LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 427

Search options

  1. Book: Recognition and prevention of major mental and substance use disorders

    Tsuang, Ming T.

    2007  

    Author's details ed. by Ming T. Tsuang
    Keywords Mental Disorders / prevention & control ; Substance-Related Disorders / prevention & control ; Mental illness/Prevention ; Substance abuse/Prevention ; Mental illness/Diagnosis ; Substance abuse/Diagnosis
    Subject code 616.89
    Language English
    Size XVII, 411 S. : Ill.
    Edition 1. ed.
    Publisher American Psychiatric Publ
    Publishing place Washington, DC u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015208915
    ISBN 978-1-58562-308-2 ; 1-58562-308-3
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 4913 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Book: Textbook of psychiatric epidemiology

    Tsuang, Ming T. / Tohen, Mauricio / Jones, Peter B.

    2011  

    Author's details ed. by Ming T. Tsuang ; Mauricio Tohen , Peter B. Jones
    Keywords Epidemiologic Methods ; Mental Disorders / epidemiology ; Mental Disorders / diagnosis ; Psychiatric epidemiology ; Mental illness--Diagnosis
    Subject code 614.5989
    Language English
    Size XIV, 646 S. : graph. Darst., 25 cm
    Edition 3. ed., 1. impr.
    Publisher Wiley-Blackwell
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT016807974
    ISBN 978-0-470-69467-1 ; 0-470-69467-X ; 9780470976722 ; 9780470976739 ; 9780470977408 ; 0470976721 ; 047097673X ; 047097740X
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 1855 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Methodology in the GBD study of China.

    Lin, Ping-I / Glatt, Stephen J / Tsuang, Ming T

    Lancet (London, England)

    2020  Volume 396, Issue 10243, Page(s) 25

    MeSH term(s) China ; Global Burden of Disease ; Morbidity ; Risk Factors ; Systems Analysis
    Keywords covid19
    Language English
    Publishing date 2020-07-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30483-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 94: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: A polygenic resilience score moderates the genetic risk for schizophrenia: Replication in 18,090 cases and 28,114 controls from the Psychiatric Genomics Consortium.

    Hess, Jonathan L / Mattheisen, Manuel / Greenwood, Tiffany A / Tsuang, Ming T / Edenberg, Howard J / Holmans, Peter / Faraone, Stephen V / Glatt, Stephen J

    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

    2023  Volume 195, Issue 2, Page(s) e32957

    Abstract: Identifying heritable factors that moderate the genetic risk for schizophrenia (SCZ) could help clarify why some individuals remain unaffected despite having relatively high genetic liability. Previously, we developed a framework to mine genome-wide ... ...

    Abstract Identifying heritable factors that moderate the genetic risk for schizophrenia (SCZ) could help clarify why some individuals remain unaffected despite having relatively high genetic liability. Previously, we developed a framework to mine genome-wide association (GWAS) data for common genetic variants that protect high-risk unaffected individuals from SCZ, leading to derivation of the first-ever "polygenic resilience score" for SCZ (resilient controls n = 3786; polygenic risk score-matched SCZ cases n = 18,619). Here, we performed a replication study to verify the moderating effect of our polygenic resilience score on SCZ risk (OR = 1.09, p = 4.03 × 10
    MeSH term(s) Humans ; Schizophrenia/genetics ; Genome-Wide Association Study ; Resilience, Psychological ; Genetic Predisposition to Disease ; Multifactorial Inheritance/genetics ; Genomics ; Polymorphism, Single Nucleotide/genetics
    Language English
    Publishing date 2023-08-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108616-3
    ISSN 1552-485X ; 1552-4841 ; 0148-7299
    ISSN (online) 1552-485X
    ISSN 1552-4841 ; 0148-7299
    DOI 10.1002/ajmg.b.32957
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1376/B: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Book: Textbook in psychiatric epidemiology

    Tsuang, Ming T.

    2002  

    Author's details ed. by Ming T. Tsuang
    Keywords Mental Disorders / epidemiology ; Mental Disorders / diagnosis ; Epidemiologic Methods
    Language English
    Size XI, 722 S. : graph. Darst.
    Edition 2. ed.
    Publisher Wiley-Liss
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013767684
    ISBN 0-471-40974-X ; 978-0-471-40974-8
    Database Catalogue ZB MED Medicine, Health

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 A 664 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Longitudinal Trajectories of Premorbid Social and Academic Adjustment in Youth at Clinical High Risk for Psychosis: Implications for Conversion.

    Cowan, Henry R / Mittal, Vijay A / Addington, Jean / Bearden, Carrie E / Cadenhead, Kristin S / Cornblatt, Barbara A / Keshavan, Matcheri / Mathalon, Daniel H / Perkins, Diana O / Stone, William / Tsuang, Ming T / Woods, Scott W / Cannon, Tyrone D / Walker, Elaine F

    Schizophrenia bulletin

    2024  

    Abstract: Background and hypothesis: Social and academic adjustment deteriorate in the years preceding a psychotic disorder diagnosis. Analyses of premorbid adjustment have recently been extended into the clinical high risk for psychosis (CHR) syndrome to ... ...

    Abstract Background and hypothesis: Social and academic adjustment deteriorate in the years preceding a psychotic disorder diagnosis. Analyses of premorbid adjustment have recently been extended into the clinical high risk for psychosis (CHR) syndrome to identify risk factors and developmental pathways toward psychotic disorders. Work so far has been at the between-person level, which has constrained analyses of premorbid adjustment, clinical covariates, and conversion to psychosis.
    Study design: Growth-curve models examined longitudinal trajectories in retrospective reports of premorbid social and academic adjustment from youth at CHR (n = 498). Interaction models tested whether known covariates of premorbid adjustment problems (attenuated negative symptoms, cognition, and childhood trauma) were associated with different premorbid adjustment trajectories in converters vs non-converters (ie, participants who did/did not develop psychotic disorders within 2-year follow-up).
    Study results: Converters reported poorer social adjustment throughout the premorbid period. Converters who developed psychosis with an affective component reported poorer academic adjustment throughout the premorbid period than those who developed non-affective psychosis. Tentatively, baseline attenuated negative symptoms may have been associated with worsening social adjustment in the premorbid period for non-converters only. Childhood trauma impact was associated with fewer academic functioning problems among converters. Cognition effects did not differ based on conversion status.
    Conclusions: Premorbid social function is an important factor in risk for conversion to psychosis. Negative symptoms and childhood trauma had different relationships to premorbid functioning in converters vs non-converters. Mechanisms linking symptoms and trauma to functional impairment may be different in converters vs non-converters, suggesting possible new avenues for risk assessment.
    Language English
    Publishing date 2024-05-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbae050
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: BrainGENIE: The Brain Gene Expression and Network Imputation Engine.

    Hess, Jonathan L / Quinn, Thomas P / Zhang, Chunling / Hearn, Gentry C / Chen, Samuel / Kong, Sek Won / Cairns, Murray / Tsuang, Ming T / Faraone, Stephen V / Glatt, Stephen J

    Translational psychiatry

    2023  Volume 13, Issue 1, Page(s) 98

    Abstract: In vivo experimental analysis of human brain tissue poses substantial challenges and ethical concerns. To address this problem, we developed a computational method called the Brain Gene Expression and Network-Imputation Engine (BrainGENIE) that leverages ...

    Abstract In vivo experimental analysis of human brain tissue poses substantial challenges and ethical concerns. To address this problem, we developed a computational method called the Brain Gene Expression and Network-Imputation Engine (BrainGENIE) that leverages peripheral-blood transcriptomes to predict brain tissue-specific gene-expression levels. Paired blood-brain transcriptomic data collected by the Genotype-Tissue Expression (GTEx) Project was used to train BrainGENIE models to predict gene-expression levels in ten distinct brain regions using whole-blood gene-expression profiles. The performance of BrainGENIE was compared to PrediXcan, a popular method for imputing gene expression levels from genotypes. BrainGENIE significantly predicted brain tissue-specific expression levels for 2947-11,816 genes (false-discovery rate-adjusted p < 0.05), including many transcripts that cannot be predicted significantly by a transcriptome-imputation method such as PrediXcan. BrainGENIE recapitulated measured diagnosis-related gene-expression changes in the brain for autism, bipolar disorder, and schizophrenia better than direct correlations from blood and predictions from PrediXcan. We developed a convenient software toolset for deploying BrainGENIE, and provide recommendations for how best to implement models. BrainGENIE complements and, in some ways, outperforms existing transcriptome-imputation tools, providing biologically meaningful predictions and opening new research avenues.
    MeSH term(s) Humans ; Genome-Wide Association Study/methods ; Genotype ; Gene Expression Profiling/methods ; Transcriptome ; Brain
    Language English
    Publishing date 2023-03-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-023-02390-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Book: Textbook in psychiatric epidemiology

    Tsuang, Ming T.

    1995  

    Author's details ed. by Ming T. Tsuang
    Keywords Mental Disorders / epidemiology ; Mental Disorders / diagnosis ; Epidemiologic Methods ; Psychiatrie ; Epidemiologie
    Subject Seelenheilkunde ; Krankheitsverbreitung
    Language English
    Size XII, 483 S. : graph. Darst., Kt.
    Publisher Wiley-Liss
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT007261681
    ISBN 0-471-59375-3 ; 978-0-471-59375-1
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 4253 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Risk of violent behaviour in young people at clinical high risk for psychosis from the North American Prodrome Longitudinal Studies consortium.

    Tronick, Lauren N / Mirzakhanian, Heline / Addington, Jean / Bearden, Carrie E / Cannon, Tyrone D / Cornblatt, Barbara A / Keshavan, Matcheri / Mathalon, Daniel H / McGlashan, Thomas H / Perkins, Diana O / Stone, William / Tsuang, Ming T / Walker, Elaine F / Woods, Scott W / Cadenhead, Kristin S

    Early intervention in psychiatry

    2023  Volume 17, Issue 8, Page(s) 759–770

    Abstract: Aim: Although violent behaviour has been studied in schizophrenia, violence risk has received little attention in individuals at clinical high risk for psychosis (CHR). This manuscript aims to report and discuss the overall results of the Structured ... ...

    Abstract Aim: Although violent behaviour has been studied in schizophrenia, violence risk has received little attention in individuals at clinical high risk for psychosis (CHR). This manuscript aims to report and discuss the overall results of the Structured Assessment for Violence Risk in Youth (SAVRY) from the NAPLS-3 project to explore the risk of violence in CHR youth and to determine the relationship between SAVRY violence risk scores, psychosis risk symptoms, and global functioning. We hypothesized that CHR young people are at higher risk of violence as compared to healthy comparison participants due to a similarity between risk factors for psychosis and risk factors for violence, and that this risk is associated with greater severity of symptoms, poor functioning, and risk for conversion to psychosis.
    Methods: Participants from the North American Prodrome Longitudinal Study consortium phase 3 (NAPLS-3) included 684 CHR and 96 HC. Assessments included the Structural Assessment of Violence Risk in Youth (SAVRY), clinical and functional measures.
    Results: The majority of participants across groups were deemed to be at low risk for violence. There were significantly more CHR participants (29.8%) who had moderate or high scores on the SAVRY Summary Risk Rating compared to HC participants (3.1%). Low versus moderate-high SAVRY scores were associated with better social (p < .005) and role (p < .002) functioning and fewer positive (p < .002), negative (p < .002), disorganized (p < .01) and general symptoms (p < .002). CHR participants with higher SAVRY scores were more likely to be diagnosed with borderline personality disorder, ADHD and substance misuse. Among CHR, overall violence risk was not associated with conversion to psychosis. However, those who converted to psychosis scored lower on the protective factors index, primarily driven by less prosocial involvement and fewer resilient personality traits.
    Conclusions: This is the first study to assess violence risk in CHR adolescents. Violence risk factors overlap with risk factors for psychosis in general, perhaps accounting for the association. These findings have implications for intervention efforts to reduce violence risk and bolster resiliency in CHR youth.
    MeSH term(s) Adolescent ; Humans ; Longitudinal Studies ; Psychotic Disorders/diagnosis ; Psychotic Disorders/epidemiology ; Schizophrenia/diagnosis ; Risk Factors ; North America ; Prodromal Symptoms
    Language English
    Publishing date 2023-01-10
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2272425-4
    ISSN 1751-7893 ; 1751-7885
    ISSN (online) 1751-7893
    ISSN 1751-7885
    DOI 10.1111/eip.13369
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top