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Book ; Audio / Video ; Conference proceedings: 25th International Conference of Alzheimer's Disease International

Tsolaki, Magda

Thessaloniki (Greece), March 10 - 13, 2010

2010

Event/congress	International Conference of Alzheimer's Disease International (25, 2010, Thessaloniki)
Author's details	[ed.: Magda Tsolaki]
Language	English
Size	1 CD-ROM, 12 cm
Publisher	Medimond
Publishing place	Bologna
Publishing country	Italy
Document type	Book ; Audio / Video ; Conference proceedings
HBZ-ID	HT016534422
ISBN	978-88-7587-582-4 ; 88-7587-582-0
Database	Catalogue ZB MED Medicine, Health

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2011 MO 133	order for loan	Magazin

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Article: In the Hands of Hypnos: Associations between Sleep, Cognitive Performance and Financial Capacity in aMCI and Mild AD.

Giannouli, Vaitsa / Tsolaki, Magda

Sleep science (Sao Paulo, Brazil)

2023 Volume 16, Issue 2, Page(s) 231–236

Abstract: ... ...

Abstract	Objective
Language	English
Publishing date	2023-07-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2697016-8
ISSN	1984-0063 ; 1984-0659
ISSN (online)	1984-0063
ISSN	1984-0659
DOI	10.1055/s-0043-1770796
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Making Pre-screening for Alzheimer's Disease (AD) and Postoperative Delirium Among Post-Acute COVID-19 Syndrome (PACS) a National Priority: The Deep Neuro Study.

Tarnanas, Ioannis / Tsolaki, Magda

Advances in experimental medicine and biology

2023 Volume 1424, Page(s) 41–47

Abstract: SARS-CoV-2 effects on cognition are a vibrant area of active research. Many researchers suggest that COVID-19 patients with severe symptoms leading to hospitalization sustain significant neurodegenerative injury, such as encephalopathy and poor discharge ...

Abstract	SARS-CoV-2 effects on cognition are a vibrant area of active research. Many researchers suggest that COVID-19 patients with severe symptoms leading to hospitalization sustain significant neurodegenerative injury, such as encephalopathy and poor discharge disposition. However, despite some post-acute COVID-19 syndrome (PACS) case series that have described elevated neurodegenerative biomarkers, no studies have been identified that directly compared levels to those in mild cognitive impairment, non-PACS postoperative delirium patients after major non-emergent surgery, or preclinical Alzheimer's disease (AD) patients that have clinical evidence of Alzheimer's without symptoms. According to recent estimates, there may be 416 million people globally on the AD continuum, which include approximately 315 million people with preclinical AD. In light of all the above, a more effective application of digital biomarker and explainable artificial intelligence methodologies that explored amyloid beta, neuronal, axonal, and glial markers in relation to neurological complications in-hospital or later outcomes could significantly assist progress in the field. Easy and scalable subjects' risk stratification is of utmost importance, yet current international collaboration initiatives are still challenging due to the limited explainability and accuracy to identify individuals at risk or in the earliest stages that might be candidates for future clinical trials. In this open letter, we propose the administration of selected digital biomarkers previously discovered and validated in other EU-funded studies to become a routine assessment for non-PACS preoperative cognitive impairment, PACS neurological complications in-hospital, or later PACS and non-PACS improvement in cognition after surgery. The open letter also includes an economic analysis of the implications for such national-level initiatives. Similar collaboration initiatives could have existing pre-diagnostic detection and progression prediction solutions pre-screen the stage before and around diagnosis, enabling new disease manifestation mapping and pushing the field into unchartered territory.
MeSH term(s)	Humans ; Alzheimer Disease/diagnosis ; Alzheimer Disease/psychology ; Amyloid beta-Peptides ; Artificial Intelligence ; Emergence Delirium ; Post-Acute COVID-19 Syndrome ; COVID-19/complications ; SARS-CoV-2 ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Biomarkers/analysis
Chemical Substances	Amyloid beta-Peptides ; Biomarkers
Language	English
Publishing date	2023-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	410187-X
ISSN	0065-2598
ISSN	0065-2598
DOI	10.1007/978-3-031-31982-2_4
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Zs.A 3192: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Stressful life events, general cognitive performance, and financial capacity in healthy older adults and Alzheimer's disease patients.

Giannouli, Vaitsa / Tsolaki, Magda

Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater

2023 Volume 37, Issue 2, Page(s) 76–79

Abstract: Background: The influence of stressful life events on general cognition and for the first time on financial capacity performance of patients with a diagnosis of Alzheimer's disease (AD) and in healthy controls (HC) is assessed.: Methods: A total of ... ...

Title translation	Belastende Lebensereignisse, allgemeine kognitive Leistung und finanzielle Kompetenzen bei gesunden älteren Erwachsenen und Alzheimer-Patienten.
Abstract	Background: The influence of stressful life events on general cognition and for the first time on financial capacity performance of patients with a diagnosis of Alzheimer's disease (AD) and in healthy controls (HC) is assessed. Methods: A total of 268 participants (122 patients and 146 HCs with similar demographics) were examined with a number of neuropsychological tests, including Mini Mental State Examination (MMSE), Geriatric Depression Scale (GDS-15), and Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS) for measuring financial capacity. The life change unit (LCU) method was also used. Results: HCs reported more stressful events than AD patients before the onset of the disease as the LCU load was higher for them (51.80 vs. 27.50), but in both groups the level of LCU load was far below 100, which is the threshold suggested for the induction of a psychosomatic disorder. The most frequently reported life event for AD patients was increased family arguments (n = 45/122), followed by increase in responsibilities (n = 32/122) and financial difficulties (n = 29/122), while the HC group reported problems within the family (n = 56/146), change in health status (n = 32/146), and a death of a beloved family member (n = 27/146). Regressions indicate no causal role for recent life events in the etiopathogenesis of AD, but an influence only of MMSE and diagnosis on financial capacity. Conclusions: Stressful life events do not seem to be important in financial capacity and relevant vulnerability to financial exploitation for either HCs or AD patients; therefore clinicians should not consider them per se as a possible aggravating factor for financial deficits.
MeSH term(s)	Humans ; Aged ; Alzheimer Disease/diagnosis ; Cognition ; Cognition Disorders ; Neuropsychological Tests ; Health Status ; Cognitive Dysfunction/diagnosis
Language	English
Publishing date	2023-01-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1027479-0
ISSN	2194-1327 ; 0948-6259
ISSN (online)	2194-1327
ISSN	0948-6259
DOI	10.1007/s40211-022-00451-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Is there a specific order of appearance of financial capacity deficits across neurocognitive disorders? What comes first and what should be treated.

Giannouli, Vaitsa / Tsolaki, Magda

International journal of geriatric psychiatry

2023 Volume 38, Issue 2, Page(s) e5880

MeSH term(s)	Humans ; Neurocognitive Disorders/therapy ; Cognition Disorders/psychology ; Neuropsychological Tests
Language	English
Publishing date	2023-01-29
Publishing country	England
Document type	Letter
ZDB-ID	806736-3
ISSN	1099-1166 ; 0885-6230
ISSN (online)	1099-1166
ISSN	0885-6230
DOI	10.1002/gps.5880
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Article ; Online: What goes wrong with the perceptions of elder financial abuse? Data from older adults, healthcare professionals and students from Greece.

Giannouli, Vaitsa / Tsolaki, Magda

Journal of elder abuse & neglect

2023 Volume 35, Issue 4-5, Page(s) 228–235

Abstract: This study examines what healthcare professionals, students and older adults believe about elder financial abuse in Greece. Participants responded to two vignettes by choosing which characteristics indicate elder financial abuse. Greeks are less likely ... ...

Abstract	This study examines what healthcare professionals, students and older adults believe about elder financial abuse in Greece. Participants responded to two vignettes by choosing which characteristics indicate elder financial abuse. Greeks are less likely to perceive financial exploitation when the perpetrator is a close family member, but are more likely to recognize it when perpetrated by paid caregivers or more distant (male) relatives. Signing over the victim's property to another is less likely to be perceived as elder abuse than is the taking of money from bank accounts, even though the property is often worth more than what is taken from the account. Although there are some differences in perception between healthcare professionals and others in Greek society, these (and other anomalies) make it difficult to accurately report and prevent elder financial abuse in Greece.
MeSH term(s)	Aged ; Humans ; Male ; Elder Abuse/prevention & control ; Greece ; Students ; Delivery of Health Care ; European People
Language	English
Publishing date	2023-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1018101-5
ISSN	1540-4129 ; 0894-6566
ISSN (online)	1540-4129
ISSN	0894-6566
DOI	10.1080/08946566.2023.2291050
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Article ; Online: The Effects of Pomegranate Seed Oil on Mild Cognitive Impairment.

Chatzikostopoulos, Thanos / Gialaouzidis, Moses / Koutoupa, Anna / Tsolaki, Magda

Journal of Alzheimer's disease : JAD

2024 Volume 97, Issue 4, Page(s) 1961–1970

Abstract: Background: In recent years, there has been a growing interest, supported by many experimental and clinical studies, about the benefits of pomegranate in preventing various pathologic conditions, including brain neurodegeneration. The pomegranate seed ... ...

Abstract	Background: In recent years, there has been a growing interest, supported by many experimental and clinical studies, about the benefits of pomegranate in preventing various pathologic conditions, including brain neurodegeneration. The pomegranate seed oil (PSO) contains high levels of fatty acids that have antioxidant and anti-inflammatory properties. Objective: Due to the lack of clinical trials, the aim of the present study was to investigate the effects of PSO on cognition of people with mild cognitive impairment (MCI). Methods: Eighty people with the diagnosis of MCI were randomized forty to take 5 drops of PSO and follow the Mediterranean Diet (MeDi) and forty just followed MeDi. All were examined with an extensive neuropsychological assessment before and after one year of treatment. Results: The results showed that the participants who took the PSO had statistically significantly better global cognition (p = 0.004), verbal episodic memory (p = 0.009), and processing and executive functions (p < 0.001) in contrast with the participants who did not take it. Conclusions: In conclusion, the PSO can be beneficial for people with MCI as it is helpful for some important cognitive domains. As PSO is a natural product that does not burden the human body, it can be used by people with MCI and be a significant and promising part of holistic approaches for the prevention of dementia.
MeSH term(s)	Humans ; Biological Products/pharmacology ; Biological Products/therapeutic use ; Cognition ; Cognitive Dysfunction/diagnosis ; Neuropsychological Tests ; Plant Oils/therapeutic use ; Plant Oils/pharmacology ; Pomegranate
Chemical Substances	Biological Products ; Plant Oils
Language	English
Publishing date	2024-03-19
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-231100
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Article: Future strategies of management of Alzheimer's Disease. The role of homotaurine.

Tsolaki, Magda

Hellenic journal of nuclear medicine

2019 Volume 22 Suppl, Page(s) 82–94

Abstract: Dementia and Alzheimer's Disease (AD) particularly will become in future one of the major problems that healthcare systems will have to face with in developed but also in developing countries, because of the progressive aging of the population and the ... ...

Abstract	Dementia and Alzheimer's Disease (AD) particularly will become in future one of the major problems that healthcare systems will have to face with in developed but also in developing countries, because of the progressive aging of the population and the age-associated increase in their incidence. There is a rapid increasing in life expectancy and in elderly percentage. Unfortunately, improvements in lifespan have not been matched by improvements in mental health span. In recent years, there has been a growing interest, supported by a large number of experimental, epidemiological and clinical studies, about the beneficial effects of some natural products in preventing various age-related pathologic conditions, including brain aging and neurodegeneration. Homotaurine, a small aminosulfonate substance that is present in different species of marine red algae, has been shown, in both in vitro and in vivo studies, to provide a relevant neuroprotective effect by its specific anti-amyloid activity and by its γ-aminobutyric acid type A receptor affinity. The name homotaurine was chosen because of its large homology with taurine (2 aminoethanesulfonate), which is one of the most abundant free amino acids in the brain. The two molecules share a very similar structure, but homotaurine contains one additional carbon. The therapeutic efficacy of homotaurine in AD has been investigated in three phase II, and in three Phase III clinical studies that did not reach their pre-defined primary endpoints. However, post-hoc analyses have shown positive and significant effects on secondary endpoints and subgroups of patients, including a reduction in hippocampal volume loss and lower decline in memory function in the overall cohort, as well as a reduction in global cognitive decline in APOE ε4 allele carriers, suggesting disease-modifying effects. Also in three post marketing (as supplement) studies in patients with Mild Cognitive Impairment (MCI) the results are very promising. In this review, we will present the pre-clinical and clinical evidence supporting the potential role of homotaurine as a promising candidate for both primary and secondary prevention of AD.
MeSH term(s)	Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Alzheimer Disease/prevention & control ; Animals ; Humans ; Neuroprotection ; Taurine/analogs & derivatives ; Taurine/metabolism
Chemical Substances	Taurine (1EQV5MLY3D) ; tramiprosate (5K8EAX0G53)
Language	English
Publishing date	2019-03-14
Publishing country	Greece
Document type	Journal Article ; Review
ZDB-ID	2186026-9
ISSN	1790-5427 ; 1108-1430
ISSN	1790-5427 ; 1108-1430
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Article ; Online: Making pre-screening for Alzheimer's disease (AD) and Postoperative delirium among post-acute COVID-19 syndrome - (PACS) a national priority: The Deep Neuro Study.

Tarnanas, Ioannis / Tsolaki, Magda

Open research Europe

2022 Volume 2, Page(s) 98

Abstract: SARS-CoV-2 effects on cognition is a vibrant area of active research. Many researchers suggest that COVID-19 patients with severe symptoms leading to hospitalization, sustain significant neurodegenerative injury, such as encephalopathy and poor discharge ...

Abstract	SARS-CoV-2 effects on cognition is a vibrant area of active research. Many researchers suggest that COVID-19 patients with severe symptoms leading to hospitalization, sustain significant neurodegenerative injury, such as encephalopathy and poor discharge disposition. However, despite some post-acute COVID-19 syndrome (PACS) case series that have described elevated neurodegenerative biomarkers, no studies have been identified that directly compared levels to those in mild cognitive impairment, non-PACS postoperative delirium patients after major non-emergent surgery or preclinical Alzheimer's Disease (AD) patients, that have clinical evidence of Alzheimer's without symptoms. According to recent estimates, there may be 416 million people globally on the AD continuum, which include approximately 315 million people with preclinical AD. In light of all the above, a more effective application of digital biomarker and explainable artificial intelligence methodologies that explored amyloid beta, neuronal, axonal, and glial markers in relation to neurological complications in-hospital or later outcomes could significantly assist progress in the field. Easy and scalable subjects' risk stratification is of utmost importance, yet current international collaboration initiatives are still challenging due to the limited explainability and accuracy to identify individuals at risk or in the earliest stages that might be candidates for future clinical trials. In this open letter, we propose the administration of selected digital biomarkers previously discovered and validated in other EU funded studies to become a routine assessment for non-PACS preoperative cognitive impairment, PACS neurological complications in-hospital or later PACS and non-PACS improvement in cognition after surgery. The open letter also includes an economic analysis of the implications for such national level initiatives. Similar collaboration initiatives could have existing prediagnostic detection and progression prediction solutions pre-screen the stage before and around diagnosis, enabling new disease manifestation mapping and pushing the field into unchartered territory.
Language	English
Publishing date	2022-08-22
Publishing country	Belgium
Document type	Journal Article
ISSN	2732-5121
ISSN (online)	2732-5121
DOI	10.12688/openreseurope.15005.1
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Article ; Online: What Biological Factors, Social Determinants, and Psychological and Behavioral Symptoms of Patients with Mild Alzheimer's Disease Correlate with Caregiver Estimations of Financial Capacity? Bringing Biases Against Older Women Into Focus.

Giannouli, Vaitsa / Tsolaki, Magda

Journal of Alzheimer's disease reports

2022 Volume 6, Issue 1, Page(s) 503–507

Abstract: This study examines the connection between biological factors, social determinants, and behavioral and psychological symptoms of dementia (BPSD) and the estimations of financial capacity made by caregivers of mild AD patients in Greece. Financial ... ...

Abstract	This study examines the connection between biological factors, social determinants, and behavioral and psychological symptoms of dementia (BPSD) and the estimations of financial capacity made by caregivers of mild AD patients in Greece. Financial capacity estimations negatively correlated with biological sex of the patients (female), but Neuropsychiatric Inventory (NPI) scores were statistically lower for older females. BPSD (measured with NPI) was found to negatively correlate with estimates of financial capacity. The existence of delusions-hallucinations was reported in all males. No correlations were found between financial capacity estimations, actual cognitive and financial capacity performance, and all other included biological and social characteristics of the patients as well as their caregivers.
Language	English
Publishing date	2022-08-05
Publishing country	Netherlands
Document type	Journal Article
ISSN	2542-4823
ISSN (online)	2542-4823
DOI	10.3233/ADR-220037
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