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  1. Article ; Online: Subregion preference in the long-range connectome of pyramidal neurons in the medial prefrontal cortex.

    Tudi, Ayizuohere / Yao, Mei / Tang, Feifang / Zhou, Jiandong / Li, Anan / Gong, Hui / Jiang, Tao / Li, Xiangning

    BMC biology

    2024  Volume 22, Issue 1, Page(s) 95

    Abstract: Background: The medial prefrontal cortex (mPFC) is involved in complex functions containing multiple types of neurons in distinct subregions with preferential roles. The pyramidal neurons had wide-range projections to cortical and subcortical regions ... ...

    Abstract Background: The medial prefrontal cortex (mPFC) is involved in complex functions containing multiple types of neurons in distinct subregions with preferential roles. The pyramidal neurons had wide-range projections to cortical and subcortical regions with subregional preferences. Using a combination of viral tracing and fluorescence micro-optical sectioning tomography (fMOST) in transgenic mice, we systematically dissected the whole-brain connectomes of intratelencephalic (IT) and pyramidal tract (PT) neurons in four mPFC subregions.
    Results: IT and PT neurons of the same subregion projected to different target areas while receiving inputs from similar upstream regions with quantitative differences. IT and PT neurons all project to the amygdala and basal forebrain, but their axons target different subregions. Compared to subregions in the prelimbic area (PL) which have more connections with sensorimotor-related regions, the infralimbic area (ILA) has stronger connections with limbic regions. The connection pattern of the mPFC subregions along the anterior-posterior axis showed a corresponding topological pattern with the isocortex and amygdala but an opposite orientation correspondence with the thalamus.
    Conclusions: By using transgenic mice and fMOST imaging, we obtained the subregional preference whole-brain connectomes of IT and pyramidal tract PT neurons in the mPFC four subregions. These results provide a comprehensive resource for directing research into the complex functions of the mPFC by offering anatomical dissections of the different subregions.
    MeSH term(s) Animals ; Prefrontal Cortex/physiology ; Prefrontal Cortex/cytology ; Pyramidal Cells/physiology ; Mice ; Mice, Transgenic ; Connectome ; Male
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2133020-7
    ISSN 1741-7007 ; 1741-7007
    ISSN (online) 1741-7007
    ISSN 1741-7007
    DOI 10.1186/s12915-024-01880-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long-range connectome of pyramidal neurons in the sensorimotor cortex.

    Yao, Mei / Tudi, Ayizuohere / Jiang, Tao / An, Xu / Sun, Qingtao / Li, Anan / Huang, Z Josh / Gong, Hui / Li, Xiangning

    iScience

    2023  Volume 26, Issue 4, Page(s) 106316

    Abstract: The neocortex mediates information processing through highly organized circuitry that contains various neuron types. Distinct populations of projection neurons in different cortical regions and layers make specific connections and participate in distinct ...

    Abstract The neocortex mediates information processing through highly organized circuitry that contains various neuron types. Distinct populations of projection neurons in different cortical regions and layers make specific connections and participate in distinct physiological functions. Herein, with the fluorescence micro-optical sectioning tomography (fMOST) and transgenetic mice that targeted intratelencephalic (IT) and pyramidal tract (PT) neurons at specific layers, we dissected the long-range connectome of pyramidal neurons in six subregions of the sensorimtor cortex. The distribution of the input neurons indicated that IT and PT neurons in the same region received information from similar regions, while the neurons in different subregions received from the preferred neuron populations. Both the input and projection areas of these six subregions showed the transverse and longitudinal correspondence in the cortico-cortical, cortico-thalamic, and cortico-striatal circuits, which indicated that the connections were topologically organized. This study provides a comprehensive resource on the anatomical connections of cortical circuits.
    Language English
    Publishing date 2023-03-02
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.106316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei.

    Xu, Zhengchao / Feng, Zhao / Zhao, Mengting / Sun, Qingtao / Deng, Lei / Jia, Xueyan / Jiang, Tao / Luo, Pan / Chen, Wu / Tudi, Ayizuohere / Yuan, Jing / Li, Xiangning / Gong, Hui / Luo, Qingming / Li, Anan

    eLife

    2021  Volume 10

    Abstract: The dorsal raphe nucleus (DR) and median raphe nucleus (MR) contain populations of glutamatergic and GABAergic neurons that regulate diverse behavioral functions. However, their whole-brain input-output circuits remain incompletely elucidated. We used ... ...

    Abstract The dorsal raphe nucleus (DR) and median raphe nucleus (MR) contain populations of glutamatergic and GABAergic neurons that regulate diverse behavioral functions. However, their whole-brain input-output circuits remain incompletely elucidated. We used viral tracing combined with fluorescence micro-optical sectioning tomography to generate a comprehensive whole-brain atlas of inputs and outputs of glutamatergic and GABAergic neurons in the DR and MR. We found that these neurons received inputs from similar upstream brain regions. The glutamatergic and GABAergic neurons in the same raphe nucleus had divergent projection patterns with differences in critical brain regions. Specifically, MR glutamatergic neurons projected to the lateral habenula through multiple pathways. Correlation and cluster analysis revealed that glutamatergic and GABAergic neurons in the same raphe nucleus received heterogeneous inputs and sent different collateral projections. This connectivity atlas further elucidates the anatomical architecture of the raphe nuclei, which could facilitate better understanding of their behavioral functions.
    MeSH term(s) Animals ; Connectome ; Dorsal Raphe Nucleus/physiology ; GABAergic Neurons/physiology ; Mice ; Midbrain Raphe Nuclei/physiology ; Neurons/physiology
    Language English
    Publishing date 2021-11-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.65502
    Database MEDical Literature Analysis and Retrieval System OnLINE

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