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Article ; Online: Perspectives.

Tsimaratos, Michel / Jacquelinet, Christian

2023 Volume 18, Issue S2, Page(s) 97–98

Title translation	Perspectives.
Language	French
Publishing date	2023-08-29
Publishing country	France
Document type	Journal Article
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1016/S1769-7255(22)00578-8
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Article ; Online: Donneur vivant, premier choix

Tsimaratos, Michel / Kerbaul, François

Nephrologie & therapeutique

2023 Volume 19, Issue 2, Page(s) 81–82

Title translation	Living donor, first choice.
MeSH term(s)	Humans ; Living Donors ; Kidney Transplantation
Language	French
Publishing date	2023-04-23
Publishing country	France
Document type	Journal Article
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1684/ndt.2023.21
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Article ; Online: La place des enfants dans la pandémie et le rôle de la COVID-19 dans leur vie.

Zaloszyc, Ariane / Tsimaratos, Michel

Nephrologie & therapeutique

2021 Volume 17, Issue 4, Page(s) 214–217

Title translation	The position of children in the pandemic and the role of COVID-19 in their lives.
MeSH term(s)	Absenteeism ; Anxiety/etiology ; COVID-19/complications ; COVID-19/virology ; Child ; Communicable Disease Control ; Humans ; Mucocutaneous Lymph Node Syndrome/virology ; Pandemics ; Social Isolation ; Systemic Inflammatory Response Syndrome/virology
Language	French
Publishing date	2021-03-11
Publishing country	France
Document type	Editorial
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1016/j.nephro.2021.01.001
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Article ; Online: Dilatation of the aorta in children with advanced chronic kidney disease.

Quennelle, Sophie / Ovaert, Caroline / Cailliez, Mathilde / Garaix, Florentine / Tsimaratos, Michel / El Louali, Fedoua

Pediatric nephrology (Berlin, Germany)

2021 Volume 36, Issue 7, Page(s) 1825–1831

Abstract: Background: The peculiarity of the cardiovascular risk profile with increased arterial vulnerability is well known in adults with chronic kidney disease (CKD). It is explained by an increased incidence of traditional cardiovascular risk factors together ...

Abstract	Background: The peculiarity of the cardiovascular risk profile with increased arterial vulnerability is well known in adults with chronic kidney disease (CKD). It is explained by an increased incidence of traditional cardiovascular risk factors together with other comorbidities related to the uremic condition and cardiorenal syndrome (CRS). The present study aimed to determine the cardiovascular impact of the uremic condition in a pediatric population with advanced CKD. Methods: From 2016 to 2018, 39 consecutive patients with advanced CKD who underwent echocardiographic evaluation were included. All echocardiographic examinations were performed by the same operator (FE). Demographic, clinical, biological, and echocardiographic data were collected. Results: The mean age at echocardiographic exam was 9.7 ± 4.6 years. Twenty-four (61.5%) patients were on hemodialysis; 17 (43.6%) patients were in a peritoneal dialysis program of whom 11 switched at a later stage to hemodialysis. Eight (20.5%) patients had an arteriovenous fistula (AVF). Hypertension was present in 30 (76.9%) patients while left ventricular hypertrophy (LVH) was described in 13 (33.3%) patients. Dilatation of the ascending aorta (Z-score > 2) was found in 15 (38.4%) patients and was statistically (in univariate analysis) related to gender, hypertension, the presence of an AVF, and the use of hemodialysis after peritoneal dialysis (p = 0.024, p = 0.016, p = 0.006, p = 0.009, respectively). Conclusion: In addition to classical and predictable abnormalities related to CKD, we found a high prevalence of dilatation of the ascending aorta in children with advanced CKD. Hypertension, AVF, and hemodialysis were associated factors.
MeSH term(s)	Aorta ; Child ; Chronic Disease ; Dilatation ; Humans ; Hypertension ; Hypertrophy, Left Ventricular/diagnostic imaging ; Hypertrophy, Left Ventricular/epidemiology ; Hypertrophy, Left Ventricular/etiology ; Renal Dialysis/adverse effects ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Risk Factors
Language	English
Publishing date	2021-01-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-020-04887-8
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Zs.A 2196: Show issues

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Article: The Invisible Threat of Non-steroidal Anti-inflammatory Drugs for Kidneys.

Clavé, Stéphanie / Rousset-Rouvière, Caroline / Daniel, Laurent / Tsimaratos, Michel

Frontiers in pediatrics

2019 Volume 7, Page(s) 520

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2019.00520
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Article ; Online: Human papillomavirus type 7-associated anal condyloma after renal transplantation in a child.

Garaix, Florentine / Hery, Geraldine / Tsimaratos, Michel / Colson, Philippe / Tamalet, Catherine

Pediatric transplantation

2019 Volume 23, Issue 5, Page(s) e13470

Abstract: The prevalence, clinical significance, and spectrum of many HPV genotypes are currently largely untapped. We report a case of anal condyloma associated with a rare HPV genotype in a 11-year-old kidney transplant recipient. Eleven months post-graft, ... ...

Abstract	The prevalence, clinical significance, and spectrum of many HPV genotypes are currently largely untapped. We report a case of anal condyloma associated with a rare HPV genotype in a 11-year-old kidney transplant recipient. Eleven months post-graft, rectal bleeding revealed a 5-cm-large anal condyloma for which immuno-histopathology revealed typical papillomatosis. HPV genotyping performed on anal biopsy identified a HPV type 7, for which a single sequence was found in the GenBank sequence database. HPV7 is classically found in hand cutaneous warts, but HPV7-associated condyloma was only described in two patients. Total resection of the anal lesion was performed by electrocoagulation with no recurrence after 6 years. Post-transplant immunosuppression may promote anal condyloma with uncommon HPV types. HPV genotyping in such lesions is useful to get a better understanding of the epidemiology and clinical significance of such unusual HPV types as HPV7.
MeSH term(s)	Anus Diseases/genetics ; Anus Diseases/immunology ; Anus Diseases/virology ; Child ; Condylomata Acuminata/genetics ; Condylomata Acuminata/immunology ; Condylomata Acuminata/virology ; Humans ; Immunosuppression/methods ; Kidney Transplantation ; Male ; Papillomavirus Infections/genetics ; Papillomavirus Infections/immunology ; Papillomavirus Infections/virology
Language	English
Publishing date	2019-05-12
Publishing country	Denmark
Document type	Case Reports
ZDB-ID	1390284-2
ISSN	1399-3046 ; 1397-3142
ISSN (online)	1399-3046
ISSN	1397-3142
DOI	10.1111/petr.13470
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Zs.A 4947: Show issues

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Article ; Online: Access to kidney transplantation for patients with end-stage renal failure in Maghreb countries: state of art and recommendations

Macher, Marie-Alice / Mongi Bacha, Mohamed / Soualmia, Amel / Laouad, Inass / Sfar, Imen / Jacquelinet, Christian / Meçabih, Fateh / Younous, Said / Bayar, Rached / Ziadi, Jalel / Nebab, Abed El Kader / Barry, Naïma / Nouvellon, Hélène / Gozzerino, Agathe / Durin, Laurent / Ben Abdallah, Taieb / Tsimaratos, Michel

Nephrologie & therapeutique

2024 Volume 20, Issue 1, Page(s) 30–40

Abstract: We present an overview of kidney transplantation activity in the Maghreb countries, based on data from the 9th Colloque France-Maghreb (Paris, May 20 and 21, 2022). For Algeria, Morocco and Tunisia, the incidence of end stage renal failure is ... ...

Title translation	Accès à la transplantation rénale des patients en insuffisance rénale chronique terminale dans les pays du Maghreb : état des lieux et recommandations
Abstract	We present an overview of kidney transplantation activity in the Maghreb countries, based on data from the 9th Colloque France-Maghreb (Paris, May 20 and 21, 2022). For Algeria, Morocco and Tunisia, the incidence of end stage renal failure is respectively 120, 130 and 130 per million inhabitants, its prevalence 626, 900 and 833 per million inhabitants and the part of patients with a functional graft of 10.3, 1.8 et 8.5% with an annual number of transplants of 6.5, 0.8 and 8.7 per million inhabitants. Living donor transplants account for 99% of transplants in Algeria, 93% in Morocco and 80% in Tunisia. In conclusion, access to transplantation remains low in the Maghreb countries. All the modalities (living donor with enlargement of the circle of donors, deceased donors) must be further developed. Recommendations were issued to support activity.
MeSH term(s)	Humans ; Kidney Transplantation ; Algeria/epidemiology ; Tunisia/epidemiology ; Kidney Failure, Chronic/surgery ; Kidney Failure, Chronic/epidemiology ; Living Donors
Language	French
Publishing date	2024-02-05
Publishing country	France
Document type	Review ; Journal Article
ZDB-ID	2229575-6
ISSN	1872-9177 ; 1769-7255
ISSN (online)	1872-9177
ISSN	1769-7255
DOI	10.1684/ndt.2024.62
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Article ; Online: Quality of life of transplanted children and their parents: a cross-sectional study.

Duvant, Pauline / Fillat, Magali / Garaix, Florentine / Roquelaure, Bertrand / Ovaert, Caroline / Fouilloux, Virginie / Tsimaratos, Michel / Auquier, Pascal / Fabre, Alexandre / Baumstarck, Karine

Orphanet journal of rare diseases

2021 Volume 16, Issue 1, Page(s) 364

Abstract: Background: Transplantation is a saving therapeutic that has heavy consequences. The quality of life (QoL) of transplanted children and their parents has been little studied and should help physicians better manage these patients. The objectives of the ... ...

Abstract	Background: Transplantation is a saving therapeutic that has heavy consequences. The quality of life (QoL) of transplanted children and their parents has been little studied and should help physicians better manage these patients. The objectives of the study were to assess: (1) the QoL of transplanted children and parents and compare it with that of children with other chronic conditions associated with long-term consequences, and (2) potential variables modulating the QoL. Methods: This cross-sectional study was performed in a multidisciplinary paediatric unit (Timone Hospital, Marseille, France). Children were less than 18 years old; had a liver, kidney or heart transplant; and had a time since transplantation of 1-10 years. Socio-demographics and clinical data were recorded from medical forms. The QoL was assessed using the VSP-A (Vécu et Santé Perçue de l'Adolescent et de l'Enfant) and the WhoQoL self-reported questionnaires. Results: Forty-five families were included (response rate: 76%). The transplanted organs were the liver for 20 children, the kidney for 15 children, and the heart for 10 children. The QoL of transplanted children reported by their parents was better than that of children with inborn errors of metabolism and similar to that of childhood leukaemia survivors. The QoL of parents of transplanted children was better than that of parents of children with inborn errors of metabolism and did not differ from French norms. The QoL did not differ according to the nature of the transplanted organ, sex or the main sociodemographic data. The main modulators decreasing QoL were residual treatment level, medications switch and the presence of another regular treatment. Conclusion: Transplanted children and their families reported a fairly preserved QoL compared to children with other chronic health conditions. Special attention should be given to QoL modulators related to therapeutic management (medication switches, regular treatments) that might be amenable to improve the QoL. Trial registration Ethics committee of Aix-Marseille University, France (reference number: 2014-08-04-03, 24/4/2015; https://www.univ-amu.fr/fr/public/comite-dethique ).
MeSH term(s)	Adolescent ; Child ; Cross-Sectional Studies ; France ; Humans ; Parents ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2021-08-17
Publishing country	England
Document type	Journal Article
ISSN	1750-1172
ISSN (online)	1750-1172
DOI	10.1186/s13023-021-01987-y
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Article ; Online: Copeptin assays in children for the differential diagnosis of polyuria-polydipsia syndrome and reference levels in hospitalized children.

Bonnet, Laura / Marquant, Emeline / Fromonot, Julien / Hamouda, Ilyes / Berbis, Julie / Godefroy, Alice / Vierge, Melody / Tsimaratos, Michel / Reynaud, Rachel

Clinical endocrinology

2021 Volume 96, Issue 1, Page(s) 47–53

Abstract: Objectives: Polyuria-polydipsia syndrome (PPS) is a common presentation in children but the differential diagnosis rests on burdensome water deprivation tests. The aims of this study were to determine a copeptin threshold to distinguish patients with ... ...

Abstract	Objectives: Polyuria-polydipsia syndrome (PPS) is a common presentation in children but the differential diagnosis rests on burdensome water deprivation tests. The aims of this study were to determine a copeptin threshold to distinguish patients with central diabetes insipidus from those with primary polydipsia and to estimate the normal range of copeptin concentrations in children. Design: Single-centre retrospective descriptive study. Patients: Two hundred and seventy-eight children aged 2 months to 18 years who consulted for PPS (N = 40) or other reasons (control group, N = 238) at La Timone University Hospital in Marseille, France, between April 2015 and September 2019 and had a copeptin assay. Measurements: Ultrasensitive copeptin assays on blood samples. Results: Among the children with PPS, the mean copeptin concentrations were 1.72, 55.2 and 15.7 pmol/l in those with central diabetes insipidus (N = 21), nephrogenic diabetes insipidus (N = 3), and primary polydipsia (N = 16), respectively. Copeptin levels lower than 3.53 pmol/l were diagnostic of central diabetes insipidus with 100% sensitivity and 87.4% specificity (p < .001). The 5th-95th copeptin percentile range in the control group was 2.53-21.03 pmol/L. Copeptin levels were significantly higher in boys than in girls but there was no association with age, pubertal stage, body mass index, or the reason for consulting. Conclusions: Our results indicate copeptin assays may be valuable in the differential diagnosis of PPS in children. Larger prospective studies are required to establish their accuracy in everyday clinical practice.
MeSH term(s)	Child ; Child, Hospitalized ; Diagnosis, Differential ; Female ; Glycopeptides ; Humans ; Male ; Polydipsia/diagnosis ; Polyuria/diagnosis ; Retrospective Studies
Chemical Substances	Glycopeptides ; copeptins
Language	English
Publishing date	2021-10-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.14620
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Article ; Online: Human Bacterial Repertoire of the Urinary Tract: a Potential Paradigm Shift.

Morand, Aurélie / Cornu, Florent / Dufour, Jean-Charles / Tsimaratos, Michel / Lagier, Jean-Christophe / Raoult, Didier

Journal of clinical microbiology

2019 Volume 57, Issue 3

Abstract: The aim of this article is to review the human repertoire of bacteria in urine already described by culture and metagenomic techniques and published in the literature. Our study led us to compare this repertoire with other available human repertoires. We ...

Abstract	The aim of this article is to review the human repertoire of bacteria in urine already described by culture and metagenomic techniques and published in the literature. Our study led us to compare this repertoire with other available human repertoires. We followed automatic and manual bibliographical methods and found 562 bacterial species reported in the literature as part of the human urinary microbiota. Of the 562 species, 322 were described only by culture, 101 by both culture and metagenomics, and 139 only by metagenomics. A total of 352 species (62.6%) have been associated with at least one case report of human infection, of which 225 (40.0%) have been described as causative agents of urinary tract infection. The urinary tract bacterial repertoire contains 21.4% of the known prokaryotic diversity associated with human beings (464 species in common), and it shares 23.6% species with the human gut microbiota (350 species in common, 62.3% of the urine species). The urinary repertoire shares a significant difference in aerointolerant species compared with those of the gut microbiota (100/562 [17.8%] and 505/1,484 [34.0%], respectively;
MeSH term(s)	Bacteria/classification ; Bacteria/genetics ; Bacteria/growth & development ; Bacteria/pathogenicity ; Bacterial Physiological Phenomena ; Biodiversity ; Dysbiosis ; Gastrointestinal Microbiome ; Humans ; Microbiota ; Urinary Tract/microbiology ; Urinary Tract Infections/microbiology ; Urine/microbiology
Language	English
Publishing date	2019-02-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.00675-18
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