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Article ; Online: Ethical Considerations of Wearable Technologies in Human Research.

Tu, Jiaobing / Gao, Wei

2021 Volume 10, Issue 17, Page(s) e2100127

Abstract: Wearable technologies hold great promise for disease diagnosis and patient care. Despite the flourishing research activities in this field, only a handful of wearable devices are commercialized and cleared for medical usage. The successful translation of ...

Abstract	Wearable technologies hold great promise for disease diagnosis and patient care. Despite the flourishing research activities in this field, only a handful of wearable devices are commercialized and cleared for medical usage. The successful translation of current proof-of-concept prototypes requires extensive in-human testing. There is a lag between current standards and operation protocols to guide the responsible and ethical conduct of researchers in such in-human studies and the rapid development of the field. This essay presents relevant ethical concerns in early-stage human research from a researcher's perspective.
MeSH term(s)	Humans ; Wearable Electronic Devices
Language	English
Publishing date	2021-04-18
Publishing country	Germany
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202100127
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Spray-on magnetic skin for robotic actuation.

Tu, Jiaobing / Gao, Wei

Science robotics

2020 Volume 5, Issue 48

Abstract: A minimalist robot construction strategy offers versatility and compatibility in actuating diverse objects on demand. ...

Abstract	A minimalist robot construction strategy offers versatility and compatibility in actuating diverse objects on demand.
Language	English
Publishing date	2020-10-28
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2470-9476
ISSN (online)	2470-9476
DOI	10.1126/scirobotics.abf1390
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Skin-Interfaced Wearable Sweat Sensors for Precision Medicine.

Min, Jihong / Tu, Jiaobing / Xu, Changhao / Lukas, Heather / Shin, Soyoung / Yang, Yiran / Solomon, Samuel A / Mukasa, Daniel / Gao, Wei

Chemical reviews

2023 Volume 123, Issue 8, Page(s) 5049–5138

Abstract: Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward personalized healthcare. Advances in flexible electronics, materials science, and electrochemistry have spurred the ... ...

Abstract	Wearable sensors hold great potential in empowering personalized health monitoring, predictive analytics, and timely intervention toward personalized healthcare. Advances in flexible electronics, materials science, and electrochemistry have spurred the development of wearable sweat sensors that enable the continuous and noninvasive screening of analytes indicative of health status. Existing major challenges in wearable sensors include: improving the sweat extraction and sweat sensing capabilities, improving the form factor of the wearable device for minimal discomfort and reliable measurements when worn, and understanding the clinical value of sweat analytes toward biomarker discovery. This review provides a comprehensive review of wearable sweat sensors and outlines state-of-the-art technologies and research that strive to bridge these gaps. The physiology of sweat, materials, biosensing mechanisms and advances, and approaches for sweat induction and sampling are introduced. Additionally, design considerations for the system-level development of wearable sweat sensing devices, spanning from strategies for prolonged sweat extraction to efficient powering of wearables, are discussed. Furthermore, the applications, data analytics, commercialization efforts, challenges, and prospects of wearable sweat sensors for precision medicine are discussed.
MeSH term(s)	Biosensing Techniques ; Electronics ; Monitoring, Physiologic ; Precision Medicine ; Sweat ; Wearable Electronic Devices ; Skin
Language	English
Publishing date	2023-03-27
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	207949-5
ISSN	1520-6890 ; 0009-2665
ISSN (online)	1520-6890
ISSN	0009-2665
DOI	10.1021/acs.chemrev.2c00823
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Article ; Online: All-printed soft human-machine interface for robotic physicochemical sensing.

Yu, You / Li, Jiahong / Solomon, Samuel A / Min, Jihong / Tu, Jiaobing / Guo, Wei / Xu, Changhao / Song, Yu / Gao, Wei

Science robotics

2022 Volume 7, Issue 67, Page(s) eabn0495

Abstract: Ultrasensitive multimodal physicochemical sensing for autonomous robotic decision-making has numerous applications in agriculture, security, environmental protection, and public health. Previously reported robotic sensing technologies have primarily ... ...

Abstract	Ultrasensitive multimodal physicochemical sensing for autonomous robotic decision-making has numerous applications in agriculture, security, environmental protection, and public health. Previously reported robotic sensing technologies have primarily focused on monitoring physical parameters such as pressure and temperature. Integrating chemical sensors for autonomous dry-phase analyte detection on a robotic platform is rather extremely challenging and substantially underdeveloped. Here, we introduce an artificial intelligence-powered multimodal robotic sensing system (M-Bot) with an all-printed mass-producible soft electronic skin-based human-machine interface. A scalable inkjet printing technology with custom-developed nanomaterial inks was used to manufacture flexible physicochemical sensor arrays for electrophysiology recording, tactile perception, and robotic sensing of a wide range of hazardous materials including nitroaromatic explosives, pesticides, nerve agents, and infectious pathogens such as SARS-CoV-2. The M-Bot decodes the surface electromyography signals collected from the human body through machine learning algorithms for remote robotic control and can perform in situ threat compound detection in extreme or contaminated environments with user-interactive tactile and threat alarm feedback. The printed electronic skin-based robotic sensing technology can be further generalized and applied to other remote sensing platforms. Such diversity was validated on an intelligent multimodal robotic boat platform that can efficiently track the source of trace amounts of hazardous compounds through autonomous and intelligent decision-making algorithms. This fully printed human-machine interactive multimodal sensing technology could play a crucial role in designing future intelligent robotic systems and can be easily reconfigured toward numerous practical wearable and robotic applications.
MeSH term(s)	Artificial Intelligence ; COVID-19 ; Humans ; Robotic Surgical Procedures ; SARS-CoV-2 ; Wearable Electronic Devices
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	2470-9476
ISSN (online)	2470-9476
DOI	10.1126/scirobotics.abn0495
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds.

Shirzaei Sani, Ehsan / Xu, Changhao / Wang, Canran / Song, Yu / Min, Jihong / Tu, Jiaobing / Solomon, Samuel A / Li, Jiahong / Banks, Jaminelli L / Armstrong, David G / Gao, Wei

Science advances

2023 Volume 9, Issue 12, Page(s) eadf7388

Abstract: Chronic nonhealing wounds are one of the major and rapidly growing clinical complications all over the world. Current therapies frequently require emergent surgical interventions, while abuse and misapplication of therapeutic drugs often lead to an ... ...

Abstract	Chronic nonhealing wounds are one of the major and rapidly growing clinical complications all over the world. Current therapies frequently require emergent surgical interventions, while abuse and misapplication of therapeutic drugs often lead to an increased morbidity and mortality rate. Here, we introduce a wearable bioelectronic system that wirelessly and continuously monitors the physiological conditions of the wound bed via a custom-developed multiplexed multimodal electrochemical biosensor array and performs noninvasive combination therapy through controlled anti-inflammatory antimicrobial treatment and electrically stimulated tissue regeneration. The wearable patch is fully biocompatible, mechanically flexible, stretchable, and can conformally adhere to the skin wound throughout the entire healing process. Real-time metabolic and inflammatory monitoring in a series of preclinical in vivo experiments showed high accuracy and electrochemical stability of the wearable patch for multiplexed spatial and temporal wound biomarker analysis. The combination therapy enabled substantially accelerated cutaneous chronic wound healing in a rodent model.
MeSH term(s)	Wearable Electronic Devices ; Biosensing Techniques ; Combined Modality Therapy ; Wound Healing
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adf7388
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A wireless patch for the monitoring of C-reactive protein in sweat.

Tu, Jiaobing / Min, Jihong / Song, Yu / Xu, Changhao / Li, Jiahong / Moore, Jeff / Hanson, Justin / Hu, Erin / Parimon, Tanyalak / Wang, Ting-Yu / Davoodi, Elham / Chou, Tsui-Fen / Chen, Peter / Hsu, Jeffrey J / Rossiter, Harry B / Gao, Wei

Nature biomedical engineering

2023 Volume 7, Issue 10, Page(s) 1293–1306

Abstract: The quantification of protein biomarkers in blood at picomolar-level sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, which would allow for point-of-care monitoring, is hindered by the typically large ... ...

Abstract	The quantification of protein biomarkers in blood at picomolar-level sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, which would allow for point-of-care monitoring, is hindered by the typically large interpersonal and intrapersonal variations in its composition. Here we report the design and performance of a wearable and wireless patch for the real-time electrochemical detection of the inflammatory biomarker C-reactive (CRP) protein in sweat. The device integrates iontophoretic sweat extraction, microfluidic channels for sweat sampling and for reagent routing and replacement, and a graphene-based sensor array for quantifying CRP (via an electrode functionalized with anti-CRP capture antibodies-conjugated gold nanoparticles), ionic strength, pH and temperature for the real-time calibration of the CRP sensor. In patients with chronic obstructive pulmonary disease, with active or past infections or who had heart failure, the elevated concentrations of CRP measured via the patch correlated well with the protein's levels in serum. Wearable biosensors for the real-time sensitive analysis of inflammatory proteins in sweat may facilitate the management of chronic diseases.
MeSH term(s)	Humans ; Sweat/chemistry ; Wearable Electronic Devices ; C-Reactive Protein/analysis ; C-Reactive Protein/metabolism ; Gold ; Monitoring, Physiologic ; Metal Nanoparticles ; Biomarkers/metabolism
Chemical Substances	C-Reactive Protein (9007-41-4) ; Gold (7440-57-5) ; Biomarkers
Language	English
Publishing date	2023-06-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2157-846X
ISSN (online)	2157-846X
DOI	10.1038/s41551-023-01059-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A wearable electrochemical biosensor for the monitoring of metabolites and nutrients.

Wang, Minqiang / Yang, Yiran / Min, Jihong / Song, Yu / Tu, Jiaobing / Mukasa, Daniel / Ye, Cui / Xu, Changhao / Heflin, Nicole / McCune, Jeannine S / Hsiai, Tzung K / Li, Zhaoping / Gao, Wei

Nature biomedical engineering

2022 Volume 6, Issue 11, Page(s) 1225–1235

Abstract: Wearable non-invasive biosensors for the continuous monitoring of metabolites in sweat can detect a few analytes at sufficiently high concentrations, typically during vigorous exercise so as to generate sufficient quantity of the biofluid. Here we report ...

Abstract	Wearable non-invasive biosensors for the continuous monitoring of metabolites in sweat can detect a few analytes at sufficiently high concentrations, typically during vigorous exercise so as to generate sufficient quantity of the biofluid. Here we report the design and performance of a wearable electrochemical biosensor for the continuous analysis, in sweat during physical exercise and at rest, of trace levels of multiple metabolites and nutrients, including all essential amino acids and vitamins. The biosensor consists of graphene electrodes that can be repeatedly regenerated in situ, functionalized with metabolite-specific antibody-like molecularly imprinted polymers and redox-active reporter nanoparticles, and integrated with modules for iontophoresis-based sweat induction, microfluidic sweat sampling, signal processing and calibration, and wireless communication. In volunteers, the biosensor enabled the real-time monitoring of the intake of amino acids and their levels during physical exercise, as well as the assessment of the risk of metabolic syndrome (by correlating amino acid levels in serum and sweat). The monitoring of metabolites for the early identification of abnormal health conditions could facilitate applications in precision nutrition.
MeSH term(s)	Humans ; Wearable Electronic Devices ; Monitoring, Physiologic ; Sweat/chemistry ; Biosensing Techniques ; Nutrients
Language	English
Publishing date	2022-08-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ISSN	2157-846X
ISSN (online)	2157-846X
DOI	10.1038/s41551-022-00916-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: SARS-CoV-2 RapidPlex: A Graphene-Based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring.

Torrente-Rodríguez, Rebeca M / Lukas, Heather / Tu, Jiaobing / Min, Jihong / Yang, Yiran / Xu, Changhao / Rossiter, Harry B / Gao, Wei

Matter

2020 Volume 3, Issue 6, Page(s) 1981–1998

Abstract: The COVID-19 pandemic is an ongoing global challenge for public health systems. Ultrasensitive and early identification of infection is critical in preventing widespread COVID-19 infection by presymptomatic and asymptomatic individuals, especially in the ...

Abstract	The COVID-19 pandemic is an ongoing global challenge for public health systems. Ultrasensitive and early identification of infection is critical in preventing widespread COVID-19 infection by presymptomatic and asymptomatic individuals, especially in the community and in-home settings. We demonstrate a multiplexed, portable, wireless electrochemical platform for ultra-rapid detection of COVID-19: the SARS-CoV-2 RapidPlex. It detects viral antigen nucleocapsid protein, IgM and IgG antibodies, as well as the inflammatory biomarker C-reactive protein, based on our mass-producible laser-engraved graphene electrodes. We demonstrate ultrasensitive, highly selective, and rapid electrochemical detection in the physiologically relevant ranges. We successfully evaluated the applicability of our SARS-CoV-2 RapidPlex platform with COVID-19-positive and COVID-19-negative blood and saliva samples. Based on this pilot study, our multiplexed immunosensor platform may allow for high-frequency at-home testing for COVID-19 telemedicine diagnosis and monitoring.
Keywords	covid19
Language	English
Publishing date	2020-10-05
Publishing country	United States
Document type	Journal Article
ISSN	2590-2385
ISSN (online)	2590-2385
DOI	10.1016/j.matt.2020.09.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: SARS-CoV-2 RapidPlex: A Graphene-based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring

Torrente-Rodríguez, Rebeca M / Lukas, Heather / Tu, Jiaobing / Min, Jihong / Yang, Yiran / Xu, Changhao / Rossiter, Harry B / Gao, Wei

Abstract: The COVID-19 pandemic is an ongoing global challenge for public health systems. Ultrasensitive and early identification of infection is critical to prevent widespread COVID-19 infection by presymptomatic and asymptomatic individuals, especially in the ... ...

Abstract	The COVID-19 pandemic is an ongoing global challenge for public health systems. Ultrasensitive and early identification of infection is critical to prevent widespread COVID-19 infection by presymptomatic and asymptomatic individuals, especially in the community and in-home settings. We demonstrate a multiplexed, portable, wireless electrochemical platform for ultra-rapid detection of COVID-19: the SARS-CoV-2 RapidPlex. It detects viral antigen nucleocapsid protein, IgM and IgG antibodies, as well as the inflammatory biomarker C-reactive protein, based on our mass-producible laser-engraved graphene electrodes. We demonstrate ultrasensitive, highly selective, and rapid electrochemical detection in the physiologically relevant ranges. We successfully evaluated the applicability of our SARS-CoV-2 RapidPlex platform with COVID-19 positive and negative blood and saliva samples. Based on this pilot study, our multiplexed immunosensor platform may allow for high frequency at-home testing for COVID-19 telemedicine diagnosis and monitoring.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #813729
Database	COVID19

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Article ; Online: SARS-CoV-2 RapidPlex

Torrente-Rodríguez, Rebeca M. / Lukas, Heather / Tu, Jiaobing / Min, Jihong / Yang, Yiran / Xu, Changhao / Rossiter, Harry B. / Gao, Wei

A Graphene-based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring

2020

Abstract	The COVID-19 pandemic is an ongoing global challenge for public health systems. Ultrasensitive and early identification of infection is critical to prevent widespread COVID-19 infection by presymptomatic and asymptomatic individuals, especially in the community and in-home settings. We demonstrate a multiplexed, portable, wireless electrochemical platform for ultra-rapid detection of COVID-19: the SARS-CoV-2 RapidPlex. It detects viral antigen nucleocapsid protein, IgM and IgG antibodies, as well as the inflammatory biomarker C-reactive protein, based on our mass-producible laser-engraved graphene electrodes. We demonstrate ultrasensitive, highly selective, and rapid electrochemical detection in the physiologically relevant ranges. We successfully evaluated the applicability of our SARS-CoV-2 RapidPlex platform with COVID-19 positive and negative blood and saliva samples. Based on this pilot study, our multiplexed immunosensor platform may allow for high frequency at-home testing for COVID-19 telemedicine diagnosis and monitoring.
Keywords	covid19
Publishing date	2020-10-01
Publisher	Elsevier
Publishing country	us
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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