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  1. Article ; Online: Folate-grafted glycyl-glycine-melphalan conjugate self-assembled amphilphilc nanomicelles augmented drug delivery, cytotoxicity and cellular uptake in human ovarian cancer cells.

    Duan, Jie / Chen, Ligang / Tu, Jiao / Cao, Li / Xiao, Xiao

    Journal of microencapsulation

    2022  Volume 39, Issue 3, Page(s) 197–209

    Abstract: Objectives: Folic acid was coupled to melphalan using glycyl-glycine (FA-Gly-Gly-Melphalan) to synthesise self-assembled nanomicelles for targeting ovarian cancer cells, SKOV3.: Methods and results: FA-Gly-Gly-Melphalan self-assembled nanomicelles ... ...

    Abstract Objectives: Folic acid was coupled to melphalan using glycyl-glycine (FA-Gly-Gly-Melphalan) to synthesise self-assembled nanomicelles for targeting ovarian cancer cells, SKOV3.
    Methods and results: FA-Gly-Gly-Melphalan self-assembled nanomicelles were prepared with critical micellar concentration (CMC) of 12-μg/ml. The mean particle size of FA-Gly-Gly-Melphalan self-assembled nanomicelles was measured to be 95.9 ± 3.4-nm significantly (
    Conclusion: FA-Gly-Gly-Melphalan self-assembled nanomicelles warrant in depth
    MeSH term(s) Drug Carriers ; Drug Delivery Systems ; Female ; Folic Acid ; Glycylglycine ; Humans ; Melphalan/pharmacology ; Micelles ; Ovarian Neoplasms/drug therapy ; Particle Size
    Chemical Substances Drug Carriers ; Micelles ; Glycylglycine (10525P22U0) ; Folic Acid (935E97BOY8) ; Melphalan (Q41OR9510P)
    Language English
    Publishing date 2022-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 843632-0
    ISSN 1464-5246 ; 0265-2048
    ISSN (online) 1464-5246
    ISSN 0265-2048
    DOI 10.1080/02652048.2020.1714764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2267: Show issues Location:
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  2. Article ; Online: Responses of Micropterus salmoides under Ammonia Stress and the Effects of a Potential Ammonia Antidote

    Wang, Zhenlu / Guo, Xingchen / Tu, Jiao / Shi, Xuan / Gan, Lei / Zhang, Muzi / Jiang, Haibo / Zhang, Xiaoxue / Shao, Jian

    Animals. 2023 Jan. 24, v. 13, no. 3

    2023  

    Abstract: Ammonia is a common environmental limiting factor in aquaculture. To investigate the effects of ammonia stress and explore the protective effect of N-carbamylglutamate (NCG) on Micropterus salmoides (M. salmoides), tissue sections and parameters related ... ...

    Abstract Ammonia is a common environmental limiting factor in aquaculture. To investigate the effects of ammonia stress and explore the protective effect of N-carbamylglutamate (NCG) on Micropterus salmoides (M. salmoides), tissue sections and parameters related to oxidative stress and the inflammatory response in M. salmoides were carried out during the ammonia stress test and feeding test. The results demonstrated that the LC50 for 24 h, 48 h, 72 h, and 96 h under ammonia stress in M. salmoides were 25.78 mg/L, 24.40 mg/L, 21.90 mg/L, and 19.61 mg/L, respectively. Under ammonia stress, the structures of the tissues were damaged, and the GSH content decreased, while the MDA content increased with the increase in stress time and ammonia concentration. The NO content fluctuated significantly after the ammonia nitrogen stress. In the 15-day feeding test, with the increased NCG addition amount and feeding time, the GSH content increased while the MDA and NO contents decreased gradually in the NCG addition groups (NL group: 150 mg/kg; NM group: 450 mg/kg; NH group: 750 mg/kg) when compared with their control group (CK group: 0 mg/kg). In the ammonia toxicology test after feeding, the damage to each tissue was alleviated in the NL, NM, and NH groups, and the contents of GSH, MDA, and NO in most tissues of the NH group were significantly different from those in the CK group. The results suggested that ammonia stress caused tissue damage in M. salmoides, provoking oxidative stress and inflammatory response. The addition of NCG to the feed enhances the anti-ammonia ability of M. salmoides. Moreover, the gill and liver might be the target organs of ammonia toxicity, and the brain and kidney might be the primary sites where NCG exerts its effects. Our findings could help us to find feasible ways to solve the existing problem of environmental stress in M. salmoides culture.
    Keywords Micropterus salmoides ; ammonia ; ammonium nitrogen ; antidotes ; aquaculture ; brain ; inflammation ; kidneys ; lethal concentration 50 ; liver ; oxidative stress ; protective effect ; toxicity
    Language English
    Dates of publication 2023-0124
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13030397
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Responses of

    Wang, Zhenlu / Guo, Xingchen / Tu, Jiao / Shi, Xuan / Gan, Lei / Zhang, Muzi / Jiang, Haibo / Zhang, Xiaoxue / Shao, Jian

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 3

    Abstract: Ammonia is a common environmental limiting factor in aquaculture. To investigate the effects of ammonia stress and explore the protective effect of N-carbamylglutamate (NCG) ... ...

    Abstract Ammonia is a common environmental limiting factor in aquaculture. To investigate the effects of ammonia stress and explore the protective effect of N-carbamylglutamate (NCG) on
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13030397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Meta analysis for interventional effect on unexpected injury among children and adolescents in China].

    Liu, Siyun / Hu, Ming / Chang, Yan / Chen, Hui / Tu, Jiao

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2016  Volume 41, Issue 5, Page(s) 527–533

    Abstract: Objective: To comprehensively evaluate the interventional effect on unexpected injury among children and adolescents in China, and to provide scientific basis for the injury control strategy.
: Methods: Meta analysis was utilized to analyze the ... ...

    Abstract Objective: To comprehensively evaluate the interventional effect on unexpected injury among children and adolescents in China, and to provide scientific basis for the injury control strategy.

    Methods: Meta analysis was utilized to analyze the selected literatures. After heterogeneity test of the data, a relevant model was chosen to estimate the combined effect values relative risk (RR) and the corresponding 95% confidence interval (95% CI). Subgroup analysis were performed based on the intervention measures, objects and places. Sensitivity and publication bias were analyzed.

    Results: A total of 18 papers were included in the Meta analysis with a sample size of 32 599. The combined RR value was 0.54 (95% CI 0.44 to 0.68). Subgroup analysis showed that the RR value of health education and comprehensive intervention were 0.59 and 0.50, respectively, with no significant difference between them (P>0.05). The RR values of the interventions in school alone, in school and community or in community alone were 0.51, 0.78 or 0.63. The RR values on children alone, children and parents or parents alone were 0.53, 0.65 or 0.35. The differences were significant when the interventions were performed among different places or objects (P<0.05). Sensitivity analysis revealed that meta-analysis results were relatively stable.

    Conclusion: The targeted interventions were significant in the prevention of unexpected injuries among children and adolescents. It is worth further promoting and spreading.
    MeSH term(s) Adolescent ; Child ; China ; Humans ; Schools ; Wounds and Injuries/epidemiology ; Wounds and Injuries/prevention & control
    Language Chinese
    Publishing date 2016-05
    Publishing country China
    Document type English Abstract ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2016.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [COMT genetic variation and clinical response to antipsychotic drug treatment: A Meta-analysis].

    Chen, Hui / Tu, Jiao / Ni, Ping / Zhang, Wei / Xu, Linyong

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2015  Volume 40, Issue 6, Page(s) 623–631

    Abstract: Objective: To examine the relationship between COMT polymorphisms and the response to antipsychotic drugs, and then provide a basis for personalized medicine of antipsychotic drugs.
: Methods: We performed a systematic search from PubMed, Embase, ... ...

    Abstract Objective: To examine the relationship between COMT polymorphisms and the response to antipsychotic drugs, and then provide a basis for personalized medicine of antipsychotic drugs.

    Methods: We performed a systematic search from PubMed, Embase, Cochrane Library, CBM, CNKI, VIP and Wanfang database for eligible studies. Stata 12.0 was used for Meta-analysis after evaluating the quality of studies and collecting the data.

    Results: Nine studies included 868 participants met inclusion criteria. Significant association was found between the COMT Val108/158Met gene polymorphism and antipsychotic drug efficacy. Evaluating the therapeutic efficacy through general symptoms: Met vs Val, RR=1.18, 95% CI: 1.04-1.35, P=0.013; Met/Met vs Val/Val, RR=1.40, 95% CI: 1.08-1.82, P=0.010. Evaluating the therapeutic efficacy through negative symptoms: Met vs Val, RR=1.24, 95% CI: 1.05-1.46, P=0.013; Met/Met vs Val/Val, RR=1.60, 95% CI: 1.04-2.46, P=0.031.

    Conclusion: COMT Val108/158Met gene polymorphism is significantly associated with antipsychotic drug efficacy, and Met gene is a dominant gene which displays a better response to antipsychotic drugs.
    MeSH term(s) Antipsychotic Agents/therapeutic use ; Catechol O-Methyltransferase/genetics ; Humans ; Polymorphism, Genetic
    Chemical Substances Antipsychotic Agents ; COMT protein, human (EC 2.1.1.6) ; Catechol O-Methyltransferase (EC 2.1.1.6)
    Language Chinese
    Publishing date 2015-07-10
    Publishing country China
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2015.06.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Prevalence and risk factors associated with hypertension in the Chinese Qiang population.

    Huang, Xiao-Bo / Chen, Fei / Dai, Wen / Song, Lei / Tu, Jiao / Xu, Jun-Bo / Liu, Jian-Xiong / Yi, Yan-Jing / Liu, Ya / Chen, Yong / Wang, Tzung-Dau / Zhao, Shui-Ping

    Clinical and experimental hypertension (New York, N.Y. : 1993)

    2017  Volume 40, Issue 5, Page(s) 427–433

    Abstract: Our aim is to investigate the prevalence and risk factors associated with hypertension among the Chinese Qiang population. From September 2012 to March 2013, a cross-sectional study was conducted in urban and rural communities of the Qiang population ... ...

    Abstract Our aim is to investigate the prevalence and risk factors associated with hypertension among the Chinese Qiang population. From September 2012 to March 2013, a cross-sectional study was conducted in urban and rural communities of the Qiang population using multistage cluster sampling. A total of 2676 people aged above 20 years were enrolled in the analysis. Standardized mercury sphygmomanometer was used to measure the blood pressure twice after a 10-minute seated rest, and the average blood pressure was obtained. The hypertension prevalence among the population aged above 20 years was 13.9%, and age-standardized prevalence was 12.3%. Male and female prevalence of hypertension, as well as the prevalence in urban and rural areas, all increased with age. There were no significant differences between males and females and between urban and rural residents. Among hypertensive patients, 44.2% were aware of their hypertension, 38.0% were undergoing antihypertensive treatment, but only 10.5% achieved blood pressure control. Multivariate logistic regression analysis showed that the risk factors of hypertension included age, low income, overweight and obesity, family history of hypertension. The prevalence of hypertension in Chinese Qiang adults is significantly lower than the national level. Awareness, treatment, and control rates of hypertension were low in the Qiang population. Thus, hypertension-related health knowledge should be more aggressively delivered to improve public awareness and the capacity of community health services should be strengthened.
    MeSH term(s) Adult ; Age Factors ; Aged ; Antihypertensive Agents/therapeutic use ; Asian Continental Ancestry Group/statistics & numerical data ; Blood Pressure ; China/epidemiology ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Hypertension/drug therapy ; Hypertension/ethnology ; Hypertension/genetics ; Income ; Male ; Middle Aged ; Obesity/epidemiology ; Prevalence ; Risk Factors ; Rural Population/statistics & numerical data ; Urban Population/statistics & numerical data ; Young Adult
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2017-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 604757-9
    ISSN 1525-6006 ; 0730-0077
    ISSN (online) 1525-6006
    ISSN 0730-0077
    DOI 10.1080/10641963.2017.1392553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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