies. The findings align with research indicating that UFPs found in aviation exhaust may induce inflammatory and oxidative injury leading to SCC. Impact: These results highlight the potential role of airport-related UFP exposure in the development of lung SCC.
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-23-0924
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Article: The association between ambient air pollutants and pancreatic cancer in the Multiethnic Cohort Study

Bogumil, David / Wu, Anna H. / Stram, Daniel / Yang, Juan / Tseng, Chiu-Chen / Le Marchand, Loïc / Wu, Jun / Cheng, Iona / Setiawan, Veronica Wendy

Environmental research. 2021 Nov., v. 202

2021

Abstract: Prior studies examining the association between ambient air pollutants and pancreatic cancer have been conducted in racially/ethnically homogeneous samples and have produced mixed results, with some studies supporting evidence of an association with fine ...

Abstract	Prior studies examining the association between ambient air pollutants and pancreatic cancer have been conducted in racially/ethnically homogeneous samples and have produced mixed results, with some studies supporting evidence of an association with fine particulate matter.To further investigate these findings, we estimated exposure levels of particulate matter (PM₂.₅, PM₁₀) and oxides of nitrogen (NOX, and NO₂) using kriging interpolation for 100,527 men and women from the Multiethnic Cohort Study, residing largely in Los Angeles County from 1993 through 2013. We measured the association between these air pollutants and incident pancreatic cancer using Cox proportional hazards models with time-varying pollutant measures, with adjustment for confounding factors.A total of 821 incident pancreatic cancer and 1,660,488 person-years accumulated over the study period, with an average follow-up time of over 16 years. PM₂.₅ (per 10 μg/m³) was associated with incident pancreatic cancer (hazard ratio [HR] = 1.61; 95% CI, 1.09, 2.37). This PM₂.₅ -association was strongest among Latinos (HR = 3.59; 95% CI, 1.60, 8.06) and ever smokers (HR = 1.76; 95% CI, 1.05, 2.94). There was no association for PM₁₀ (HR = 1.12; 95% CI, 0.94, 1.32, per 10 μg/m³), NOₓ (HR = 1.14; 95% CI, 0.88, 1.48, per 50 ppb), or NO₂ (HR = 1.14; 95% CI, 0.85, 1.54, per 20 ppb).Our findings support prior research identifying an association between fine particulate matter, PM₂.₅, and pancreatic cancer. Although not statistically heterogeneous, this association was most notable among Latinos and smokers. Future studies are needed to replicate these results in an urban setting and in a racially/ethnically diverse population.
Keywords	Latinos ; air ; cohort studies ; ethnic differences ; hazard ratio ; kriging ; nitrogen ; pancreatic neoplasms ; particulates ; research
Language	English
Dates of publication	2021-11
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2021.111608
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 726: Show issues

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Article ; Online: Particulate matter, traffic-related air pollutants, and circulating C-reactive protein levels: The Multiethnic Cohort Study.

Sangaramoorthy, Meera / Yang, Juan / Tseng, Chiuchen / Wu, Jun / Ritz, Beate / Larson, Timothy V / Fruin, Scott / Stram, Daniel O / Park, Sung-Shim Lani / Franke, Adrian A / Wilkens, Lynne R / Samet, Jonathan M / Le Marchand, Loïc / Shariff-Marco, Salma / Haiman, Christopher A / Wu, Anna H / Cheng, Iona

Environmental pollution (Barking, Essex : 1987)

2023 Volume 332, Page(s) 121962

Abstract: Inhaled particles and gases can harm health by promoting chronic inflammation in the body. Few studies have investigated the relationship between outdoor air pollution and inflammation by race and ethnicity, socioeconomic status, and lifestyle risk ... ...

Abstract	Inhaled particles and gases can harm health by promoting chronic inflammation in the body. Few studies have investigated the relationship between outdoor air pollution and inflammation by race and ethnicity, socioeconomic status, and lifestyle risk factors. We examined associations of particulate matter (PM) and other markers of traffic-related air pollution with circulating levels of C-reactive protein (CRP), a biomarker of systemic inflammation. CRP was measured from blood samples obtained in 1994-2016 from 7,860 California residents participating in the Multiethnic Cohort (MEC) Study. Exposure to PM (aerodynamic diameter ≤2.5 μm [PM
MeSH term(s)	Male ; Female ; Humans ; Aged ; Particulate Matter/analysis ; Vehicle Emissions/analysis ; Air Pollutants/analysis ; C-Reactive Protein/analysis ; Cohort Studies ; Benzene/analysis ; Environmental Exposure/analysis ; Air Pollution/analysis ; Ozone/analysis ; Nitrogen Dioxide/analysis ; Inflammation/chemically induced ; Inflammation/epidemiology
Chemical Substances	Particulate Matter ; Vehicle Emissions ; Air Pollutants ; C-Reactive Protein (9007-41-4) ; Benzene (J64922108F) ; Ozone (66H7ZZK23N) ; Nitrogen Dioxide (S7G510RUBH)
Language	English
Publishing date	2023-06-03
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.121962
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Zs.A 2599: Show issues

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Article ; Online: Metabolic conditions and breast cancer risk among Los Angeles County Filipina Americans compared with Chinese and Japanese Americans.

Wu, Anna H / Vigen, Cheryl / Butler, Lesley M / Tseng, Chiu-Chen

International journal of cancer

2017 Volume 141, Issue 12, Page(s) 2450–2461

Abstract: Accumulating evidence suggests that the aggregation of common metabolic conditions (high blood pressure, diabetes and dyslipidemia) is a risk factor for breast cancer. Breast cancer incidence has risen steadily in Asian American women, and whether these ... ...

Abstract	Accumulating evidence suggests that the aggregation of common metabolic conditions (high blood pressure, diabetes and dyslipidemia) is a risk factor for breast cancer. Breast cancer incidence has risen steadily in Asian American women, and whether these metabolic conditions contribute to breast cancer risk in certain Asian American subgroups is unknown. We investigated the role of physician-diagnosed hypertension, high cholesterol and diabetes separately, and in combination, in relation to the risk of breast cancer in a population-based case-control study of 2,167 Asian Americans diagnosed with breast cancer and 2,035 age and ethnicity matched control women in Los Angeles County. Compared to Asian American women who did not have any of the metabolic conditions, those with 1, 2 or 3 conditions showed a steady increase in risk (respective odds ratios were 1.12, 1.42 and 1.62; P trend = 0.001) with adjustment for covariates including body mass index. Similar significant trends were observed in Filipina Americans (P trend = 0.021), postmenopausal women (P trend =0.001), Asian women who were born in the United States (US) (P trend = 0.052) and migrants who have lived in the US for at least 20 years (P trend = 0.004), but not migrants who lived in the US for <20 years (P trend = 0.64). These results suggest that westernization in lifestyle (diet and physical inactivity) and corresponding increase in adiposity have contributed to the rising prevalence of these metabolic conditions, which in turn, are associated with an increase in breast cancer.
MeSH term(s)	Adult ; Age Distribution ; Aged ; Asian Americans/classification ; Breast Neoplasms/epidemiology ; Breast Neoplasms/ethnology ; Breast Neoplasms/etiology ; Case-Control Studies ; China/ethnology ; Female ; Humans ; Incidence ; Japan/ethnology ; Life Style ; Los Angeles/epidemiology ; Metabolic Syndrome/complications ; Metabolic Syndrome/ethnology ; Middle Aged ; Odds Ratio ; Philippines/ethnology
Language	English
Publishing date	2017-09-06
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	218257-9
ISSN	1097-0215 ; 0020-7136
ISSN (online)	1097-0215
ISSN	0020-7136
DOI	10.1002/ijc.31018
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Zs.A 478: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Racial, Ethnic, and Socioeconomic Differences in a Deficit Accumulation Frailty Index in the Multiethnic Cohort Study.

Wu, Anna H / Setiawan, V Wendy / Stram, Daniel O / Crimmins, Eileen M / Tseng, Chiu-Chen / Lim, Unhee / Park, Song-Yi / White, Kami K / Cheng, Iona / Haiman, Christopher A / Wilkens, Lynne R / Le Marchand, Loïc

The journals of gerontology. Series A, Biological sciences and medical sciences

2022 Volume 78, Issue 7, Page(s) 1246–1257

Abstract: Background: Frailty status has been sparsely studied in some groups including Native Hawaiians and Asian Americans.: Methods: We developed a questionnaire-based deficit accumulation frailty index (FI) in the Multiethnic Cohort (MEC) and examined ... ...

Abstract	Background: Frailty status has been sparsely studied in some groups including Native Hawaiians and Asian Americans. Methods: We developed a questionnaire-based deficit accumulation frailty index (FI) in the Multiethnic Cohort (MEC) and examined frailty status (robust, FI 0 to <0.2, prefrail, FI 0.2 to <0.35, and frail FI ≥ 0.35) among 29 026 men and 40 756 women. Results: After adjustment for age, demographic, lifestyle factors, and chronic conditions, relative to White men, odds of being frail was significantly higher (34%-54%) among African American, Native Hawaiian, and other Asian American men, whereas odds was significantly lower (36%) in Japanese American men and did not differ in Latino men. However, among men who had high school or less, none of the groups displayed significantly higher odds of prefrail or frail compared with White men. Relative to White women, odds of being frail were significantly higher (14%-33%) in African American and Latino women, did not differ for other Asian American women and lower (14%-36%) in Native Hawaiian and Japanese American women. These racial and ethnic differences in women were observed irrespective of education. Risk of all-cause mortality was higher in prefrail and frail men than robust men (adjusted hazard ratio [HR] = 1.69, 1.59-1.81; HR = 3.27, 3.03-3.53); results were similar in women. All-cause mortality was significantly positively associated with frailty status and frailty score across all sex, race, and ethnic groups. Conclusions: Frailty status differed significantly by race and ethnicity and was consistently associated with all-cause mortality. The FI may be a useful tool for aging studies in this multiethnic population.
MeSH term(s)	Female ; Humans ; Male ; Cohort Studies ; Educational Status ; Ethnicity ; Frailty ; Hispanic or Latino ; Black or African American ; Asian American Native Hawaiian and Pacific Islander ; White
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223643-3
ISSN	1758-535X ; 1079-5006
ISSN (online)	1758-535X
ISSN	1079-5006
DOI	10.1093/gerona/glac216
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Article ; Online: Outdoor ambient air pollution and breast cancer survival among California participants of the Multiethnic Cohort Study.

Cheng, Iona / Yang, Juan / Tseng, Chiuchen / Wu, Jun / Conroy, Shannon M / Shariff-Marco, Salma / Lin Gomez, Scarlett / Whittemore, Alice S / Stram, Daniel O / Le Marchand, Loïc / Wilkens, Lynne R / Ritz, Beate / Wu, Anna H

Environment international

2022 Volume 161, Page(s) 107088

Abstract: Background: Within the Multiethnic Cohort (MEC), we examined the association between air pollution and mortality among African American, European American, Japanese American, and Latina American women diagnosed with breast cancer.: Methods: We used a ...

Abstract	Background: Within the Multiethnic Cohort (MEC), we examined the association between air pollution and mortality among African American, European American, Japanese American, and Latina American women diagnosed with breast cancer. Methods: We used a land use regression (LUR) model and kriging interpolation to estimate nitrogen oxides (NO Results: We identified 1,125 deaths from all causes (474 breast cancer, 272 CVD, 379 non-breast cancer/non-CVD deaths) among the 3,089 breast cancer cases with 8.1 years of average follow-up. LUR and kriged NO Conclusion: In this study, air pollutants have a harmful impact on breast cancer survival. Additional studies should evaluate potential confounding by socioeconomic factors. These data support maintaining clean air laws to improve survival for women with breast cancer.
MeSH term(s)	Air Pollutants/analysis ; Air Pollutants/toxicity ; Air Pollution/analysis ; Air Pollution/statistics & numerical data ; Breast Neoplasms ; California/epidemiology ; Cohort Studies ; Environmental Exposure/analysis ; Environmental Exposure/statistics & numerical data ; Female ; Humans ; Particulate Matter/analysis ; Particulate Matter/toxicity
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2022-01-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107088
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Zs.A 3131: Show issues

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Article: Outdoor ambient air pollution and breast cancer survival among California participants of the Multiethnic Cohort Study

Cheng, Iona / Yang, Juan / Tseng, Chiuchen / Wu, Jun / Conroy, Shannon M. / Shariff-Marco, Salma / Lin Gomez, Scarlett / Whittemore, Alice S. / Stram, Daniel O. / Le Marchand, Loïc / Wilkens, Lynne R. / Ritz, Beate / Wu, Anna H.

Environment international. 2022 Mar., v. 161

2022

Abstract: Within the Multiethnic Cohort (MEC), we examined the association between air pollution and mortality among African American, European American, Japanese American, and Latina American women diagnosed with breast cancer. We used a land use regression (LUR) ...

Abstract	Within the Multiethnic Cohort (MEC), we examined the association between air pollution and mortality among African American, European American, Japanese American, and Latina American women diagnosed with breast cancer. We used a land use regression (LUR) model and kriging interpolation to estimate nitrogen oxides (NOₓ , NO₂) and particulate matter (PM₂.₅, PM₁₀) exposures for 3,089 breast cancer cases in the MEC, who were diagnosed from 1993 through 2013 and resided largely in Los Angeles County, California. Cox proportional hazards models were used to examine the association of time-varying air pollutants with all-cause, breast cancer, cardiovascular disease (CVD), and non-breast cancer/non-CVD mortality, accounting for key covariates. We identified 1,125 deaths from all causes (474 breast cancer, 272 CVD, 379 non-breast cancer/non-CVD deaths) among the 3,089 breast cancer cases with 8.1 years of average follow-up. LUR and kriged NOX (per 50 ppb) and NO₂ (per 20 ppb), PM₂.₅ (per 10 µg/m³), and PM₁₀ (per 10 µg/m³) were positively associated with risks of all-cause (Hazard Ratio (HR) range = 1.13–1.25), breast cancer (HR range = 1.19–1.45), and CVD mortality (HR range = 1.37–1.60). Associations were statistically significant for LUR NOX and CVD mortality (HR = 1.60; 95% CI: 1.08–2.37) and kriged NO₂ and breast cancer mortality (HR = 1.45; 95% CI 1.02–2.07). Gaseous and PM pollutants were positively associated with breast cancer mortality across racial/ethnic group. In this study, air pollutants have a harmful impact on breast cancer survival. Additional studies should evaluate potential confounding by socioeconomic factors. These data support maintaining clean air laws to improve survival for women with breast cancer.
Keywords	Latinos ; air ; air pollution ; breast neoplasms ; breasts ; cardiovascular diseases ; cohort studies ; environment ; hazard ratio ; kriging ; land use ; models ; mortality ; nitrogen ; particulates ; California
Language	English
Dates of publication	2022-03
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107088
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Article ; Online: Gut microbiome associations with breast cancer risk factors and tumor characteristics: a pilot study.

Wu, Anna H / Tseng, Chiuchen / Vigen, Cheryl / Yu, Yang / Cozen, Wendy / Garcia, Agustin A / Spicer, Darcy

Breast cancer research and treatment

2020 Volume 182, Issue 2, Page(s) 451–463

Abstract: Objective: To investigate the association between gut microbiome with breast tumor characteristics (receptor status, stage and grade) and known breast cancer risk factors.: Methods: In a pilot cross-sectional study of 37 incident breast cancer ... ...

Abstract	Objective: To investigate the association between gut microbiome with breast tumor characteristics (receptor status, stage and grade) and known breast cancer risk factors. Methods: In a pilot cross-sectional study of 37 incident breast cancer patients, fecal samples collected prior to chemotherapy were analyzed by 16S ribosomal RNA (rRNA) gene-based sequencing protocol. Alpha diversity and specific taxa by tumor characteristics and breast cancer risk factors were tested by Wilcoxon rank sum test, and by differential abundance analysis, using a zero-inflated negative binomial regression model with adjustment for total counts, age and race/ethnicity. Results: There were no significant alpha diversity or phyla differences by estrogen/progesterone receptor status, tumor grade, stage, parity and body mass index. However, women with human epidermal growth factor receptor 2 positive (HER2+) (n = 12) compared to HER2- (n = 25) breast cancer showed 12-23% lower alpha diversity [number of species (OTU) p = 0.033, Shannon index p = 0.034], lower abundance of Firmicutes (p = 0.005) and higher abundance of Bacteroidetes (p = 0.089). Early menarche (ages ≤ 11) (n = 11) compared with later menarche (ages ≥ 12) (n = 26) was associated with lower OTU (p = 0.036), Chao1 index (p = 0.020) and lower abundance of Firmicutes (p = 0.048). High total body fat (TBF) (> 46%) (n = 12) compared to lower (≤ 46%) TBF was also associated with lower Chao 1 index (p = 0.011). There were other significant taxa abundance differences by HER2 status, menarche age, as well as other tumor and breast cancer risk factors. Conclusions and relevance: Further studies are needed to identify characteristics of the human microbiome and the interrelationships between breast cancer hormone receptor status and established breast cancer risk factors.
MeSH term(s)	Adult ; Age Factors ; Aged ; Bacteroidetes/genetics ; Bacteroidetes/isolation & purification ; Biomarkers, Tumor/metabolism ; Body Mass Index ; Breast/pathology ; Breast Neoplasms/epidemiology ; Breast Neoplasms/pathology ; Breast Neoplasms/physiopathology ; Cross-Sectional Studies ; DNA, Bacterial/isolation & purification ; Feces/microbiology ; Female ; Firmicutes/genetics ; Firmicutes/isolation & purification ; Gastrointestinal Microbiome/physiology ; Humans ; Menarche/physiology ; Middle Aged ; Parity/physiology ; Pilot Projects ; RNA, Ribosomal, 16S/genetics ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Risk Factors
Chemical Substances	Biomarkers, Tumor ; DNA, Bacterial ; RNA, Ribosomal, 16S ; Receptors, Estrogen ; Receptors, Progesterone ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2020-05-28
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-020-05702-6
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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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