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Article: ERS Early Career Members meet EAACI Junior Members: the launch of a strong, fruitful collaboration.

Mathioudakis, Alexander G / Eguiluz Gracia, Ibon / Bartel, Sabine / Tsilochristou, Olympia

2017 Volume 13, Issue 3, Page(s) 231–233

Abstract: Learn about the collaboration between @EarlyCareerERS and @ ... ...

Abstract	Learn about the collaboration between @EarlyCareerERS and @EAACI_JM
Language	English
Publishing date	2017-08-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2562899-9
ISSN	2073-4735 ; 1810-6838
ISSN (online)	2073-4735
ISSN	1810-6838
DOI	10.1183/20734735.009017
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Article ; Online: The roadmap for allergology in Europe: The European training requirements for the specialty of allergology.

Gerth van Wijk, Roy / Mülleneisen, Norbert / Demoly, Pascal / Olaguibel, Jose Maria / Popov, Todor A / Schmid-Grendelmeier, Peter / Tsilochristou, Olympia

Allergy

2020 Volume 76, Issue 5, Page(s) 1588–1591

MeSH term(s)	Europe ; Humans ; Medicine
Language	English
Publishing date	2020-10-24
Publishing country	Denmark
Document type	Letter
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.14614
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Article ; Online: Successful rapid desensitization to imiglucerase in an adult patient with Gaucher disease and documented IgE-mediated hypersensitivity.

Tsilochristou, Olympia / Gkavogiannakis, Nikolaos A / Ioannidou, Eleni N / Makris, Michael

The journal of allergy and clinical immunology. In practice

2015 Volume 3, Issue 4, Page(s) 624–626

MeSH term(s)	Adult ; Desensitization, Immunologic ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/therapy ; Enzyme Replacement Therapy/adverse effects ; Female ; Gaucher Disease/drug therapy ; Glucosylceramidase/adverse effects ; Glucosylceramidase/therapeutic use ; Humans ; Hypersensitivity, Immediate/diagnosis ; Hypersensitivity, Immediate/etiology ; Hypersensitivity, Immediate/therapy ; Skin Tests ; Young Adult
Chemical Substances	Glucosylceramidase (EC 3.2.1.45) ; imiglucerase (Q6U6J48BWY)
Language	English
Publishing date	2015-07
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2014.11.013
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Article ; Online: Piperacillin-Tazobactam Hypersensitivity: A Large, Multicenter Analysis.

Casimir-Brown, Rosamund Sara / Kennard, Lucinda / Kayode, Oyindamola Stephanie / Siew, Leonard Q C / Makris, Michael / Tsilochristou, Olympia / Chytiroglou, Evangelia / Nakonechna, Alla / Rutkowski, Krzysztof / Mirakian, Rita / Wagner, Annette

The journal of allergy and clinical immunology. In practice

2021 Volume 9, Issue 5, Page(s) 2001–2009

Abstract: Background: Piperacillin/tazobactam is a broad-spectrum penicillin. Hypersensitivity reactions are less commonly reported than with other penicillins except in patients with cystic fibrosis.: Objective: Detailed clinical characterization of a patient ...

Abstract	Background: Piperacillin/tazobactam is a broad-spectrum penicillin. Hypersensitivity reactions are less commonly reported than with other penicillins except in patients with cystic fibrosis. Objective: Detailed clinical characterization of a patient cohort referred with suspected piperacillin-tazobactam hypersensitivity. Methods: Retrospective analysis of the demographic characteristics, clinical presentation, investigation, and management of 87 patients presenting to 5 European allergy centers. Patients underwent skin prick and intradermal testing with piperacillin/tazobactam, major (penicilloyl-polylysine) and minor (sodium penilloate) determinants, amoxicillin, benzylpenicillin, flucloxacillin, co-amoxiclav, clavulanic acid, and meropenem with immediate and, where appropriate, delayed reading of tests. Skin test-negative patients underwent drug provocation to piperacillin/tazobactam and/or other penicillins. A multistep protocol was used, depending on risk assessment. Results: Forty-eight of 87 (55%) patients were diagnosed with hypersensitivity to piperacillin/tazobactam with either positive skin or drug provocation test results, of whom 10 (21%) had a diagnosis of cystic fibrosis. Twenty-six (54%) patients presented with immediate and 22 (45%) with nonimmediate hypersensitivity. Patients with cystic fibrosis predominantly presented with nonimmediate hypersensitivity (70%). Reactions were severe in 52% of immediate reactors (Brown's anaphylaxis grade 3) and moderately severe (systemic involvement) in 75% of nonimmediate reactors. The number of patients with negative skin test results tolerating reintroduction was comparable in immediate (80%) and nonimmediate (88%) hypersensitivity. One-third of patients were cross-sensitized to other penicillins. The cross-sensitization pattern raised the possibility of tazobactam allergy in 3 patients. In 21 patients selectively sensitized to piperacillin/tazobactam (12 immediate, 9 nonimmediate), tolerance to other beta-lactams was demonstrated by drug provocation testing. Conclusions: Piperacillin-tazobactam caused immediate and nonimmediate hypersensitivity with similar frequency. Most patients were selectively sensitized and tolerated other penicillins. Some patients may be allergic to the beta-lactamase inhibitor only.
MeSH term(s)	Amoxicillin ; Anti-Bacterial Agents/adverse effects ; Drug Hypersensitivity/diagnosis ; Drug Hypersensitivity/epidemiology ; Humans ; Hypersensitivity, Immediate/diagnosis ; Hypersensitivity, Immediate/epidemiology ; Penicillins/adverse effects ; Retrospective Studies ; Skin Tests
Chemical Substances	Anti-Bacterial Agents ; Penicillins ; Amoxicillin (804826J2HU)
Language	English
Publishing date	2021-01-11
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2020.12.051
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Article ; Online: Detection of local allergic rhinitis in children with chronic, difficult-to-treat, non-allergic rhinitis using multiple nasal provocation tests.

Tsilochristou, Olympia / Kyriakakou, Marialena / Manolaraki, Ioanna / Lakoumentas, John / Tiligada, Ekaterini / Maragkoudakis, Pavlos / Douladiris, Nikolaos / Papadopoulos, Nikolaos G

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

2019 Volume 30, Issue 3, Page(s) 296–304

Abstract: Background: There is little evidence on the incidence and characteristics of local allergic rhinitis (LAR) in children. Most studies have included subjects with perennial rhinitis only, and results are based on the investigation of no more than three ... ...

Abstract	Background: There is little evidence on the incidence and characteristics of local allergic rhinitis (LAR) in children. Most studies have included subjects with perennial rhinitis only, and results are based on the investigation of no more than three allergens per study. Our aim was to determine the proportion of children with LAR amongst children with chronic, difficult-to-treat, perennial or seasonal, rhinitis but no evidence of sensitization to aeroallergens, or other alternative diagnosis. Methods: We performed multiple nasal provocation tests (M-NPTs) with four locally relevant aeroallergens (Phleum pratense, Olea europea, Alternaria alternata, and Dermatophagoides pteronyssinus) in children with absence of aeroallergen sensitization, seen during a calendar year in a specialized rhinitis clinic. We additionally performed single NPT to children with allergic rhinitis (AR; positive control group). The result of the NPT was based on symptoms and acoustic rhinometry. Identification of nasal hyper-reactivity (NHR) triggers was through a questionnaire. Results: Local allergic rhinitis was confirmed in 29.2% (7/24) of the negative SPT/blood testing population. All but one of the children reacted to one allergen and one to two. All AR children had positive single NPT with results similar to the LAR. There were no differences in age at examination and rhinitis onset, gender distribution, family atopy, and past or current environment of residency, while the prevalence of reported NHR triggers was comparable amongst the three groups. Conclusion: This is the first pediatric study where the seasonal or perennial rhinitis population was thoroughly tested for LAR against four aeroallergens. LAR is present in a considerable proportion of children with chronic, difficult-to-treat rhinitis and no sensitization to aeroallergens, and therefore, the performance of NPT should be strongly considered in these cases. There were no distinct clinical characteristics between LAR, AR, and non-allergic rhinitis in children.
MeSH term(s)	Adolescent ; Allergens/immunology ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Nasal Provocation Tests/methods ; Prevalence ; Rhinitis, Allergic/diagnosis ; Rhinometry, Acoustic
Chemical Substances	Allergens
Language	English
Publishing date	2019-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1057059-7
ISSN	1399-3038 ; 0905-6157 ; 0906-5784
ISSN (online)	1399-3038
ISSN	0905-6157 ; 0906-5784
DOI	10.1111/pai.13021
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Article ; Online: Mentoring as the cornerstone of continued education in Allergy and Clinical Immunology: 10th anniversary of the EAACI mentorship program.

Giovannini, Mattia / Beken, Burcin / Agache, Ioana / Akdis, Cezmi A / Carvalho, Daniela / Chivato, Tomas / Comberiati, Pasquale / De Las Vecillas, Leticia / Eguiluz-Gracia, Ibon / Heffler, Enrico / Jutel, Marek / Eyice Karabacak, Deniz / Kolkhir, Pavel / Moya, Beatriz / Ollert, Markus / O'Neil, Serena / Santos, Alexandra F / Schwarze, Jurgen / Skevaki, Chrysanthi /

Sokolowska, Milena / Tsilochristou, Olympia / van Wijk, Roy Gerth / Del Giacco, Stefano / Riggioni, Carmen

Allergy

2023 Volume 79, Issue 1, Page(s) 7–11

MeSH term(s)	Humans ; Mentoring ; Mentors ; Anniversaries and Special Events ; Hypersensitivity/therapy
Language	English
Publishing date	2023-09-18
Publishing country	Denmark
Document type	Editorial
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.15878
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Article ; Online: ERS/EAACI statement on adherence to international adult asthma guidelines.

Mathioudakis, Alexander G / Tsilochristou, Olympia / Adcock, Ian M / Bikov, Andras / Bjermer, Leif / Clini, Enrico / Flood, Breda / Herth, Felix / Horvath, Ildiko / Kalayci, Omer / Papadopoulos, Nikolaos G / Ryan, Dermot / Sanchez Garcia, Silvia / Correia-de-Sousa, Jaime / Tonia, Thomy / Pinnock, Hillary / Agache, Ioana / Janson, Christer

European respiratory review : an official journal of the European Respiratory Society

2021 Volume 30, Issue 161

Abstract: Guidelines aim to standardise and optimise asthma diagnosis and management. Nevertheless, adherence to guidelines is suboptimal and may vary across different healthcare professional (HCP) groups.Further to these concerns, this European Respiratory ... ...

Abstract	Guidelines aim to standardise and optimise asthma diagnosis and management. Nevertheless, adherence to guidelines is suboptimal and may vary across different healthcare professional (HCP) groups.Further to these concerns, this European Respiratory Society (ERS)/European Academy of Allergy and Clinical Immunology (EAACI) statement aims to: 1) evaluate the understanding of and adherence to international asthma guidelines by HCPs of different specialties
MeSH term(s)	Adult ; Asthma/diagnosis ; Asthma/drug therapy ; Guideline Adherence ; Health Personnel ; Humans ; Surveys and Questionnaires
Language	English
Publishing date	2021-09-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1077620-5
ISSN	1600-0617 ; 0905-9180
ISSN (online)	1600-0617
ISSN	0905-9180
DOI	10.1183/16000617.0132-2021
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Article ; Online: Pediatric allergic rhinitis and asthma: can the march be halted?

Tsilochristou, Olympia A / Douladiris, Nikolaos / Makris, Michael / Papadopoulos, Nikolaos G

Paediatric drugs

2013 Volume 15, Issue 6, Page(s) 431–440

Abstract: The strong epidemiologic and pathophysiologic link between allergic rhinitis (AR) and asthma has led to the concept of 'united airways disease' or 'respiratory allergy', implying that allergy, in its widest sense, underlies this clinical syndrome. ... ...

Abstract	The strong epidemiologic and pathophysiologic link between allergic rhinitis (AR) and asthma has led to the concept of 'united airways disease' or 'respiratory allergy', implying that allergy, in its widest sense, underlies this clinical syndrome. Progression from AR to asthma is frequent and part of the 'atopic march'. Since pediatric immune responses are more adaptable and therefore may be more amenable to treatment, interventions at early childhood are characterized by a higher chance to affect the natural history of respiratory allergy. Although current treatments are quite effective in alleviating respiratory allergy symptoms, it has proven much more difficult to confirm any influence on the progression of the disease. Much more promising is the field of specific allergen immunotherapy, where current evidence, although not yet of ideal robustness, points towards a disease-modifying effect. In addition, newer or emerging, possibly more effective or more targeted interventions are promising in the preventive sense.
MeSH term(s)	Adolescent ; Asthma/epidemiology ; Asthma/immunology ; Asthma/prevention & control ; Child ; Disease Progression ; Histamine Antagonists/therapeutic use ; Humans ; Immunotherapy ; Prevalence ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial/epidemiology ; Rhinitis, Allergic, Perennial/physiopathology ; Rhinitis, Allergic, Perennial/therapy
Chemical Substances	Histamine Antagonists
Language	English
Publishing date	2013-08-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1492748-2
ISSN	1179-2019 ; 1174-5878
ISSN (online)	1179-2019
ISSN	1174-5878
DOI	10.1007/s40272-013-0043-3
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Article ; Online: The EAACI-AAAAI-WAO Junior Members' joint survey: A worldwide snapshot of Allergy and Clinical Immunology specialty.

Caminati, Marco / Antolín-Amérigo, Darío / Bonini, Matteo / Buelow, Becky / Bundy, Vanessa / Couto, Mariana / Darlenski, Razvigor / Fassio, Filippo / Kelly, Brian / Kwong, Christina / Santos, Alexandra / Tsilochristou, Olympia / Kase Tanno, Luciana

Allergy

2019 Volume 75, Issue 3, Page(s) 588–595

Abstract: Background: Education and training in Allergy and Clinical Immunology (A/I) are characterized by a great variability worldwide. However, objective and worldwide data regarding this topic are lacking.: Methods: To investigate personal information, ... ...

Abstract	Background: Education and training in Allergy and Clinical Immunology (A/I) are characterized by a great variability worldwide. However, objective and worldwide data regarding this topic are lacking. Methods: To investigate personal information, education, and involvement in scientific societies of juniors engaged in A/I field, a questionnaire was developed by representatives from the JMs' boards of the European Academy of Allergy and Clinical Immunology (EAACI), the American Academy of Allergy, Asthma, and Immunology (AAAAI), and the World Allergy Organization (WAO). Results: A total of 543 questionnaires were collected from 76 regions of all continents. The geographic distribution of responders was as follows: Africa-Middle East 3.0%, Asia-Pacific 21.4%, Europe 48.2%, Latin America 12.1%, and North America 15.3%. 59.0% of responders declared that A/I is recognized as a separate specialty in their country, Europe mostly accounting for that proportion. Primary interest in the field represents the main motivation for choosing A/I specialty. Concerning involvement in scientific societies, 41.1% of responders ever attended an EAACI Congress, 20.6% an AAAAI Congress, and 20.4% a WAO Congress. According to 40.3% of responders, scientific societies do not provide enough opportunities for young members, and 96.4% believes in a more intensive cooperation between the A/I Societies. Conclusions: The survey provides the first worldwide perspective about A/I specialty. It represents the first ever example of a structured collaboration between the junior members (JMs) of the three main A/I Societies. The findings suggest the need for harmonization, at least in terms of training and formation in the field of A/I worldwide.
MeSH term(s)	Academies and Institutes ; Allergy and Immunology ; Asthma ; Europe/epidemiology ; Humans ; Hypersensitivity/epidemiology
Language	English
Publishing date	2019-10-21
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	391933-x
ISSN	1398-9995 ; 0105-4538
ISSN (online)	1398-9995
ISSN	0105-4538
DOI	10.1111/all.14052
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Article ; Online: Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity.

Tsilochristou, Olympia / du Toit, George / Sayre, Peter H / Roberts, Graham / Lawson, Kaitie / Sever, Michelle L / Bahnson, Henry T / Radulovic, Suzana / Basting, Monica / Plaut, Marshall / Lack, Gideon

The Journal of allergy and clinical immunology

2019 Volume 144, Issue 2, Page(s) 494–503

Abstract: Background: Staphylococcus aureus has been implicated in the pathophysiology of eczema, allergic rhinitis, asthma, and food allergy. S aureus is a marker of more severe eczema, which is a risk factor for food sensitization/allergy. Therefore it might be ...

Abstract	Background: Staphylococcus aureus has been implicated in the pathophysiology of eczema, allergic rhinitis, asthma, and food allergy. S aureus is a marker of more severe eczema, which is a risk factor for food sensitization/allergy. Therefore it might be that the association between S aureus and food allergy in eczematous patients is related to eczema severity. Objective: We sought to investigate the association of S aureus colonization with specific IgE (sIgE) production to common food allergens and allergies in early childhood independent of eczema severity. We additionally determined the association of S aureus colonization with eczema severity and persistence. Methods: In Learning Early About Peanut Allergy (LEAP) study participants eczema severity was assessed, and skin/nasal swabs were cultured for S aureus. Sensitization was identified by measuring sIgE levels. Peanut allergy was primarily determined by means of oral food challenge, and persistent egg allergy was primarily determined by using skin prick tests. Results: Skin S aureus colonization was significantly associated with eczema severity across the LEAP study, whereas at 12 and 60 months of age, it was related to subsequent eczema deterioration. Skin S aureus colonization at any time point was associated with increased levels of hen's egg white and peanut sIgE independent of eczema severity. Participants with S aureus were more likely to have persistent egg allergy and peanut allergy at 60 and 72 months of age independent of eczema severity. All but one of the 9 LEAP study consumers with peanut allergy (9/312) were colonized at least once with S aureus. Conclusion: S aureus, independent of eczema severity, is associated with food sensitization and allergy and can impair tolerance to foods. This could be an important consideration in future interventions aimed at inducing and maintaining tolerance to food allergens in eczematous infants.
MeSH term(s)	Asthma/immunology ; Asthma/microbiology ; Child ; Child, Preschool ; Dermatitis, Atopic/immunology ; Dermatitis, Atopic/microbiology ; Egg Hypersensitivity/immunology ; Egg Hypersensitivity/microbiology ; Female ; Humans ; Infant ; Male ; Peanut Hypersensitivity/immunology ; Peanut Hypersensitivity/microbiology ; Rhinitis, Allergic/immunology ; Rhinitis, Allergic/microbiology ; Severity of Illness Index ; Staphylococcal Infections/immunology ; Staphylococcus aureus/immunology
Language	English
Publishing date	2019-05-31
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2019.04.025
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