LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 29

Search options

  1. Article ; Online: Thyroid hormone upregulates LAMP2 expression and lysosome activity.

    Tseng, Yi-Hsin / Chang, Cheng-Chih / Lin, Kwang-Huei

    Biochemical and biophysical research communications

    2023  Volume 662, Page(s) 66–75

    Abstract: Thyroid hormone ( ... ...

    Abstract Thyroid hormone (T
    MeSH term(s) Animals ; Mice ; Lysosomal-Associated Membrane Protein 2/genetics ; Lysosomal-Associated Membrane Protein 2/metabolism ; Lysosomal Membrane Proteins/genetics ; Lysosomal Membrane Proteins/metabolism ; Lysosomal-Associated Membrane Protein 1/metabolism ; Lysosomes/metabolism ; Thyroid Hormones/metabolism ; Autophagy/physiology
    Chemical Substances Lysosomal-Associated Membrane Protein 2 ; Lysosomal Membrane Proteins ; Lysosomal-Associated Membrane Protein 1 ; Thyroid Hormones
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.04.061
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Thyroid hormone upregulates LAMP2 expression and lysosome activity

    Tseng, Yi-Hsin / Chang, Cheng-Chih / Lin, Kwang-Huei

    Biochemical and Biophysical Research Communications. 2023 Apr. 20,

    2023  

    Abstract: Thyroid hormone (T₃)-induced autophagy and its biological significance have been extensively investigated in recent years. However, limited studies to date have focused on the important role of lysosomes in autophagy. In this study, we explored the ... ...

    Abstract Thyroid hormone (T₃)-induced autophagy and its biological significance have been extensively investigated in recent years. However, limited studies to date have focused on the important role of lysosomes in autophagy. In this study, we explored the effects of T₃ on lysosomal protein expression and trafficking in detail. Our findings showed that T₃ activates rapid lysosomal turnover and expression of numerous lysosomal genes, including TFEB, LAMP2, ARSB, GBA, PSAP, ATP6V0B, ATP6V0D1, ATP6V1E1, CTSB, CTSH, CTSL, and CTSS, in a thyroid hormone receptor-dependent manner. In a murine model, LAMP2 protein was specifically induced in mice with hyperthyroidism. T₃-promoted microtubule assembly was significantly disrupted by vinblastine, resulting in accumulation of the lipid droplet marker PLIN2. In the presence of the lysosomal autophagy inhibitors bafilomycin A1, chloroquine and ammonium chloride, we observed substantial accumulation of LAMP2 but not LAMP1 protein. T₃ further enhanced the protein levels of ectopically expressed LAMP1 and LAMP2. Upon knockdown of LAMP2, cavities of lysosomes and lipid droplets accumulated in the presence of T₃, although the changes in LAMP1 and PLIN2 expression were less pronounced. More specifically, the protective effect of T₃ against ER stress-induced death was abolished by knockdown of LAMP2. Our collective results indicate that T₃ not only promotes lysosomal gene expression but also LAMP protein stability and microtubule assembly, leading to enhancement of lysosomal activity in digesting any additional autophagosomal burden.
    Keywords ammonium chloride ; animal models ; autophagy ; chloroquine ; death ; droplets ; gene expression ; hyperthyroidism ; lipids ; lysosomes ; microtubules ; protective effect ; protein synthesis ; research ; thyroid hormones ; vinblastine ; Thyroid hormone ; Lysosome ; LAMP2 ; Vesicle trafficking ; ER stress
    Language English
    Dates of publication 2023-0420
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.04.061
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 71/706: Show issues
    Z 3.8: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Benzo[a]pyrene induces fibrotic changes and impairs differentiation in lung stem cells.

    Tseng, Yi-Hsin / Chen, Yu-Chi / Yu, Alice L / Yu, John

    Ecotoxicology and environmental safety

    2021  Volume 210, Page(s) 111892

    Abstract: Human activities have generated air pollution, with extremely small particles (PM 2.5, particulate matter less than 2.5 µm in diameter) and liquid droplets, which become a menace to human health. Among the pollutants, polycyclic aromatic hydrocarbons ( ... ...

    Abstract Human activities have generated air pollution, with extremely small particles (PM 2.5, particulate matter less than 2.5 µm in diameter) and liquid droplets, which become a menace to human health. Among the pollutants, polycyclic aromatic hydrocarbons (PAHs), which enhance the risks of pulmonary dysfunction and cancer development, have been extensively studied. Numerous studies have addressed the effects of PAHs on the respiratory system, whereas the effects on lung stem/progenitor cells remain unknown. Here, we provide evidence that benzo[a]pyrene (BaP), a major toxic PAH, induces fibrotic changes with a loss of α-1,6-fucosylation in CD54
    MeSH term(s) Air Pollutants/toxicity ; Animals ; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors ; Benzo(a)pyrene/toxicity ; Cell Differentiation/drug effects ; Cells, Cultured ; Fibrosis ; Lung/cytology ; Mice ; Receptors, Aryl Hydrocarbon/antagonists & inhibitors ; Stem Cells/drug effects ; Stem Cells/pathology ; Transforming Growth Factor beta/antagonists & inhibitors
    Chemical Substances Ahr protein, mouse ; Air Pollutants ; Basic Helix-Loop-Helix Transcription Factors ; Receptors, Aryl Hydrocarbon ; Transforming Growth Factor beta ; Benzo(a)pyrene (3417WMA06D)
    Language English
    Publishing date 2021-01-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2021.111892
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Loss of core-fucosylation of SPARC impairs collagen binding and contributes to COPD.

    Wu, Tsai-Jung / Wang, Sheng-Hung / Chen, Eric Sheng-Wen / Tsai, Hsiu-Hui / Chang, Yi-Chieh / Tseng, Yi-Hsin / Yu, John

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 7, Page(s) 348

    Abstract: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with high morbidity and mortality worldwide. Although several mechanisms to account for deleterious immune effects were proposed, molecular description for the underlying alveolar ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with high morbidity and mortality worldwide. Although several mechanisms to account for deleterious immune effects were proposed, molecular description for the underlying alveolar structural alterations for COPD is lacking. Here, silencing of α1,6-fucosyltransferase (Fut8), the enzyme for core-fucosylation and highly expressed in lung stem cells, resulted in alveolar structural changes in lung organoids, recapitulating COPD. Site-specific mass spectrometry analysis demonstrated that the secreted protein acidic and rich in cysteine (SPARC), which binds collagen, contains a core-fucosylation site in its VCSNDN
    MeSH term(s) Collagen/metabolism ; Fucosyltransferases/genetics ; Fucosyltransferases/metabolism ; Glycosylation ; Humans ; Osteonectin/genetics ; Osteonectin/metabolism ; Pulmonary Disease, Chronic Obstructive/genetics
    Chemical Substances Osteonectin ; SPARC protein, human ; Collagen (9007-34-5) ; Fucosyltransferases (EC 2.4.1.-)
    Language English
    Publishing date 2022-06-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04381-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Loss of core-fucosylation of SPARC impairs collagen binding and contributes to COPD

    Wu, Tsai-Jung / Wang, Sheng-Hung / Chen, Eric Sheng-Wen / Tsai, Hsiu-Hui / Chang, Yi-Chieh / Tseng, Yi-Hsin / Yu, John

    Cellular and molecular life sciences. 2022 July, v. 79, no. 7

    2022  

    Abstract: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with high morbidity and mortality worldwide. Although several mechanisms to account for deleterious immune effects were proposed, molecular description for the underlying alveolar ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with high morbidity and mortality worldwide. Although several mechanisms to account for deleterious immune effects were proposed, molecular description for the underlying alveolar structural alterations for COPD is lacking. Here, silencing of α1,6-fucosyltransferase (Fut8), the enzyme for core-fucosylation and highly expressed in lung stem cells, resulted in alveolar structural changes in lung organoids, recapitulating COPD. Site-specific mass spectrometry analysis demonstrated that the secreted protein acidic and rich in cysteine (SPARC), which binds collagen, contains a core-fucosylation site in its VCSNDNᶜᶠK glycopeptide. Biacore assay showed markedly reduced collagen binding of SPARC lacking core fucosylation. Molecular dynamics analysis revealed that core fucosylation of SPARC-induced dynamic conformational changes in its N-glycan, allowing terminal galactose and N-acetylglucosamine to interact with K150, P261 and H264 residues, thereby promoting collagen binding. Site-specific mutagenesis of these residues also resulted in low affinity for collagen binding. Moreover, loss of collagen and decline of core fucosylation were observed in COPD lung tissues. These findings provide a new mechanistic insight into the role of core fucosylation of SPARC in cell–matrix communication and contribution to the abnormal alveolar structures in COPD.
    Keywords N-acetylglucosamine ; collagen ; cysteine ; galactose ; glycopeptides ; lungs ; mass spectrometry ; molecular dynamics ; morbidity ; mortality ; organoids ; protein secretion ; respiratory tract diseases ; site-directed mutagenesis
    Language English
    Dates of publication 2022-07
    Size p. 348.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04381-4
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 4' 47/14: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article: Id2 exerts tumor suppressor properties in lung cancer through its effects on cancer cell invasion and migration.

    Chen, Jian-Ting / Hsu, Yuan-Ling / Hsu, Yi-Chiung / Tseng, Yi-Hsin / Liu, Ming-Han / Weng, Chia-Wei / Lin, Ching-Hao / Pan, Szu-Hua / Chen, Jeremy J W / Wang, Chi-Chung

    Frontiers in oncology

    2022  Volume 12, Page(s) 801300

    Abstract: Background: Despite advances in prognosis and treatment of lung adenocarcinoma (LADC), a notable non-small cell lung cancer subtype, patient outcomes are still unsatisfactory. New insight on novel therapeutic strategies for LADC may be gained from a ... ...

    Abstract Background: Despite advances in prognosis and treatment of lung adenocarcinoma (LADC), a notable non-small cell lung cancer subtype, patient outcomes are still unsatisfactory. New insight on novel therapeutic strategies for LADC may be gained from a more comprehensive understanding of cancer progression mechanisms. Such strategies could reduce the mortality and morbidity of patients with LADC. In our previous study, we performed cDNA microarray screening and found an inverse relationship between inhibitor of DNA binding 2 (Id2) expression levels and the invasiveness of LADC cells.
    Materials and methods: To identify the functional roles of Id2 and its action mechanisms in LADC progression, we successfully established several Id2-overexpressing and Id2-silenced LADC cell clones. Subsequently, we examined
    Results: Our data revealed that Id2 overexpression could inhibit LADC cells' migratory, invasive, proliferation, and colony formation capabilities. Silencing Id2 expression in LADC cells reversed the aforementioned inhibitory effects, and knockdown of Id2 increased LADC cells' metastatic abilities
    Language English
    Publishing date 2022-08-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.801300
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Dysregulated FAM215A Stimulates LAMP2 Expression to Confer Drug-Resistant and Malignant in Human Liver Cancer.

    Huang, Po-Shuan / Lin, Yang-Hsiang / Chi, Hsiang-Cheng / Tseng, Yi-Hsin / Chen, Cheng Yi / Lin, Tzu-Kang / Yeh, Chau-Ting / Lin, Kwang-Huei

    Cells

    2020  Volume 9, Issue 4

    Abstract: Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies worldwide. Long non-coding (lnc) RNAs regulate complex cellular functions, such as cell growth, differentiation, metabolism, and metastasis. Although deregulation ... ...

    Abstract Hepatocellular carcinoma (HCC) is one of the most common and aggressive human malignancies worldwide. Long non-coding (lnc) RNAs regulate complex cellular functions, such as cell growth, differentiation, metabolism, and metastasis. Although deregulation of lncRNA expression has been detected in HCC, many of the hepato-carcinogenesis-associated lncRNAs remain yet unidentified. Here, we aimed to investigate the involvement of a specific HCC-dysregulated lncRNA, FAM215A, and characterize its molecular regulation mechanism. We show for the first time that FAM215A is overexpressed in HCC, and its expression level correlates with tumor size, vascular invasion, and pathology stage. Overexpression of FAM215A accelerates cell proliferation and metastasis in HCC cells. According to Gene Expression Omnibus Dataset analysis, FAM215A is induced in doxorubicin (DOX)-resistant HCC cells. Overexpression of FAM215A increases DOX resistance in two HCC cell lines, and this is associated with enhanced expression of lysosome-associated membrane protein 2 (LAMP2). FAM215A interacts with LAMP2 to protect it from ubiquitination. Together, our results show that the lncRNA, FAM215A, is highly expressed in HCC, where it interacts with and stabilizes LAMP2 to increase tumor progression while decreasing doxorubicin sensitivity.
    MeSH term(s) Animals ; Antibiotics, Antineoplastic/pharmacology ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Doxorubicin/pharmacology ; Drug Resistance, Neoplasm ; Gene Knockdown Techniques ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Lysosomal-Associated Membrane Protein 2/genetics ; Lysosomal-Associated Membrane Protein 2/metabolism ; Mice ; Mice, SCID ; Neoplasm Metastasis ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Transfection ; Up-Regulation ; Xenograft Model Antitumor Assays
    Chemical Substances Antibiotics, Antineoplastic ; LAMP2 protein, human ; Lysosomal-Associated Membrane Protein 2 ; RNA, Long Noncoding ; long non-coding RNA FAM215A, human ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2020-04-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9040961
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Emerging regulation and function of betatrophin.

    Tseng, Yi-Hsin / Yeh, Yung-Hsin / Chen, Wei-Jan / Lin, Kwang-Huei

    International journal of molecular sciences

    2014  Volume 15, Issue 12, Page(s) 23640–23657

    Abstract: Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver. To date, several betatrophin orthologs have been identified in mammals. Increasing evidence has revealed an association between ... ...

    Abstract Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver. To date, several betatrophin orthologs have been identified in mammals. Increasing evidence has revealed an association between betatrophin expression and serum lipid profiles, particularly in patients with obesity or diabetes. Stimulators of betatrophin, such as insulin, thyroid hormone, irisin and caloric intake, are usually relevant to energy expenditure or thermogenesis. In murine models, serum triglyceride levels as well as pancreatic cell proliferation are potently enhanced by betatrophin. Intriguingly, conflicting phenomena have also been reported that betatrophin suppresses hepatic triglyceride levels, suggesting that betatrophin function is mediated by complex regulatory processes. However, its precise physiological role remains unclear at present. In this review, we have summarized the current findings on betatrophin and their implications.
    MeSH term(s) Amino Acid Sequence ; Angiopoietin-like Proteins ; Animals ; Humans ; Molecular Sequence Data ; Peptide Hormones/chemistry ; Peptide Hormones/genetics ; Peptide Hormones/metabolism
    Chemical Substances ANGPTL8 protein, human ; Angiopoietin-like Proteins ; Peptide Hormones
    Language English
    Publishing date 2014-12-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms151223640
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Corrigendum to "MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer" [Cancer Lett 351 (2014) 222-231].

    Tsai, Ming-Ming / Wang, Chia-Siu / Tsai, Chung-Ying / Chen, Cheng-Yi / Chi, Hsiang-Cheng / Tseng, Yi-Hsin / Chung, Pei-Jung / Lin, Yang-Hsiang / Chung, I-Hsiao / Chen, Ching-Ying / Lin, Kwang-Huei

    Cancer letters

    2017  Volume 393, Page(s) 129

    Language English
    Publishing date 2017--01
    Publishing country Ireland
    Document type Journal Article ; Published Erratum
    ZDB-ID 195674-7
    ISSN 1872-7980 ; 0304-3835
    ISSN (online) 1872-7980
    ISSN 0304-3835
    DOI 10.1016/j.canlet.2017.01.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Potential prognostic, diagnostic and therapeutic markers for human gastric cancer.

    Tsai, Ming-Ming / Wang, Chia-Siu / Tsai, Chung-Ying / Chi, Hsiang-Cheng / Tseng, Yi-Hsin / Lin, Kwang-Huei

    World journal of gastroenterology

    2013  Volume 20, Issue 38, Page(s) 13791–13803

    Abstract: The high incidence of gastric cancer (GC) and its consequent mortality rate severely threaten human health. GC is frequently not diagnosed until a relatively advanced stage. Surgery is the only potentially curative treatment. Thus, early screening and ... ...

    Abstract The high incidence of gastric cancer (GC) and its consequent mortality rate severely threaten human health. GC is frequently not diagnosed until a relatively advanced stage. Surgery is the only potentially curative treatment. Thus, early screening and diagnosis are critical for improving prognoses in patients with GC. Gastroscopy with biopsy is an appropriate method capable of aiding the diagnosis of specific early GC tumor types; however, the stress caused by this method together with it being excessively expensive makes it difficult to use it as a routine method for screening for GC on a population basis. The currently used tumor marker assays for detecting GC are simple and rapid, but their use is limited by their low sensitivity and specificity. In recent years, several markers have been identified and tested for their clinical relevance in the management of GC. Here, we review the serum-based tumor markers for GC and their clinical significance, focusing on discoveries from microarray/proteomics research. We also review tissue-based GC tumor markers and their clinical application, focusing on discoveries from immunohistochemical research. This review provides a brief description of various tumor markers for the purposes of diagnosis, prognosis and therapeutics, and we include markers already in clinical practice and various forthcoming biomarkers.
    MeSH term(s) Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Humans ; Neoplasm Staging ; Predictive Value of Tests ; Reproducibility of Results ; Stomach Neoplasms/blood ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Stomach Neoplasms/therapy
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2013-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v20.i38.13791
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top