Article ; Online: Case Report: Pulmonary Tumor Thrombotic Microangiopathy in a Cervical Cancer Patient.
Gynecologic and obstetric investigation
2018 Volume 83, Issue 1, Page(s) 99–104
Abstract: Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly progressive and often fatal pulmonary disease induced by tumor emboli within the small pulmonary arteries. PTTM presents clinically as progressive hypoxia and pulmonary hypertension. Most ... ...
| Abstract | Pulmonary tumor thrombotic microangiopathy (PTTM) is a rapidly progressive and often fatal pulmonary disease induced by tumor emboli within the small pulmonary arteries. PTTM presents clinically as progressive hypoxia and pulmonary hypertension. Most cases of PTTM are caused by an adenocarcinoma of the stomach. We present the first case report of PTTM caused by cervical squamous cell carcinoma. An 82-year-old woman presented with vaginal bleeding and exertional dyspnea. A cervical mass biopsy showed squamous cell carcinoma. Computed tomography revealed ground glass opacity of the bilateral peripheral lung fields. Hypoxia and pulmonary hypertension gradually worsened after admission. Treatment for acute heart failure was started, but was ineffective. She died of respiratory failure 31 days after admission. She was diagnosed at autopsy as having PTTM induced by cervical squamous cell carcinoma. PTTM needs to be considered in any patient with advanced cancer and lung-related issues to rule out metastatic disease, even in the absence of imaging findings. |
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| MeSH term(s) | Aged, 80 and over ; Autopsy ; Carcinoma, Squamous Cell/secondary ; Fatal Outcome ; Female ; Humans ; Hypertension, Pulmonary/etiology ; Lung/pathology ; Lung Neoplasms/secondary ; Neoplastic Cells, Circulating ; Thrombotic Microangiopathies/etiology ; Tomography, X-Ray Computed ; Uterine Cervical Neoplasms/complications ; Uterine Cervical Neoplasms/pathology |
| Language | English |
| Publishing date | 2018 |
| Publishing country | Switzerland |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 800003-7 |
| ISSN | 1423-002X ; 0378-7346 |
| ISSN (online) | 1423-002X |
| ISSN | 0378-7346 |
| DOI | 10.1159/000480400 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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