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Article: Effect of temperature on the shift of Pseudomonas fluorescens from an environmental microorganism to a potential human pathogen.

Donnarumma, G / Buommino, E / Fusco, A / Paoletti, I / Auricchio, L / Tufano, M A

International journal of immunopathology and pharmacology

2010 Volume 23, Issue 1, Page(s) 227–234

Abstract: Pseudomonas fluorescens is a Gram-negative bacterium generally considered of scarce clinical significance. However, in the last few years, the isolation of P. fluorescens as the causative agent of nosocomial infections has rapidly increased. P. ... ...

Abstract	Pseudomonas fluorescens is a Gram-negative bacterium generally considered of scarce clinical significance. However, in the last few years, the isolation of P. fluorescens as the causative agent of nosocomial infections has rapidly increased. P. fluorescens is a psychrophile microorganism which grows at an optimal temperature of 25-30 degrees Celcius. In spite of this constraint, it has recently been reported that the human physiological temperature does not appear to be a barrier for this microorganism. In this study we examined the ability of P. fluorescens, grown at 28 degrees C or at 37 degrees C, to adhere to cultured human A549 pulmonary cells and to form biofilm. The ability of P. fluorescens to induce expression of proinflammatory cytokines, beta-defensin 2 and the intercellular adhesion molecule-1 was also investigated. Our results clearly indicate that inflammatory mediators are induced when the microorganism is grown at a lower temperature, while biofilm is formed only at 37 degrees C. The results presented are consistent with previous reports indicating P. fluorescens as an opportunistic pathogen and underscore the urgent need for further studies to better characterize the virulence of this microorganism.
MeSH term(s)	Bacterial Adhesion ; Biofilms ; Cell Line ; Cytokines/biosynthesis ; Humans ; Intercellular Adhesion Molecule-1/biosynthesis ; Pseudomonas fluorescens/pathogenicity ; Pseudomonas fluorescens/physiology ; Temperature ; beta-Defensins/biosynthesis
Chemical Substances	Cytokines ; DEFB4A protein, human ; beta-Defensins ; Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2010-01
Publishing country	England
Document type	Journal Article
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/039463201002300120
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Article ; Online: Hepatocyte growth factor (HGF) modulates Leydig cell extracellular matrix components.

Catizone, A / Ricci, G / Tufano, M A / Perfetto, B / Canipari, R / Galdieri, M

Journal of andrology

2010 Volume 31, Issue 3, Page(s) 306–313

Abstract: Hepatocyte growth factor (HGF) is a pleiotropic factor that plays multiple roles during mammalian development. We previously demonstrated that in the postnatal testes, the HGF receptor, c-met, is expressed by Leydig cells and HGF increases the ... ...

Abstract	Hepatocyte growth factor (HGF) is a pleiotropic factor that plays multiple roles during mammalian development. We previously demonstrated that in the postnatal testes, the HGF receptor, c-met, is expressed by Leydig cells and HGF increases the steroidogenetic activity of the cells. In the present article, we report that HGF modifies the composition of the extracellular matrix of cultured Leydig cells. We show that HGF increases the metabolic activity of isolated Leydig cells; in particular, the factor increases urokinase plasminogen activator and matrix metalloproteinase 2 secretion. We have also shown that the levels of active transforming growth factor beta are increased by HGF. On the contrary, using the Western blotting technique, a strong reduction in the amount of fibronectin present in the culture medium of cells cultured in the presence of HGF has been detected. The presented data demonstrate that HGF modulates several functional activities of Leydig cells, further supporting the hypothesis that this factor has a relevant role in the regulation of mammalian spermatogenesis.
MeSH term(s)	Animals ; Cells, Cultured ; Extracellular Matrix/metabolism ; Fibronectins/biosynthesis ; Hepatocyte Growth Factor/physiology ; Leydig Cells/drug effects ; Leydig Cells/metabolism ; Male ; Matrix Metalloproteinase 2/biosynthesis ; Rats ; Rats, Wistar ; Transforming Growth Factor beta/metabolism ; Urokinase-Type Plasminogen Activator/biosynthesis
Chemical Substances	Fibronectins ; Transforming Growth Factor beta ; Hepatocyte Growth Factor (67256-21-7) ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2010-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	604624-1
ISSN	1939-4640 ; 0196-3635
ISSN (online)	1939-4640
ISSN	0196-3635
DOI	10.2164/jandrol.109.007658
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Article ; Online: Modification of osteopontin and MMP-9 levels in patients with psoriasis on anti-TNF-α therapy.

Buommino, E / De Filippis, A / Gaudiello, F / Balato, A / Balato, N / Tufano, M A / Ayala, Fabio

Archives of dermatological research

2012 Volume 304, Issue 6, Page(s) 481–485

Abstract: Psoriasis is a chronic skin inflammatory disease in which a pleiotropic cytokine, tumor necrosis factor alpha (TNF-α), plays a central role, as demonstrated by the clinical success of anti-TNF-α therapy. Among the multiple effects of TNF-α on ... ...

Abstract	Psoriasis is a chronic skin inflammatory disease in which a pleiotropic cytokine, tumor necrosis factor alpha (TNF-α), plays a central role, as demonstrated by the clinical success of anti-TNF-α therapy. Among the multiple effects of TNF-α on keratinocytes, the induction of matrix metalloproteinase-9 (MMP-9), a collagenase implicated in joint inflammation, might be one of the key mechanisms in psoriasis pathogenesis. Interestingly, MMP-9 expression can be enhanced also by osteopontin (OPN), a glycosylated protein whose levels are increased in skin and peripheral blood mononuclear cells (PBMC) of psoriasis patients. The aim of the current study is to investigate the relationship between OPN, MMP-9 and TNF-α in psoriasis. Our survey identified high levels of both OPN and MMP-9 in PBMC as well as skin of psoriatic patients with respect to healthy controls. Significant reduction of OPN and MMP-9 levels in PBMC, plasma and lesional skin of psoriasis patients was observed after 24 weeks of anti-TNF-α therapy. Moreover, OPN and MMP-9 were enhanced by TNF-α and down-regulated by anti-TNF-α treatment in healthy PBMC. These findings may suggest that OPN and MMP-9 may be regulated by TNF-α, indicating a possible role in the pathogenesis of psoriasis.
MeSH term(s)	Humans ; Leukocytes, Mononuclear/chemistry ; Matrix Metalloproteinase 9/blood ; Matrix Metalloproteinase 9/physiology ; Osteopontin/blood ; Osteopontin/physiology ; Psoriasis/blood ; Psoriasis/drug therapy ; Psoriasis/etiology ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Chemical Substances	Tumor Necrosis Factor-alpha ; Osteopontin (106441-73-0) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2012-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-012-1251-3
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Article ; Online: 3-O-methylfunicone, from Penicillium pinophilum, is a selective inhibitor of breast cancer stem cells.

Buommino, E / Tirino, V / De Filippis, A / Silvestri, F / Nicoletti, R / Ciavatta, M L / Pirozzi, G / Tufano, M A

Cell proliferation

2011 Volume 44, Issue 5, Page(s) 401–409

Abstract: Objectives: Cancer stem cells make up a subpopulation of cells within tumours that drive tumour initiation, growth and recurrence. They are resistant to many current types of cancer treatment, causing failure of such therapeutic approaches, including ... ...

Abstract	Objectives: Cancer stem cells make up a subpopulation of cells within tumours that drive tumour initiation, growth and recurrence. They are resistant to many current types of cancer treatment, causing failure of such therapeutic approaches, including chemotherapy and radiotherapy. In the study described here, anti-proliferative effects of 3-O-methylfunicone (OMF), a metabolite from Penicillium pinophilum, were investigated on human breast cancer MCF-7 cells and cancer stem cells selected as mammospheres derived from MCF-7s. Materials and methods: Stemness markers were analysed on isolated mammospheres showing positive expression of CD24, CD29, CD44, CD133, CD184 and CD338. Cell proliferation and apoptosis were analysed by flow cytometry and RT-PCR. Cell colony formation assays were performed to evaluate colony formation of mammospheres. Results and conclusion: OMF treatment affected both MCF-7 and mammosphere growth, inducing apoptosis. In addition, OMF strongly reduced stemness markers and survivin, hTERT and Nanog-1 gene expression. Growth of colonies in soft-agar was significantly affected by OMF treatment, too. Lastly, we tested ability of MCF-7 cells to form mammospheres after treatment with OMF or cisplatin, demonstrating that OMF treatment resulted in drastic reduction in number of mammospheres. These results introduce OMF as an effective molecule in suppressing breast cancer stem cells.
MeSH term(s)	Antineoplastic Agents/isolation & purification ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Base Sequence ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Primers/genetics ; Female ; Gene Expression/drug effects ; Homeodomain Proteins/genetics ; Humans ; Inhibitor of Apoptosis Proteins/genetics ; Nanog Homeobox Protein ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Penicillium/chemistry ; Polymerase Chain Reaction ; Pyrones/isolation & purification ; Pyrones/pharmacology ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/pathology ; Survivin ; Telomerase/genetics ; Tumor Stem Cell Assay
Chemical Substances	3-O-methylfunicone ; Antineoplastic Agents ; BIRC5 protein, human ; DNA Primers ; Homeodomain Proteins ; Inhibitor of Apoptosis Proteins ; NANOG protein, human ; Nanog Homeobox Protein ; Pyrones ; Survivin ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2011-09-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/j.1365-2184.2011.00766.x
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Article: Effects of toluidine blue-mediated photodynamic therapy on periopathogens and periodontal biofilm: in vitro evaluation.

Nastri, L / Donnarumma, G / Porzio, C / De Gregorio, V / Tufano, M A / Caruso, F / Mazza, C / Serpico, R

International journal of immunopathology and pharmacology

2010 Volume 23, Issue 4, Page(s) 1125–1132

Abstract: Photodynamic therapy (PDT) is a selective modality of killing targeted cells, mostly known for its application in neoplasms. PDT can be considered to be an alternative method for the elimination of periodontal bacteria from the pocket without harms for ... ...

Abstract	Photodynamic therapy (PDT) is a selective modality of killing targeted cells, mostly known for its application in neoplasms. PDT can be considered to be an alternative method for the elimination of periodontal bacteria from the pocket without harms for the resident tissues. Therefore, PDT may replace systemic antibiotics and enhance the effect of mechanical treatments of periodontal defects. This effort focused on the in vitro sensitization of periopathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Fusobacterium nucleatum and Prevotella intermedia ) Toluidine Blue mediated and on the use of a Diode laser emitting source. The objective of this research was to evaluate the bactericidal in vitro effect of laser diodes 830 nm (as the light source) after photosensitization with Toluidine Blue (TBO) on the following periopathogenic bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Fusobacterium nucleatum and Prevotella intermedia. After evaluating the effect on the single bacterial strain, the ability of Diode Laser to disrupt the structure of biofilms produced by A. actinomycetemcomitans after photosensitization with TBO was also analyzed. The study suggests that the association of TBO and diode laser light 830 nm is effective for the killing of bacteria strains and determines the photoinactivation of Aggregatibacter biofilms. In summary, photodynamic therapy has effectively shown its capabilities and, therefore, it can be considered a valid alternative approach to antimicrobial therapy of periodontitis.
MeSH term(s)	Bacteria/drug effects ; Biofilms/drug effects ; Humans ; Lasers, Semiconductor ; Periodontal Diseases/microbiology ; Photochemotherapy ; Tolonium Chloride/pharmacology
Chemical Substances	Tolonium Chloride (15XUH0X66N)
Language	English
Publishing date	2010-10
Publishing country	England
Document type	Journal Article
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/039463201002300416
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Article ; Online: 3-O-Methylfunicone, a metabolite produced by Penicillium pinophilum, modulates ERK1/2 activity, affecting cell motility of human mesothelioma cells.

Buommino, E / Paoletti, I / De Filippis, A / Nicoletti, R / Ciavatta, M L / Menegozzo, S / Menegozzo, M / Tufano, M A

Cell proliferation

2010 Volume 43, Issue 2, Page(s) 114–123

Abstract: Objectives: 3-O-methylfunicone (OMF), a secondary metabolite produced by Penicillium pinophilum, affects cell proliferation and motility in a variety of human solid tumours. The aim of this study was to demonstrate whether OMF has the ability to arrest ... ...

Abstract	Objectives: 3-O-methylfunicone (OMF), a secondary metabolite produced by Penicillium pinophilum, affects cell proliferation and motility in a variety of human solid tumours. The aim of this study was to demonstrate whether OMF has the ability to arrest cell division and motility, in a human mesothelioma cell line. Malignant mesothelioma is an aggressive cancer that does not respond to standard therapies the cells of which are considered to be highly resistant to apoptosis. Material and methods: Cell motility and invasion were measured using a modified Boyden chamber. Gene expression was examined by RT-PCR, while ERK1/2 was investigated by Western blot analysis. All experiments were also performed on primary cultures of mesothelial cells. Results: The present study shows that OMF inhibited motility of the NCI mesothelioma cell line by modulating ERK signalling activity, and affected alphaVbeta5 integrin and MMP-2 expression, inducing marked downregulation at both mRNA and protein levels. Substantial downregulation of VEGF gene expression was also demonstrated. These effects were not observed in normal mesothelial cell cultures. Conclusion: OMF may have potential as a naturally derived anti-tumour drug for treatment of mesothelioma.
MeSH term(s)	Cell Line, Tumor ; Cell Movement/drug effects ; Down-Regulation ; Humans ; Matrix Metalloproteinase 2/metabolism ; Mesothelioma/genetics ; Mesothelioma/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Penicillium/metabolism ; Pyrones/pharmacology ; Receptors, Vitronectin/metabolism ; Signal Transduction/genetics
Chemical Substances	3-O-methylfunicone ; Pyrones ; Receptors, Vitronectin ; integrin alphaVbeta5 ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2010-06-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/j.1365-2184.2010.00663.x
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Article ; Online: 3-O-methylfunicone, a metabolite of Penicillium pinophilum, inhibits proliferation of human melanoma cells by causing G(2) + M arrest and inducing apoptosis.

Baroni, A / De Luca, A / De Filippis, A / Petrazzuolo, M / Manente, L / Nicoletti, R / Tufano, M A / Buommino, E

Cell proliferation

2009 Volume 42, Issue 4, Page(s) 541–553

Abstract: Objectives: Melanoma cells take advantage of impaired ability to undergo programmed cell death in response to different external stimuli and chemotherapeutic drugs; this makes prevention of tumour progression very difficult. The aim of this study was to ...

Abstract	Objectives: Melanoma cells take advantage of impaired ability to undergo programmed cell death in response to different external stimuli and chemotherapeutic drugs; this makes prevention of tumour progression very difficult. The aim of this study was to demonstrate whether 3-O-methylfunicone (OMF), a metabolite of Penicillium pinophilum, has the ability to arrest cell population growth and to induce apoptosis in A375P (parental) and A375M (metastasis derivatived) melanoma cell lines. Materials and methods: Cell proliferation and apoptosis were analysed by flow cytometry, DNA fragmentation, caspase-3 and caspase-9 activation, and PARP-1 cleavage. Results: We demonstrated that OMF affected cell proliferation in a time- and dose-dependent manner, reaching the best effect at concentration of 80 microg/ml for 24 h. Flow cytometry revealed that OMF caused significant G(2) phase arrest, which was associated with marked decrease in cyclin B1/p34(cdc2) complex and p21 induction. OMF also induced marked decrease of survivin expression. Reduced levels of apoptosis were evident after silencing p21 expression in both cell lines. Finally, the effect exercised by OMF on hTERT and TEP-1 gene expression confirmed the ability of this molecule to interfere with replicative ability of cells. Conclusions: The results reported here seem to suggest that OMF as a promising molecule to include in strategies for treatment of melanoma.
MeSH term(s)	Apoptosis/drug effects ; Caspase 3/metabolism ; Caspase 9/metabolism ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Melanoma/drug therapy ; Penicillium/metabolism ; Poly (ADP-Ribose) Polymerase-1 ; Poly(ADP-ribose) Polymerases/metabolism ; Pyrones/isolation & purification ; Pyrones/pharmacology ; RNA, Small Interfering/genetics ; rho GTP-Binding Proteins/genetics
Chemical Substances	3-O-methylfunicone ; Pyrones ; RNA, Small Interfering ; PARP1 protein, human (EC 2.4.2.30) ; Poly (ADP-Ribose) Polymerase-1 (EC 2.4.2.30) ; Poly(ADP-ribose) Polymerases (EC 2.4.2.30) ; Caspase 3 (EC 3.4.22.-) ; Caspase 9 (EC 3.4.22.-) ; rho GTP-Binding Proteins (EC 3.6.5.2)
Language	English
Publishing date	2009-05-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1064202-x
ISSN	1365-2184 ; 0008-8730 ; 0960-7722
ISSN (online)	1365-2184
ISSN	0008-8730 ; 0960-7722
DOI	10.1111/j.1365-2184.2009.00609.x
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Article ; Online: Antibacterial activity of cefditoren against major community-acquired respiratory pathogens recently isolated in Italy.

Stefani, S / Mezzatesta, M L / Fadda, G / Mattina, R / Palù, G / Rossano, F / Tufano, M A / Schito, G C / Nicoletti, G

Journal of chemotherapy (Florence, Italy)

2008 Volume 20, Issue 5, Page(s) 561–569

Abstract: In this study we evaluated the in vitro activities of cefditoren--a broad-spectrum oral cephalosporin--and other comparator agents against 2,396 fresh isolates from community-acquired respiratory tract infections, collected from 6 clinical Italian ... ...

Abstract	In this study we evaluated the in vitro activities of cefditoren--a broad-spectrum oral cephalosporin--and other comparator agents against 2,396 fresh isolates from community-acquired respiratory tract infections, collected from 6 clinical Italian microbiology laboratories. On penicillin-susceptible pneumococci and Streptococcus pyogenes, cefditoren demonstrated to be the most active antibiotic (MIC(90)values of 0.03 and 0.06 mg/L respectively), showing only a slight decrease in potency on penicillin-intermediate and resistant pneumococci (MIC(90)value 0.5 mg/L, 1.0 mg/L respectively). All the other comparators displayed MIC(90 )values of 4 - 8 mg/L for penicillins and of 4 to >64 mg/L for the oral cephalosporins. Cefditoren and levofloxacin were the most active against MSSA (MIC(90)0.5 mg/mL). Cefditoren displayed a uniformly potent inhibitory activity (MIC(90)of 0.03 mg/L) against all strains of Haemophilus influenzae, regardless of their ampicillin resistance (mediated or not by beta-lactamase production), while against Moraxella catarrhalis MIC(90)values were higher against beta-lactamase-positive (0.25 mg/L). Cefditoren was active also against Klebsiella pneumoniae and Escherichia coli : in this case its activity was comparable with that of levofloxacin. In conclusion, cefditoren, due to its potent activity, is a new effective therapeutic option for the treatment of respiratory tract infections.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Cephalosporins/pharmacology ; Community-Acquired Infections/drug therapy ; Community-Acquired Infections/microbiology ; Haemophilus influenzae/drug effects ; Humans ; Italy ; Klebsiella pneumoniae/drug effects ; Microbial Sensitivity Tests ; Moraxella (Branhamella) catarrhalis/drug effects ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/microbiology ; Streptococcus pneumoniae/drug effects ; Streptococcus pyogenes/drug effects
Chemical Substances	Anti-Bacterial Agents ; Cephalosporins ; cefditoren (81QS09V3YW)
Language	English
Publishing date	2008-10
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1036294-0
ISSN	1973-9478 ; 1120-009X
ISSN (online)	1973-9478
ISSN	1120-009X
DOI	10.1179/joc.2008.20.5.561
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Article: Ricerche sulla O-streptolisina.

Tufano, M A

Rivista dell'Istituto sieroterapico italiano

1968 Volume 43, Issue 4, Page(s) 212–215

Title translation	Research on streptolysin O.
MeSH term(s)	Amino Acids/analysis ; Hemolysin Proteins/analysis ; Peptides/analysis ; Spectrum Analysis ; Streptolysins/analysis
Chemical Substances	Amino Acids ; Hemolysin Proteins ; Peptides ; Streptolysins
Language	Italian
Publishing date	1968-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	840700-9
ISSN	0300-9904
ISSN	0300-9904
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Article: Antiviral effects of quinine sulfate on HSV-1 HaCat cells infected: analysis of the molecular mechanisms involved.

Baroni, A / Paoletti, I / Ruocco, E / Ayala, F / Corrado, F / Wolf, R / Tufano, M A / Donnarumma, G

Journal of dermatological science

2007 Volume 47, Issue 3, Page(s) 253–255

MeSH term(s)	Animals ; Antimalarials/pharmacology ; Antiviral Agents/pharmacology ; Cell Line, Tumor ; Cercopithecus aethiops ; HSP70 Heat-Shock Proteins/biosynthesis ; Herpes Simplex Virus Protein Vmw65/biosynthesis ; Herpesvirus 1, Human/metabolism ; Humans ; Immediate-Early Proteins/biosynthesis ; NF-kappa B/metabolism ; Quinine/pharmacology ; Vero Cells ; Virus Replication/drug effects
Chemical Substances	Antimalarials ; Antiviral Agents ; HSP70 Heat-Shock Proteins ; Herpes Simplex Virus Protein Vmw65 ; ICP27 protein, human herpesvirus 1 ; Immediate-Early Proteins ; NF-kappa B ; Quinine (A7V27PHC7A)
Language	English
Publishing date	2007-09
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1024446-3
ISSN	0923-1811
ISSN	0923-1811
DOI	10.1016/j.jdermsci.2007.05.009
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In stock of ZB MED Cologne/Königswinter

Order via subito

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Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito