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Article: Risk Factors for the Incidence of the Volar Lunate Facet Fragments in Distal Radius Fractures.

Mitsuzawa, Sadaki / Takeuchi, Hisataka / Tsukamoto, Yoshihiro / Yamashita, Shinnosuke / Ota, Satoshi / Onishi, Eijiro / Yasuda, Tadashi

Journal of wrist surgery

2023 Volume 12, Issue 4, Page(s) 353–358

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2678060-4
ISSN	2163-3924 ; 2163-3916
ISSN (online)	2163-3924
ISSN	2163-3916
DOI	10.1055/s-0042-1760125
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Article: Preoperative Lower-Limb Muscle Predictors for Gait Speed Improvement after Total Hip Arthroplasty for Patients with Osteoarthritis.

Yasuda, Tadashi / Ota, Satoshi / Mitsuzawa, Sadaki / Yamashita, Shinnosuke / Tsukamoto, Yoshihiro / Takeuchi, Hisataka / Onishi, Eijiro

Journal of personalized medicine

2023 Volume 13, Issue 8

Abstract: This study aimed to identify preoperative lower-limb muscle predictors for gait speed improvement after total hip arthroplasty (THA) with hip osteoarthritis. Gait speed improvement was evaluated as the subtraction of preoperative speed from postoperative ...

Abstract	This study aimed to identify preoperative lower-limb muscle predictors for gait speed improvement after total hip arthroplasty (THA) with hip osteoarthritis. Gait speed improvement was evaluated as the subtraction of preoperative speed from postoperative speed. The preoperative muscle composition of ipsilateral hip abductors was evaluated using computed tomography. The females (
Language	English
Publishing date	2023-08-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13081279
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Article ; Online: Correction loss following short-segment posterior fixation for traumatic thoracolumbar burst fractures related to endplate and intervertebral disc destruction.

Hashimura, Takumi / Onishi, Eijiro / Ota, Satoshi / Tsukamoto, Yoshihiro / Yamashita, Shinnosuke / Yasuda, Tadashi

BMC musculoskeletal disorders

2023 Volume 24, Issue 1, Page(s) 174

Abstract: Background: There has been widespread use of short-segment posterior fixation (SSPF) for traumatic thoracolumbar burst fractures. The relationship between the destruction of the vertebral endplate and adjacent disc and postoperative correction loss has ... ...

Abstract	Background: There has been widespread use of short-segment posterior fixation (SSPF) for traumatic thoracolumbar burst fractures. The relationship between the destruction of the vertebral endplate and adjacent disc and postoperative correction loss has been studied in only a few studies. This study investigated the risk factors for correction loss following SSPF. Methods: Forty-eight patients (mean age 35.0 years) who underwent SSPF for thoracolumbar burst fractures were enrolled. The mean follow-up period was 25.7 months (12-98 months). The neurological status and postoperative back pain were assessed by the medical records. Segmental kyphotic angle (SKA) and anterior vertebral body height ratio (AVBHR) were measured radiographically to assess indirect vertebral body reduction and local kyphosis. Preoperative Sander's traumatic intervertebral disc lesion (TIDL) classification and AO classification were used to evaluate the severity of disc and vertebral endplate injury. The corrective loss was considered present if ΔSKA was ≥10°. A multivariate logistic regression analysis was performed to identify the risk factors associated with postoperative loss of correction. Results: The fracture distribution was as follows: 10 at T12, 17 at L1, 10 at L2, 9 at L3, and 2 at L4. Vertebral fractures were classified in the following way: A3 in 13 patients, A4 in 11, B1 in 11, and B2 in 13. In 47 patients (98%), a union of the fractured vertebrae was achieved. SKA and AVBHR improved significantly after surgery from 11.6° to 3.5° and from 67.2 to 90.0%, respectively. However, the correction loss at follow-up was 10.4° and 9.7%, respectively. Twenty patients (42%) had severe TIDL (grade 3). Postoperative ΔSKA and ΔAVBHR were significantly higher in patients with TIDL grade 3 than with TIDL grade 0-2. The presence of cranial TIDL grade 3 and older age were significant risk factors for ΔSKA ≥10° on multivariate logistic regression analysis. All patients could walk at follow-up. TIDL grade 3 and ΔSKA ≥10° were associated with severe postoperative back pain. Conclusions: Risk factors for loss of correction after SSPF for thoracolumbar burst fractures were severe disc and endplate destruction at the time of injury and older age.
MeSH term(s)	Humans ; Adult ; Fracture Fixation, Internal/adverse effects ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Lumbar Vertebrae/injuries ; Fractures, Bone/complications ; Spinal Fractures/diagnostic imaging ; Spinal Fractures/etiology ; Spinal Fractures/surgery ; Intervertebral Disc/diagnostic imaging ; Intervertebral Disc/surgery ; Intervertebral Disc/injuries ; Fractures, Comminuted ; Thoracic Vertebrae/diagnostic imaging ; Thoracic Vertebrae/surgery ; Thoracic Vertebrae/injuries ; Pain, Postoperative/etiology ; Kyphosis/diagnostic imaging ; Kyphosis/etiology ; Kyphosis/surgery ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2023-03-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2041355-5
ISSN	1471-2474 ; 1471-2474
ISSN (online)	1471-2474
ISSN	1471-2474
DOI	10.1186/s12891-023-06288-y
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Article ; Online: Association of preoperative variables of ipsilateral hip abductor muscles with gait function after total hip arthroplasty: a retrospective study.

Yasuda, Tadashi / Ota, Satoshi / Yamashita, Shinnosuke / Tsukamoto, Yoshihiro / Onishi, Eijiro

Arthroplasty (London, England)

2022 Volume 4, Issue 1, Page(s) 23

Abstract: Background: This study aimed to identify the association of preoperative variables of ipsilateral hip abductors with gait function after total hip arthroplasty (THA).: Methods: This study enrolled 42 patients who underwent unilateral primary THA for ... ...

Abstract	Background: This study aimed to identify the association of preoperative variables of ipsilateral hip abductors with gait function after total hip arthroplasty (THA). Methods: This study enrolled 42 patients who underwent unilateral primary THA for osteoarthritis. Gait speed and Timed Up-and-Go test were conducted 6 months postoperatively. Preoperative composition of the glutei medius and minimus and the upper portion of gluteus maximus was evaluated by computed tomography. Cross-sectional area ratio of individual composition to the total muscle was calculated. Preoperative variables associated with gait speed and Timed Up-and-Go test after THA were identified by using stepwise regression analysis. Results: Faster gait speed and shorter Timed Up-and-Go test correlated with smaller cross-sectional area of low-density lean tissue or intramuscular adipose tissue (low-density lean tissue plus intramuscular fat) in the glutei medius and minimus and lower cross-sectional area ratio of low-density lean tissue to the total glutei medius and minimus. Faster gait speed and shorter Timed Up-and-Go test also correlated with larger cross-sectional area of lean muscle mass in the gluteus maximus, higher cross-sectional area ratio of lean muscle mass to the total gluteus maximus, and lower cross-sectional area ratio of intramuscular fat or intramuscular adipose tissue to the total gluteus maximus. Faster gait speed additionally correlated with larger total cross-sectional area of the gluteus maximus. Regression analysis showed that the total cross-sectional area of the gluteus maximus and the low-density lean tissue cross-sectional area of the glutei medius and minimus were the explanatory variables of gait speed and Timed Up-and-Go test after THA, respectively. Conclusions: There was a potential association between preoperative composition of ipsilateral hip abductors and gait function 6 months after THA. This study indicates a predictive role of preoperative assessment of ipsilateral hip abductor composition in the recovery of gait function after THA.
Language	English
Publishing date	2022-07-01
Publishing country	England
Document type	Journal Article
ISSN	2524-7948
ISSN (online)	2524-7948
DOI	10.1186/s42836-022-00126-7
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Article ; Online: Preoperative three-dimensional multifusion imaging aiding successful microvascular decompression of a cerebellopontine angle lipoma: associated hemifacial spasm. Illustrative case.

Seto, Hiroki / Ogura, Ryosuke / Hiraishi, Tetsuya / Tsukamoto, Yoshihiro / Saito, Taiki / Shibuma, Satoshi / Shibuya, Kohei / Okamoto, Kouichirou / Oishi, Makoto / Fujii, Yukihiko

Journal of neurosurgery. Case lessons

2023 Volume 5, Issue 12

Abstract: Background: Cerebellopontine angle (CPA) lipoma-associated hemifacial spasm (HFS) is rare. As the removal of CPA lipomas has a high risk of worsening the neurological symptoms, surgical exploration is warranted only in selected patients. Preoperative ... ...

Abstract	Background: Cerebellopontine angle (CPA) lipoma-associated hemifacial spasm (HFS) is rare. As the removal of CPA lipomas has a high risk of worsening the neurological symptoms, surgical exploration is warranted only in selected patients. Preoperative identification of the lipoma affected site of the facial nerve, and offending artery are crucial for patient selection and successful microvascular decompression (MVD). Observations: Presurgical simulation using three-dimensional (3D) multifusion imaging showed a tiny CPA lipoma wedged between the facial and auditory nerves, as well as an affected facial nerve by the anterior inferior cerebellar artery (AICA) at the cisternal segment. Although a recurrent perforating artery from the AICA anchored the AICA to the lipoma, successful MVD was achieved without lipoma removal. Lessons: The presurgical simulation using 3D multifusion imaging could identify the CPA lipoma, affected site of the facial nerve, and offending artery. It was helpful for patient selection and successful MVD.
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Journal Article
ISSN	2694-1902
ISSN (online)	2694-1902
DOI	10.3171/CASE2318
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Article ; Online: Risk Factors for Reintubation After Anterior Cervical Spine Surgery: Comparative Study of Patients With Cervical Spine Trauma and Patients With Cervical Degenerative Disease.

Tanaka, Atsushi / Onishi, Eijiro / Hashimura, Takumi / Ota, Satoshi / Takeuchi, Hisataka / Tsukamoto, Yoshihiro / Yamashita, Shinnosuke / Mitsuzawa, Sadaki / Yasuda, Tadashi

Clinical spine surgery

2023

Abstract: Study design: Single-center retrospective study.: Objectives: The aim was to compare the postoperative outcomes of anterior cervical spine surgery (ACSS) in patients with and without cervical spine trauma.: Summary of background: Few papers have ... ...

Abstract	Study design: Single-center retrospective study. Objectives: The aim was to compare the postoperative outcomes of anterior cervical spine surgery (ACSS) in patients with and without cervical spine trauma. Summary of background: Few papers have addressed airway obstruction after anterior ACSS for patients with cervical spine trauma. This study aimed to compare airway obstruction after ACSS between patients with cervical degenerative disorders and cervical spine injuries and identify the risk factors for unplanned postoperative reintubation. Materials and methods: Seventy-seven patients who underwent ACSS were enrolled in this retrospective study. There were 52 men and 25 women, with a mean age of 60.3±15.5 years old. The causes of surgery were as follows: 24 cervical spine fractures or dislocations, 12 spinal cord injuries without bony fracture, 19 disc herniations, and 22 myelopathies. The patients' characteristics, operative data, and risk factors for unplanned reintubation within 5 days postoperatively were analyzed using medical records. Results: Postoperative reintubation was performed in 3 patients (3.9%), all of whom suffered trauma. We further examined risk factors for reintubation in patients in the trauma group. There was no significant difference between the reintubation (R) and nonreintubation (non-R) groups in age, sex, body mass index, amount of blood loss and operation time, preoperative paralysis severity, and the number of fused segments. Patients in group R had significantly higher rates of severe anterior element injury (100% vs. 27.3%, P=0.0011). Airway obstruction due to laryngopharyngeal edema and swelling was confirmed by laryngoscopy and computed tomography images. Conclusions: Unplanned reintubation after ACSS occurred at a higher rate in trauma patients than in patients with degenerative disorders. Our results suggested that the severe damage to the anterior element of the cervical spine was associated with postoperative reintubation. Evidence level: Level IV.
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2849646-2
ISSN	2380-0194 ; 2380-0186
ISSN (online)	2380-0194
ISSN	2380-0186
DOI	10.1097/BSD.0000000000001544
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Article: Risk Factors for the Incidence of the Volar Lunate Facet Fragments in Distal Radius Fractures

Mitsuzawa, Sadaki / Takeuchi, Hisataka / Tsukamoto, Yoshihiro / Yamashita, Shinnosuke / Ota, Satoshi / Onishi, Eijiro / Yasuda, Tadashi

Journal of Wrist Surgery

2023 Volume 12, Issue 04, Page(s) 353–358

Abstract: Background: The volar lip of the distal radius is the key structure for wrist joint stability. Rigid fixation of the volar lunate facet (VLF) fragment is difficult because of its unique anatomy, and a high rate of postoperative displacement was ... ...

Abstract	Background: The volar lip of the distal radius is the key structure for wrist joint stability. Rigid fixation of the volar lunate facet (VLF) fragment is difficult because of its unique anatomy, and a high rate of postoperative displacement was demonstrated. Purposes: The aim of the study is to identify risk factors for VLF in distal radius fractures (DRFs) and to reconsider the important point for primary fixation. Patients and Methods: One hundred fifty-five patients who underwent open reduction and internal fixation for an DRF were included and classified into one of the following two groups: VLF(+)or VLF(−). Demographic data, including age, sex, body mass index (BMI), laterality, trauma mechanism, and AO Foundation/Orthopaedic Trauma Association (AO/OTA) classification were recorded. Several parameters were investigated using wrist radiographs of the uninjured side and computed tomography scans of the injured side. Univariate and multivariate logistic regression analyses were performed to evaluate the risk factors for VLF. Results: There were 25 patients in the VLF(+) group and 130 patients in the VLF(−) group. The incidence of VLF was 16.1%. The VLF(+) group tended to have a higher BMI and higher energy trauma mechanism. The odds ratio for the sigmoid notch angle (SNA), volar tilt (VT), and lunate facet curvature radius (LFCR) were 0.84, 1.32, and 0.70, respectively, with multivariate analysis, which was significant. A smaller SNA, larger VT, and smaller LFCR are potential risk factors for VLF. Conclusion: Over-reduction of the VT at primary fixation should be avoided because it could place an excess burden on the VLF and cause subsequent postoperative fixation failure and volar carpal subluxation. Level of Evidence: IV
Keywords	distal radius fracture ; volar lunate facet fragment ; loss of reduction ; risk factor
Language	English
Publishing date	2023-01-11
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2678060-4
ISSN	2163-3924 ; 2163-3916 ; 2163-3924
ISSN (online)	2163-3924
ISSN	2163-3916 ; 2163-3924
DOI	10.1055/s-0042-1760125
Database	Thieme publisher's database

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Article ; Online: Multi-omics analyses of choroid plexus carcinoma cell lines reveal potential targetable pathways and alterations.

Hesham, Dina / On, Jotaro / Alshahaby, Nouran / Amer, Nada / Magdeldin, Sameh / Okada, Masayasu / Tsukamoto, Yoshihiro / Hiraishi, Tetsuya / Imai, Chihaya / Okuda, Shujiro / Wakai, Toshifumi / Kakita, Akiyoshi / Oishi, Makoto / El-Naggar, Shahenda / Natsumeda, Manabu

Journal of neuro-oncology

2024 Volume 166, Issue 1, Page(s) 27–38

Abstract: Purpose: Choroid plexus carcinomas (CPCs) are extremely rare brain tumors and carry a dismal prognosis. Treatment options are limited and there is an urgent need to develop models to further research. In the present study, we established two CPC cell ... ...

Abstract	Purpose: Choroid plexus carcinomas (CPCs) are extremely rare brain tumors and carry a dismal prognosis. Treatment options are limited and there is an urgent need to develop models to further research. In the present study, we established two CPC cell lines and performed multi-omics analyses. These cell lines serve as valuable models to propose new treatments in these rare but deadly brain tumors. Methods: Multi-omic profiling including, (i) methylation array (EPIC 850 K), (ii) whole genome sequencing (WGS), (iii) CANCERPLEX cancer genome panel testing, (iv) RNA sequencing (RNA-seq), and (v) proteomics analyses were performed in CCHE-45 and NGT131 cell lines. Results: Both cell lines were classified as methylation class B. Both harbored pathogenic TP53 point mutations; CCHE-45 additionally displayed TP53 loss. Furthermore, alterations of the NOTCH and WNT pathways were also detected in both cell lines. Two protein-coding gene fusions, BZW2-URGCP, and CTTNBP2-ERBB4, mutations of two oncodrivers, GBP-4 and KRTAP-12-2, and several copy number alterations were observed in CCHE-45, but not NGT131. Transcriptome and proteome analysis identified shared and unique signatures, suggesting that variability in choroid plexus carcinoma tumors may exist. The discovered difference's importance and implications highlight the possible diversity of choroid plexus carcinoma and call for additional research to fully understand disease pathogenesis. Conclusion: Multi-omics analyses revealed that the two choroid plexus carcinoma cell lines shared TP53 mutations and other common pathway alterations and activation of NOTCH and WNT pathways. Noticeable differences were also observed. These cell lines can serve as valuable models to propose new treatments in these rare but deadly brain tumors.
MeSH term(s)	Humans ; Multiomics ; Tumor Suppressor Protein p53/genetics ; Choroid Plexus Neoplasms/genetics ; Choroid Plexus Neoplasms/pathology ; Cell Line ; Choroid Plexus/chemistry ; Choroid Plexus/metabolism ; Choroid Plexus/pathology ; DNA-Binding Proteins/metabolism ; Carcinoma
Chemical Substances	Tumor Suppressor Protein p53 ; BZW2 protein, human ; DNA-Binding Proteins
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	604875-4
ISSN	1573-7373 ; 0167-594X
ISSN (online)	1573-7373
ISSN	0167-594X
DOI	10.1007/s11060-023-04484-3
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Zs.A 1825: Show issues

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Article ; Online: Recent advances in liquid biopsy of central nervous system lymphomas: case presentations and review of the literature.

Natsumeda, Manabu / Shibuma, Satoshi / Takahashi, Haruhiko / On, Jotaro / Mouri, Yoshihiro / Tomikawa, Kaoru / Fujiwara, Hidemoto / Watanabe, Jun / Tsukamoto, Yoshihiro / Okada, Masayasu / Takeda, Rui / Shimizu, Hiroshi / Takizawa, Jun / Kakita, Akiyoshi / Oishi, Makoto

Brain tumor pathology

2024 Volume 41, Issue 2, Page(s) 85–91

Abstract: Surgical biopsy is the gold standard for diagnosing central nervous system (CNS) lymphomas. However, reliable liquid biopsy methods for diagnosing CNS lymphomas have quickly developed and have been implicated in clinical decision-making. In the current ... ...

Abstract	Surgical biopsy is the gold standard for diagnosing central nervous system (CNS) lymphomas. However, reliable liquid biopsy methods for diagnosing CNS lymphomas have quickly developed and have been implicated in clinical decision-making. In the current report, we introduce two patients for whom liquid biopsy was essential for diagnosing CNS lymphomas and discuss the rapidly growing applications of this technology.
MeSH term(s)	Aged ; Female ; Humans ; Male ; Central Nervous System Neoplasms/diagnosis ; Central Nervous System Neoplasms/pathology ; Liquid Biopsy/methods ; Lymphoma/diagnosis ; Lymphoma/pathology
Language	English
Publishing date	2024-04-10
Publishing country	Japan
Document type	Journal Article ; Case Reports ; Review
ZDB-ID	1193775-0
ISSN	1861-387X ; 1433-7398 ; 0914-8108
ISSN (online)	1861-387X
ISSN	1433-7398 ; 0914-8108
DOI	10.1007/s10014-024-00483-y
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Zs.A 4555: Show issues

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Article ; Online: The Efficacy and Complications of Preoperative Embolization of Metastatic Spinal Tumors: Risk of Paralysis after Embolization.

Onishi, Eijiro / Hashimura, Takumi / Ota, Satoshi / Fujita, Satoshi / Tsukamoto, Yoshihiro / Matsunaga, Kazuhiro / Yasuda, Tadashi

Spine surgery and related research

2021 Volume 6, Issue 3, Page(s) 288–293

Abstract: Introduction: This study investigated the efficacy and complications of preoperative embolization for spinal metastatic tumors, focusing on the etiology of post-embolization paralysis.: Methods: We retrospectively reviewed the data of 44 consecutive ... ...

Abstract	Introduction: This study investigated the efficacy and complications of preoperative embolization for spinal metastatic tumors, focusing on the etiology of post-embolization paralysis. Methods: We retrospectively reviewed the data of 44 consecutive patients with spinal metastases treated between September 2012 and December 2020. Intraoperative blood loss and postoperative transfusion requirement were compared between the embolization (+) and (-) groups. Complications associated with embolization were reviewed. Results: Overall, 30 patients (68%) underwent preoperative embolization. All the patients in both groups underwent palliative posterior decompression and fusion. The mean intraoperative blood loss in the overall population was 359 ml (range, minimum-2190 ml) and was 401 ml and 267 ml in the embolization (+) and embolization (-) groups, respectively. Four patients (9%) (2 patients from each group) required blood transfusion. There were no significant between-group differences in blood loss and blood transfusion requirements. All 7 patients with hypervascular tumors were in the embolization (+) group. Two patients experienced muscle weakness in the lower extremities on days 1 and 3 after embolization. There were metastases in T5 and T1-2, and magnetic resonance imaging after embolization showed slight exacerbation of spinal cord compression. The patients showed partial recovery after surgery. Conclusions: With the predominance of hypervascular tumors in the embolization (+) group, preoperative embolization may positively affect intraoperative bleeding. Embolization of metastatic spinal tumors may pose a risk of paralysis. Although the cause of paralysis remains unclear, it might be due to the aggravation of spinal cord compression. Considering this risk of paralysis, we advocate performing surgery as soon as possible after embolization.
Language	English
Publishing date	2021-12-14
Publishing country	Japan
Document type	Journal Article
ISSN	2432-261X
ISSN (online)	2432-261X
DOI	10.22603/ssrr.2021-0171
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