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  1. Article: [A Case of Pancreatic Cancer That Developed Peritoneal Recurrence after Radical Surgery following Neoadjuvant Chemoradiation Therapy(NACRT)with Pathological Complete Response(pCR)].

    Tsukida, Shigeyuki / Ishigame, Teruhide / Nishimagi, Atsushi / Muto, Makoto / Sato, Naoya / Kofunato, Yasuhide / Haga, Junichiro / Kimura, Takashi / Kenjo, Akira / Marubashi, Shigeru

    Gan to kagaku ryoho. Cancer & chemotherapy

    2024  Volume 50, Issue 12, Page(s) 1311–1313

    Abstract: A 71-year-old woman was diagnosed with a tumor in the pancreatic head on CT imaging, which was performed as a close examination of an exacerbation of diabetes mellitus. The pancreatic tumor was diagnosed as resectable pancreatic cancer, and after ... ...

    Abstract A 71-year-old woman was diagnosed with a tumor in the pancreatic head on CT imaging, which was performed as a close examination of an exacerbation of diabetes mellitus. The pancreatic tumor was diagnosed as resectable pancreatic cancer, and after preoperative adjuvant chemoradiotherapy, pancreatoduodenectomy was performed as a radical surgery. There were no residual tumor cells in the resected specimen histopathologically, and the patient was judged to have a pathological complete response(pCR). Six months of postoperative adjuvant chemotherapy was administered, but peritoneal recurrence was observed at 20 months postoperatively, and the patient is currently undergoing treatment for recurrence. There have been other reports of recurrence even after pCR was achieved with preoperative treatment, so it is important to follow up carefully, keeping in mind that pancreatic cancer is a latent systemic disease.
    MeSH term(s) Female ; Humans ; Aged ; Neoadjuvant Therapy ; Peritoneal Neoplasms ; Pancreatic Neoplasms/therapy ; Pancreas ; Peritoneum
    Language Japanese
    Publishing date 2024-01-22
    Publishing country Japan
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Tissue-Engineered Hepatocyte Sheets Supplemented with Adipose-Derived Stem Cells.

    Suzushino, Seiko / Sato, Naoya / Ishigame, Teruhide / Okada, Ryo / Kofunato, Yasuhide / Watanabe, Junichiro / Muto, Makoto / Tsukida, Shigeyuki / Nishimagi, Atsushi / Kimura, Takashi / Kenjo, Akira / Waguri, Satoshi / Marubashi, Shigeru

    Tissue engineering. Part A

    2023  Volume 29, Issue 13-14, Page(s) 384–396

    Abstract: The ability to engineer biologically viable hepatocytes and tissue matrices with long-term functional maintenance has attracted considerable interest in the fields of hepatocyte transplantation and liver tissue engineering. Here, newly developed ... ...

    Abstract The ability to engineer biologically viable hepatocytes and tissue matrices with long-term functional maintenance has attracted considerable interest in the fields of hepatocyte transplantation and liver tissue engineering. Here, newly developed hepatocyte sheets supplemented with adipose-derived stem cells (ADSCs) were evaluated to assess the effects of ADSCs on hepatocyte function and engraftment into the subcutaneous space. Eight-week-old male C57BL/6J mice were used as donors, and 6-week-old male C.B-17/Icr-scid/scid mice were used as recipients. Hepatocyte-ADSC composite sheets were developed using temperature-responsive culture dishes. Hepatocyte viability in the hepatocyte-ADSC composite sheets was evaluated in an
    MeSH term(s) Mice ; Animals ; Male ; Adipose Tissue ; Tissue Engineering ; Mice, Inbred C57BL ; Hepatocytes ; Stem Cells
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2420582-5
    ISSN 1937-335X ; 1937-3341
    ISSN (online) 1937-335X
    ISSN 1937-3341
    DOI 10.1089/ten.TEA.2022.0197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5500/A: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: [FOLFIRINOX for Locally Advanced and Recurrent Pancreatic Cancer with UGT1A1 *6 and or UGT1A1*28 Polymorphisms-A Report of Two Cases].

    Ishigame, Teruhide / Kimura, Takashi / Tsukida, Shigeyuki / Suzushino, Seiko / Muto, Makoto / Sato, Naoya / Kofunato, Yasuhide / Okada, Ryo / Kenjo, Akira / Shimura, Tatsuo / Marubashi, Shigeru

    Gan to kagaku ryoho. Cancer & chemotherapy

    2019  Volume 46, Issue 4, Page(s) 754–756

    Abstract: Treatment containing FOLFIRINOX was planned to be administered to a 51-year-old man with locally advanced pancreatic cancer as second-line chemotherapy and to a 66-year-old woman with recurrent pancreatic cancer as third-line chemotherapy in their ... ...

    Abstract Treatment containing FOLFIRINOX was planned to be administered to a 51-year-old man with locally advanced pancreatic cancer as second-line chemotherapy and to a 66-year-old woman with recurrent pancreatic cancer as third-line chemotherapy in their treatments. Since both patients were revealed to harbor UGT1A1 polymorphisms, which were highly associated with irinotecan-induced toxicity(the former: UGT1A1 *6/*28, the latter: UGT1A1*6/*6), there was no alternative hopeful treatment other than FOLFIRINOX for them. Therefore, FOLFIRINOX was administered very carefully. Although both patients showed Grade 4 neutropenia during the initial course, it was controllable with G-CSF administration and following stepwise reduction of the irinotecan dose. Severe diarrhea and other adverse events were not observed in both cases. Since the determined regimen of FOLFIRINOX for patients with high-risk UGT1A1 polymorphisms has not been developed yet, it would be critical to accumulate and review an experience of FOLFIRINOX administration for these patients.
    MeSH term(s) Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Camptothecin ; Female ; Fluorouracil/administration & dosage ; Glucuronosyltransferase/genetics ; Humans ; Irinotecan/administration & dosage ; Leucovorin/administration & dosage ; Male ; Middle Aged ; Oxaliplatin/administration & dosage ; Pancreatic Neoplasms/drug therapy ; Pancreatic Neoplasms/genetics ; Polymorphism, Genetic
    Chemical Substances folfirinox ; Oxaliplatin (04ZR38536J) ; Irinotecan (7673326042) ; UGT1A1 enzyme (EC 2.4.1.-) ; Glucuronosyltransferase (EC 2.4.1.17) ; Leucovorin (Q573I9DVLP) ; Fluorouracil (U3P01618RT) ; Camptothecin (XT3Z54Z28A)
    Language Japanese
    Publishing date 2019-06-04
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 604842-0
    ISSN 0385-0684
    ISSN 0385-0684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2573: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Concomitant existence of pheochromocytoma in a patient with multiple endocrine neoplasia type 1.

    Okada, Ryo / Shimura, Tatsuo / Tsukida, Shigeyuki / Ando, Jin / Kofunato, Yasuhide / Momma, Tomoyuki / Yashima, Rei / Koyama, Yoshihisa / Suzuki, Shinichi / Takenoshita, Seiichi

    Surgical case reports

    2016  Volume 2, Issue 1, Page(s) 84

    Abstract: Background: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant inherited disorder that is classically characterized by the presence of neoplastic lesions of the parathyroid glands, the anterior pituitary gland, and the pancreas. However, ...

    Abstract Background: Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant inherited disorder that is classically characterized by the presence of neoplastic lesions of the parathyroid glands, the anterior pituitary gland, and the pancreas. However, MEN1 with concomitant pheochromocytoma is extremely rare.
    Case report: We report a case of MEN1 concomitant with pheochromocytoma. A 44-year-old Japanese man, who had undergone total parathyroidectomy due to primary hyperparathyroidism at the age of 18, was referred to our hospital with a complaint of a large abdominal tumor. He was diagnosed as having a giant insulinoma (maximum diameter 18 cm) in the pancreatic tail, five other non-functional neuroendocrine tumors in the pancreatic body and tail, multiple liver metastases of pancreatic neuroendocrine tumors, a pituitary prolactinoma, non-functional adrenal cortical adenomas, a pheochromocytoma in addition to a subcutaneous neurofibroma, and a cutaneous fibroma. The genetic screening revealed a deletion mutation at codons 83-84 in exon 2 of the MEN1 gene. He underwent distal pancreatectomy, splenectomy, cholecystectomy, right adrenalectomy, abdominal subcutaneous tumor excision, and cutaneous tumor biopsy for the purpose of tumor volume reduction. Extended right posterior segmentectomy with partial hepatectomy of S2, S3, and S8 was performed to resect residual tumors 9 months after the initial surgery. Although a newly formed liver metastasis was found 19 months after the hepatectomy, he is still alive 4 years and 4 months after the initial surgery.
    Conclusions: We reported an extremely rare case of giant insulinoma and simultaneous occurrence of pheochromocytoma and adrenal cortical adenoma in the ipsilateral adrenal gland in a patient clinically and genetically diagnosed as having MEN1.
    Language English
    Publishing date 2016-08-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2809613-7
    ISSN 2198-7793
    ISSN 2198-7793
    DOI 10.1186/s40792-016-0214-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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