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  1. Article ; Online: Voxel-wise multivariate analysis of brain-psychosocial associations in adolescents reveals six latent dimensions of cognition and psychopathology.

    Adams, Rick A / Zor, Cemre / Mihalik, Agoston / Tsirlis, Konstantinos / Brudfors, Mikael / Chapman, James / Ashburner, John / Paulus, Martin P / Mourão-Miranda, Janaina

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2024  

    Abstract: Background: Adolescence heralds the onset of much psychopathology, which may be conceptualized as an emergence of altered covariation between symptoms and brain measures. Multivariate methods can detect such modes of covariation or latent dimensions, ... ...

    Abstract Background: Adolescence heralds the onset of much psychopathology, which may be conceptualized as an emergence of altered covariation between symptoms and brain measures. Multivariate methods can detect such modes of covariation or latent dimensions, but none specifically relating to psychopathology have yet been found using population-level structural brain data. Using voxel-wise (instead of parcellated) brain data may strengthen latent dimensions' brain-psychosocial relationships, but this creates computational challenges.
    Methods: We obtained voxel-wise grey matter density and psychosocial variables from the baseline (aged 9-10 years) Adolescent Brain and Cognitive Development cohort (n=11288), and employed a state-of-the-art segmentation method, sparse partial least squares, and a rigorous machine learning framework to prevent overfitting.
    Results: We found six latent dimensions, four pertaining specifically to mental health. The mental health dimensions related to overeating, anorexia/internalizing, oppositional symptoms (all p<0.002) and ADHD symptoms (p=0.03). ADHD related to increased and internalizing related to decreased grey matter density in dopaminergic and serotonergic midbrain areas, whereas oppositional symptoms related to increased grey matter in a noradrenergic nucleus. Internalizing related to increased and oppositional symptoms to reduced grey matter density in insula, cingulate and auditory cortices. Striatal regions featured strongly, with reduced caudate nucleus grey matter in ADHD, and reduced putamen grey matter in oppositional/conduct problems. Voxel-wise grey matter density generated stronger brain-psychosocial correlations than brain parcellations.
    Conclusions: Voxel-wise brain data strengthen latent dimensions of brain-psychosocial covariation and sparse multivariate methods increase their psychopathological specificity. Internalizing and externalizing are associated with opposite grey matter changes in similar cortical and subcortical areas.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2024.03.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Changing memories by interference: the effect of emotional dimensions in reconsolidation of episodic memories.

    Antypa, Despina / Kagialis, Antonios / Tsirlis, Konstantinos / Tsepeneka, Sophia / Simos, Panagiotis

    Cognition & emotion

    2021  Volume 35, Issue 7, Page(s) 1400–1406

    Abstract: Episodes with an emotional component preoccupy memory formation and this advantage facilitates their preservation and mitigates the impact of interfering episodes. The present study examined the relation of the emotional dimensions of original and ... ...

    Abstract Episodes with an emotional component preoccupy memory formation and this advantage facilitates their preservation and mitigates the impact of interfering episodes. The present study examined the relation of the emotional dimensions of original and interfering episodes to the memory outcome, using a reconsolidation paradigm. In a between-subjects design, 102 healthy young adults were presented with an emotional or neutral image and learned either an emotional or neutral story, respectively (day 1). On day 2, experimental groups were presented with an image of the opposite emotionality, reactivated the original story, and learned a story of the opposite emotionality. On day 3, experimental and control groups were tested for their memory on target and filler clues of the original story and rated both stories for arousal and valence. Overall, there was evidence of interference on the long-term retention of target clues only for the neutral story (i.e. when the interfering story was emotional), and of filler clues for both types of stories. Moreover, individual target clue retention rates correlated with the arousal ratings for both the original neutral story and the interfering emotional story, while they were not related to arousal ratings for the original emotional story or the interfering neutral one.
    MeSH term(s) Arousal ; Emotions ; Humans ; Memory, Episodic ; Mental Recall ; Young Adult
    Language English
    Publishing date 2021-06-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 639123-0
    ISSN 1464-0600 ; 0269-9931
    ISSN (online) 1464-0600
    ISSN 0269-9931
    DOI 10.1080/02699931.2021.1947198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3087: Show issues Location:
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  3. Article: Vulnerability and Protective Factors for PTSD and Depression Symptoms Among Healthcare Workers During COVID-19: A Machine Learning Approach.

    Portugal, Liana C L / Gama, Camila Monteiro Fabricio / Gonçalves, Raquel Menezes / Mendlowicz, Mauro Vitor / Erthal, Fátima Smith / Mocaiber, Izabela / Tsirlis, Konstantinos / Volchan, Eliane / David, Isabel Antunes / Pereira, Mirtes Garcia / de Oliveira, Leticia

    Frontiers in psychiatry

    2022  Volume 12, Page(s) 752870

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2021.752870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Challenges in the Multivariate Analysis of Mass Cytometry Data: The Effect of Randomization.

    Papoutsoglou, Georgios / Lagani, Vincenzo / Schmidt, Angelika / Tsirlis, Konstantinos / Cabrero, David-Gómez / Tegnér, Jesper / Tsamardinos, Ioannis

    Cytometry. Part A : the journal of the International Society for Analytical Cytology

    2019  Volume 95, Issue 11, Page(s) 1178–1190

    Abstract: Cytometry by time-of-flight (CyTOF) has emerged as a high-throughput single cell technology able to provide large samples of protein readouts. Already, there exists a large pool of advanced high-dimensional analysis algorithms that explore the observed ... ...

    Abstract Cytometry by time-of-flight (CyTOF) has emerged as a high-throughput single cell technology able to provide large samples of protein readouts. Already, there exists a large pool of advanced high-dimensional analysis algorithms that explore the observed heterogeneous distributions making intriguing biological inferences. A fact largely overlooked by these methods, however, is the effect of the established data preprocessing pipeline to the distributions of the measured quantities. In this article, we focus on randomization, a transformation used for improving data visualization, which can negatively affect multivariate data analysis methods such as dimensionality reduction, clustering, and network reconstruction algorithms. Our results indicate that randomization should be used only for visualization purposes, but not in conjunction with high-dimensional analytical tools. © 2019 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.
    MeSH term(s) Algorithms ; B-Lymphocytes/cytology ; B-Lymphocytes/metabolism ; Blood Buffy Coat/cytology ; Blood Buffy Coat/metabolism ; Cluster Analysis ; Flow Cytometry/methods ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism ; Multivariate Analysis ; Neural Networks, Computer ; Random Allocation ; Single-Cell Analysis ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism
    Language English
    Publishing date 2019-11-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2099868-5
    ISSN 1552-4930 ; 0196-4763 ; 1552-4922
    ISSN (online) 1552-4930
    ISSN 0196-4763 ; 1552-4922
    DOI 10.1002/cyto.a.23908
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1688: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MG 68: Show issues

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  5. Article ; Online: Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia.

    Adams, Rick A / Pinotsis, Dimitris / Tsirlis, Konstantinos / Unruh, Leonhardt / Mahajan, Aashna / Horas, Ana Montero / Convertino, Laura / Summerfelt, Ann / Sampath, Hemalatha / Du, Xiaoming Michael / Kochunov, Peter / Ji, Jie Lisa / Repovs, Grega / Murray, John D / Friston, Karl J / Hong, L Elliot / Anticevic, Alan

    Biological psychiatry

    2021  Volume 91, Issue 2, Page(s) 202–215

    Abstract: Background: Diminished synaptic gain-the sensitivity of postsynaptic responses to neural inputs-may be a fundamental synaptic pathology in schizophrenia. Evidence for this is indirect, however. Furthermore, it is unclear whether pyramidal cells or ... ...

    Abstract Background: Diminished synaptic gain-the sensitivity of postsynaptic responses to neural inputs-may be a fundamental synaptic pathology in schizophrenia. Evidence for this is indirect, however. Furthermore, it is unclear whether pyramidal cells or interneurons (or both) are affected, or how these deficits relate to symptoms.
    Methods: People with schizophrenia diagnoses (PScz) (n = 108), their relatives (n = 57), and control subjects (n = 107) underwent 3 electroencephalography (EEG) paradigms-resting, mismatch negativity, and 40-Hz auditory steady-state response-and resting functional magnetic resonance imaging. Dynamic causal modeling was used to quantify synaptic connectivity in cortical microcircuits.
    Results: Classic group differences in EEG features between PScz and control subjects were replicated, including increased theta and other spectral changes (resting EEG), reduced mismatch negativity, and reduced 40-Hz power. Across all 4 paradigms, characteristic PScz data features were all best explained by models with greater self-inhibition (decreased synaptic gain) in pyramidal cells. Furthermore, disinhibition in auditory areas predicted abnormal auditory perception (and positive symptoms) in PScz in 3 paradigms.
    Conclusions: First, characteristic EEG changes in PScz in 3 classic paradigms are all attributable to the same underlying parameter change: greater self-inhibition in pyramidal cells. Second, psychotic symptoms in PScz relate to disinhibition in neural circuits. These findings are more commensurate with the hypothesis that in PScz, a primary loss of synaptic gain on pyramidal cells is then compensated by interneuron downregulation (rather than the converse). They further suggest that psychotic symptoms relate to this secondary downregulation.
    MeSH term(s) Computer Simulation ; Electroencephalography ; Evoked Potentials, Auditory ; Humans ; Magnetic Resonance Imaging ; Pyramidal Cells ; Schizophrenia/diagnostic imaging
    Language English
    Publishing date 2021-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2021.07.024
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 720: Show issues Location:
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