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  1. Article ; Online: Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids: A Potentially Overlooked Diagnosis.

    Tsibonakis, Athanasios / Theodorou, Aikaterini / Korkolopoulou, Penelope / Tsivgoulis, Georgios

    Annals of neurology

    2023  Volume 95, Issue 2, Page(s) 407–409

    MeSH term(s) Humans ; Steroids/therapeutic use ; Inflammation/drug therapy ; Inflammation/diagnosis ; Pons ; Magnetic Resonance Imaging
    Chemical Substances Steroids
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.26821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multiple cerebral microinfarcts: an uncommon presentation of Cerebral Amyloid Angiopathy-related inflammation.

    Theodorou, Aikaterini / Tsibonakis, Athanasios / Pateras, Ioannis S / Kaloudi, Georgia / Bakola, Eleni / Chondrogianni, Maria / Andreadou, Elissavet / Panayiotides, Ioannis G / Tsivgoulis, Georgios

    Neurological research and practice

    2023  Volume 5, Issue 1, Page(s) 28

    Abstract: Background: Cerebral Amyloid Angiopathy-related inflammation (CAA-ri) is a distinct but rare subset of CAA. The greater availability of high resolution Magnetic Resonance Imaging (MRI) has currently allowed the increasing recognition and diagnosis of ... ...

    Abstract Background: Cerebral Amyloid Angiopathy-related inflammation (CAA-ri) is a distinct but rare subset of CAA. The greater availability of high resolution Magnetic Resonance Imaging (MRI) has currently allowed the increasing recognition and diagnosis of this entity, without the risk of a brain biopsy. However, in rare cases with typical clinical characteristics but uncommon neuroimaging findings at presentation, the brain-biopsy is required for an early and reliable diagnosis.
    Case description: A 71-year-old man with arterial hypertension presented due to 1-week history of headache, vomiting, disorientation and impaired consciousness. Brain MRI revealed multiple acute cortical/subcortical microinfarcts, scarce microbleeds, extensive right parietooccipital and left frontotemporal leptomeningeal enhancement. After an extensive diagnostic work-up, excluding infectious, neoplastic and autoimmune etiologies, the patient underwent brain-biopsy. Histology disclosed amyloid deposition in an arteriolar wall and the patient fulfilled diagnostic criteria for probable CAA-ri with supporting pathology. He received intravenous methylprednisolone, followed by oral tapering with steroids showing clinical and radiological improvement with complete resolution of gadolinium enhancement. Follow-up MRI revealed an increase of cerebral microbleeds and the patient fulfilled CAA-ri neuroimaging criteria.
    Conclusions: This case highlights the importance of continuous vigilance from clinical neurologists to detect CAA-ri diagnosis and the diagnostic value of brain-biopsy in CAA-ri patients with atypical neuroimaging presentation, such as acute microinfarcts. The early diagnosis and the prompt treatment initiation can improve the prognosis and the evolution of this rare disorder.
    Language English
    Publishing date 2023-06-22
    Publishing country England
    Document type Letter
    ISSN 2524-3489
    ISSN (online) 2524-3489
    DOI 10.1186/s42466-023-00253-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Clinical Characteristics, Neuroimaging Markers, and Outcomes in Patients with Cerebral Amyloid Angiopathy: A Prospective Cohort Study.

    Theodorou, Aikaterini / Palaiodimou, Lina / Papagiannopoulou, Georgia / Kargiotis, Odysseas / Psychogios, Klearchos / Safouris, Apostolos / Bakola, Eleni / Chondrogianni, Maria / Kotsali-Peteinelli, Vasiliki / Melanis, Konstantinos / Tsibonakis, Athanasios / Andreadou, Elissavet / Vasilopoulou, Sofia / Lachanis, Stefanos / Velonakis, Georgios / Tzavellas, Elias / Tzartos, John S / Voumvourakis, Konstantinos / Paraskevas, Georgios P /
    Tsivgoulis, Georgios

    Journal of clinical medicine

    2023  Volume 12, Issue 17

    Abstract: Background and purpose: ...

    Abstract Background and purpose:
    Language English
    Publishing date 2023-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12175591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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