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  1. Article: Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy.

    Tu, Teng / Zhang, Hongying / Xu, Huanji

    Frontiers in oncology

    2023  Volume 13, Page(s) 1197502

    Abstract: Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain ... ...

    Abstract Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain fatty acids in cells. Many studies have implicated that SOAT1 plays a vital role in cancer initiation and progression and is an attractive target for novel anticancer therapy. In this review, we provide an overview of the mechanism and regulation of SOAT1 in cancer and summarize the updates of anticancer therapy targeting SOAT1.
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1197502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Surgery in the era of ChatGPT: A bibliometric analysis based on web of science.

    He, Si-Ke / Tu, Teng / Deng, Bo-Wen / Bai, Yun-Jin

    Asian journal of surgery

    2023  Volume 47, Issue 1, Page(s) 784–785

    MeSH term(s) Bibliometrics ; Surgical Procedures, Operative ; Artificial Intelligence
    Language English
    Publishing date 2023-10-23
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.10.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Progress in investigating the relationship between Schlafen5 genes and malignant tumors.

    Tu, Teng / Yuan, Ye / Liu, Xiaoxue / Liang, Xin / Yang, Xiaofan / Yang, Yue

    Frontiers in oncology

    2023  Volume 13, Page(s) 1248825

    Abstract: The Schlafen5(SLFN5)gene belongs to the third group of the Schlafen protein family. As a tumor suppressor gene, SLFN5 plays a pivotal role in inhibiting tumor growth, orchestrating cell cycle regulation, and modulating the extent of cancer cell ... ...

    Abstract The Schlafen5(SLFN5)gene belongs to the third group of the Schlafen protein family. As a tumor suppressor gene, SLFN5 plays a pivotal role in inhibiting tumor growth, orchestrating cell cycle regulation, and modulating the extent of cancer cell infiltration and metastasis in various malignancies. However, the high expression of SLFN 5 in some tumors was positively correlated with lymph node metastasis, tumor stage, and tumor grade. This article endeavors to elucidate the reciprocal relationship between the SLFN5 gene and malignant tumors, thereby enhancing our comprehension of the intricate mechanisms underlying the SLFN5 gene and its implications for the progression, invasive potential, and metastatic behavior of malignant tumors. At the same time, this paper summarizes the basis of SLFN 5 as a new biomarker of tumor diagnosis and prognosis, and provides new ideas for the target treatment of tumor.
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1248825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diagnostic performance of metagenomic next-generation sequencing for the detection of pathogens in cerebrospinal fluid in pediatric patients with central nervous system infection: a systematic review and meta-analysis.

    He, Sike / Xiong, Ying / Tu, Teng / Feng, Jiaming / Fu, Yu / Hu, Xu / Wang, Neng / Li, Dapeng

    BMC infectious diseases

    2024  Volume 24, Issue 1, Page(s) 103

    Abstract: Background: Detecting pathogens in pediatric central nervous system infection (CNSI) is still a major challenge in medicine. In addition to conventional diagnostic patterns, metagenomic next-generation sequencing (mNGS) shows great potential in pathogen ...

    Abstract Background: Detecting pathogens in pediatric central nervous system infection (CNSI) is still a major challenge in medicine. In addition to conventional diagnostic patterns, metagenomic next-generation sequencing (mNGS) shows great potential in pathogen detection. Therefore, we systematically evaluated the diagnostic performance of mNGS in cerebrospinal fluid (CSF) in pediatric patients with CNSI.
    Methods: Related literature was searched in the Web of Science, PubMed, Embase, and Cochrane Library. We screened the literature and extracted the data according to the selection criteria. The quality of included studies was assessed by the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool and the certainty of the evidence was measured by the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) score system. Then, the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odd's ratio (DOR), and area under the curve (AUC) of the summary receiver operating characteristic curve (sROC) were estimated in Stata Software and MetaDisc. Subgroup analyses were performed to investigate the potential factors that influence the diagnostic performance.
    Results: A total of 10 studies were included in the meta-analysis. The combined sensitivity was 0.68 (95% confidence interval [CI]: 0.59 to 0.76, I
    Conclusions: Current evidence shows that mNGS presents a good diagnostic performance in pediatric CNSI. Due to the limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusion.
    MeSH term(s) Humans ; Child ; ROC Curve ; Central Nervous System Infections/diagnosis ; High-Throughput Nucleotide Sequencing
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2041550-3
    ISSN 1471-2334 ; 1471-2334
    ISSN (online) 1471-2334
    ISSN 1471-2334
    DOI 10.1186/s12879-024-09010-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Pan-genome analysis of

    Zhou, You / Tu, Teng / Yao, Xueping / Luo, Yan / Yang, Zexiao / Ren, Meishen / Zhang, Ge / Yu, Yuanyuan / Lu, Aiping / Wang, Yin

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1362316

    Abstract: Streptococcus ... ...

    Abstract Streptococcus suis
    Language English
    Publishing date 2024-02-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1362316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Detection of a new emerging strain of rabbit haemorrhagic disease virus 2 (GI.2) in China

    Chen Wanting / Tu Teng / Luo Yan / Yang Zexiao / Yao Xueping / Wu Xulong / Wang Yin

    Journal of Veterinary Research, Vol 66, Iss 3, Pp 289-

    2022  Volume 295

    Abstract: In May 2020, an outbreak of rabbit haemorrhagic disease 2 (RHD2) caused by the rabbit haemorrhagic disease virus 2 (RHDV2, GI.2) occurred in Sichuan, China. The acute onset and short disease course resulted in rabbit mortality as high as 42.86%. ... ...

    Abstract In May 2020, an outbreak of rabbit haemorrhagic disease 2 (RHD2) caused by the rabbit haemorrhagic disease virus 2 (RHDV2, GI.2) occurred in Sichuan, China. The acute onset and short disease course resulted in rabbit mortality as high as 42.86%. Currently, basic research on the aetiology and genetic characteristics of GI.2 is lacking in China.
    Keywords china ; rabbit haemorrhagic disease virus 2 ; whole genome sequence ; genetic variation ; Veterinary medicine ; SF600-1100
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article: [Multiple differentiation potential of human periodontal ligament stem cells expressing stromal cell antigen 1 (STRO-1) sorted by MACS].

    Zhao, Ying / Tu, Teng / Feng, Fan / Zhang, Min

    Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

    2020  Volume 36, Issue 11, Page(s) 971–976

    Abstract: Objective To perform in vitro characterization and comparison of stromal cell antigen 1 (STRO-1) positive (STRO- ... ...

    Abstract Objective To perform in vitro characterization and comparison of stromal cell antigen 1 (STRO-1) positive (STRO-1
    MeSH term(s) Antigens, Surface/metabolism ; Cell Differentiation ; Cell Separation ; Cells, Cultured ; Humans ; Osteogenesis ; Periodontal Ligament/cytology ; Stem Cells ; Stromal Cells
    Chemical Substances Antigens, Surface ; STRO-1 antigen, human
    Language Chinese
    Publishing date 2020-11-19
    Publishing country China
    Document type Journal Article
    ISSN 1007-8738
    ISSN 1007-8738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Detection of a New Emerging Strain of Rabbit Haemorrhagic Disease Virus 2 (GI.2) in China.

    Chen, Wanting / Tu, Teng / Luo, Yan / Yang, Zexiao / Yao, Xueping / Wu, Xulong / Wang, Yin

    Journal of veterinary research

    2022  Volume 66, Issue 3, Page(s) 289–295

    Abstract: Introduction: In May 2020, an outbreak of rabbit haemorrhagic disease 2 (RHD2) caused by the rabbit haemorrhagic disease virus 2 (RHDV2, GI.2) occurred in Sichuan, China. The acute onset and short disease course resulted in rabbit mortality as high as ... ...

    Abstract Introduction: In May 2020, an outbreak of rabbit haemorrhagic disease 2 (RHD2) caused by the rabbit haemorrhagic disease virus 2 (RHDV2, GI.2) occurred in Sichuan, China. The acute onset and short disease course resulted in rabbit mortality as high as 42.86%. Currently, basic research on the aetiology and genetic characteristics of GI.2 is lacking in China.
    Material and methods: Pathological changes in various tissues from infected rabbits were investigated and the viral genome was characterised. This study used RT-PCR, histopathology and scanning electron microscopy to identify the pathogen in samples from infected rabbits that had died. Phylogenetic trees were constructed based on whole genome sequence analysis, and recombination events were analysed.
    Results: RT-PCR identified the presence of GI.2. Histopathology revealed liver cell necrosis and haemorrhaging into lung alveoli. Electron microscopy demonstrated spherical GI.2 particles that were 40 nm in size. The gene sequence length of the isolate was 7,445 bp (GenBank accession number MW178244). A phylogenetic analysis based on the genome of the isolated strain and 60 reference strains showed that the isolate was grouped together with GI.2 strain MT586027.1 in a relatively independent sub-branch. The results of the recombination analysis showed that the strain was recombined from the MT586027.1 (major parent) and MN90145.1 (minor parent) strains, and recombination breakpoints were at locations in the 2858-5137 nt range.
    Conclusion: The results of this study extend our understanding of the molecular epidemiology of GI.2.
    Language English
    Publishing date 2022-09-14
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2855010-9
    ISSN 2450-8608 ; 2450-7393
    ISSN (online) 2450-8608
    ISSN 2450-7393
    DOI 10.2478/jvetres-2022-0048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Epidemiological investigation and pathogenicity of porcine reproductive and respiratory syndrome virus in Sichuan, China.

    Jiang, Dike / Tu, Teng / Zhou, You / Li, Yanwei / Luo, Yan / Yao, Xueping / Yang, Zexiao / Ren, Meishen / Wang, Yin

    Frontiers in microbiology

    2023  Volume 14, Page(s) 1241354

    Abstract: Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) lineage 8 was first detected in mainland China in 2006 and has since rapidly spread to become the primary epidemic strain in the country. In this study, samples such as lung tissue, ... ...

    Abstract Porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2) lineage 8 was first detected in mainland China in 2006 and has since rapidly spread to become the primary epidemic strain in the country. In this study, samples such as lung tissue, hilar lymph nodes, abortion fetuses, and blood were collected from large-scale pig farms across 11 prefecture-level cities in Sichuan province between 2019 and 2020 for antigen detection and PRRS virus isolation. The antigen detection results indicated that the positive rate of HP-PRRSV (JXA1-Like strain) was 44.74% (51/114), NADC30-Like PRRSV was 17.54% (20/114), and classical PRRSV (VR2332-Like strain) was 37.72% (43/114). The predominant strain was HP-PRRSV. Positive samples were further inoculated into Marc-145 cells for virus isolation and identification, leading to the isolation of a new JXA1-Like PRRSV strain named SCSN2020. The strain was characterized by RT-qPCR, indirect immunofluorescence assay (IFA), plaque purification, electron microscopy, and whole genome sequencing. The total length of the viral genome was determined to be approximately 15,374 bp. A comparison of the SCSN2020 genome with VR2332 revealed that both strains had the same discontinuous 30-amino acid deletion on the Nsp2 gene. ORF5 genotyping classified the SCSN2020 strain as sublineage 8.7, with a whole genome sequence identity of 99.34% with JXA1. Furthermore, we evaluated the pathogenicity of the SCSN2020 strain in 28-day-old piglets and observed persistent fever from day 4 to day 10, weight loss started on day 7, dyspnea and severe lung lesions began started on day 14. The results of this study highlight the current PRRSV epidemic situation in Sichuan province and provide a scientific reference for subsequent prevention and control measures.
    Language English
    Publishing date 2023-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2023.1241354
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: RVG Peptide-Functionalized Favipiravir Nanoparticle Delivery System Facilitates Antiviral Therapy of Neurotropic Virus Infection in a Mouse Model.

    Ren, Meishen / Zhou, You / Tu, Teng / Jiang, Dike / Pang, Maonan / Li, Yanwei / Luo, Yan / Yao, Xueping / Yang, Zexiao / Wang, Yin

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Neurotropic viruses severely damage the central nervous system (CNS) and human health. Common neurotropic viruses include rabies virus (RABV), Zika virus, and poliovirus. When treating neurotropic virus infection, obstruction of the blood-brain barrier ( ... ...

    Abstract Neurotropic viruses severely damage the central nervous system (CNS) and human health. Common neurotropic viruses include rabies virus (RABV), Zika virus, and poliovirus. When treating neurotropic virus infection, obstruction of the blood-brain barrier (BBB) reduces the efficiency of drug delivery to the CNS. An efficient intracerebral delivery system can significantly increase intracerebral delivery efficiency and facilitate antiviral therapy. In this study, a rabies virus glycopeptide (RVG) functionalized mesoporous silica nanoparticle (MSN) packaging favipiravir (T-705) was developed to generate T-705@MSN-RVG. It was further evaluated for drug delivery and antiviral treatment in a VSV-infected mouse model. The RVG, a polypeptide consisting of 29 amino acids, was conjugated on the nanoparticle to enhance CNS delivery. The T-705@MSN-RVG caused a significant decrease in virus titers and virus proliferation without inducing substantial cell damage in vitro. By releasing T-705, the nanoparticle promoted viral inhibition in the brain during infection. At 21 days post-infection (dpi), a significantly enhanced survival ratio (77%) was observed in the group inoculated with nanoparticle compared with the non-treated group (23%). The viral RNA levels were also decreased in the therapy group at 4 and 6 dpi compared with that of the control group. The T-705@MSN-RVG could be considered a promising system for CNS delivery for treating neurotropic virus infection.
    MeSH term(s) Humans ; Animals ; Mice ; Rabies virus/physiology ; Glycopeptides ; Peptides/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Virus Diseases ; Nanoparticles ; Zika Virus ; Zika Virus Infection
    Chemical Substances rabies virus glycoprotein peptide ; favipiravir (EW5GL2X7E0) ; Glycopeptides ; Peptides ; Antiviral Agents
    Language English
    Publishing date 2023-03-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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