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Article ; Online: Oxytocin: A Multi-Functional Biomolecule with Potential Actions in Dysfunctional Conditions; From Animal Studies and Beyond.

Tsingotjidou, Anastasia S

2022 Volume 12, Issue 11

Abstract: Oxytocin is a hormone secreted from definite neuroendocrine neurons located in specific nuclei in the hypothalamus (mainly from paraventricular and supraoptic nuclei), and its main known function is the contraction of uterine and/or mammary gland cells ... ...

Abstract	Oxytocin is a hormone secreted from definite neuroendocrine neurons located in specific nuclei in the hypothalamus (mainly from paraventricular and supraoptic nuclei), and its main known function is the contraction of uterine and/or mammary gland cells responsible for parturition and breastfeeding. Among the actions of the peripherally secreted oxytocin is the prevention of different degenerative disorders. These actions have been proven in cell culture and in animal models or have been tested in humans based on hypotheses from previous studies. This review presents the knowledge gained from the previous studies, displays the results from oxytocin intervention and/or treatment and proposes that the well described actions of oxytocin might be connected to other numerous, diverse actions of the biomolecule.
MeSH term(s)	Humans ; Animals ; Oxytocin/pharmacology ; Supraoptic Nucleus/physiology ; Hypothalamus ; Neurons
Chemical Substances	Oxytocin (50-56-6)
Language	English
Publishing date	2022-10-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12111603
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A systematic review on reporting of refinement measures in mouse ECG telemetry implantation surgery

Gkrouzoudi, Alexandra / Tsingotjidou, Anastasia / Jirkof, Paulin

Laboratory Animals. 2023 Feb., v. 57, no. 1 p.9-25

2023

Abstract: Telemetric monitoring is used in many scientific fields, such as cardiovascular research, neurology, endocrinology, as well as animal welfare research. Nowadays, implanted electrocardiogram (ECG) radiotelemetry units are the gold standard for monitoring ... ...

Abstract	Telemetric monitoring is used in many scientific fields, such as cardiovascular research, neurology, endocrinology, as well as animal welfare research. Nowadays, implanted electrocardiogram (ECG) radiotelemetry units are the gold standard for monitoring ECG traces, heart rate and heart rate variability in freely moving mice. Telemetry technology can be a valuable tool when studies utilize it adequately, while prioritizing animal welfare. Recently, concerns have been raised in many research fields, including animal research, regarding the reproducibility of research findings, with insufficient reporting being one of the underlying causes. A systematic review was performed by making use of three literature databases, in order to include all publications until 31.12.2019, where the surgical placing of ECG recording telemetry devices in adult mice was involved. Data extracted from the publications included selected items recommended by the ARRIVE guidelines. We focused on aspects related to the refinement of the surgery and experimental conditions that aim to improve animal welfare. In general, the quality of reporting was low in the analyzed 234 publications. Based on our analyses, we assume there has been no improvement in this field’s reporting quality since 2010 when the ARRIVE guidelines on reporting were introduced. Additionally, even though expert recommendations on telemetry surgery refinement have been available since many years now, no increase in uptake (or reporting) of these measures prior (e.g., acclimatization), during (e.g., asepsis) or after (e.g., social housing) the surgery could be observed.
Keywords	acclimation ; adults ; animal research ; animal welfare ; electrocardiography ; endocrinology ; heart rate ; laboratories ; mice ; radio telemetry ; surgery ; systematic review ; ARRIVE guidelines ; electrocardiogram ; ethics and welfare ; refinement ; reporting ; techniques ; telemetry
Language	English
Dates of publication	2023-02
Size	p. 9-25.
Publishing place	SAGE Publications
Document type	Article ; Online
ZDB-ID	391008-8
ISSN	1758-1117 ; 0023-6772
ISSN (online)	1758-1117
ISSN	0023-6772
DOI	10.1177/00236772221115492
Database	NAL-Catalogue (AGRICOLA)

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Article: A systematic review on the reporting quality in mouse telemetry implantation surgery using electrocardiogram recording devices

Gkrouzoudi, Alexandra / Tsingotjidou, Anastasia / Jirkof, Paulin

Physiology & behavior. 2022 Feb. 01, v. 244

2022

Abstract: Telemetric monitoring is used in many scientific fields, such as cardiovascular research, neurology, endocrinology, animal welfare research and many more. Nowadays, implanted electrocardiogram (ECG) radiotelemetry units are the gold standard for ... ...

Abstract	Telemetric monitoring is used in many scientific fields, such as cardiovascular research, neurology, endocrinology, animal welfare research and many more. Nowadays, implanted electrocardiogram (ECG) radiotelemetry units are the gold standard for monitoring ECG traces, heart rate and heart rate variability in freely moving mice. This technology can be a valuable tool when studies utilise it adequately, while also prioritizing animal welfare. Recently, concerns about the reproducibility of research findings have been raised in many scientific fields with insufficient reporting being one of the underlying causes. A systematic review was performed in three literature databases to include all published studies until 31.12.2019 using surgery that involves the placing of ECG recording telemetry devices in adult mice. Data extracted from the publications included selected items recommended by the ARRIVE guidelines and SYRCLE`s tool for assessing risk of bias. We focused on aspects related to quality of reporting, risk of bias reduction measures and ECG measurements characteristics. In general, the quality of reporting was low to moderate in the 234 analyzed publications regarding the animal, husbandry, statistics, and risk of bias related items, but good for more specific telemetry study characteristics. Based on our analyses we assume that there is no or only slight improvement in the reporting quality since 2010, when the ARRIVE guidelines were published.
Keywords	adults ; animal welfare ; behavior ; electrocardiography ; endocrinology ; heart rate ; mice ; radio telemetry ; risk ; surgery ; systematic review
Language	English
Dates of publication	2022-0201
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2021.113645
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Article ; Online: A systematic review on reporting of refinement measures in mouse ECG telemetry implantation surgery.

Gkrouzoudi, Alexandra / Tsingotjidou, Anastasia / Jirkof, Paulin

Laboratory animals

2022 Volume 57, Issue 1, Page(s) 9–25

Abstract	Telemetric monitoring is used in many scientific fields, such as cardiovascular research, neurology, endocrinology, as well as animal welfare research. Nowadays, implanted electrocardiogram (ECG) radiotelemetry units are the gold standard for monitoring ECG traces, heart rate and heart rate variability in freely moving mice. Telemetry technology can be a valuable tool when studies utilize it adequately, while prioritizing animal welfare. Recently, concerns have been raised in many research fields, including animal research, regarding the reproducibility of research findings, with insufficient reporting being one of the underlying causes.A systematic review was performed by making use of three literature databases, in order to include all publications until 31.12.2019, where the surgical placing of ECG recording telemetry devices in adult mice was involved. Data extracted from the publications included selected items recommended by the ARRIVE guidelines. We focused on aspects related to the refinement of the surgery and experimental conditions that aim to improve animal welfare. In general, the quality of reporting was low in the analyzed 234 publications. Based on our analyses, we assume there has been no improvement in this field's reporting quality since 2010 when the ARRIVE guidelines on reporting were introduced. Additionally, even though expert recommendations on telemetry surgery refinement have been available since many years now, no increase in uptake (or reporting) of these measures prior (e.g., acclimatization), during (e.g., asepsis) or after (e.g., social housing) the surgery could be observed.
MeSH term(s)	Animals ; Mice ; Reproducibility of Results ; Electrocardiography ; Heart Rate ; Animal Experimentation ; Telemetry
Language	English
Publishing date	2022-09-19
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	391008-8
ISSN	1758-1117 ; 0023-6772
ISSN (online)	1758-1117
ISSN	0023-6772
DOI	10.1177/00236772221115492
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Article ; Online: Surgical Anatomy of the Gastrointestinal Tract in Cats

Angelou, Vasileia / Fiska, Aliki / Tsingotjidou, Anastasia / Patsikas, Michael / Papazoglou, Lysimachos G.

Animals. 2023 Aug. 19, v. 13, no. 16

2023

Abstract: In cats, the gastrointestinal tract is one of the regions in which surgical procedures are most frequently performed by veterinary surgeons; therefore, knowledge of the surgical anatomy of the feline gastrointestinal tract is of high importance. The main ...

Abstract	In cats, the gastrointestinal tract is one of the regions in which surgical procedures are most frequently performed by veterinary surgeons; therefore, knowledge of the surgical anatomy of the feline gastrointestinal tract is of high importance. The main surgical procedures performed include gastrotomy, gastrectomy, enterotomy, and enterectomy, as well as procedures in the liver and pancreas. There are also anatomical differences between dogs and cats, increasing the need for deep knowledge of the anatomy treated in the different surgical approaches. The aim of the present review is to describe in detail the anatomy of the gastrointestinal tract in cats highlighting the anatomical regions of significant importance in different surgical procedures.
Keywords	cats ; digestive tract ; liver ; pancreas
Language	English
Dates of publication	2023-0819
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13162670
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Article: Surgical Anatomy of the Gastrointestinal Tract in Cats.

Angelou, Vasileia / Fiska, Aliki / Tsingotjidou, Anastasia / Patsikas, Michael / Papazoglou, Lysimachos G

Animals : an open access journal from MDPI

2023 Volume 13, Issue 16

Abstract	In cats, the gastrointestinal tract is one of the regions in which surgical procedures are most frequently performed by veterinary surgeons; therefore, knowledge of the surgical anatomy of the feline gastrointestinal tract is of high importance. The main surgical procedures performed include gastrotomy, gastrectomy, enterotomy, and enterectomy, as well as procedures in the liver and pancreas. There are also anatomical differences between dogs and cats, increasing the need for deep knowledge of the anatomy treated in the different surgical approaches. The aim of the present review is to describe in detail the anatomy of the gastrointestinal tract in cats highlighting the anatomical regions of significant importance in different surgical procedures.
Language	English
Publishing date	2023-08-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13162670
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Article ; Online: Inactivation of the Tumor Suppressor CYLD Sensitizes Mice to Breast Cancer Development.

Pseftogas, Athanasios / Xanthopoulos, Konstantinos / Siasiaridis, Athanasios / Poutahidis, Theofilos / Gonidas, Christos / Tsingotjidou, Anastasia / Hatzivassiliou, Eudoxia / Mosialos, George

Anticancer research

2024 Volume 44, Issue 5, Page(s) 1885–1894

Abstract: Background/aim: Breast cancer is a leading cause of cancer-related deaths among women. Down-regulation of the tumor suppressor gene Cyld in breast cancer has been linked to a poor prognosis. This study investigated the role of Cyld in breast cancer ... ...

Abstract	Background/aim: Breast cancer is a leading cause of cancer-related deaths among women. Down-regulation of the tumor suppressor gene Cyld in breast cancer has been linked to a poor prognosis. This study investigated the role of Cyld in breast cancer using conditional mutant mouse models carrying a Cyld mutation, which inactivates the deubiquitinating activity of its protein product CYLD in mammary epithelial cells. Materials and methods: We examined the potential of CYLD inactivation to induce mammary tumors spontaneously or modify the susceptibility of mice to mammary tumorigenesis by DMBA treatment or ErbB2 over-expression. Results: CYLD inactivation significantly increased susceptibility to breast cancer induced by either DMBA treatment or ErbB2 over-expression. Moreover, while CYLD inactivation alone did not lead to spontaneous mammary tumorigenesis, it did contribute to the formation of multifocal hyperplastic lesions in virgin mice of predominantly FVB/NJ background. Conclusion: Our study demonstrates the tumor enhancing potential of CYLD inactivation in mammary tumorigenesis in vivo and establishes novel relevant mouse models that can be exploited for developing prognostic and therapeutic protocols.
MeSH term(s)	Animals ; Female ; Mice ; 9,10-Dimethyl-1,2-benzanthracene/toxicity ; Breast Neoplasms/pathology ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; Deubiquitinating Enzyme CYLD/genetics ; Deubiquitinating Enzyme CYLD/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mammary Neoplasms, Experimental/genetics ; Mutation ; Receptor, ErbB-2/genetics ; Receptor, ErbB-2/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Chemical Substances	9,10-Dimethyl-1,2-benzanthracene (57-97-6) ; CYLD protein, mouse (EC 3.4.19.12) ; Deubiquitinating Enzyme CYLD (EC 3.4.19.12) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Tumor Suppressor Proteins
Language	English
Publishing date	2024-04-25
Publishing country	Greece
Document type	Journal Article
ZDB-ID	604549-2
ISSN	1791-7530 ; 0250-7005
ISSN (online)	1791-7530
ISSN	0250-7005
DOI	10.21873/anticanres.16990
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A systematic review on the reporting quality in mouse telemetry implantation surgery using electrocardiogram recording devices.

Gkrouzoudi, Alexandra / Tsingotjidou, Anastasia / Jirkof, Paulin

Physiology & behavior

2021 Volume 244, Page(s) 113645

Abstract	Telemetric monitoring is used in many scientific fields, such as cardiovascular research, neurology, endocrinology, animal welfare research and many more. Nowadays, implanted electrocardiogram (ECG) radiotelemetry units are the gold standard for monitoring ECG traces, heart rate and heart rate variability in freely moving mice. This technology can be a valuable tool when studies utilise it adequately, while also prioritizing animal welfare. Recently, concerns about the reproducibility of research findings have been raised in many scientific fields with insufficient reporting being one of the underlying causes. A systematic review was performed in three literature databases to include all published studies until 31.12.2019 using surgery that involves the placing of ECG recording telemetry devices in adult mice. Data extracted from the publications included selected items recommended by the ARRIVE guidelines and SYRCLE`s tool for assessing risk of bias. We focused on aspects related to quality of reporting, risk of bias reduction measures and ECG measurements characteristics. In general, the quality of reporting was low to moderate in the 234 analyzed publications regarding the animal, husbandry, statistics, and risk of bias related items, but good for more specific telemetry study characteristics. Based on our analyses we assume that there is no or only slight improvement in the reporting quality since 2010, when the ARRIVE guidelines were published.
MeSH term(s)	Animal Welfare ; Animals ; Electrocardiography ; Heart Rate/physiology ; Mice ; Reproducibility of Results ; Telemetry
Language	English
Publishing date	2021-11-11
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	3907-x
ISSN	1873-507X ; 0031-9384
ISSN (online)	1873-507X
ISSN	0031-9384
DOI	10.1016/j.physbeh.2021.113645
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Article: Adrenal glands of mice and rats: A comparative morphometric study

Siasios, Athanasios / Delis, Georgios / Tsingotjidou, Anastasia / Pourlis, Aris / Grivas, Ioannis

Laboratory animals. 2022 June, v. 56, no. 3

2022

Abstract: Mice and rats are among the most used laboratory animals. They share numerous similarities along with differences, some yet unexplored. One of them is the morphometry of their adrenal glands, whose characteristics may be related to differences in energy ... ...

Abstract	Mice and rats are among the most used laboratory animals. They share numerous similarities along with differences, some yet unexplored. One of them is the morphometry of their adrenal glands, whose characteristics may be related to differences in energy management, immune response, drug metabolism, behaviour and temperament. The present study tries to fill this knowledge gap with the evaluation and comparison of adrenal gland anatomical/morphometric parameters of mice and rats. In groups of 10 (n = 10) adult, male and female BALB/c mice and Wistar rats, one in every 20 sections transverse to the longitudinal axis of the gland was used for measuring entire gland area, capsule, entire cortex, cortex zones and medulla with the aid of an image analysis system and subjected to statistical analysis. Quotients of the individual areas were calculated and comparison between the resulting ratios was performed. Gland length and volume were also calculated. Statistically significant differences were revealed between the rat female and male cortex area, rat and mouse medulla/cortex, medulla/gland, zona glomerulosa/cortex and cortex/gland ratios, male and female rats’ medulla/cortex, medulla/gland, capsule/gland, zona glomerulosa/cortex, zona reticularis/cortex and zona glomerulosa/zona fasciculata ratios, length and volume. The correlation evaluation revealed that in male rats and in female mice the larger medulla area was accompanied by a larger cortex area and vice versa. In general, a larger cortex area was accompanied by larger areas of cortex zones. The collected data and the revealed differences can possibly contribute to the understanding of the physiology of the two species.
Keywords	adrenal cortex ; adults ; cortex ; energy ; females ; image analysis ; immune response ; laboratories ; males ; mice ; morphometry ; pharmacokinetics ; rats ; statistical analysis ; temperament
Language	English
Dates of publication	2022-06
Size	p. 247-258.
Publishing place	SAGE Publications
Document type	Article
ZDB-ID	391008-8
ISSN	1758-1117 ; 0023-6772
ISSN (online)	1758-1117
ISSN	0023-6772
DOI	10.1177/00236772211044352
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Adrenal glands of mice and rats: A comparative morphometric study.

Siasios, Athanasios / Delis, Georgios / Tsingotjidou, Anastasia / Pourlis, Aris / Grivas, Ioannis

Laboratory animals

2021 Volume 56, Issue 3, Page(s) 247–258

Abstract	Mice and rats are among the most used laboratory animals. They share numerous similarities along with differences, some yet unexplored. One of them is the morphometry of their adrenal glands, whose characteristics may be related to differences in energy management, immune response, drug metabolism, behaviour and temperament. The present study tries to fill this knowledge gap with the evaluation and comparison of adrenal gland anatomical/morphometric parameters of mice and rats. In groups of 10 (
MeSH term(s)	Adrenal Glands ; Adrenal Medulla ; Animals ; Female ; Male ; Rats ; Rats, Wistar
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	391008-8
ISSN	1758-1117 ; 0023-6772
ISSN (online)	1758-1117
ISSN	0023-6772
DOI	10.1177/00236772211044352
Database	MEDical Literature Analysis and Retrieval System OnLINE

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