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  1. Article ; Online: Validating MCM2 as a clinically relevant surrogate immunohistochemical marker for an aggressive meningioma molecular subtype.

    Shelbourn, Allison / Nuechterlein, Nicholas / Parada, Carolina Angelica / Eaton, Jessica / Tucker, Mallory / Ferreira, Manuel / Cimino, Patrick J

    Journal of neuropathology and experimental neurology

    2023  Volume 82, Issue 12, Page(s) 1037–1039

    MeSH term(s) Humans ; Meningioma ; Meningeal Neoplasms ; Minichromosome Maintenance Complex Component 2
    Chemical Substances MCM2 protein, human (EC 3.6.4.12) ; Minichromosome Maintenance Complex Component 2 (EC 3.6.4.12)
    Language English
    Publishing date 2023-10-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 3088-0
    ISSN 1554-6578 ; 0022-3069
    ISSN (online) 1554-6578
    ISSN 0022-3069
    DOI 10.1093/jnen/nlad082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui II Zs.134: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
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  2. Article ; Conference proceedings: Clinical Characteristics and Genetic Evolution of Skull Base Chondrosarcomas

    Eaton, Jessica C. / Parada, Carolina A. / Parrish, Oscar / Tucker, Mallory / Zhao, Zirun / Delegard, Jennifer / Lassiter, Eric / Tyrtova, Evgeniya / Emerson, Samuel / Ruzevick, Jacob / Cranmer, Lee / Ferreira, Manuel

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1779832
    Database Thieme publisher's database

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    Zs.A 3425: Show issues Location:
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  3. Article ; Online: A Clinical and Correlative Study of Elotuzumab, Carfilzomib, Lenalidomide, and Dexamethasone (Elo-KRd) for Lenalidomide Refractory Multiple Myeloma in First Relapse.

    Bhutani, Manisha / Foureau, David M / Robinson, Myra / Guo, Fei / Fesenkova, Kateryna / Atrash, Shebli / Paul, Barry / Varga, Cindy / Friend, Reed / Pineda-Roman, Mauricio / Rigby, Katherine / Symanowski, James T / Norek, Sarah / Tucker, Mallory R / Druhan, Lawrence J / Voorhees, Peter M / Usmani, Saad Z

    Clinical lymphoma, myeloma & leukemia

    2023  Volume 23, Issue 7, Page(s) 535–544.e1

    Abstract: Introduction: Treatment of patients with multiple myeloma (MM) in first relapse remains a challenge. This phase II study combined elotuzumab (Elo) with carfilzomib, lenalidomide, and dexamethasone (KRd) for treatment of MM in first relapse with the aim ... ...

    Abstract Introduction: Treatment of patients with multiple myeloma (MM) in first relapse remains a challenge. This phase II study combined elotuzumab (Elo) with carfilzomib, lenalidomide, and dexamethasone (KRd) for treatment of MM in first relapse with the aim of improving efficacy.
    Methods: Enrolled patients received Elo-KRd induction for 4 cycles, and Elo-lenalidomide maintenance until progression. The primary endpoint was VGPR or better (≥VGPR) postinduction. Secondary endpoints were MRD by flow cytometry, OS, PFS, and safety. Correlatives included characterization of the impact of Elo-KRd on NK and T cell subsets via flow cytometry. Target accrual of 40 patients was not met due to COVID-19 pandemic.
    Results: Of 15 patients enrolled, 10 (67%) had high-risk features (del17p, t[4;14], t[14;16], 1q gain/amplification, plasma cell leukemia, extramedullary MM, or functional high risk), 12 (80%) were lenalidomide-refractory, and 5 (33.3%) bortezomib-refractory. Postinduction ≥VGPR was 7/15 (46.7%) and MRD-negative (10
    Conclusion: A short course of Elo-KRd induction followed by Elo-lenalidomide maintenance demonstrated activity in predominantly lenalidomide-refractory and / or high-risk MM. The results with this well-tolerated combination are comparable to other contemporary approved triplet combinations.
    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Lenalidomide/pharmacology ; Lenalidomide/therapeutic use ; Pandemics ; Dexamethasone/therapeutic use ; Dexamethasone/pharmacology ; COVID-19 ; COVID-19 Drug Treatment ; Recurrence ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemical Substances Lenalidomide (F0P408N6V4) ; carfilzomib (72X6E3J5AR) ; elotuzumab (1351PE5UGS) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2023.03.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5903: Show issues Location:
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