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Article ; Online: Effect of Hybridization on Somatic Mutations and Genomic Rearrangements in Plants

Tufail Bashir / Ratnesh Chandra Mishra / Md. Mohidul Hasan / Tapan Kumar Mohanta / Hanhong Bae

International Journal of Molecular Sciences, Vol 19, Iss 12, p

2018 Volume 3758

Abstract: Hybridization has been routinely practiced in agriculture to enhance the crop yield. Principally, it can cause hybrid vigor where hybrid plants display increased size, biomass, fertility, and resistance to diseases, when compared to their parents. During ...

Abstract	Hybridization has been routinely practiced in agriculture to enhance the crop yield. Principally, it can cause hybrid vigor where hybrid plants display increased size, biomass, fertility, and resistance to diseases, when compared to their parents. During hybridization, hybrid offspring receive a genomic shock due to mixing of distant parental genomes, which triggers a myriad of genomic rearrangements, e.g., transpositions, genome size changes, chromosomal rearrangements, and other effects on the chromatin. Recently, it has been reported that, besides genomic rearrangements, hybridization can also alter the somatic mutation rates in plants. In this review, we provide in-depth insights about hybridization triggered genomic rearrangements and somatic mutations in plants.
Keywords	allopolyploids ; somatic mutation ; transposition ; hybrid plants ; chromosomal rearrangements ; chromosomal elimination ; chromosomal expansion ; centromere ; homologous recombination ; genome size ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	580
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Origin of petiole and midrib in Arabidopsis thaliana

JASMINE M SHAH and TUFAIL BASHIR

Proceedings of Indian National Science Academy, Vol 79, Iss

2014 Volume 1

Abstract: Origin of petiole and midrib in Arabidopsis ... ...

Abstract	Origin of petiole and midrib in Arabidopsis thaliana
Keywords	Science ; Q
Language	English
Publishing date	2014-11-01T00:00:00Z
Publisher	Indian National Science Academy
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Leucine and perindopril to improve physical performance in people over 70 years with sarcopenia

Miles D Witham / Simon Adamson / Alison Avenell / Margaret M Band / Tufail Bashir / Peter T Donnan / Jacob George / Adrian Hapca / Cheryl Hume / Paul Kemp / Emma McKenzie / Kristina Pilvinyte / Christos Rossios / Karen Smith / Allan D Struthers / Deepa Sumukadas

Efficacy and Mechanism Evaluation, Vol 9, Iss

the LACE factorial RCT

2022 Volume 8

Abstract: Background: Angiotensin-converting enzyme inhibitors and leucine are promising potential treatments for sarcopenia. Neither has yet been tested in adequately powered randomised trials in patients with sarcopenia. Objectives: To determine the efficacy of ... ...

Abstract	Background: Angiotensin-converting enzyme inhibitors and leucine are promising potential treatments for sarcopenia. Neither has yet been tested in adequately powered randomised trials in patients with sarcopenia. Objectives: To determine the efficacy of leucine and perindopril in improving physical function in older people with sarcopenia, to evaluate the effect of leucine and perindopril on muscle mass and to evaluate the predictive biomarkers of sarcopenia. Design: A placebo-controlled, parallel group, double-blind, randomised 2 × 2 factorial trial. Setting: Primary care and geriatric medicine secondary care departments in 14 UK centres. Participants: Adults aged ≥ 70 years with low muscle strength and mass, without contraindications to angiotensin-converting enzyme inhibitors and without known diagnosis-specific skeletal myopathy. Interventions: Eligible participants were randomised 1 : 1 to receive 4 mg of oral perindopril or a matching placebo and, separately, were randomised 1 : 1 to receive 2.5 g of oral leucine powder or a matching placebo powder taken thrice daily with meals. Randomisation was performed using an interactive web-based randomisation system run independently of the research team to preserve allocation concealment. Main outcome measures: The primary outcome was the between-group difference in the Short Physical Performance Battery (SPPB) score over the 12-month follow-up period. Other outcome measures included appendicular muscle mass, EQ-5D (EuroQol-5 Dimensions) quality-of-life score, grip strength, quadriceps strength, 6-minute walk distance, activities of daily living, hip bone mineral density and insulin resistance. All adverse events and falls were recorded. Protein-, DNA (deoxyribonucleic acid)- and RNA (ribonucleic acid)-based biomarkers were collected at baseline and at 3 and 12 months. Results: We screened 320 people and randomised 145 participants. Participants had a mean age of 79 (standard deviation 6) years, 78 (54%) were women and the mean SPPB was 7.0 (standard deviation ...
Keywords	angiotensin-converting enzyme inhibitor ; leucine ; sarcopenia ; randomised controlled trial ; Medicine ; R
Subject code	796
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	NIHR Journals Library
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: An Overview of LEDs’ Effects on the Production of Bioactive Compounds and Crop Quality

Md. Mohidul Hasan / Tufail Bashir / Ritesh Ghosh / Sun Keun Lee / Hanhong Bae

Molecules, Vol 22, Iss 9, p

2017 Volume 1420

Abstract: Light-emitting diodes (LEDs) are characterized by their narrow-spectrum, non-thermal photon emission, greater longevity, and energy-saving characteristics, which are better than traditional light sources. LEDs thus hold the potential to revolutionize ... ...

Abstract	Light-emitting diodes (LEDs) are characterized by their narrow-spectrum, non-thermal photon emission, greater longevity, and energy-saving characteristics, which are better than traditional light sources. LEDs thus hold the potential to revolutionize horticulture lighting technology for crop production, protection, and preservation. Exposure to different LED wavelengths can induce the synthesis of bioactive compounds and antioxidants, which in turn can improve the nutritional quality of horticultural crops. Similarly, LEDs increase the nutrient contents, reduce microbial contamination, and alter the ripening of postharvest fruits and vegetables. LED-treated agronomic products can be beneficial for human health due to their good nutrient value and high antioxidant properties. Besides that, the non-thermal properties of LEDs make them easy to use in closed-canopy or within-canopy lighting systems. Such configurations minimize electricity consumption by maintaining optimal incident photon fluxes. Interestingly, red, blue, and green LEDs can induce systemic acquired resistance in various plant species against fungal pathogens. Hence, when seasonal clouds restrict sunlight, LEDs can provide a controllable, alternative source of selected single or mixed wavelength photon source in greenhouse conditions.
Keywords	light-emitting diode ; bioactive compounds ; nutrition ; antioxidant ; fruit decay ; disease resistance ; Organic chemistry ; QD241-441
Subject code	535
Language	English
Publishing date	2017-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Molecular players of auxin transport systems

Tapan Kumar Mohanta / Tufail Bashir / Abeer Hashem / Elsayed Fathi Abd_Allah / Abdul Latif Khan / Ahmed Sulaiman Al-Harrasi

Journal of Plant Interactions, Vol 13, Iss 1, Pp 483-

advances in genomic and molecular events

2018 Volume 495

Abstract: Phytohormone auxin plays an indispensable role in the plethora of plant developmental process starting from the cell division, and cell elongation to morphogenesis. Auxins are transported to different parts of the plant by different sophisticated ... ...

Abstract	Phytohormone auxin plays an indispensable role in the plethora of plant developmental process starting from the cell division, and cell elongation to morphogenesis. Auxins are transported to different parts of the plant by different sophisticated transporter molecules known as ‘auxin transporters’.There are four auxin transporter families that have been reported so far in the plant kingdom which includes AUX/LAX (AUXIN-RESISTANT1–LIKES), PIN (PIN-FORMED, auxin efflux carriers), ABCB ((ATP-binding cassette-B (ABCB)/P-glycoprotein (PGP)) and PILS (PIN-Likes). Auxin influx and efflux carriers are distributed in a polar fashion in the plasma membrane whereas ABCB and PILS are present in a non-polar fashion. Other than AUX/LAX, other auxin transporters harbor N-and C-terminal conserved domains along with a variable hydrophilic loop in the transmembrane domain. The AUX/LAX, ABCB and PIN transporters mediate long distance auxin transport whereas PILS and PIN5 protein involved in intracellular auxin homeostasis.
Keywords	Auxin ; influx carrier ; efflux carrier ; AUX/LAX ; PIN ; ABCB ; PILS ; transmembrane domain ; Plant culture ; SB1-1110 ; Plant ecology ; QK900-989
Subject code	580
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Parental Age Affects Somatic Mutation Rates in the Progeny of Flowering Plants

Singh, Amit Kumar / Anantha Maharasi Ramakrishnan / Christian Sailer / Ramamurthy Baskar / Shanmuhapreya Dhanapal / Tufail Bashir / Ueli Grossniklaus / Viswanathan Gurumoorthy

Plant physiology. 2015 May, v. 168, no. 1

2015

Abstract: In humans, it is well known that the parental reproductive age has a strong influence on mutations transmitted to their progeny. Meiotic nondisjunction is known to increase in older mothers, and base substitutions tend to go up with paternal reproductive ...

Abstract	In humans, it is well known that the parental reproductive age has a strong influence on mutations transmitted to their progeny. Meiotic nondisjunction is known to increase in older mothers, and base substitutions tend to go up with paternal reproductive age. Hence, it is clear that the germinal mutation rates are a function of both maternal and paternal ages in humans. In contrast, it is unknown whether the parental reproductive age has an effect on somatic mutation rates in the progeny, because these are rare and difficult to detect. To address this question, we took advantage of the plant model system Arabidopsis ( Arabidopsis thaliana ), where mutation detector lines allow for an easy quantitation of somatic mutations, to test the effect of parental age on somatic mutation rates in the progeny. Although we found no significant effect of parental age on base substitutions, we found that frameshift mutations and transposition events increased in the progeny of older parents, an effect that is stronger through the maternal line. In contrast, intrachromosomal recombination events in the progeny decrease with the age of the parents in a parent-of-origin-dependent manner. Our results clearly show that parental reproductive age affects somatic mutation rates in the progeny and, thus, that some form of age-dependent information, which affects the frequency of double-strand breaks and possibly other processes involved in maintaining genome integrity, is transmitted through the gametes. The reproductive age of the parents has a significant influence on the kind and rate of somatic mutations in their progeny.
Keywords	Magnoliophyta ; parents ; progeny ; somatic mutation
Language	English
Dates of publication	2015-05
Size	p. 247-257.
Publishing place	American Society of Plant Biologists
Document type	Article
ZDB-ID	208914-2
ISSN	1532-2548 ; 0032-0889
ISSN (online)	1532-2548
ISSN	0032-0889
DOI	10.1104/pp.15.00291
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: ACE I/D genotype associates with strength in sarcopenic men but not with response to ACE inhibitor therapy in older adults with sarcopenia

Christos Rossios / Tufail Bashir / Marcus Achison / Simon Adamson / Asangaedem Akpan / Terry Aspray / Alison Avenell / Margaret M Band / Louise A Burton / Vera Cvoro / Peter T Donnan / Gordon W Duncan / Jacob George / Adam L Gordon / Celia L Gregson / Adrian Hapca / Cheryl Hume / Thomas A Jackson / Simon Kerr /

Alixe Kilgour / Tahir Masud / Andrew McKenzie / Emma McKenzie / Harnish Patel / Kristina Pilvinyte / Helen C Roberts / Avan A Sayer / Karen T Smith / Roy L Soiza / Claire J Steves / Allan D Struthers / Divya Tiwari / Julie Whitney / Miles D Witham / Paul R Kemp

PLoS ONE, Vol 18, Iss 10, p e

Results from the LACE trial.

2023 Volume 0292402

Abstract: Background Angiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as a method to inhibit muscle loss. The LACE clinical trial was designed to ... ...

Abstract	Background Angiotensin II (AII), has been suggested to promote muscle loss. Reducing AII synthesis, by inhibiting angiotensin converting enzyme (ACE) activity has been proposed as a method to inhibit muscle loss. The LACE clinical trial was designed to determine whether ACE inhibition would reduce further muscle loss in individuals with sarcopenia but suffered from low recruitment and returned a negative result. Polymorphic variation in the ACE promoter (I/D alleles) has been associated with differences in ACE activity and muscle physiology in a range of clinical conditions. This aim of this analysis was to determine whether I/D polymorphic variation is associated with muscle mass, strength, in sarcopenia or contributed to the lack of response to treatment in the LACE study. Methods Sarcopenic individuals were recruited into a 2x2 factorial multicentre double-blind study of the effects of perindopril and/or leucine versus placebo on physical performance and muscle mass. DNA extracted from blood samples (n = 130 72 women and 58 men) was genotyped by PCR for the ACE I/D polymorphism. Genotypes were then compared with body composition measured by DXA, hand grip and quadriceps strength before and after 12 months' treatment with leucine and/or perindopril in a cross-sectional analysis of the influence of genotype on these variables. Results Allele frequencies for the normal UK population were extracted from 13 previous studies (I = 0.473, D = 0.527). In the LACE cohort the D allele was over-represented (I = 0.412, D = 0.588, p = 0.046). This over-representation was present in men (I = 0.353, D = 0.647, p = 0.010) but not women (I = 0.458, D = 0.532, p = 0.708). In men but not women, individuals with the I allele had greater leg strength (II/ID = 18.00 kg (14.50, 21.60) vs DD = 13.20 kg (10.50, 15.90), p = 0.028). Over the 12 months individuals with the DD genotype increased in quadriceps strength but those with the II or ID genotype did not. Perindopril did not increase muscle strength or mass in any polymorphism ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia—Analyses from the LACE randomised controlled trial

Tufail Bashir / Marcus Achison / Simon Adamson / Asangaedem Akpan / Terry Aspray / Alison Avenell / Margaret M. Band / Louise A. Burton / Vera Cvoro / Peter T. Donnan / Gordon W. Duncan / Jacob George / Adam L. Gordon / Celia L. Gregson / Adrian Hapca / Cheryl Hume / Thomas A. Jackson / Simon Kerr / Alixe Kilgour /

Tahir Masud / Andrew McKenzie / Emma McKenzie / Harnish Patel / Kristina Pilvinyte / Helen C. Roberts / Christos Rossios / Avan A. Sayer / Karen T. Smith / Roy L. Soiza / Claire J. Steves / Allan D. Struthers / Divya Tiwari / Julie Whitney / Miles D. Witham / Paul R. Kemp

PLoS ONE, Vol 18, Iss

2023 Volume 11

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Activin type I receptor polymorphisms and body composition in older individuals with sarcopenia-Analyses from the LACE randomised controlled trial.

Tufail Bashir / Marcus Achison / Simon Adamson / Asangaedem Akpan / Terry Aspray / Alison Avenell / Margaret M Band / Louise A Burton / Vera Cvoro / Peter T Donnan / Gordon W Duncan / Jacob George / Adam L Gordon / Celia L Gregson / Adrian Hapca / Cheryl Hume / Thomas A Jackson / Simon Kerr / Alixe Kilgour /

Tahir Masud / Andrew McKenzie / Emma McKenzie / Harnish Patel / Kristina Pilvinyte / Helen C Roberts / Christos Rossios / Avan A Sayer / Karen T Smith / Roy L Soiza / Claire J Steves / Allan D Struthers / Divya Tiwari / Julie Whitney / Miles D Witham / Paul R Kemp

PLoS ONE, Vol 18, Iss 11, p e

2023 Volume 0294330

Abstract: Background Ageing is associated with changes in body composition including an overall reduction in muscle mass and a proportionate increase in fat mass. Sarcopenia is characterised by losses in both muscle mass and strength. Body composition and muscle ... ...

Abstract	Background Ageing is associated with changes in body composition including an overall reduction in muscle mass and a proportionate increase in fat mass. Sarcopenia is characterised by losses in both muscle mass and strength. Body composition and muscle strength are at least in part genetically determined, consequently polymorphisms in pathways important in muscle biology (e.g., the activin/myostatin signalling pathway) are hypothesised to contribute to the development of sarcopenia. Methods We compared regional body composition measured by DXA with genotypes for two polymorphisms (rs10783486, minor allele frequency (MAF) = 0.26 and rs2854464, MAF = 0.26) in the activin 1B receptor (ACVR1B) determined by PCR in a cross-sectional analysis of DNA from 110 older individuals with sarcopenia from the LACE trial. Results Neither muscle mass nor strength showed any significant associations with either genotype in this cohort. Initial analysis of rs10783486 showed that males with the AA/AG genotype were taller than GG males (174±7cm vs 170±5cm, p = 0.023) and had higher arm fat mass, (median higher by 15%, p = 0.008), and leg fat mass (median higher by 14%, p = 0.042). After correcting for height, arm fat mass remained significantly higher (median higher by 4% padj = 0.024). No associations (adjusted or unadjusted) were seen in females. Similar analysis of the rs2854464 allele showed a similar pattern with the presence of the minor allele (GG/AG) being associated with greater height (GG/AG = 174±7 cm vs AA = 170 ±5cm, p = 0.017) and greater arm fat mass (median higher by 16%, p = 0.023). Again, the difference in arm fat remained after correction for height. No similar associations were seen in females analysed alone. Conclusion These data suggest that polymorphic variation in the ACVR1B locus could be associated with body composition in older males. The activin/myostatin pathway might offer a novel potential target to prevent fat accumulation in older individuals.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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