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Article ; Online: Detoxification treatment in Gynecology using a modified molded sorbent.

Barinov, S V / Di Renzo, G C / Tsibizova, V I / Shifman, E М / Leont'eva, N N / Arbuzov, A B

Best practice & research. Clinical obstetrics & gynaecology

2023 Volume 88, Page(s) 102346

Abstract: Postpartum endometritis is a common complication of cesarean section, the progression of which often leads to the loss of the uterus and the patient's fertility. We evaluated a detoxification therapy for treating patients with postpartum endometritis ... ...

Abstract	Postpartum endometritis is a common complication of cesarean section, the progression of which often leads to the loss of the uterus and the patient's fertility. We evaluated a detoxification therapy for treating patients with postpartum endometritis using an intrauterine application of a modified molded sorbent containing polyvinylpyrrolidone. A retrospective, controlled study included 124 patients with postpartum endometritis. The study group, n = 63, was composed of puerperae with postpartum endometritis after cesarean section, receiving antibacterial therapy in combination with the intrauterine application of a molded modified sorbent containing polyvinylpyrrolidone (FSMP) for 24 h daily for 5 days. The control group, n = 61, was composed of puerperae with postpartum endometritis after cesarean section, receiving antibacterial treatment only. The uterine cavity was infected by coccal flora (Enterococcus faecalis (26.6%), Staphylococcus spp. (21.3%), E. faecium (14.3%), and Gram-negative Escherichia coli (9.6%). A combination of these microorganisms was present in 40.5% of crops. Antibiotic resistance was detected in 53.6%-68.3% of the cases. In the study group, we observed: a faster and higher decrease in neutrophils (p < 0.05); a lower uterine concentration of pro-inflammatory cytokines: interleukin-1 beta (IL-1β) and tumor necrosis factor α (TNFα) - 4.0 and 3.2 times, respectively, compared with the control group (p < 0.05); and a significant decrease in the uterus volume and cavity (M-echo). Using a newly modified sorbent associated with antibiotic treatment in patients with postpartum endometritis, compared with antibiotics alone, we showed a sharp reduction of inflammatory parameters, residual microorganism growth, and faster uterine volume involution. Moreover, the frequency of hysterectomy decreased by 14.4 times.
MeSH term(s)	Humans ; Pregnancy ; Female ; Endometritis ; Cesarean Section ; Gynecology ; Retrospective Studies ; Povidone ; Uterus ; Anti-Bacterial Agents/therapeutic use ; Postpartum Period
Chemical Substances	Povidone (FZ989GH94E) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-05-06
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2050090-7
ISSN	1532-1932 ; 1521-6934
ISSN (online)	1532-1932
ISSN	1521-6934
DOI	10.1016/j.bpobgyn.2023.102346
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Article ; Online: Novel coronavirus infection and Kawasaki disease.

Bitsadze, V O / Grigoreva, K / Khizroeva, J Kh / Pervunina, T M / Tsibizova, V I / Tretyakova, M V / Makatsariya, A D

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2020 Volume 35, Issue 16, Page(s) 3044–3048

Abstract: There is a global problem of increment of the number of children with clinical features that mimic Kawasaki Disease (KD) during the ongoing Coronavirus Disease 2019 (COVID-19) pandemic. The disease was first reported by Tomisaku Kawasaki, a Japanese ... ...

Abstract	There is a global problem of increment of the number of children with clinical features that mimic Kawasaki Disease (KD) during the ongoing Coronavirus Disease 2019 (COVID-19) pandemic. The disease was first reported by Tomisaku Kawasaki, a Japanese pediatrician, in a four-year-old child with a rash and fever at the Red Cross Hospital in Tokyo in January 1961. Now Kawasaki disease is recognized worldwide. The complexity of symptoms was defined as an «acute febrile mucocutaneous lymphnode syndrome". At the moment, it is still unclear whether the coronavirus itself can lead to development of mucocutaneous lymph node syndrome. However, it is believed that COVID-19 virus infection worsens the course of Kawasaki disease, and in some cases, children affected by SARS-V-2 may develop a disease that has a clinical picture similar to Kawasaki disease.
MeSH term(s)	COVID-19/complications ; Child ; Child, Preschool ; Fever ; Humans ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Pandemics ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2020.1800633
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Article ; Online: Obstetric and perinatal care units functioning during the COVID-19 pandemic ; О принципах работы перинатального стационара в условиях пандемии коронавируса

Di Renzo G. / Makatsariya A.D. / Tsibizova V.I. / Capanna F. / Rasero B. / Komlichenko E.V. / Pervunina T.M. / Khizroeva J.K. / Bitsadze V.O. / Shkoda A.S.

Annals of the Russian academy of medical sciences; Vol 75, No; 83-92 ; Вестник Российской академии медицинских наук; Vol 75, No 1 (2020); 83-92 ; 2414-3545 ; 0869-6047 ; 10.15690/vramn.751

2020 Volume 1

Abstract: The rapid spread of COVID-19 and the large number of cases put a significant burden on the health systems of any developed country. Specialists in natural disasters and military medicine should be involved in the provision of medical care and observance ... ...

Abstract	The rapid spread of COVID-19 and the large number of cases put a significant burden on the health systems of any developed country. Specialists in natural disasters and military medicine should be involved in the provision of medical care and observance of anti-epidemic measures. In some countries, including Italy, they were involved only after the situation was dramatically worsening with many clinical units and hospitals overloaded by infected patients. To curb the spread of COVID-19, most countries declared a state of emergency, and unprecedented measures have been taken to strengthen quarantine in suspected or positive symptomatic subjects. Nevertheless, the crisis associated with the unexpectedly global scale and tragedy of the pandemic and the inconsistency of actions of both society and individuals and specialized medical services, lead to insufficient effectiveness of the measures taken in a number of regions. In the present day, it is vital for every person to change its mindset ― relying on personal responsibility to comply with all recommendations of quarantine and anti-epidemic measures, and to reorganize departments and resources of medical institutions at all levels in order to withstand the spread of infection and at the same time provide all those in need with the necessary and appropriate medical care. Particular attention should be paid to the obstetric care service, given that even in normal times, the obstetric hospital is an area of increased responsibility for the life and health of mother and child and future mankind. Fulfillment of existing orders, instructions of national and regional committees, international and national protocols and clinical protocols should undoubtedly lead to a positive result, but this requires additional training of medical personnel at all levels. The purpose of this review is to propose quick key strategies for reassessing the maternity and neonatal wards/ hospitals based on the experience of health systems and organizations which faced the spread of this new coronavirus; this advice may be applied along with binding tight instructions in obstetric hospitals in order to proactively respond to a likely wave of growth in COVID-19. Актуальность. Быстрое распространение COVID-19 и большое количество заболевших накладывает значительную нагрузку на системы здравоохранения развитых государств. В ряде стран к оказанию медицинской помощи и соблюдению противоэпидемических мероприятий привлекаются специалисты по стихийным бедствиям и военной медицине, однако в некоторых странах, в том числе в Италии, они были задействованы после того, как многие клинические подразделения и стационары были перегружены. Для сдерживания распространения COVID-19 большинство стран объявили чрезвычайное положение, были приняты беспрецедентные меры по усилению карантинных мероприятий. Тем не менее кризис, связанный с неожиданно глобальным масштабом и трагичностью пандемии, и несогласованность действий как общества и отдельных граждан, так и специализированных медицинских служб приводят к недостаточной эффективности проводимых мероприятий в ряде регионов. Особое внимание следует уделить службе родовспоможения, учитывая, что и в спокойное время акушерский стационар является зоной повышенной ответственности за жизнь и здоровье матери и ребенка. Исполнение действующих приказов, указаний национальных и региональных комитетов, международных/национальных и клинических протоколов, несомненно, приведет к положительному результату, но требует дополнительного обучения и тренировки медицинского персонала всех уровней. Цель обзора ― предложить ключевые стратегии, основываясь на опыте регионов, ранее столкнувшихся с распространением нового коронавируса, которые могут быть быстро применены наряду с обязательными к исполнению действующими приказами и распоряжениями в акушерских стационарах, чтобы превентивно отреагировать на вероятную волну роста заболеваемости и носительства COVID-19.
Keywords	SARS-CoV-2 ; COVID-19 ; COVID+ zone ; coronavirus ; obstetrics ; tips in COVID ; delivery and COVID ; childbirth ; COVID+ зона ; коронавирус ; акушерство-гинекология ; советы при коронавирусной инфекции ; роды и коронавирус ; covid19
Language	Russian
Publishing date	2020-03-30
Publisher	"Paediatrician" Publishers LLC
Publishing country	ru
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Novel coronavirus infection and Kawasaki disease

Bitsadze, V O / Grigoreva, K / Khizroeva, J Kh / Pervunina, T M / Tsibizova, V I / Tretyakova, M V / Makatsariya, A D

J Matern Fetal Neonatal Med

Abstract	There is a global problem of increment of the number of children with clinical features that mimic Kawasaki Disease (KD) during the ongoing Coronavirus Disease 2019 (COVID-19) pandemic. The disease was first reported by Tomisaku Kawasaki, a Japanese pediatrician, in a four-year-old child with a rash and fever at the Red Cross Hospital in Tokyo in January 1961. Now Kawasaki disease is recognized worldwide. The complexity of symptoms was defined as an «acute febrile mucocutaneous lymphnode syndrome". At the moment, it is still unclear whether the coronavirus itself can lead to development of mucocutaneous lymph node syndrome. However, it is believed that COVID-19 virus infection worsens the course of Kawasaki disease, and in some cases, children affected by SARS-V-2 may develop a disease that has a clinical picture similar to Kawasaki disease.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #690285
Database	COVID19

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Article ; Online: COVID-19, hemostasis disorders and risk of thrombotic complications ; COVID-19, нарушения гемостаза и риск тромботических осложнений

Makatsariya A.D. / Slukhanchuk E.V. / Bitsadze V.O. / Khizroeva J.K. / Tretyakova M.V. / Tsibizova V.I. / Shkoda A.S. / Grandone E. / Elalamy I. / Rizzo G. / Gris J.R. / Schulman S. / Brenner B.

Annals of the Russian academy of medical sciences; Vol 75, No; 306-317 ; Вестник Российской академии медицинских наук; Vol 75, No 4 (2020); 306-317 ; 2414-3545 ; 0869-6047 ; 10.15690/vramn.754

2020 Volume 4

Abstract: The spread of a new coronavirus infection worldwide since the end of 2019 has becomes a pandemic. Thrombotic complications are the leading cause of death in this disease. After entering the human body, the virus starts a cascade of reactions leading to ... ...

Abstract	The spread of a new coronavirus infection worldwide since the end of 2019 has becomes a pandemic. Thrombotic complications are the leading cause of death in this disease. After entering the human body, the virus starts a cascade of reactions leading to the development of a cytokine storm, activation of all parts of the hemostasis and complement systems and other changes that result in disturbances in the circulation system with the development of multiple organ failures. Numerous studies have shown that a predictor of a severe course of COVID-19 is a sharp increase of D-dimer concentration in the blood and rise of some other markers of hemostasis activation. Based on the pathogenesis, the developed schemes for the prevention and treatment of COVID-19 severe complications include low molecular weight heparins (LMWH) which are also recommended for an outpatient COVID-19 patient. The prescription of low molecular weight heparin, the duration of their use and doses should be decided on the basis of a risk assessment of factors for each individual patient in combination with laboratory monitoring. Распространение новой коронавирусной инфекции по всему миру с конца 2019 г. превратилось в пандемию. Тромботические осложнения являются ведущей причиной смерти при этом заболевании. После попадания в организм человека вирус запускает каскад реакций, приводящих к развитию цитокинового шторма, активации всех звеньев системы гемостаза и комплемента, другим изменениям, приводящим к нарушениям в системе кровообращения с развитием полиорганных нарушений. Многочисленные исследования показали, что предиктором тяжелого течения заболевания является резкое повышение концентрации D-димера в крови и некоторых других маркеров активации гемостаза. Исходя из патогенеза, разработанные схемы профилактики и лечения тяжелых осложнений COVID-19 включают низкомолекулярные гепарины, которые также рекомендуют для применения в амбулаторных условиях. Назначение низкомолекулярных гепаринов, длительность их применения и дозы должны определяться на основе оценки факторов риска для каждого отдельного пациента в сочетании с лабораторным мониторингом.
Keywords	COVID-19 ; SARS-COV-2 ; coagulopathy ; DIC-syndrome ; D-dimer ; fibrinogen ; hyperferritinemia ; hypercytokinemia ; cytokine storm ; antiphospholipid antibodies ; low molecular weight heparin ; коагулопатия ; ДВС-синдром ; Д-димер ; фибриноген ; гиперферритинемия ; гиперцитокинемия ; цитокиновый «шторм» ; антифосфолипидные антитела ; низкомолекулярные гепарины ; covid19
Language	Russian
Publishing date	2020-10-14
Publisher	"Paediatrician" Publishers LLC
Publishing country	ru
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Thrombotic microangiopathy, DIC-syndrome and COVID-19: link with pregnancy prothrombotic state.

Makatsariya, A D / Slukhanchuk, E V / Bitsadze, V O / Khizroeva, J K H / Tretyakova, M V / Tsibizova, V I / Elalamy, I / Gris, J-C / Grandone, E / Makatsariya, N A / Mashkova, T

2020 Volume 35, Issue 13, Page(s) 2536–2544

Abstract: For last months, humanity has faced a formidable unknown enemy, which is presented as a new coronavirus infection. Despite the fact that the causative agents of new diseases appear at a certain frequency and that the virus SARS-CoV-2 has certain common ... ...

Abstract	For last months, humanity has faced a formidable unknown enemy, which is presented as a new coronavirus infection. Despite the fact that the causative agents of new diseases appear at a certain frequency and that the virus SARS-CoV-2 has certain common properties with its predecessors, at the moment we are dealing with a new unknown pathogenesis of the development of severe complications in patients with risk factors. A final understanding of pathological process mechanisms is the goal of the scientific community. Summarizing research data from different countries, it became obvious that in severe cases of viral infection, we are dealing with a combination of the systemic inflammatory response syndrome, disseminated intravascular coagulation and thrombotic microangiopathy (TMA). Thrombotic microangiopathy is represented by a group of different conditions in which thrombocytopenia, hemolytic anemia, and multiple organ failure occur. The article reflects the main types of TMA, pathogenesis and principles of therapy. The main participants in the process are described in detail, including the von Willebrand factor and ADAMTS-13. Based on the knowledge available, as well as new data obtained from patients with COVID-19, we proposed possible models for the implementation of conditions such as sepsis, TMA, and DIC in patients with severe new coronavirus infection. Through a deeper understanding of pathogenesis, it will be possible to develop more effective diagnosis and therapy.
MeSH term(s)	COVID-19/complications ; Disseminated Intravascular Coagulation/diagnosis ; Female ; Humans ; Pregnancy ; SARS-CoV-2 ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/etiology ; Thrombotic Microangiopathies/therapy
Keywords	covid19
Language	English
Publishing date	2020-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2020.1786811
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Article: Pregnancy and Zika virus

Startseva, T. V. / Kanshina, N. N. / Tretyakova, M. V. / Bitsadze, V. O. / Khizroeva, J. Kh / Radetskaya, L. S. / Stuleva, N. S. / Tsibizova, V. I. / Shkoda, A. S. / Blinov, D. V. / Makatsariya, A. D.

Obstetrics, Gynecology and Reproduction

Abstract: Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the Flaviviridae family In 1947 and 1948 ZIKV was first isolated from a nonhuman primate as well as from mosquitoes in Africa, respectively For half a century, ZIKV ... ...

Abstract	Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the Flaviviridae family In 1947 and 1948 ZIKV was first isolated from a nonhuman primate as well as from mosquitoes in Africa, respectively For half a century, ZIKV infections in human were sporadic prior to 2015-2016 pandemic spreading Transmission of ZIKV from mother to fetus can occur in any trimester of pregnancy, even if mother was an asymptomatic carrier The clinical signs of ZIKV infection are nonspecific and can be misdiagnosed as some other infectious diseases, especially those caused by arboviruses such as Dengue and Chikungunya ZIKV infection was solely associated with mild illness prior to the large French Polynesian and Brazil outbreaks, when severe neurological complications, Guillain-Barre syndrome and dramatically increased rate of severe congenital malformations (including microcephaly) were reported The adaptation of ZIKV to an urban cycle in endemic areas suggests that the incidence of ZIKV infections may be underestimated The pandemic of novel coronavirus infection (COVID-19) demonstrates that lessons from ZIKV pandemic propagation has not been learned properly © 2020 Universidad de Antioquia All rights reserved
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #831744
Database	COVID19

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Article: Obstetric and perinatal care units functioning during the COVID-19 pandemic

Di Renzo, G. / Makatsariya, A. D. / Tsibizova, V. I. / Capanna, F. / Rasero, B. / Komlichenko, E. V. / Pervunina, T. M. / Khizroeva, J. K. / Bitsadze, V. O. / Shkoda, A. S.

Annals of the Russian academy of medical sciences / Вестник Российской академии медицинских наук

Abstract: The rapid spread of COVID-19 and the large number of cases put a significant burden on the health systems of any developed country Specialists in natural disasters and military medicine should be involved in the provision of medical care and observance ... ...

Abstract	The rapid spread of COVID-19 and the large number of cases put a significant burden on the health systems of any developed country Specialists in natural disasters and military medicine should be involved in the provision of medical care and observance of anti-epidemic measures In some countries, including Italy, they were involved only after the situation was dramatically worsening with many clinical units and hospitals overloaded by infected patients To curb the spread of COVID-19, most countries declared a state of emergency, and unprecedented measures have been taken to strengthen quarantine in suspected or positive symptomatic subjects Nevertheless, the crisis associated with the unexpectedly global scale and tragedy of the pandemic and the inconsistency of actions of both society and individuals and specialized medical services, lead to insufficient effectiveness of the measures taken in a number of regions In the present day, it is vital for every person to change its mindset â€• relying on personal responsibility to comply with all recommendations of quarantine and anti-epidemic measures, and to reorganize departments and resources of medical institutions at all levels in order to withstand the spread of infection and at the same time provide all those in need with the necessary and appropriate medical care Particular attention should be paid to the obstetric care service, given that even in normal times, the obstetric hospital is an area of increased responsibility for the life and health of mother and child and future mankind Fulfillment of existing orders, instructions of national and regional committees, international and national protocols and clinical protocols should undoubtedly lead to a positive result, but this requires additional training of medical personnel at all levels The purpose of this review is to propose quick key strategies for reassessing the maternity and neonatal wards/ hospitals based on the experience of health systems and organizations which faced the spread of this new coronavirus;this advice may be applied along with binding tight instructions in obstetric hospitals in order to proactively respond to a likely wave of growth in COVID-19 ;ÐÐºÑ‚ÑƒÐ°Ð»ÑŒÐ½Ð¾ÑÑ‚ÑŒ Ð‘Ñ‹ÑÑ‚Ñ€Ð¾Ðµ Ñ€Ð°ÑÐ¿Ñ€Ð¾ÑÑ‚Ñ€Ð°Ð½ÐµÐ½Ð¸Ðµ COVID-19 Ð¸ Ð±Ð¾Ð»ÑŒÑˆÐ¾Ðµ ÐºÐ¾Ð»Ð¸Ñ‡ÐµÑÑ‚Ð²Ð¾ Ð·Ð°Ð±Ð¾Ð»ÐµÐ²ÑˆÐ¸Ñ… Ð½Ð°ÐºÐ»Ð°Ð´Ñ‹Ð²Ð°ÐµÑ‚ Ð·Ð½Ð°Ñ‡Ð¸Ñ‚ÐµÐ»ÑŒÐ½ÑƒÑŽ Ð½Ð°Ð³Ñ€ÑƒÐ·ÐºÑƒ Ð½Ð° ÑÐ¸ÑÑ‚ÐµÐ¼Ñ‹ Ð·Ð´Ñ€Ð°Ð²Ð¾Ð¾Ñ…Ñ€Ð°Ð½ÐµÐ½Ð¸Ñ Ñ€Ð°Ð·Ð²Ð¸Ñ‚Ñ‹Ñ… Ð³Ð¾ÑÑƒÐ´Ð°Ñ€ÑÑ‚Ð² Ð’ Ñ€ÑÐ´Ðµ ÑÑ‚Ñ€Ð°Ð½ Ðº Ð¾ÐºÐ°Ð·Ð°Ð½Ð¸ÑŽ Ð¼ÐµÐ´Ð¸Ñ†Ð¸Ð½ÑÐºÐ¾Ð¹ Ð¿Ð¾Ð¼Ð¾Ñ‰Ð¸ Ð¸ ÑÐ¾Ð±Ð»ÑŽÐ´ÐµÐ½Ð¸ÑŽ Ð¿Ñ€Ð¾Ñ‚Ð¸Ð²Ð¾ÑÐ¿Ð¸Ð´ÐµÐ¼Ð¸Ñ‡ÐµÑÐºÐ¸Ñ… Ð¼ÐµÑ€Ð¾Ð¿Ñ€Ð¸ÑÑ‚Ð¸Ð¹ Ð¿Ñ€Ð¸Ð²Ð»ÐµÐºÐ°ÑŽÑ‚ÑÑ ÑÐ¿ÐµÑ†Ð¸Ð°Ð»Ð¸ÑÑ‚Ñ‹ Ð¿Ð¾ ÑÑ‚Ð¸Ñ…Ð¸Ð¹Ð½Ñ‹Ð¼ Ð±ÐµÐ´ÑÑ‚Ð²Ð¸ÑÐ¼ Ð¸ Ð²Ð¾ÐµÐ½Ð½Ð¾Ð¹ Ð¼ÐµÐ´Ð¸Ñ†Ð¸Ð½Ðµ, Ð¾Ð´Ð½Ð°ÐºÐ¾ Ð² Ð½ÐµÐºÐ¾Ñ‚Ð¾Ñ€Ñ‹Ñ… ÑÑ‚Ñ€Ð°Ð½Ð°Ñ…, Ð² Ñ‚Ð¾Ð¼ Ñ‡Ð¸ÑÐ»Ðµ Ð² Ð˜Ñ‚Ð°Ð»Ð¸Ð¸, Ð¾Ð½Ð¸ Ð±Ñ‹Ð»Ð¸ Ð·Ð°Ð´ÐµÐ¹ÑÑ‚Ð²Ð¾Ð²Ð°Ð½Ñ‹ Ð¿Ð¾ÑÐ»Ðµ Ñ‚Ð¾Ð³Ð¾, ÐºÐ°Ðº Ð¼Ð½Ð¾Ð³Ð¸Ðµ ÐºÐ»Ð¸Ð½Ð¸Ñ‡ÐµÑÐºÐ¸Ðµ Ð¿Ð¾Ð´Ñ€Ð°Ð·Ð´ÐµÐ»ÐµÐ½Ð¸Ñ Ð¸ ÑÑ‚Ð°Ñ†Ð¸Ð¾Ð½Ð°Ñ€Ñ‹ Ð±Ñ‹Ð»Ð¸ Ð¿ÐµÑ€ÐµÐ³Ñ€ÑƒÐ¶ÐµÐ½Ñ‹ Ð”Ð»Ñ ÑÐ´ÐµÑ€Ð¶Ð¸Ð²Ð°Ð½Ð¸Ñ Ñ€Ð°ÑÐ¿Ñ€Ð¾ÑÑ‚Ñ€Ð°Ð½ÐµÐ½Ð¸Ñ COVID-19 Ð±Ð¾Ð»ÑŒÑˆÐ¸Ð½ÑÑ‚Ð²Ð¾ ÑÑ‚Ñ€Ð°Ð½ Ð¾Ð±ÑŠÑÐ²Ð¸Ð»Ð¸ Ñ‡Ñ€ÐµÐ·Ð²Ñ‹Ñ‡Ð°Ð¹Ð½Ð¾Ðµ Ð¿Ð¾Ð»Ð¾Ð¶ÐµÐ½Ð¸Ðµ, Ð±Ñ‹Ð»Ð¸ Ð¿Ñ€Ð¸Ð½ÑÑ‚Ñ‹ Ð±ÐµÑÐ¿Ñ€ÐµÑ†ÐµÐ´ÐµÐ½Ñ‚Ð½Ñ‹Ðµ Ð¼ÐµÑ€Ñ‹ Ð¿Ð¾ ÑƒÑÐ¸Ð»ÐµÐ½Ð¸ÑŽ ÐºÐ°Ñ€Ð°Ð½Ñ‚Ð¸Ð½Ð½Ñ‹Ñ… Ð¼ÐµÑ€Ð¾Ð¿Ñ€Ð¸ÑÑ‚Ð¸Ð¹ Ð¢ÐµÐ¼ Ð½Ðµ Ð¼ÐµÐ½ÐµÐµ ÐºÑ€Ð¸Ð·Ð¸Ñ, ÑÐ²ÑÐ·Ð°Ð½Ð½Ñ‹Ð¹ Ñ Ð½ÐµÐ¾Ð¶Ð¸Ð´Ð°Ð½Ð½Ð¾ Ð³Ð»Ð¾Ð±Ð°Ð»ÑŒÐ½Ñ‹Ð¼ Ð¼Ð°ÑÑˆÑ‚Ð°Ð±Ð¾Ð¼ Ð¸ Ñ‚Ñ€Ð°Ð³Ð¸Ñ‡Ð½Ð¾ÑÑ‚ÑŒÑŽ Ð¿Ð°Ð½Ð´ÐµÐ¼Ð¸Ð¸, Ð¸ Ð½ÐµÑÐ¾Ð³Ð»Ð°ÑÐ¾Ð²Ð°Ð½Ð½Ð¾ÑÑ‚ÑŒ Ð´ÐµÐ¹ÑÑ‚Ð²Ð¸Ð¹ ÐºÐ°Ðº Ð¾Ð±Ñ‰ÐµÑÑ‚Ð²Ð° Ð¸ Ð¾Ñ‚Ð´ÐµÐ»ÑŒÐ½Ñ‹Ñ… Ð³Ñ€Ð°Ð¶Ð´Ð°Ð½, Ñ‚Ð°Ðº Ð¸ ÑÐ¿ÐµÑ†Ð¸Ð°Ð»Ð¸Ð·Ð¸Ñ€Ð¾Ð²Ð°Ð½Ð½Ñ‹Ñ… Ð¼ÐµÐ´Ð¸Ñ†Ð¸Ð½ÑÐºÐ¸Ñ… ÑÐ»ÑƒÐ¶Ð± Ð¿Ñ€Ð¸Ð²Ð¾Ð´ÑÑ‚ Ðº Ð½ÐµÐ´Ð¾ÑÑ‚Ð°Ñ‚Ð¾Ñ‡Ð½Ð¾Ð¹ ÑÑ„Ñ„ÐµÐºÑ‚Ð¸Ð²Ð½Ð¾ÑÑ‚Ð¸ Ð¿Ñ€Ð¾Ð²Ð¾Ð´Ð¸Ð¼Ñ‹Ñ… Ð¼ÐµÑ€Ð¾Ð¿Ñ€Ð¸ÑÑ‚Ð¸Ð¹ Ð² Ñ€ÑÐ´Ðµ Ñ€ÐµÐ³Ð¸Ð¾Ð½Ð¾Ð² ÐžÑÐ¾Ð±Ð¾Ðµ Ð²Ð½Ð¸Ð¼Ð°Ð½Ð¸Ðµ ÑÐ»ÐµÐ´ÑƒÐµÑ‚ ÑƒÐ´ÐµÐ»Ð¸Ñ‚ÑŒ ÑÐ»ÑƒÐ¶Ð±Ðµ Ñ€Ð¾Ð´Ð¾Ð²ÑÐ¿Ð¾Ð¼Ð¾Ð¶ÐµÐ½Ð¸Ñ, ÑƒÑ‡Ð¸Ñ‚Ñ‹Ð²Ð°Ñ, Ñ‡Ñ‚Ð¾ Ð¸ Ð² ÑÐ¿Ð¾ÐºÐ¾Ð¹Ð½Ð¾Ðµ Ð²Ñ€ÐµÐ¼Ñ Ð°ÐºÑƒÑˆÐµÑ€ÑÐºÐ¸Ð¹ Ñ ‚Ð°Ñ†Ð¸Ð¾Ð½Ð°Ñ€ ÑÐ²Ð»ÑÐµÑ‚ÑÑ Ð·Ð¾Ð½Ð¾Ð¹ Ð¿Ð¾Ð²Ñ‹ÑˆÐµÐ½Ð½Ð¾Ð¹ Ð¾Ñ‚Ð²ÐµÑ‚ÑÑ‚Ð²ÐµÐ½Ð½Ð¾ÑÑ‚Ð¸ Ð·Ð° Ð¶Ð¸Ð·Ð½ÑŒ Ð¸ Ð·Ð´Ð¾Ñ€Ð¾Ð²ÑŒÐµ Ð¼Ð°Ñ‚ÐµÑ€Ð¸ Ð¸ Ñ€ÐµÐ±ÐµÐ½ÐºÐ° Ð˜ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸Ðµ Ð´ÐµÐ¹ÑÑ‚Ð²ÑƒÑŽÑ‰Ð¸Ñ… Ð¿Ñ€Ð¸ÐºÐ°Ð·Ð¾Ð², ÑƒÐºÐ°Ð·Ð°Ð½Ð¸Ð¹ Ð½Ð°Ñ†Ð¸Ð¾Ð½Ð°Ð»ÑŒÐ½Ñ‹Ñ… Ð¸ Ñ€ÐµÐ³Ð¸Ð¾Ð½Ð°Ð»ÑŒÐ½Ñ‹Ñ… ÐºÐ¾Ð¼Ð¸Ñ‚ÐµÑ‚Ð¾Ð², Ð¼ÐµÐ¶Ð´ÑƒÐ½Ð°Ñ€Ð¾Ð´Ð½Ñ‹Ñ…/Ð½Ð°Ñ†Ð¸Ð¾Ð½Ð°Ð»ÑŒÐ½Ñ‹Ñ… Ð¸ ÐºÐ»Ð¸Ð½Ð¸Ñ‡ÐµÑÐºÐ¸Ñ… Ð¿Ñ€Ð¾Ñ‚Ð¾ÐºÐ¾Ð»Ð¾Ð², Ð½ÐµÑÐ¾Ð¼Ð½ÐµÐ½Ð½Ð¾, Ð¿Ñ€Ð¸Ð²ÐµÐ´ÐµÑ‚ Ðº Ð¿Ð¾Ð»Ð¾Ð¶Ð¸Ñ‚ÐµÐ»ÑŒÐ½Ð¾Ð¼Ñƒ Ñ€ÐµÐ·ÑƒÐ»ÑŒÑ‚Ð°Ñ‚Ñƒ, Ð½Ð¾ Ñ‚Ñ€ÐµÐ±ÑƒÐµÑ‚ Ð´Ð¾Ð¿Ð¾Ð»Ð½Ð¸Ñ‚ÐµÐ»ÑŒÐ½Ð¾Ð³Ð¾ Ð¾Ð±ÑƒÑ‡ÐµÐ½Ð¸Ñ Ð¸ Ñ‚Ñ€ÐµÐ½Ð¸Ñ€Ð¾Ð²ÐºÐ¸ Ð¼ÐµÐ´Ð¸Ñ†Ð¸Ð½ÑÐºÐ¾Ð³Ð¾ Ð¿ÐµÑ€ÑÐ¾Ð½Ð°Ð»Ð° Ð²ÑÐµÑ… ÑƒÑ€Ð¾Ð²Ð½ÐµÐ¹ Ð¦ÐµÐ»ÑŒ Ð¾Ð±Ð·Ð¾Ñ€Ð° â€• Ð¿Ñ€ÐµÐ´Ð»Ð¾Ð¶Ð¸Ñ‚ÑŒ ÐºÐ»ÑŽÑ‡ÐµÐ²Ñ‹Ðµ ÑÑ‚Ñ€Ð°Ñ‚ÐµÐ³Ð¸Ð¸, Ð¾ÑÐ½Ð¾Ð²Ñ‹Ð²Ð°ÑÑÑŒ Ð½Ð° Ð¾Ð¿Ñ‹Ñ‚Ðµ Ñ€ÐµÐ³Ð¸Ð¾Ð½Ð¾Ð², Ñ€Ð°Ð½ÐµÐµ ÑÑ‚Ð¾Ð»ÐºÐ½ÑƒÐ²ÑˆÐ¸Ñ…ÑÑ Ñ Ñ€Ð°ÑÐ¿Ñ€Ð¾ÑÑ‚Ñ€Ð°Ð½ÐµÐ½Ð¸ÐµÐ¼ Ð½Ð¾Ð²Ð¾Ð³Ð¾ ÐºÐ¾Ñ€Ð¾Ð½Ð°Ð²Ð¸Ñ€ÑƒÑÐ°, ÐºÐ¾Ñ‚Ð¾Ñ€Ñ‹Ðµ Ð¼Ð¾Ð³ÑƒÑ‚ Ð±Ñ‹Ñ‚ÑŒ Ð±Ñ‹ÑÑ‚Ñ€Ð¾ Ð¿Ñ€Ð¸Ð¼ÐµÐ½ÐµÐ½Ñ‹ Ð½Ð°Ñ€ÑÐ´Ñƒ Ñ Ð¾Ð±ÑÐ·Ð°Ñ‚ÐµÐ»ÑŒÐ½Ñ‹Ð¼Ð¸ Ðº Ð¸ÑÐ¿Ð¾Ð»Ð½ÐµÐ½Ð¸ÑŽ Ð´ÐµÐ¹ÑÑ‚Ð²ÑƒÑŽÑ‰Ð¸Ð¼Ð¸ Ð¿Ñ€Ð¸ÐºÐ°Ð·Ð°Ð¼Ð¸ Ð¸ Ñ€Ð°ÑÐ¿Ð¾Ñ€ÑÐ¶ÐµÐ½Ð¸ÑÐ¼Ð¸ Ð² Ð°ÐºÑƒÑˆÐµÑ€ÑÐºÐ¸Ñ… ÑÑ‚Ð°Ñ†Ð¸Ð¾Ð½Ð°Ñ€Ð°Ñ…, Ñ‡Ñ‚Ð¾Ð±Ñ‹ Ð¿Ñ€ÐµÐ²ÐµÐ½Ñ‚Ð¸Ð²Ð½Ð¾ Ð¾Ñ‚Ñ€ÐµÐ°Ð³Ð¸Ñ€Ð¾Ð²Ð°Ñ‚ÑŒ Ð½Ð° Ð²ÐµÑ€Ð¾ÑÑ‚Ð½ÑƒÑŽ Ð²Ð¾Ð»Ð½Ñƒ Ñ€Ð¾ÑÑ‚Ð° Ð·Ð°Ð±Ð¾Ð»ÐµÐ²Ð°ÐµÐ¼Ð¾ÑÑ‚Ð¸ Ð¸ Ð½Ð¾ÑÐ¸Ñ‚ÐµÐ»ÑŒÑÑ‚Ð²Ð° COVID-19
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #71763
Database	COVID19

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Article: Laboratory monitoring of COVID-19 patients and importance of coagulopathy markers

Khizroeva, J. Kh / Makatsariya, A. D. / Bitsadze, V. O. / Tretyakova, M. V. / Slukhanchuk, E. V. / Elalamy, I. / Gris, J. C. / Radetskaya, L. S. / Makatsariya, N. A. / Sulina, Y. Yu / Tsibizova, V. I. / Shkoda, A. S. / Blinov, D. V.

Obstetrics, Gynecology and Reproduction

Abstract: The pandemic of a novel coronavirus infection COVID-19 has become a real challenge to the mankind and medical community and has raised a number of medical and social issues Based on the currently available information on COVID-19 clinical cases, it ... ...

Abstract	The pandemic of a novel coronavirus infection COVID-19 has become a real challenge to the mankind and medical community and has raised a number of medical and social issues Based on the currently available information on COVID-19 clinical cases, it follows that COVID-19 patients in critical condition exhibit a clinical picture of disseminated intravascular coagulation (DIC), septic shock with developing multiple organ failure, which justifies use of anticoagulant therapy in COVID-19 patients In addition to isolating virus RNA from biological material and polymerase chain reaction diagnostics, use of simple and easily accessible laboratory blood markers is necessary for management of COVID-19 patients If the activation of coagulation processes is sufficient enough, consumption of platelets and blood clotting factors can be diagnosed by laboratory methods as prolongation of routine blood clotting tests and increasing thrombocytopenia Hyperfibrinogenemia, increased D-dimer level, prolonged prothrombin time, thrombocytopenia, lymphopenia, leukocytopenia, increased concentration of interleukin-6 and ferritin are observed in most COVID-19 patients The degree of increase in these changes correlates with severity of the inflammatory process and serves as a prognostically unfavorable sign Here we discuss value of laboratory monitoring playing an essential role in such pathological crisis that contributes to patient screening, diagnosis as well as further monitoring, treatment and rehabilitation
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #842276
Database	COVID19

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Article: Thrombotic microangiopathy, DIC-syndrome and COVID-19: link with pregnancy prothrombotic state

Makatsariya, A D / Slukhanchuk, E V / Bitsadze, V O / Khizroeva, J K H / Tretyakova, M V / Tsibizova, V I / Elalamy, I / Gris, J-C / Grandone, E / Makatsariya, N A / Mashkova, T

J Matern Fetal Neonatal Med

Abstract	For last months, humanity has faced a formidable unknown enemy, which is presented as a new coronavirus infection. Despite the fact that the causative agents of new diseases appear at a certain frequency and that the virus SARS-CoV-2 has certain common properties with its predecessors, at the moment we are dealing with a new unknown pathogenesis of the development of severe complications in patients with risk factors. A final understanding of pathological process mechanisms is the goal of the scientific community. Summarizing research data from different countries, it became obvious that in severe cases of viral infection, we are dealing with a combination of the systemic inflammatory response syndrome, disseminated intravascular coagulation and thrombotic microangiopathy (TMA). Thrombotic microangiopathy is represented by a group of different conditions in which thrombocytopenia, hemolytic anemia, and multiple organ failure occur. The article reflects the main types of TMA, pathogenesis and principles of therapy. The main participants in the process are described in detail, including the von Willebrand factor and ADAMTS-13. Based on the knowledge available, as well as new data obtained from patients with COVID-19, we proposed possible models for the implementation of conditions such as sepsis, TMA, and DIC in patients with severe new coronavirus infection. Through a deeper understanding of pathogenesis, it will be possible to develop more effective diagnosis and therapy.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #632431
Database	COVID19

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