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  1. Article ; Online: Letter re: SARS-CoV-2 vaccine in patients with thymic epithelial tumours with and without active or pre-existing autoimmune disorders: Brief report of a TYME network safety analysis.

    Baba, Atsunori / Tokunaga, Takuya / Sakasegawa, Koichi / Kanekura, Takuro / Tsubouchi, Hirohito

    European journal of cancer (Oxford, England : 1990)

    2023  Volume 187, Page(s) 96–98

    MeSH term(s) Humans ; Autoimmune Diseases ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Neoplasms, Glandular and Epithelial ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-04-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2023.03.036
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  2. Article: [Reactivation of Hepatitis B Virus and Guidelines for Its Prevention].

    Tsubouchi, Hirohito

    Rinsho byori. The Japanese journal of clinical pathology

    2015  Volume 63, Issue 9, Page(s) 1046–1051

    Abstract: Since the discovery of hepatitis B virus (HBV) as Australia antigen by Dr. Baruch Blumberg in 1964, significant advances have been made in understanding the pathophysiology of HBV infection, and in developing therapy for infected patients. Today, the ... ...

    Abstract Since the discovery of hepatitis B virus (HBV) as Australia antigen by Dr. Baruch Blumberg in 1964, significant advances have been made in understanding the pathophysiology of HBV infection, and in developing therapy for infected patients. Today, the progression of chronic hepatitis B to cirrhosis or hepatocellular carcinoma can be prevented using nucleic acid analogs. HBV is thought to be eliminated from patients with acute hepatitis B after they are cured. However, a 1996 study showed that cured hepatitis B patients were positive for HBV DNA and the HBV-specific cytotoxic T-cell response approximately 5 years after acute infection. These results indicate that HBV persists in the livers of patients who have been cured of acute HBV infection. HBV can be activated in chronic hepatitis B patients following steroid treatment. Recent clinical reports described cases of malignant lymphoma with fulminant hepatitis B arising during or after immunosuppressive regimens, such as R-CHOP therapy. Prior to immunosuppressive treatment, such patients are negative for HBs antigen and/or positive for HBs antibody, indicative of previous HBV infection. Sixteen cases of fulminant hepatitis B due to HBV reactivation in previously HBV-infected patients were collected between 2004 and 2009, and all of them had fatal prognoses despite treatment with nucleic acid analogs. Hence, guidelines for the prevention of HBV reactivation in immunosuppressive therapy were originally formulated by the Intractable Hepatobiliary Disease Study Group in 2009, and recently updated by the Japanese Society of Hepatology in 2013. The usefulness of these guidelines has been confirmed by several research groups. Dissemination and further improvement of the guidelines are necessary to prevent HBV reactivation in various types of patient receiving immunosuppressive or anti-cancer treatments.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Hepatitis B/drug therapy ; Hepatitis B/immunology ; Hepatitis B/prevention & control ; Hepatitis B/transmission ; Hepatitis B virus/physiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Liver Transplantation/adverse effects ; Male ; Middle Aged ; Practice Guidelines as Topic ; Virus Activation
    Chemical Substances Immunosuppressive Agents
    Language Japanese
    Publishing date 2015-09
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604196-6
    ISSN 0047-1860 ; 0485-1404
    ISSN 0047-1860 ; 0485-1404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Discovery and clinical application of hepatocyte growth factor].

    Tsubouchi, Hirohito

    Nihon Shokakibyo Gakkai zasshi The Japanese journal of gastro-enterology

    2013  Volume 110, Issue 12, Page(s) 2033–2041

    MeSH term(s) Animals ; Hepatocyte Growth Factor/isolation & purification ; Hepatocyte Growth Factor/physiology ; Humans ; Proto-Oncogene Proteins c-met/physiology
    Chemical Substances Hepatocyte Growth Factor (67256-21-7) ; Proto-Oncogene Proteins c-met (EC 2.7.10.1)
    Language Japanese
    Publishing date 2013-12-04
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
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  4. Article ; Online: Lichenoid drug eruption after coronavirus disease 2019 vaccination.

    Baba, Atsunori / Kanekura, Takuro / Tsubouchi, Hirohito

    The Journal of dermatology

    2021  Volume 49, Issue 5, Page(s) e159–e160

    MeSH term(s) COVID-19/prevention & control ; Drug Eruptions/diagnosis ; Drug Eruptions/etiology ; Humans ; Lichen Planus ; Lichenoid Eruptions/chemically induced ; Lichenoid Eruptions/diagnosis ; Vaccination
    Language English
    Publishing date 2021-12-27
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16294
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  5. Article: [Lifestyle-related liver diseases].

    Tsubouchi, Hirohito

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2011  Volume 100, Issue 3, Page(s) 700–706

    MeSH term(s) Adult ; Aged ; Female ; Humans ; Life Style ; Liver Diseases/etiology ; Male ; Middle Aged
    Language Japanese
    Publishing date 2011-04-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.100.700
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  6. Article: [Current state of fulminant hepatitis and countermeasure for de novo B hepatitis].

    Tsubouchi, Hirohito

    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

    2011  Volume 100, Issue 3, Page(s) 686–691

    MeSH term(s) Female ; Hepatic Encephalopathy ; Hepatitis/complications ; Hepatitis B ; Humans ; Male ; Middle Aged ; Virus Activation
    Language Japanese
    Publishing date 2011-04-19
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 952816-7
    ISSN 1883-2083 ; 0021-5384
    ISSN (online) 1883-2083
    ISSN 0021-5384
    DOI 10.2169/naika.100.686
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  7. Article ; Online: Extrahepatic portal vein aneurysm in which the acute thrombogenic process triggered by trauma confirmed by abdominal ultrasonography: a case report.

    Tanaka, Hozuka / Muromachi, Kaori / Tamai, Tsutomu / Hashiguchi, Masafumi / Enokizono, Ryuhei / Nakajyo, Yuuki / Iryo, Yumi / Hori, Takeshi / Tsubouchi, Hirohito / Ido, Akio

    Clinical journal of gastroenterology

    2023  Volume 16, Issue 5, Page(s) 702–708

    Abstract: Extrahepatic portal vein aneurysm (PVA) is a rare condition in which the extrahepatic portal vein is partially dilated into a sac-like or spindle-like shape. Usually, patients are followed, but surgery is considered in cases of rupture, thrombus, or ... ...

    Abstract Extrahepatic portal vein aneurysm (PVA) is a rare condition in which the extrahepatic portal vein is partially dilated into a sac-like or spindle-like shape. Usually, patients are followed, but surgery is considered in cases of rupture, thrombus, or enlargement. We report a case of thrombus formation in an extrahepatic portal vein aneurysm following trauma that resulted in regression of the aneurysm and extrahepatic portal vein occlusion. Immediately after the trauma, ultrasonography showed moderately hyperechoic structures and comet signs along the vessel wall of the aneurysm and turbulent blood flow in the aneurysm, like in a whirlpool. There were floating point-like echogenic features, which were presumed to be microthrombi. In other words, the trauma might have triggered Virchow's triad: changes in the vessel wall, changes in blood properties, and blood stagnation. This is a valuable case in which ultrasonography imaging revealed interesting changes during the thrombus formation process inside an extrahepatic portal vein aneurysm. The aneurysm's size was reduced by thrombus-induced organization, but the main trunk of the portal vein became deficient in blood flow, resulting in extrahepatic portal vein occlusion. This case is suggestive of the mechanism of extrahepatic portal vein occlusion.
    MeSH term(s) Humans ; Portal Vein/diagnostic imaging ; Aneurysm/diagnostic imaging ; Aneurysm/etiology ; Ultrasonography ; Dilatation, Pathologic ; Thrombosis/diagnostic imaging ; Thrombosis/etiology
    Language English
    Publishing date 2023-05-29
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 2429411-1
    ISSN 1865-7265 ; 1865-7257
    ISSN (online) 1865-7265
    ISSN 1865-7257
    DOI 10.1007/s12328-023-01815-9
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  8. Article: Editorial.

    Tsubouchi, Hirohito

    Hepatology research : the official journal of the Japan Society of Hepatology

    2007  Volume 37, Issue 1, Page(s) 1

    Language English
    Publishing date 2007-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1387041-5
    ISSN 1386-6346 ; 0928-4346
    ISSN 1386-6346 ; 0928-4346
    DOI 10.1111/j.1872-034X.2007.00027.x
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  9. Article: [MSI-high ascending colon cancer treated with second-line ipilimumab plus nivolumab for conversion surgery:a case report].

    Kodama, Tomoko / Nakazawa, Junichi / Kawahira, Masahiro / Hori, Takeshi / Motoi, Shunsuke / Yanagi, Masayuki / Hamada, Nobuo / Sueyoshi, Kazuyoshi / Tsubouchi, Hirohito / Ido, Akio

    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

    2022  Volume 120, Issue 3, Page(s) 256–262

    Abstract: A 68-year-old woman with ascending colon cancer was the patient (cT4bN2M1a [LYM] cStage IVA, BRAF V600E mutation-positive, and MSI-high). She was given modified FOLFOXIRI as first-line therapy but did not respond. The infiltration of the primary lesion ... ...

    Abstract A 68-year-old woman with ascending colon cancer was the patient (cT4bN2M1a [LYM] cStage IVA, BRAF V600E mutation-positive, and MSI-high). She was given modified FOLFOXIRI as first-line therapy but did not respond. The infiltration of the primary lesion in the abdominal wall was alleviated, allowing conversion surgery to be performed.
    MeSH term(s) Female ; Humans ; Aged ; Nivolumab ; Ipilimumab ; Colon, Ascending ; Antineoplastic Combined Chemotherapy Protocols ; Colonic Neoplasms
    Chemical Substances Nivolumab (31YO63LBSN) ; Ipilimumab
    Language Japanese
    Publishing date 2022-08-15
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 708695-7
    ISSN 1349-7693 ; 0446-6586
    ISSN (online) 1349-7693
    ISSN 0446-6586
    DOI 10.11405/nisshoshi.120.256
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  10. Article ; Online: Infectious complications and timing for liver transplantation in autoimmune acute liver failure in Japan: a subanalysis based on nationwide surveys between 2010 and 2015.

    Fujiwara, Keiichi / Nakayama, Nobuaki / Kato, Naoya / Yokosuka, Osamu / Tsubouchi, Hirohito / Takikawa, Hajime / Mochida, Satoshi

    Journal of gastroenterology

    2020  Volume 55, Issue 9, Page(s) 888–898

    Abstract: Background: The prognosis of autoimmune acute liver failure (ALF) without liver transplantation (LT) is poor worldwide. We subanalyzed infectious complications of autoimmune ALF using data of nationwide surveys between 2010 and 2015 retrospectively and ... ...

    Abstract Background: The prognosis of autoimmune acute liver failure (ALF) without liver transplantation (LT) is poor worldwide. We subanalyzed infectious complications of autoimmune ALF using data of nationwide surveys between 2010 and 2015 retrospectively and tried to determine when to evaluate the efficacy of corticosteroid (CS) treatment or abandon it for LT based on objective data.
    Methods: One hundred and forty-four patients with autoimmune ALF, comprising 79 ALF with coma ≤ I, 52 ALF with coma ≥ II and 13 late onset hepatic failure (LOHF), were analyzed.
    Results: CS was administered to 140 (97%) patients. Thirty-seven (26%) patients had infectious complications. Patients with infection revealed more advanced disease type (p < 0.001) and poorer spontaneous survival (p < 0.001) than those without infection. Median (interquartile range) duration between diagnosis of ALF and onset of infection was 18.5 (11-36) days, and that between introduction of CS and onset of infection was 17 (10.5-36) days. Seventy-nine (55%) recovered without LT, 14 (10%) received LT and 51 (35%) died without LT. Dead or transplanted patients were older (p = 0.0057), and revealed more advanced liver failure (p < 0.001) and more occurrence of infection (p < 0.001).
    Conclusions: A critical point for evaluating the efficacy of CS treatment and switching to LT is at most 2-week after diagnosis of ALF and introduction of CS. More important, we should accelerate the point and prepare for LT in cases of ALF with coma ≥ II and LOHF, and we should have performed LT by then at the latest in case of failure to improve.
    MeSH term(s) Aged ; Female ; Glucocorticoids/therapeutic use ; Hepatitis, Autoimmune/complications ; Hepatitis, Autoimmune/mortality ; Hepatitis, Autoimmune/therapy ; Humans ; Infections/epidemiology ; Infections/etiology ; Japan ; Liver Failure, Acute/complications ; Liver Failure, Acute/mortality ; Liver Failure, Acute/therapy ; Liver Transplantation/statistics & numerical data ; Male ; Middle Aged ; Prognosis ; Retrospective Studies ; Surveys and Questionnaires ; Time Factors ; Treatment Outcome
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2020-06-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1186495-3
    ISSN 1435-5922 ; 0944-1174
    ISSN (online) 1435-5922
    ISSN 0944-1174
    DOI 10.1007/s00535-020-01699-3
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