LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: IFN beta 1a as Glucocorticoids-Sparing Therapy in a Patient with CLIPPERS.

    Rico, María / Villafani, Javier / Tuñón, Alberto / Mateos, Valentín / Oliva-Nacarino, Pedro

    The American journal of case reports

    2016  Volume 17, Page(s) 47–50

    Abstract: Background: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described inflammatory disease of the central nervous system, distinguished by brainstem- and spinal cord-centered lesions ...

    Abstract Background: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently described inflammatory disease of the central nervous system, distinguished by brainstem- and spinal cord-centered lesions with a characteristic contrast enhancement on MRI, a lymphocytic perivascular infiltrate on pathological exam, and a dramatic response to and dependence on steroids therapy. Since its initial description in 2010, different glucocorticoid-sparing agents, mostly immunosuppressant drugs, have been used to minimize the dosage, but these therapies also carry the risk of important secondary effects. We present the first reported case of CLIPPERS treated with interferon beta 1a as add-on therapy.
    Case report: A previously healthy 31-year-old man presented with gait ataxia and dysarthria. MRI showed pons-centered hyperintense patchy lesions on T2-weighted images. Additional tests ruled out other possible diagnoses and symptoms reversed with intravenous methylprednisolone. Over the years the patient presented with several episodes of deterioration each year, which were partly reversed with glucocorticoid therapy, but leaving him with growing sequelae. Four years after the initial event, treatment with interferon-beta-1a was initiated, achieving reduced frequency of the relapses to 1 every 4 years, which were no longer associated to increasing disability. This allowed reducing glucocorticoids to 30 mg of Deflazacort every other day.
    Conclusions: Interferon beta-1a could be an alternative to corticosteroid-combined therapy in CLIPPERS and its more benign profile of secondary effects compared to immunosuppressants could make it an attractive choice.
    MeSH term(s) Adjuvants, Immunologic/therapeutic use ; Adult ; Anti-Inflammatory Agents/administration & dosage ; Encephalomyelitis/drug therapy ; Humans ; Interferon beta-1a/therapeutic use ; Lymphatic Diseases/drug therapy ; Magnetic Resonance Imaging ; Male ; Pons/pathology ; Pregnenediones/administration & dosage
    Chemical Substances Adjuvants, Immunologic ; Anti-Inflammatory Agents ; Pregnenediones ; deflazacort (KR5YZ6AE4B) ; Interferon beta-1a (XRO4566Q4R)
    Language English
    Publishing date 2016-01-27
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/ajcr.896102
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: CADASIL: how to avoid the unavoidable?

    Delgado, Montserrat G / Coto, Elicer / Tuñon, Alberto / Sáiz, Antonio

    BMJ case reports

    2011  Volume 2011

    Abstract: All three siblings (one female/two males) of a family presented successively with cerebrovascular events at the ages of 55, 63 and 65. The first one manifested extensive left subcortical haemorrhage and both the second and third patient, showed left ... ...

    Abstract All three siblings (one female/two males) of a family presented successively with cerebrovascular events at the ages of 55, 63 and 65. The first one manifested extensive left subcortical haemorrhage and both the second and third patient, showed left lacunar ischemic stroke. Their mother had died from vascular dementia at the age of 60 after several subcortical ischaemic strokes. Their maternal grandfather had died in his fifties from haemorrhagic stroke. All of them showed extensive white matter involvement. The genetic study revealed a mutation in exon 11 of the Notch3 gene in two family members. They were diagnosed with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Although CADASIL is a well-established disease, little is known about this disorder. The fact that all three siblings presented with CADASIL successively may appear disheartening, further studies are needed in order to control the clinical course of this devastating and unavoidable disorder.
    MeSH term(s) Aged ; CADASIL/diagnosis ; CADASIL/genetics ; Female ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2011-12-20
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr.08.2011.4727
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function.

    Marcos-Ramiro, Beatriz / Oliva Nacarino, Pedro / Serrano-Pertierra, Esther / Blanco-Gelaz, Miguel Angel / Weksler, Babette B / Romero, Ignacio A / Couraud, Pierre O / Tuñón, Alberto / López-Larrea, Carlos / Millán, Jaime / Cernuda-Morollón, Eva

    BMC neuroscience

    2014  Volume 15, Page(s) 110

    Abstract: Background: Cell-derived microparticles are secreted in response to cell damage or dysfunction. Endothelial and platelet dysfunction are thought to contribute to the development of multiple sclerosis (MS). Our aim here is, first, to compare the presence ...

    Abstract Background: Cell-derived microparticles are secreted in response to cell damage or dysfunction. Endothelial and platelet dysfunction are thought to contribute to the development of multiple sclerosis (MS). Our aim here is, first, to compare the presence of microparticles of endothelial and platelet origin in plasma from patients with different clinical forms of MS and with clinically isolated syndrome. Second, to investigate the effect of microparticles on endothelial barrier function.
    Results: Platelet-poor plasma from 95 patients (12 with clinically isolated syndrome, 51 relapsing-remitting, 23 secondary progressive, 9 primary progressive) and 49 healthy controls were analyzed for the presence of platelet-derived and endothelium-derived microparticles by flow cytometry. The plasma concentration of platelet-derived and endothelium-derived microparticles increased in all clinical forms of MS and in clinically isolated syndrome versus controls. The response of endothelial barriers to purified microparticles was measured by electric cell-substrate impedance sensing. Microparticles from relapsing-remitting MS patients induced, at equivalent concentrations, a stronger disruption of endothelial barriers than those from healthy donors or from patients with clinically isolated syndrome. MS microparticles acted synergistically with the inflammatory mediator thrombin to disrupt the endothelial barrier function.
    Conclusions: Plasma microparticles should be considered not only as markers of early stages of MS, but also as pathological factors with the potential to increase endothelial permeability and leukocyte infiltration.
    MeSH term(s) Adolescent ; Adult ; Aged ; Blood Platelets/metabolism ; Capillary Permeability ; Cell-Derived Microparticles/metabolism ; Child ; Demyelinating Diseases/physiopathology ; Electric Impedance ; Endothelium, Vascular/metabolism ; Female ; Flow Cytometry ; Humans ; Male ; Middle Aged ; Multiple Sclerosis, Chronic Progressive/physiopathology ; Multiple Sclerosis, Relapsing-Remitting/physiopathology ; Thrombin/metabolism ; Young Adult
    Chemical Substances Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2014-09-22
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2202
    ISSN (online) 1471-2202
    DOI 10.1186/1471-2202-15-110
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Soluble MHC class I chain-related protein B serum levels correlate with disease activity in relapsing-remitting multiple sclerosis.

    Fernández-Morera, Juan Luís / Rodríguez-Rodero, Sandra / Lahoz, Carlos / Tuñon, Alberto / Astudillo, Aurora / Garcia-Suarez, Olivia / Martínez-Borra, Jesús / López-Vázquez, Antonio / Rodrigo, Luis / Gonzalez, Segundo / López-Larrea, Carlos

    Human immunology

    2008  Volume 69, Issue 4-5, Page(s) 235–240

    Abstract: Recent studies demonstrated that dysregulation of NKG2D and its ligands, leading to activation of autoreactive effector cells, can trigger autoimmune diseases, but soluble forms of these ligands can downmodulate NKG2D expression in T effector cells. We ... ...

    Abstract Recent studies demonstrated that dysregulation of NKG2D and its ligands, leading to activation of autoreactive effector cells, can trigger autoimmune diseases, but soluble forms of these ligands can downmodulate NKG2D expression in T effector cells. We investigated the presence of soluble major histocompatibility complex class I chain-related A or B (MICA or MICB) molecules in sera of multiple sclerosis (MS) patients and whether they play a role in the progression of the disease. Although soluble MICA serum levels did not differ, soluble MICB serum levels were higher in MS patients compared with controls. Moreover, the highest MICB levels were in MS patients during relapses. Using immunohistochemistry techniques, it was possible to locate MIC expression in neurons of MS demyelinating plaques that were intracellularly accumulated. Elevated soluble MICB levels exist in serum of multiple sclerosis patients related with disease activity. This may contribute to the modulation of immune response activity during relapses.
    MeSH term(s) Adult ; Astrocytes/immunology ; Astrocytes/pathology ; Disease Progression ; Female ; Histocompatibility Antigens Class I/blood ; Humans ; Immunohistochemistry ; Longitudinal Studies ; Male ; Microscopy, Confocal ; Middle Aged ; Multiple Sclerosis, Relapsing-Remitting/blood ; Multiple Sclerosis, Relapsing-Remitting/immunology ; Multiple Sclerosis, Relapsing-Remitting/pathology ; Neurons/immunology ; Neurons/pathology
    Chemical Substances Histocompatibility Antigens Class I ; MHC class I-related chain A ; MICB antigen
    Language English
    Publishing date 2008-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2008.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1597: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Lipid-specific immunoglobulin M bands in cerebrospinal fluid are associated with a reduced risk of developing progressive multifocal leukoencephalopathy during treatment with natalizumab.

    Villar, Luisa M / Costa-Frossard, Lucienne / Masterman, Thomas / Fernandez, Oscar / Montalban, Xavier / Casanova, Bonaventura / Izquierdo, Guillermo / Coret, Francisco / Tumani, Hayrettin / Saiz, Albert / Arroyo, Rafael / Fink, Katharina / Leyva, Laura / Espejo, Carmen / Simó-Castelló, María / García-Sánchez, María I / Lauda, Florian / Llufriú, Sara / Álvarez-Lafuente, Roberto /
    Olascoaga, Javier / Prada, Alvaro / Oterino, Agustín / de Andrés, Clara / Tintoré, Mar / Ramió-Torrentà, Lluis / Rodríguez-Martín, Eulalia / Picón, Carmen / Comabella, Manuel / Quintana, Ester / Agüera, Eduardo / Díaz, Santiago / Fernandez-Bolaños, Ricardo / García-Merino, Juan A / Landete, Lamberto / Menéndez-González, Manuel / Navarro, Laura / Pérez, Domingo / Sánchez-López, Fernando / Serrano-Castro, Pedro J / Tuñón, Alberto / Espiño, Mercedes / Muriel, Alfonso / Bar-Or, Amit / Álvarez-Cermeño, José C

    Annals of neurology

    2015  Volume 77, Issue 3, Page(s) 447–457

    Abstract: Objective: Progressive multifocal leukoencephalopathy (PML) is a serious side effect associated with natalizumab treatment in multiple sclerosis (MS). PML risk increases in individuals seropositive for anti-John Cunningham virus (JC) antibodies, with ... ...

    Abstract Objective: Progressive multifocal leukoencephalopathy (PML) is a serious side effect associated with natalizumab treatment in multiple sclerosis (MS). PML risk increases in individuals seropositive for anti-John Cunningham virus (JC) antibodies, with prolonged duration of natalizumab treatment, and with prior exposure to immunosuppressants. We explored whether the presence of lipid-specific immunoglobulin M oligoclonal bands in cerebrospinal fluid (CSF; IgM bands), a recognized marker of highly inflammatory MS, may identify individuals better able to counteract the potential immunosuppressive effect of natalizumab and hence be associated with a reduced risk of developing PML.
    Methods: We studied 24 MS patients who developed PML and another 343 who did not suffer this opportunistic infection during natalizumab treatment. Patients were recruited at 25 university hospitals. IgM bands were studied by isoelectric focusing and immunodetection. CSF lymphocyte counts were explored in 151 MS patients recruited at Ramon y Cajal Hospital in Madrid, Spain.
    Results: IgM bands were independently associated with decreased PML risk (odds ratio [OR] = 45.9, 95% confidence interval [CI] = 5.9-339.3, p < 0.0001) in patients treated with natalizumab. They were also associated with significantly higher CSF CD4, CD8, and B-cell numbers. Patients positive for IgM bands and anti-JC antibodies had similar levels of reduced PML risk to those who were anti-JC negative (OR = 1.55, 95% CI = 0.09-25.2, p = 1.0). Higher risk was observed in patients positive for anti-JC antibodies and negative for IgM bands (19% of the total cohort, OR = 59.71, 95% CI = 13.6-262.2).
    Interpretation: The presence of IgM bands reflects a process that may diminish the risk of PML by counteracting the excess of immunosuppression that may occur during natalizumab therapy.
    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/adverse effects ; Biomarkers/cerebrospinal fluid ; Female ; Humans ; JC Virus/immunology ; Leukoencephalopathy, Progressive Multifocal/cerebrospinal fluid ; Leukoencephalopathy, Progressive Multifocal/chemically induced ; Male ; Middle Aged ; Multiple Sclerosis/cerebrospinal fluid ; Multiple Sclerosis/drug therapy ; Natalizumab ; Oligoclonal Bands/cerebrospinal fluid ; Risk
    Chemical Substances Antibodies, Monoclonal, Humanized ; Biomarkers ; Natalizumab ; Oligoclonal Bands
    Language English
    Publishing date 2015-03
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.24345
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1370: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 478: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top