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  1. AU="Tudoran, Lucian Barbu"
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  1. Article ; Online: Facile Preparation of PVDF/CoFe

    Popa, Adriana / Stefan, Maria / Macavei, Sergiu / Perhaita, Ioana / Tudoran, Lucian Barbu / Toloman, Dana

    Polymers

    2023  Volume 15, Issue 23

    Abstract: In this investigation, ... ...

    Abstract In this investigation, CoFe
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15234547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Genome-wide transcriptional response to silver stress in extremely halophilic archaeon Haloferax alexandrinus DSM 27206

    Buda, Doriana Mădălina / Szekeres, Edina / Tudoran, Lucian Barbu / Esclapez, Julia / Banciu, Horia Leonard

    BMC microbiology

    2023  Volume 23, Issue 1, Page(s) 381

    Abstract: Background: The extremely halophilic archaeon Haloferax (Hfx.) alexandrinus DSM 27206: Results: The growth curves confirmed the capacity of Hfx. alexandrinus to surmount silver stress, while the SEM-EDS analysis illustrated the presence of silver ... ...

    Abstract Background: The extremely halophilic archaeon Haloferax (Hfx.) alexandrinus DSM 27206
    Results: The growth curves confirmed the capacity of Hfx. alexandrinus to surmount silver stress, while the SEM-EDS analysis illustrated the presence of silver nanoparticles in cultures exposed to 0.5 mM silver nitrate. The RNA-Seq based transcriptomic analysis of Hfx. alexandrinus cells exposed to 0.1, 0.25, and 0.5 mM silver nitrate revealed the differential expression of multiple sets of genes potentially employed in heavy-metal stress response, genes mostly related to metal transporters, basic metabolism, oxidative stress response and cellular motility. The RT-qPCR analysis of selected transcripts was conducted to verify and validate the generated RNA-Seq data.
    Conclusions: Our results indicated that copA, encoding the copper ATPase, is essential for the survival of Hfx. alexandrinus cells in silver-containing saline media. The silver-exposed cultures underwent several metabolic adjustments that enabled the activation of enzymes involved in the oxidative stress response and impairment of the cellular movement capacity. To our knowledge, this study represents the first comprehensive analysis of gene expression in halophillic archaea facing increased levels of heavy metals.
    MeSH term(s) Haloferax/genetics ; Haloferax/metabolism ; Silver Nitrate/metabolism ; Metal Nanoparticles ; Silver/pharmacology ; Gene Expression Profiling ; Haloferax volcanii/genetics
    Chemical Substances Silver Nitrate (95IT3W8JZE) ; Silver (3M4G523W1G)
    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-023-03133-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In Vitro Study of Composite Cements on Mesenchymal Stem Cells of Palatal Origin.

    Ardelean, Alina Ioana / Dragomir, Madalina Florina / Moldovan, Marioara / Sarosi, Codruta / Paltinean, Gertrud Alexandra / Pall, Emoke / Tudoran, Lucian Barbu / Petean, Ioan / Oana, Liviu

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: Uniform filler distribution in composites is an important requirement. Therefore, BaO glass, nano hydroxyapatite and quartz filler distribution was realized through PCL microcapsules which progressively release filler during matrix polymerization. Two ... ...

    Abstract Uniform filler distribution in composites is an important requirement. Therefore, BaO glass, nano hydroxyapatite and quartz filler distribution was realized through PCL microcapsules which progressively release filler during matrix polymerization. Two composites were realized based on a complex matrix containing BisGMA, UDMA, HEMA and PEG400 mixed with a previously described mineral filler: 33% for C1 and 31% for C2. The spreading efficiency was observed via SEM, revealing a complete disintegration of the microcapsules during C1 polymerization, while C2 preserved some microcapsule parts that were well embedded into the matrix beside BaO filler particles; this was confirmed by means of the EDS spectra. Mesenchymal stem cells of palatal origin were cultured on the composites for 1, 3, 5 and 7 days. The alkaline phosphatase (ALP) level was measured at each time interval and the cytotoxicity was tested after 3, 5 and 7 days of co-culture on the composite samples. The SEM investigation showed that both composites allowed for robust proliferation of the cells. The MSC cell pluripotency stage was observed from 1 to 3 days with an average level of ALP of 209.2 u/L for C1 and 193.0 u/L for C2 as well as a spindle cell morphology. Cell differentiation occurred after 5 and 7 days of culture, implied by morphological changes such as flattened, star and rounded shapes, observed via SEM, which were correlated with an increased ALP level (279.4 u/L for C1 and 284.3 u/L for C2). The EDX spectra after 7 days of co-culture revealed increasing amounts of P and Ca close to the hydroxyapatite stoichiometry, indicating the stimulation of the osteoinductive behavior of MSCs by C1 and C2. The MTT assay test showed a cell viability of 98.08% for C1 and 97.33% for C2 after 3 days, proving the increased biocompatibility of the composite samples. The cell viability slightly decreased at 5 and 7 days but the results were still excellent: 89.5% for C1 and 87.3% for C2. Thus, both C1 and C2 are suitable for further in vivo testing.
    MeSH term(s) Capsules ; Mesenchymal Stem Cells ; Durapatite ; Glass ; Cells, Cultured ; Materials Testing
    Chemical Substances Capsules ; Durapatite (91D9GV0Z28)
    Language English
    Publishing date 2023-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241310911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Biofilms and inflammation in patients with chronic rhinosinusitis.

    Manciula, Lavinia-Gianina / Jeican, Ionut Isaia / Tudoran, Lucian Barbu / Albu, Silviu

    Medicine and pharmacy reports

    2020  Volume 93, Issue 4, Page(s) 374–383

    Abstract: Introduction: The aim of the present study is to evaluate the presence of biofilms in patients with chronic rhinosinusitis (CRS), with or without nasal polyps, and their relationship to eosinophils and plasma cells. We compared the results with those ... ...

    Abstract Introduction: The aim of the present study is to evaluate the presence of biofilms in patients with chronic rhinosinusitis (CRS), with or without nasal polyps, and their relationship to eosinophils and plasma cells. We compared the results with those obtained in nonCRS patients.
    Methods: A total of 50 patients were included in the study, 30 CRSwNP patients, 10 CRSsNP cases and 10 control patients who were operated for deviated septum. Biofilm detection was performed by means of H&E staining and SEM. Eosinophil and plasma cell values were recorded and compared between groups.
    Results: Biofilms were identified in 30 patients (60%), 76.6% (23 out of 30) of the CRSwNP patients, 70% (7 out of 10) of the CRSsNP patients and none of the septoplasty patients. Eosinophil and plasma cell values were more elevated in CRS patients, being strongly correlated to biofilm presence and nasal polyposis.
    Conclusion: Biofilm presence was demonstrated in many of the CRS patients, with no evidence in the control cases. Our study findings indicate that inflammatory cell counts are higher in patients with CRS compared to controls, but also more elevated in patients with polyposis. In biofilm-positive patients, eosinophil and plasma cell counts were greater than those in patients without biofilms, demonstrating the proinflammatory action of the biofilm in the sino-nasal pathology.
    Language English
    Publishing date 2020-10-25
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2974425-8
    ISSN 2668-0572 ; 2602-0807
    ISSN (online) 2668-0572
    ISSN 2602-0807
    DOI 10.15386/mpr-1691
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Material Evidence of Sediments Recovered from Ancient Amphorae Found at the Potaissa Roman Fortress.

    Farcas, Iulia Alexandra / Dippong, Thomas / Petean, Ioan / Moldovan, Marioara / Filip, Miuta Rafila / Ciotlaus, Irina / Tudoran, Lucian Barbu / Borodi, Gheorghe / Paltinean, Gertrud Alexandra / Pripon, Emanoil / Bunea, Claudiu Ioan

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 7

    Abstract: Methods for material investigation are powerful tools that allow specialists to elucidate important aspects regarding ancient artifacts such as the Roman amphorae deposits discovered at Potaissa Fortress in Turda, Romania. Archeological debate states ... ...

    Abstract Methods for material investigation are powerful tools that allow specialists to elucidate important aspects regarding ancient artifacts such as the Roman amphorae deposits discovered at Potaissa Fortress in Turda, Romania. Archeological debate states that the deposit contained olive oil and wine amphorae, but no material evidence has been presented until now. The current research is focused on the most representative large amphora fragments found in the Potaissa deposit, with a significant amount of sediment on their walls, to give archeologists the material proof to elucidate their debate. Sediment was collected from each fragment and subjected to complex analysis. XRD investigation combined with cross-polarized light microscopy demonstrated mineral particles such as quartz, clay (muscovite and traces of biotite), and calcite. Quartz and calcite particles have a rounded shape and diameters in a range of 20-200 µm, and clay particles have a lamellar shape and dimensions from 1 to 20 µm, a fact confirmed by SEM microscopy. Sample 2 presented a large amount of amorphous phase followed by Samples 1 and 3, with a low amount of organic phase. FTIR investigation confirms organic phase presence owing to strong absorption bands regarding C-H, C=O, and O-H chemical bonds related to aliphatic compounds in Sample 2, and to some decayed wine residue in Samples 1 and 3. EDS elemental analysis was used for organic particle identification in the amphora sediments and to obtain a correlation with their microstructure. GC-MS investigation showed volatile compounds related to wine residue for Samples 1 and 3 and decomposed fats for Sample 2. Tartaric and malic acid were identified by HPLC in Samples 1 and 3, which are wine biomarkers. The correlation of all experimental results concludes with no doubt that Amphora 2 contained olive oil and Amphorae 1 and 3 contained wine in ancient times.
    Language English
    Publishing date 2023-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16072628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Stochastic biosensors based on N- and S-doped graphene for the enantioanalysis of aspartic acid in biological samples.

    Stefan-van Staden, Raluca-Ioana / Gheorghe, Damaris-Cristina / Ilie-Mihai, Ruxandra-Maria / Tudoran, Lucian-Barbu / Pruneanu, Stela Maria

    RSC advances

    2021  Volume 11, Issue 38, Page(s) 23301–23309

    Abstract: Metabolomics plays a very important role in cancer mechanism and also in the early diagnosis of cancer. The enantioanalysis of aminoacids found in biological samples may favor the development of new screening tests for the early diagnosis of cancer. Two ... ...

    Abstract Metabolomics plays a very important role in cancer mechanism and also in the early diagnosis of cancer. The enantioanalysis of aminoacids found in biological samples may favor the development of new screening tests for the early diagnosis of cancer. Two stochastic biosensors, based on the immobilization of α-hemolysin and hemin in exfoliated reduced graphene modified with nitrogen and sulphur, were proposed for the enantioanalysis of aspartic acid in biological samples (whole blood, urine, saliva, and tissue). The proposed biosensors showed low limits of quantification, high sensitivity, and large linear concentration ranges. The recoveries of d- and l-aspartic acid in biological samples were higher than 95.00%, with a relative standard deviation lower than 1.00%.
    Language English
    Publishing date 2021-07-01
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d1ra02066h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Stochastic biosensors based on N- and S-doped graphene for the enantioanalysis of aspartic acid in biological samples

    Stefan-van Staden, Raluca-Ioana / Gheorghe, Damaris-Cristina / Ilie-Mihai, Ruxandra-Maria / Tudoran, Lucian-Barbu / Pruneanu, Stela Maria

    RSC advances. 2021 July 01, v. 11, no. 38

    2021  

    Abstract: Metabolomics plays a very important role in cancer mechanism and also in the early diagnosis of cancer. The enantioanalysis of aminoacids found in biological samples may favor the development of new screening tests for the early diagnosis of cancer. Two ... ...

    Abstract Metabolomics plays a very important role in cancer mechanism and also in the early diagnosis of cancer. The enantioanalysis of aminoacids found in biological samples may favor the development of new screening tests for the early diagnosis of cancer. Two stochastic biosensors, based on the immobilization of α-hemolysin and hemin in exfoliated reduced graphene modified with nitrogen and sulphur, were proposed for the enantioanalysis of aspartic acid in biological samples (whole blood, urine, saliva, and tissue). The proposed biosensors showed low limits of quantification, high sensitivity, and large linear concentration ranges. The recoveries of d- and l-aspartic acid in biological samples were higher than 95.00%, with a relative standard deviation lower than 1.00%.
    Keywords aspartic acid ; biosensors ; blood ; early diagnosis ; graphene ; metabolomics ; nitrogen ; saliva ; standard deviation ; sulfur ; urine
    Language English
    Dates of publication 2021-0701
    Size p. 23301-23309.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ISSN 2046-2069
    DOI 10.1039/d1ra02066h
    Database NAL-Catalogue (AGRICOLA)

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  8. Article: Biosynthesis of Iron Oxide Nanoparticles: Physico-Chemical Characterization and Their In Vitro Cytotoxicity on Healthy and Tumorigenic Cell Lines.

    Moacă, Elena-Alina / Watz, Claudia Geanina / Flondor Ionescu, Daniela / Păcurariu, Cornelia / Tudoran, Lucian Barbu / Ianoș, Robert / Socoliuc, Vlad / Drăghici, George-Andrei / Iftode, Andrada / Liga, Sergio / Dragoș, Dan / Dehelean, Cristina Adriana

    Nanomaterials (Basel, Switzerland)

    2022  Volume 12, Issue 12

    Abstract: Iron oxide nanoparticles were synthesized starting from two aqueous extracts based ... ...

    Abstract Iron oxide nanoparticles were synthesized starting from two aqueous extracts based on
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12122012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Green Synthesis of Silver Nanoparticles Using

    Kis, Brigitta / Moacă, Elena-Alina / Tudoran, Lucian Barbu / Muntean, Delia / Magyari-Pavel, Ioana Zinuca / Minda, Daliana Ionela / Lombrea, Adelina / Diaconeasa, Zorita / Dehelean, Cristina Adriana / Dinu, Ștefania / Danciu, Corina

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 14

    Abstract: Green route is an economic, facile and eco-friendly method, employed for the synthesis of various types of nanoparticles, having it as a starting point biological entity, especially as a plant extract. The present study aims to obtain silver ... ...

    Abstract Green route is an economic, facile and eco-friendly method, employed for the synthesis of various types of nanoparticles, having it as a starting point biological entity, especially as a plant extract. The present study aims to obtain silver nanoparticles (AgNPs) starting from an ethanolic extract of
    Language English
    Publishing date 2022-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15145006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Characterization and In Vitro Biocompatibility of Two New Bioglasses for Application in Dental Medicine-A Preliminary Study.

    Clichici, Andra / Filip, Gabriela Adriana / Achim, Marcela / Baldea, Ioana / Cristea, Cecilia / Melinte, Gheorghe / Pana, Ovidiu / Tudoran, Lucian Barbu / Dudea, Diana / Stefan, Razvan

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 24

    Abstract: Bioactive glasses (BGs), also known as bioglasses, are very attractive and versatile materials that are increasingly being used in dentistry. For this study, two new bioglasses-one with boron (BG1) and another with boron and vanadium (BG2)-were ... ...

    Abstract Bioactive glasses (BGs), also known as bioglasses, are very attractive and versatile materials that are increasingly being used in dentistry. For this study, two new bioglasses-one with boron (BG1) and another with boron and vanadium (BG2)-were synthesized, characterized, and tested on human dysplastic keratinocytes. The in vitro biological properties were evaluated through pH and zeta potential measurement, weight loss, Ca
    Language English
    Publishing date 2022-12-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15249060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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