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  1. AU="Tsukui, Daisuke"
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  42. AU="Di Meglio, Florent"
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  1. Article ; Online: Discordance Between Mucosal Appearances and Pathologic Findings in Intestinal Mycobacterial Infection in an Immunocompromised Patient.

    Tsukui, Daisuke / Haga, Toshihiro / Abe, Koichiro

    Mayo Clinic proceedings

    2024  

    Language English
    Publishing date 2024-05-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2024.02.012
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  2. Article ; Online: GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis.

    Tsukui, Daisuke / Kimura, Yoshitaka / Kono, Hajime

    iScience

    2023  Volume 26, Issue 8, Page(s) 107293

    Abstract: Atherosclerosis complicates chronic inflammatory diseases, such as rheumatoid arthritis and systemic lupus erythematosus, suggesting that a shared physiological pathway regulates inflammatory responses in these diseases wherein spleen tyrosine kinase ( ... ...

    Abstract Atherosclerosis complicates chronic inflammatory diseases, such as rheumatoid arthritis and systemic lupus erythematosus, suggesting that a shared physiological pathway regulates inflammatory responses in these diseases wherein spleen tyrosine kinase (SYK) is involved. We aimed to identify a shared therapeutic target for atherosclerosis and inflammatory diseases. We used
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107293
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  3. Article ; Online: Multiple Renal Microaneurysms in Polyarteritis Nodosa.

    Tsukui, Daisuke / Kono, Hajime

    Mayo Clinic proceedings

    2021  Volume 96, Issue 8, Page(s) 2277–2278

    MeSH term(s) Angiography ; Diagnosis, Differential ; Humans ; Male ; Microaneurysm/diagnosis ; Microaneurysm/etiology ; Polyarteritis Nodosa/complications ; Renal Artery ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2021-04-30
    Publishing country England
    Document type Case Reports ; Journal Article ; Video-Audio Media
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2021.05.001
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  4. Article ; Online: Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis.

    Kimura, Yoshitaka / Tsukui, Daisuke / Kono, Hajime

    International journal of molecular sciences

    2021  Volume 22, Issue 22

    Abstract: Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks ... ...

    Abstract Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks and hyperuricemia. In hyperuricemia, reactive oxygen species (ROS) are produced simultaneously with the formation of uric acid by xanthine oxidases. Intracellular uric acid has also been reported to promote the production of ROS. The ROS and the intracellular uric acid itself regulate several intracellular signaling pathways, and alterations in these pathways may result in the development of atherosclerotic lesions. In this review, we describe the effect of uric acid on various molecular signals and the potential mechanisms of atherosclerosis development in hyperuricemia. Furthermore, we discuss the efficacy of treatments for hyperuricemia to protect against the development of atherosclerosis.
    MeSH term(s) Animals ; Atherosclerosis/blood ; Atherosclerosis/epidemiology ; Comorbidity ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/epidemiology ; Gout/blood ; Gout/epidemiology ; Humans ; Hypertension/blood ; Hypertension/epidemiology ; Hyperuricemia/blood ; Hyperuricemia/epidemiology ; Metabolic Syndrome/blood ; Metabolic Syndrome/epidemiology ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/epidemiology ; Risk Factors ; Uric Acid/blood ; Xanthine Oxidase/metabolism
    Chemical Substances Reactive Oxygen Species ; Uric Acid (268B43MJ25) ; Xanthine Oxidase (EC 1.17.3.2)
    Language English
    Publishing date 2021-11-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222212394
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  5. Article ; Online: Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis.

    Tsukui, Daisuke / Kimura, Yoshitaka / Kono, Hajime

    Journal of translational autoimmunity

    2021  Volume 4, Page(s) 100094

    Abstract: AAV is characterized by necrotizing small vessel vasculitis with positive serum ANCA.•MPO/PR3-ANCA and neutrophils play central roles in AAV pathogenicity.•Dysregulated complement system primes neutrophils.•MPO-ANCA directly activates neutrophils to ... ...

    Abstract •AAV is characterized by necrotizing small vessel vasculitis with positive serum ANCA.•MPO/PR3-ANCA and neutrophils play central roles in AAV pathogenicity.•Dysregulated complement system primes neutrophils.•MPO-ANCA directly activates neutrophils to induce NETosis followed by releasing NETs.•B cells, T cells, and dendritic cells also contribute to the pathogenicity of AAV.
    Language English
    Publishing date 2021-03-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2589-9090
    ISSN (online) 2589-9090
    DOI 10.1016/j.jtauto.2021.100094
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  6. Article: Histopathology of pulmonary thromboembolism in a patient with Behçet's disease.

    Tsukui, Daisuke / Hirohata, Shunsei / Kikuchi, Hirotoshi / Uozaki, Hiroshi / Kono, Hajime

    Clinical and experimental rheumatology

    2022  Volume 40, Issue 8, Page(s) 1584–1587

    Abstract: Pulmonary involvement in vascular Behçet's disease (BD) (VBD) is a serious manifestation. Among the pulmonary manifestations, pulmonary embolism is considered a rare manifestation because deep vein thrombosis (DVT) has been thought to detach from the ... ...

    Abstract Pulmonary involvement in vascular Behçet's disease (BD) (VBD) is a serious manifestation. Among the pulmonary manifestations, pulmonary embolism is considered a rare manifestation because deep vein thrombosis (DVT) has been thought to detach from the vessel wall, whereas pulmonary thrombus has been suggested to result from in situ pulmonary arteritis.In this case report, we present histopathological evidence of pulmonary embolism derived from DVT in an autopsy case of VBD. This observation emphasises that DVT causes pulmonary embolism in BD, indicating that anticoagulants are required for its prevention.
    MeSH term(s) Anticoagulants/therapeutic use ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Humans ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/etiology ; Thrombosis/etiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2022-06-15
    Publishing country Italy
    Document type Case Reports
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/il4pc7
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    Zs.A 2002: Show issues Location:
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  7. Article ; Online: Ultrasound diagnosis of carotid artery stenosis and occlusion.

    Takekawa, Hidehiro / Tsukui, Daisuke / Kobayasi, Saro / Suzuki, Keisuke / Hamaguchi, Hirotoshi

    Journal of medical ultrasonics (2001)

    2022  Volume 49, Issue 4, Page(s) 675–687

    Abstract: Carotid artery ultrasonography is capable of diagnosing or inferring the presence or absence of stenosis or occlusion of the internal carotid artery (ICA) and vertebral artery (VA), as well as the not directly observable distal ICA, middle cerebral ... ...

    Abstract Carotid artery ultrasonography is capable of diagnosing or inferring the presence or absence of stenosis or occlusion of the internal carotid artery (ICA) and vertebral artery (VA), as well as the not directly observable distal ICA, middle cerebral artery (MCA), and basilar artery (BA). Stenosis at the origin of the ICA is mainly evaluated using the parameter peak systolic velocity (PSV), with values of ≥ 200-230 cm/s indicating severe stenosis. Recently, the acceleration time ratio has been reported for diagnosis of ICA origin stenosis. An indicator called the end-diastolic (ED) ratio can be used for diagnosing occlusion of the distal ICA or the M1 segment of the MCA. The PSV of stenosis can be used to diagnose stenosis at the beginning of the VA or V1, and mean flow velocity, mean ratio, and diameter ratio can be used to diagnose distal VA occlusion. Furthermore, the usefulness of the VA pulsatility index and resistance index has been suggested for diagnosing stenosis or occlusion of the BA. This review outlines diagnostic sonography criteria for stenosis and occlusion of extracranial and intracranial arteries.
    MeSH term(s) Humans ; Carotid Stenosis/diagnostic imaging ; Carotid Artery, Internal/diagnostic imaging ; Constriction, Pathologic ; Blood Flow Velocity ; Ultrasonography ; Sensitivity and Specificity
    Language English
    Publishing date 2022-09-29
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-022-01259-7
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  8. Article ; Online: Point-of-care ultrasound for stroke patients in the emergency room.

    Takekawa, Hidehiro / Tsukui, Daisuke / Kobayasi, Saro / Suzuki, Keisuke / Hamaguchi, Hirotoshi

    Journal of medical ultrasonics (2001)

    2022  Volume 49, Issue 4, Page(s) 581–592

    Abstract: Stroke requires rapid determination of the cause to provide timely and appropriate initial management. Various ultrasonographic techniques have been evaluated as ways to determine the cause of stroke; among them, carotid artery ultrasonography is ... ...

    Abstract Stroke requires rapid determination of the cause to provide timely and appropriate initial management. Various ultrasonographic techniques have been evaluated as ways to determine the cause of stroke; among them, carotid artery ultrasonography is particularly useful since it provides considerable information within a short time period when used to evaluate a specific site. In the emergency room, carotid artery ultrasonography can be used to diagnose internal carotid artery stenosis, predict an occluded vessel, and infer the cause of ischemic stroke. Additionally, carotid artery ultrasonography can diagnose different conditions including subclavian artery steal syndrome, bow hunter's stroke, Takayasu's arteritis, moyamoya disease, and dural arteriovenous fistula. Furthermore, patients with ischemic stroke with a pulse deficit or hypotension must be differentiated from acute type A aortic dissection, which requires emergency surgery; carotid artery ultrasonography can immediately differentiate between the two conditions by identifying the intimal flap of the common carotid artery. The following article provides an overview of carotid artery ultrasonography performed as point-of-care ultrasound in the emergency room in patients with suspected stroke.
    MeSH term(s) Humans ; Point-of-Care Systems ; Subclavian Steal Syndrome/etiology ; Takayasu Arteritis ; Ultrasonography/adverse effects ; Stroke/diagnostic imaging ; Stroke/complications ; Emergency Service, Hospital ; Ischemic Stroke
    Language English
    Publishing date 2022-02-03
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-021-01185-0
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  9. Article ; Online: Usefulness of "AcT ratio" in diagnosis of internal carotid artery stenosis: a multicenter, retrospective, observational study.

    Tsukui, Daisuke / Takekawa, Hidehiro / Saito, Kozue / Okabe, Ryuta / Tanaka, Akito / Kobayasi, Saro / Igarasi, Haruki / Suzuki, Keisuke / Hamaguchi, Hirotoshi

    Journal of medical ultrasonics (2001)

    2024  Volume 51, Issue 2, Page(s) 347–353

    Abstract: Purpose: The ratio of the internal carotid artery (ICA) to the common carotid artery (CCA), especially the "AcT ratio," which is a modified measurement method of acceleration time, is useful for diagnosing ICA-origin stenosis. However, previous studies ... ...

    Abstract Purpose: The ratio of the internal carotid artery (ICA) to the common carotid artery (CCA), especially the "AcT ratio," which is a modified measurement method of acceleration time, is useful for diagnosing ICA-origin stenosis. However, previous studies were single-center studies. Therefore, this multicenter, retrospective, cross-sectional study aimed to determine whether a method using the AcT ratio is useful for estimating stenosis rates.
    Methods: This study included 461 vessels subjected to carotid artery ultrasonography and evaluation for ICA-origin stenosis via NASCET at four hospitals. The duration from the steep rise point to the inflection point or the first peak was defined as AcT on pulsed wave Doppler. The AcT ratio was calculated as AcT of ICA/AcT of ipsilateral CCA. The AcT ratio and rate of ICA-origin stenosis were analyzed using Pearson's correlation coefficient, simple regression analysis, and ROC curve.
    Results: A significant positive correlation was observed between the AcT ratio and NASCET stenosis. NASCET stenosis of ≥ 50% had a sensitivity, specificity, and negative predictive value (NPV) of 70.2%, 71.6%, and 91.5%, respectively, when the cut-off value of the AcT ratio was 1.17. NASCET stenosis of ≥ 70% had a sensitivity, specificity, and NPV of 70.5%, 72.1%, and 95.9%, respectively, when the cut-off value of the AcT ratio was 1.22.
    Conclusions: The findings of this multicenter, retrospective, cross-sectional study suggest that the AcT ratio is useful for diagnosing ICA-origin stenosis, especially for diagnosis by exclusion. NASCET stenosis of ≥ 50% was considered unlikely if the Act ratio was ≤ 1.17, whereas NASCET stenosis of ≥ 70% was considered unlikely if it was ≤ 1.22.
    MeSH term(s) Humans ; Carotid Stenosis/diagnostic imaging ; Retrospective Studies ; Male ; Cross-Sectional Studies ; Female ; Carotid Artery, Internal/diagnostic imaging ; Aged ; Middle Aged ; Sensitivity and Specificity ; Aged, 80 and over
    Language English
    Publishing date 2024-04-06
    Publishing country Japan
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-024-01409-z
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  10. Article ; Online: Ultraviolet Purpura in IgA Vasculitis.

    Tsukui, Daisuke / Kono, Hajime

    Mayo Clinic proceedings

    2018  Volume 93, Issue 1, Page(s) 122

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Asian Continental Ancestry Group ; Female ; Humans ; Immunoglobulin A/analysis ; Purpura/drug therapy ; Purpura/etiology ; Purpura/physiopathology ; Treatment Outcome ; Ultraviolet Rays/adverse effects ; Vasculitis/drug therapy ; Vasculitis/etiology ; Vasculitis/physiopathology ; Young Adult
    Chemical Substances Adrenal Cortex Hormones ; Immunoglobulin A
    Language English
    Publishing date 2018-01-05
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2017.09.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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