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  1. Article ; Online: Publication interests and priorities for Insect Molecular Biology.

    Brisson, Jennifer / Asgari, Sassan / Tu, Zhijian

    Insect molecular biology

    2024  

    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Editorial
    ZDB-ID 33602-6
    ISSN 1365-2583 ; 0962-1075
    ISSN (online) 1365-2583
    ISSN 0962-1075
    DOI 10.1111/imb.12906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The novel mechanism facilitating chronic hepatitis B infection: immunometabolism and epigenetic modification reprogramming.

    Wang, Zhengmin / Liu, Nan / Yang, Yang / Tu, Zhengkun

    Frontiers in immunology

    2024  Volume 15, Page(s) 1349867

    Abstract: Hepatitis B Virus (HBV) infections pose a global public health challenge. Despite extensive research on this disease, the intricate mechanisms underlying persistent HBV infection require further in-depth elucidation. Recent studies have revealed the ... ...

    Abstract Hepatitis B Virus (HBV) infections pose a global public health challenge. Despite extensive research on this disease, the intricate mechanisms underlying persistent HBV infection require further in-depth elucidation. Recent studies have revealed the pivotal roles of immunometabolism and epigenetic reprogramming in chronic HBV infection. Immunometabolism have identified as the process, which link cell metabolic status with innate immunity functions in response to HBV infection, ultimately contributing to the immune system's inability to resolve Chronic Hepatitis B (CHB). Within hepatocytes, HBV replication leads to a stable viral covalently closed circular DNA (cccDNA) minichromosome located in the nucleus, and epigenetic modifications in cccDNA enable persistence of infection. Additionally, the accumulation or depletion of metabolites not only directly affects the function and homeostasis of immune cells but also serves as a substrate for regulating epigenetic modifications, subsequently influencing the expression of antiviral immune genes and facilitating the occurrence of sustained HBV infection. The interaction between immunometabolism and epigenetic modifications has led to a new research field, known as metabolic epigenomics, which may form a mutually reinforcing relationship with CHB. Herein, we review the recent studies on immunometabolism and epigenetic reprogramming in CHB infection and discuss the potential mechanisms of persistent HBV infection. A deeper understanding of these mechanisms will offer novel insights and targets for intervention strategies against chronic HBV infection, thereby providing new hope for the treatment of related diseases.
    MeSH term(s) Humans ; Hepatitis B, Chronic/genetics ; Virus Replication/genetics ; Hepatitis B ; Hepatitis B virus ; Epigenesis, Genetic
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1349867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Poly(butylene oxalate-co-terephthalate): A PBAT-like but rapid hydrolytic degradation plastic.

    Wang, Lizheng / Tu, Zhu / Liang, Jiaming / Wei, Zhiyong

    Journal of hazardous materials

    2024  Volume 471, Page(s) 134349

    Abstract: Concerns over worldwide plastic pollution have led to the development of biodegradable polyester materials with excellent physical and chemical properties through the copolymerization of poly(butylene oxalate) (PBOx). As a result, poly(butylene oxalate- ... ...

    Abstract Concerns over worldwide plastic pollution have led to the development of biodegradable polyester materials with excellent physical and chemical properties through the copolymerization of poly(butylene oxalate) (PBOx). As a result, poly(butylene oxalate-co-terephthalate)s (PBOTs) with varying compositions, were prepared by incorporating aromatic units. Studies have indicated that PBOT-47 (with a 47% molar terephthalate), exhibits exceptional mechanical properties. With an elongation at break of 1160% and a tensile strength that remains above 30 MPa, similar to or even better than those of the commercial biodegradable plastic poly(butylene adipate-co-terephthalate) PBAT-47 (47% molar terephthalate). Moreover, the permeability coefficients of PBAT-47 for H
    Language English
    Publishing date 2024-04-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.134349
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  4. Book ; Online: Predicting Eye Fixations Under Distortion Using Bayesian Observers

    Tu, Zhengzhong

    2021  

    Abstract: Visual attention is very an essential factor that affects how human perceives visual signals. This report investigates how distortions in an image could distract human's visual attention using Bayesian visual search models, specifically, Maximum-a- ... ...

    Abstract Visual attention is very an essential factor that affects how human perceives visual signals. This report investigates how distortions in an image could distract human's visual attention using Bayesian visual search models, specifically, Maximum-a-posteriori (MAP) \cite{findlay1982global}\cite{eckstein2001quantifying} and Entropy Limit Minimization (ELM) \cite{najemnik2009simple}, which predict eye fixation movements based on a Bayesian probabilistic framework. Experiments on modified MAP and ELM models on JPEG-compressed images containing blocking or ringing artifacts were conducted and we observed that compression artifacts can affect visual attention. We hope this work sheds light on the interactions between visual attention and perceptual quality.

    Comment: 18 pages, single-column. Project report
    Keywords Electrical Engineering and Systems Science - Image and Video Processing ; Computer Science - Computer Vision and Pattern Recognition
    Subject code 700
    Publishing date 2021-02-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Development of poly(n-alkylene oxalate)s toward a new kind of seawater degradable plastics

    Tu, Z. / Lu, Y. / Zhang, Y. / Li, Y. / Wei, Z.

    Materials Today Sustainability. 2023 June, v. 22 p.100378-

    2023  

    Abstract: The preparation and development of polyester materials with appropriate degradability, especially in the marine environment, have become the primary choice to solve the problem of environmental pollution in the context of the increasingly popular concept ...

    Abstract The preparation and development of polyester materials with appropriate degradability, especially in the marine environment, have become the primary choice to solve the problem of environmental pollution in the context of the increasingly popular concept of environmental protection. In this work, a series of sustainable and biodegradable poly(n-alkylene oxalate)s (PAOx) were synthesized with dimethyl oxalate and n-alkylene diols. Special emphasis was given to the studies of the reactivity of diols, thermal behavior, and degradation performance of PAOx. Results showed that the crystallization-melting behaviors of PAOx performed a significant parity effect with various n, which was reflected in that PAOx with n = even had higher crystallization and melting temperatures than those of n = odd. More appealingly, the PAOx with lower n exhibited better heat resistance and outstanding seawater degradability. Accordingly, the current work systematically revealed the influences of molecular chain aggregate structure on the macroscopic properties of PAOx materials, highlighting the potential commercial opportunity of PAOx materials towards seawater degradable plastics.
    Keywords crystallization ; environmental protection ; glycols ; heat tolerance ; marine environment ; oxalates ; pollution ; polyesters ; seawater ; thermal properties ; Polyoxalates ; Parity effect ; Seawater degradable plastics
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ISSN 2589-2347
    DOI 10.1016/j.mtsust.2023.100378
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Natural and Engineered Sex Ratio Distortion in Insects.

    Compton, Austin / Tu, Zhijian

    Frontiers in ecology and evolution

    2022  Volume 10

    Abstract: Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively balanced male to female sex ratio is generally expected. However, selection may shift the optimal sex ratio while meiotic drive and endosymbiont manipulation can ... ...

    Abstract Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively balanced male to female sex ratio is generally expected. However, selection may shift the optimal sex ratio while meiotic drive and endosymbiont manipulation can result in sex ratio distortion (SRD). Recent advances in sex chromosome genomics and CRISPR/Cas9-mediated genome editing brought significant insights into the molecular regulators of sex determination in an increasing number of insects and provided new ways to engineer SRD. We review these advances and discuss both naturally occurring and engineered SRD in the context of the Anthropocene. We emphasize SRD-mediated biological control of insects to help improve One Health, sustain agriculture, and conserve endangered species.
    Language English
    Publishing date 2022-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2745634-1
    ISSN 2296-701X
    ISSN 2296-701X
    DOI 10.3389/fevo.2022.884159
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  7. Article ; Online: In vivo

    Tu, Zhenbo / Karnoub, Antoine E

    STAR protocols

    2022  Volume 3, Issue 2, Page(s) 101413

    Abstract: We provide a protocol for gain-of-function (GOF) cDNA screen of genes that foster cancer cell colonization of secondary tissues, the last and most lethal step of the metastasis cascade. We present techniques for cDNA viral library preparation and ... ...

    Abstract We provide a protocol for gain-of-function (GOF) cDNA screen of genes that foster cancer cell colonization of secondary tissues, the last and most lethal step of the metastasis cascade. We present techniques for cDNA viral library preparation and delivery leading up to the recovery of colonization-promoting sequences in a proof-of-concept DU145-based mouse model of pulmonary metastasis. Adapted to other cDNA libraries and cancer models, this approach would prove widely useful in enumerating intrinsic genetic determinants underlying metastatic colonization. For complete details on the use and execution of this protocol, please refer to Tu et al. (2021).
    MeSH term(s) Animals ; DNA, Complementary/genetics ; Disease Models, Animal ; Gain of Function Mutation ; Gene Library ; Lung Neoplasms/genetics ; Mice
    Chemical Substances DNA, Complementary
    Language English
    Publishing date 2022-05-25
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Role of ATP-dependent chromatin remodelers in hematopoietic stem and progenitor cell maintenance.

    Tu, Zhaowei / Zheng, Yi

    Current opinion in hematology

    2022  Volume 29, Issue 4, Page(s) 174–180

    Abstract: Purpose of review: ATP-dependent chromatin remodeling factors utilize energy from ATP hydrolysis to modulate DNA-histone structures and regulate gene transcription. They are essential during hematopoiesis and for hematopoietic stem and progenitor cell ( ... ...

    Abstract Purpose of review: ATP-dependent chromatin remodeling factors utilize energy from ATP hydrolysis to modulate DNA-histone structures and regulate gene transcription. They are essential during hematopoiesis and for hematopoietic stem and progenitor cell (HSPC) function. This review discusses the recently unveiled roles of these chromatin remodelers in HSPC regulation, with an emphasis on the mechanism of chromodomain helicase DNA-binding (CHD) family members.
    Recent findings: Recent studies of ATP-dependent chromatin remodelers have revealed that individual CHD family members engage in distinct mechanisms in regulating HSPC cell fate. For example, CHD8 is required for HSPC survival by restricting both P53 transcriptional activity and protein stability in steady state hematopoiesis while the related CHD7 physically interacts with RUNX family transcription factor 1 (RUNX1) and suppresses RUNX1-induced expansion of HSPCs during blood development. Moreover, other CHD subfamily members such as CHD1/CHD2 and CHD3/CHD4, as well as the switch/sucrose non-fermentable, imitation SWI, and SWI2/SNF2 related (SWR) families of chromatin modulators, have also been found important for HSPC maintenance by distinct mechanisms.
    Summary: The expanding knowledge of ATP-dependent chromatin remodelers in hematopoiesis illustrates their respective critical roles in HSPC maintenance including the regulation of HSPC differentiation, survival, and self-renewal. Further studies are warranted to elucidate how different chromatin remodeling complexes are integrated in various HSPC cell fate decisions during steady-state and stress hematopoiesis.
    MeSH term(s) Adenosine Triphosphate ; Chromatin/genetics ; Core Binding Factor Alpha 2 Subunit ; Hematopoietic Stem Cells ; Histones ; Humans
    Chemical Substances Chromatin ; Core Binding Factor Alpha 2 Subunit ; Histones ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2022-02-18
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3703: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Permutation Invariant Graph-to-Sequence Model for Template-Free Retrosynthesis and Reaction Prediction.

    Tu, Zhengkai / Coley, Connor W

    Journal of chemical information and modeling

    2022  Volume 62, Issue 15, Page(s) 3503–3513

    Abstract: Synthesis planning and reaction outcome prediction are two fundamental problems in computer-aided organic chemistry for which a variety of data-driven approaches have emerged. Natural language approaches that model each problem as a SMILES-to-SMILES ... ...

    Abstract Synthesis planning and reaction outcome prediction are two fundamental problems in computer-aided organic chemistry for which a variety of data-driven approaches have emerged. Natural language approaches that model each problem as a SMILES-to-SMILES translation lead to a simple end-to-end formulation, reduce the need for data preprocessing, and enable the use of well-optimized machine translation model architectures. However, SMILES representations are not efficient for capturing information about molecular structures, as evidenced by the success of SMILES augmentation to boost empirical performance. Here, we describe a novel Graph2SMILES model that combines the power of Transformer models for text generation with the permutation invariance of molecular graph encoders that mitigates the need for input data augmentation. In our encoder, a directed message passing neural network (D-MPNN) captures local chemical environments, and the global attention encoder allows for long-range and intermolecular interactions, enhanced by graph-aware positional embedding. As an end-to-end architecture, Graph2SMILES can be used as a drop-in replacement for the Transformer in any task involving molecule(s)-to-molecule(s) transformations, which we empirically demonstrate leads to improved performance on existing benchmarks for both retrosynthesis and reaction outcome prediction.
    MeSH term(s) Molecular Structure ; Neural Networks, Computer
    Language English
    Publishing date 2022-07-26
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.2c00321
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  10. Article ; Online: Mesenchymal stem/stromal cells in breast cancer development and management.

    Tu, Zhenbo / Karnoub, Antoine E

    Seminars in cancer biology

    2022  Volume 86, Issue Pt 2, Page(s) 81–92

    Abstract: Mesenchymal stem/stromal cells (MSCs) encompass a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body. They are endowed with capacities to differentiate into multiple connective tissue lineages, ... ...

    Abstract Mesenchymal stem/stromal cells (MSCs) encompass a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body. They are endowed with capacities to differentiate into multiple connective tissue lineages, including chondrocytes, adipocytes, and osteoblasts, and are thought to function as trophic cells recruited to sites of injury and inflammation where they contribute to tissue regeneration. In keeping with these roles, MSCs also to home to sites of breast tumorigenesis, akin to their migration to wounds, and participate in tumor stroma formation. Mounting evidence over the past two decades has described the critical regulatory roles for tumor-associated MSCs in various aspects of breast tumor pathogenesis, be it tumor initiation, growth, angiogenesis, tumor microenvironment formation, immune evasion, cancer cell migration, invasion, survival, therapeutic resistance, dissemination, and metastatic colonization. In this review, we present a brief summary of the role of MSCs in breast tumor development and progression, highlight some of the molecular frameworks underlying their pro-malignant contributions, and present evidence of their promising utility in breast cancer therapy.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/etiology ; Breast Neoplasms/therapy ; Breast Neoplasms/pathology ; Mesenchymal Stem Cells/pathology ; Tumor Microenvironment ; Cell Movement ; Adipocytes ; Cell Transformation, Neoplastic/pathology
    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2022.09.002
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