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Article ; Online: Nicardipine constant rate infusion alleviates the cardiovascular effects of dexmedetomidine infusions without affecting the minimal alveolar concentration in sevoflurane-anesthetized dogs.

Akashi, Natsuki / Murahata, Yusuke / Tsuno, Sayaka / Kanazawa, Aomi / Hikasa, Yoshiaki / Imagawa, Tomohiro

2024 Volume 172, Page(s) 105254

Abstract: Two randomized crossover trials evaluated the effects of nicardipine constant rate infusion (CRI) on 1) the anesthetic potency of sevoflurane and 2) the ability to attenuate dexmedetomidine-induced cardiovascular depression in anesthetized dogs. First, ... ...

Abstract	Two randomized crossover trials evaluated the effects of nicardipine constant rate infusion (CRI) on 1) the anesthetic potency of sevoflurane and 2) the ability to attenuate dexmedetomidine-induced cardiovascular depression in anesthetized dogs. First, six healthy Beagle dogs weighing 11.7 ± 0.9 kg were allocated to one of three treatments that administered a CRI of carrier (saline) or dexmedetomidine 0.5 or 3.0 μg/kg/h following a loading dose. The minimum alveolar concentration (MAC) of sevoflurane was determined utilizing electric stimuli before and after the loading dose of nicardipine (20 μg/kg intravenously for 10 min), followed by CRI at 40 μg/kg/h with 60 min of equilibration. Subsequently, cardiovascular and blood gas variables were evaluated in another trial under sevoflurane anesthesia at the individual 1.5 MAC. After baseline measurements, the dogs were assigned to two treatments (dexmedetomidine CRI at 0.5 or 3.0 μg/kg/h following a loading dose) with sevoflurane doses adjusted to 1.5 times of MAC equivalent, and the measurements were repeated every 15 min for 120 min. After 60 min, nicardipine CRI at 40 μg/kg/h with a loading dose was added to the dexmedetomidine CRI. Dexmedetomidine infusions significantly decreased the sevoflurane MAC but nicardipine did not significantly alter the MAC either with or without dexmedetomidine CRI in dogs. Dexmedetomidine dose-dependently decreased the cardiac index and increased the systemic vascular resistance index; these effects were fully counteracted by concomitant nicardipine CRI. Nicardipine CRI can be useful for controlling the cardiovascular depression elicited by dexmedetomidine in anesthetized dogs without affecting the anesthetic potency of sevoflurane.
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2024.105254
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Article ; Online: Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study.

Eda, Nobuhiko / Tsuno, Saki / Nakamura, Nobuhiro / Sone, Ryota / Akama, Takao / Matsumoto, Mitsuharu

Nutrients

2022 Volume 14, Issue 22

Abstract: This study aimed to examine the effects of hydrogen gas ( ... ...

Abstract	This study aimed to examine the effects of hydrogen gas (H
MeSH term(s)	Adult ; Male ; Humans ; Pilot Projects ; Cross-Over Studies ; Exercise/physiology ; Muscle, Skeletal ; Hydrogen
Chemical Substances	Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2022-11-18
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14224875
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Article ; Online: Distinct lactate metabolism between hepatocytes and myotubes revealed by live cell imaging with genetically encoded indicators.

Horikoshi, Mina / Harada, Kazuki / Tsuno, Saki / Kitaguchi, Tetsuya / Hirai, Masami Yokota / Matsumoto, Mitsuharu / Terada, Shin / Tsuboi, Takashi

Biochemical and biophysical research communications

2023 Volume 694, Page(s) 149416

Abstract: The process of glycolysis breaks down glycogen stored in muscles, producing lactate through pyruvate to generate energy. Excess lactate is then released into the bloodstream. When lactate reaches the liver, it is converted to glucose, which muscles ... ...

Abstract	The process of glycolysis breaks down glycogen stored in muscles, producing lactate through pyruvate to generate energy. Excess lactate is then released into the bloodstream. When lactate reaches the liver, it is converted to glucose, which muscles utilize as a substrate to generate ATP. Although the biochemical study of lactate metabolism in hepatocytes and skeletal muscle cells has been extensive, the spatial and temporal dynamics of this metabolism in live cells are still unknown. We observed the dynamics of metabolism-related molecules in primary cultured hepatocytes and a skeletal muscle cell line upon lactate overload. Our observations revealed an increase in cytoplasmic pyruvate concentration in hepatocytes, which led to glucose release. Skeletal muscle cells exhibited elevated levels of lactate and pyruvate levels in both the cytoplasm and mitochondrial matrix. However, mitochondrial ATP levels remained unaffected, indicating that the increased lactate can be converted to pyruvate but is unlikely to be utilized for ATP production. The findings suggest that excess lactate in skeletal muscle cells is taken up into mitochondria with little contribution to ATP production. Meanwhile, lactate released into the bloodstream can be converted to glucose in hepatocytes for subsequent utilization in skeletal muscle cells.
MeSH term(s)	Hepatocytes/metabolism ; Glucose/metabolism ; Muscle Fibers, Skeletal/metabolism ; Lactic Acid ; Adenosine Triphosphate/metabolism ; Pyruvates
Chemical Substances	Glucose (IY9XDZ35W2) ; Lactic Acid (33X04XA5AT) ; Adenosine Triphosphate (8L70Q75FXE) ; Pyruvates
Language	English
Publishing date	2023-12-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.149416
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Article ; Online: Mitochondrial ATP concentration decreases immediately after glucose administration to glucose-deprived hepatocytes.

Tsuno, Saki / Harada, Kazuki / Horikoshi, Mina / Mita, Marie / Kitaguchi, Tetsuya / Hirai, Masami Yokota / Matsumoto, Mitsuharu / Tsuboi, Takashi

FEBS open bio

2023 Volume 14, Issue 1, Page(s) 79–95

Abstract: Hepatocytes can switch their metabolic processes in response to nutrient availability. However, the dynamics of metabolites (such as lactate, pyruvate, and ATP) in hepatocytes during the metabolic switch remain unknown. In this study, we visualized ... ...

Abstract	Hepatocytes can switch their metabolic processes in response to nutrient availability. However, the dynamics of metabolites (such as lactate, pyruvate, and ATP) in hepatocytes during the metabolic switch remain unknown. In this study, we visualized metabolite dynamics in primary cultured hepatocytes during recovery from glucose-deprivation. We observed a decrease in the mitochondrial ATP concentration when glucose was administered to hepatocytes under glucose-deprivation conditions. In contrast, there was slight change in the cytoplasmic ATP concentration. A decrease in mitochondrial ATP concentration was associated with increased protein synthesis rather than glycogen synthesis, activation of urea cycle, and production of reactive oxygen species. These results suggest that mitochondrial ATP is important in switching metabolic processes in the hepatocytes.
MeSH term(s)	Glucose/metabolism ; Liver/metabolism ; Adenosine Triphosphate/metabolism ; Hepatocytes/metabolism ; Lactic Acid/metabolism ; Pyruvic Acid/metabolism
Chemical Substances	Glucose (IY9XDZ35W2) ; Adenosine Triphosphate (8L70Q75FXE) ; Lactic Acid (33X04XA5AT) ; Pyruvic Acid (8558G7RUTR)
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.13744
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Article ; Online: Inhibition of SARS-CoV-2 nucleocapsid protein-RNA interaction by guanosine oligomeric RNA.

Sekine, Ryoya / Tsuno, Satsuki / Irokawa, Hayato / Sumitomo, Kazuhiro / Han, Tianxue / Sato, Yusuke / Nishizawa, Seiichi / Takeda, Kouki / Kuge, Shusuke

Journal of biochemistry

2023 Volume 173, Issue 6, Page(s) 447–457

Abstract: The interaction of the β-coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) nucleocapsid (N) protein with genomic RNA is initiated by specific RNA regions and subsequently induces the formation of a continuous polymer with ... ...

Abstract	The interaction of the β-coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) nucleocapsid (N) protein with genomic RNA is initiated by specific RNA regions and subsequently induces the formation of a continuous polymer with characteristic structural units for viral formation. We hypothesized that oligomeric RNAs, whose sequences are absent in the 29.9-kb genome sequence of SARS-CoV-2, might affect RNA-N protein interactions. We identified two such hexameric RNAs, In-1 (CCGGCG) and G6 (GGGGGG), and investigated their effects on the small filamentous/droplet-like structures (< a few μm) of N protein-genomic RNA formed by liquid-liquid phase separation. The small N protein structures were sequence-specifically enhanced by In-1, whereas G6 caused them to coalesce into large droplets. Moreover, we found that a guanosine 12-mer (G12, GGGGGGGGGGGG) expelled preexisting genomic RNA from the small N protein structures. The presence of G12 with the genomic RNA suppressed the formation of the small N protein structures, and alternatively apparently altered phase separation to induce the formation of large droplets with unclear phase boundaries. We showed that the N-terminal RNA-binding domain is required for the stability of the small N protein structures. Our results suggest that G12 may be a strong inhibitor of the RNA-N protein interaction.
MeSH term(s)	Humans ; SARS-CoV-2/genetics ; Nucleocapsid Proteins/chemistry ; Nucleocapsid Proteins/genetics ; Nucleocapsid Proteins/metabolism ; RNA, Viral/genetics ; RNA, Viral/chemistry ; RNA, Viral/metabolism ; COVID-19 ; Protein Binding
Chemical Substances	Nucleocapsid Proteins ; RNA, Viral
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	218073-x
ISSN	1756-2651 ; 0021-924X
ISSN (online)	1756-2651
ISSN	0021-924X
DOI	10.1093/jb/mvad008
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Article ; Online: Design of a transmissive optical system of a laser metal deposition three-dimensional printer with metal powder.

Ohno, Hiroshi / Shiomi, Yasutomo / Tsuno, Satoshi / Sasaki, Mitsuo

Applied optics

2019 Volume 58, Issue 15, Page(s) 4127–4138

Abstract: A transmissive optical system of a three-dimensional (3D) printer using the laser metal deposition (LMD) technique with a metal powder is proposed here, together with its design method. An f-number of the focused laser beam emitted from the optical ... ...

Abstract	A transmissive optical system of a three-dimensional (3D) printer using the laser metal deposition (LMD) technique with a metal powder is proposed here, together with its design method. An f-number of the focused laser beam emitted from the optical system should be large enough for the laser beam not to be absorbed or reflected by the metal powder injection nozzle. On the other hand, owing to the Lagrange-Helmholtz relation, the f-number should be small enough to form a minute laser spot diameter for high-resolution building. A temperature rise induced by the high-power laser may cause damage or a thermal lens effect on the optical system, which can be reduced by using lenses having plano-surfaces contacting thermally with holders. A formula of the relationship of the thermal lens effect with an f-number of each lens is derived to determine the lens specifications. A formula of longitudinal spherical aberration (LSA) of these lenses is also derived, and the total LSA is shown to be able to be zero with an acceptable f-number of the focused laser beam. The prototype LMD 3D printer with 6 kW laser is fabricated and shows favorable properties, such as a minimum building width of 0.3 mm and a building speed of over 500 cc/h.
Language	English
Publishing date	2019-06-03
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.58.004127
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Article ; Online: Hydrogen-producing milk to prevent reduction in tear stability in persons using visual display terminals.

Kawashima, Motoko / Tsuno, Saki / Matsumoto, Mitsuharu / Tsubota, Kazuo

The ocular surface

2019 Volume 17, Issue 4, Page(s) 714–721

Abstract: Purpose: To examine the effect of hydrogen (H: Methods: A randomized, double-blind, placebo-controlled, parallel-group comparative study was conducted in humans. Of 118 candidates aged 20-60 years who were using visual display terminals daily, 54 ... ...

Abstract	Purpose: To examine the effect of hydrogen (H Methods: A randomized, double-blind, placebo-controlled, parallel-group comparative study was conducted in humans. Of 118 candidates aged 20-60 years who were using visual display terminals daily, 54 subjects (mean age, 42.4 years) with mild-to-moderate dry eye symptoms, who were not dry eye patients based on the 2006 Japanese Diagnostic Criteria for Dry Eye, were included in the study. Subjects were assigned to the H Results: Change in fTBUT in the H Conclusions: H
MeSH term(s)	Adult ; Animals ; Computer Terminals ; Double-Blind Method ; Dry Eye Syndromes/etiology ; Dry Eye Syndromes/metabolism ; Dry Eye Syndromes/prevention & control ; Female ; Humans ; Hydrogen/metabolism ; Male ; Middle Aged ; Milk ; Ophthalmic Solutions/administration & dosage ; Tears/metabolism ; Young Adult
Chemical Substances	Ophthalmic Solutions ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2019-07-25
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2208578-6
ISSN	1937-5913 ; 1542-0124
ISSN (online)	1937-5913
ISSN	1542-0124
DOI	10.1016/j.jtos.2019.07.008
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Article ; Online: Retraction Note: Hsa-miR-520d induces hepatoma cells to form normal liver tissues via a stemness-mediated process.

Tsuno, Satoshi / Wang, Xinhui / Shomori, Kohei / Hasegawa, Junichi / Miura, Norimasa

Scientific reports

2018 Volume 8, Issue 1, Page(s) 14898

Abstract: This paper has been retracted. ...

Abstract	This paper has been retracted.
Language	English
Publishing date	2018-10-09
Publishing country	England
Document type	Retraction of Publication
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-32380-8
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Book: GRPPA_4b: A four bottom quark production event generator for [rho] [rho]/[rho] [rho] collisions

Tsuno, S

(KEK Preprint ; 2002,7)

2002

Author's details	S. Tsuno
Series title	KEK Preprint ; 2002,7
Language	English
Size	34 S, graph. Darst
Publisher	High Energy Accelerator Research Organization (KEK)
Publishing place	Tsukuba
Document type	Book
Note	Submitted to Comput. Phys. Commun.
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Psychological Characteristics in Patients during Treatment for Tobacco Dependence.

Matsuda, Akiko / Hasegawa, Junichi / Wang, Xinhui / Tsuno, Satoshi / Miura, Norimasa

Yonago acta medica

2015 Volume 58, Issue 2, Page(s) 81–84

Abstract: Background: Few studies compare mood in tobacco cessation patients with mood in continuing smokers and then estimate the effects of a tobacco cessation program according to status of mood. We investigated whether mood in patients (n = 7) dependent on ... ...

Abstract	Background: Few studies compare mood in tobacco cessation patients with mood in continuing smokers and then estimate the effects of a tobacco cessation program according to status of mood. We investigated whether mood in patients (n = 7) dependent on tobacco improved through the standard Japanese 12-week program for smoking cessation comparing smokers (n = 11) and nonsmokers (n = 16). Methods: A brief Japanese version of the short profile of mood states (POMS) was used in this study. The subscale includes 5 negative mood factors (tension-anxiety, depression, anger-hostility, fatigue and confusion-bewilderment) and positive mood factors (vigor-activity). We also examined expiratory CO concentration (ppm), percentage of COHb, urinary nicotine and its metabolite concentration, Brinkman index, and tobacco dependence score (TDS) for both smoking cessation group and smokers group. Results: All the short profiles for mood state points in nonsmokers were below 50. Two of TDS items in smoking cessation patients were significantly higher in percentage than those in smokers. Brinkman indices and expiratory CO concentration were significantly higher in smoking cessation patients than those in smokers. The rate of improvement in tension-anxiety points in smoking cessation patients was significantly higher than that in smokers. Conclusion: Counseling according to the standard program in the treatment of tobacco dependence may be an effective procedure to improve mood status.
Language	English
Publishing date	2015-08-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	840719-8
ISSN	1346-8049 ; 0513-5710
ISSN (online)	1346-8049
ISSN	0513-5710
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