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  1. Article ; Online: A Management of Ureteral Obstruction After Lichtenstein Tension-Free Hernia Repair in a Kidney Transplant Recipient: A Case Report.

    Avci, Emran Kuzey / Capar, Ahmet Ergin / Tugmen, Cem / Sert, Ismail

    Transplantation proceedings

    2021  Volume 53, Issue 4, Page(s) 1275–1278

    Abstract: Background: The number of renal transplants has been increasing in recent years. Recent literature data show that abdominal operations performed on patients who undergo renal transplant have higher morbidity and mortality.: Case presentation: A 49- ... ...

    Abstract Background: The number of renal transplants has been increasing in recent years. Recent literature data show that abdominal operations performed on patients who undergo renal transplant have higher morbidity and mortality.
    Case presentation: A 49-year-old man who had received a renal transplant from a living donor 19 years ago underwent Lichtenstein tension-free hernia repair. Anuria was observed after the operation. Renal ultrasound demonstrated massive hydronephrosis and an elevated serum creatinine level (4.6 mg/dL). It was thought that the ureter may have been obstructed because of the operation, and, with the patient under local anesthesia, all sutures and polypropylene mesh were removed. Urine output was still not present, so a percutaneous nephrostomy catheter was inserted to normalize renal function. The patient underwent reoperation under general anesthesia 45 hours after the first operation. It was observed that the ureter was ligated during high ligation. The ureter was released, and no additional intervention was performed. The patient was discharged 6 days later with a return to basal creatinine level and a percutaneous nephrostomy catheter. The patient was hospitalized twice for severe urinary tract infection and urosepsis within 3 months and received appropriate treatment. The patient has had an uneventful postoperative course for 18 months.
    Discussion: Inguinal hernia repair is seen as a safe surgical procedure, but the risk of emerging urological complications is higher in patients with renal transplant. Imaging before surgery to identify the anatomy of the kidney and ureter may be useful. Delicate dissection of the extraperitoneal area during the operation will reduce surgical complications.
    MeSH term(s) Hernia, Inguinal/etiology ; Hernia, Inguinal/surgery ; Herniorrhaphy/adverse effects ; Herniorrhaphy/methods ; Humans ; Hydronephrosis/etiology ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Living Donors ; Male ; Middle Aged ; Nephrostomy, Percutaneous ; Postoperative Complications/etiology ; Postoperative Complications/surgery ; Reoperation/methods ; Ureter/surgery ; Ureteral Obstruction/etiology
    Language English
    Publishing date 2021-04-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2021.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effect of preoperative skeletal muscle area and prognostic nutritional index values on postoperative morbidity and mortality in patients with gastric cancer: a single-center retrospective analysis.

    Tuncer, Korhan / Sert, Ismail / Kilinc, Gizem / Tugmen, Cem / Emiroglu, Mustafa

    Acta chirurgica Belgica

    2021  Volume 123, Issue 3, Page(s) 251–256

    Abstract: Introduction: The aim of this study was to determine the impact of preoperative prognostic nutritional index (PNI) value and skeletal muscle area (SMA) on short-term outcomes of patients with gastric cancer.: Patients and methods: A total of 107 ... ...

    Abstract Introduction: The aim of this study was to determine the impact of preoperative prognostic nutritional index (PNI) value and skeletal muscle area (SMA) on short-term outcomes of patients with gastric cancer.
    Patients and methods: A total of 107 patients underwent gastrectomy due to gastric cancer between January 2016 and December 2019 were retrospectively analyzed. The patients were divided into groups according to the determined PNI and SMA cutoff values. Clinicopathological features and short-term results were compared.
    Results: Overall morbidity was 29% (
    Conclusions: As a result, preoperative SMA and PNI values were found closely related to the postoperative hospital stay, morbidity and mortality results of patients with gastric cancer. Preoperative nutritional support may help to overcome longer hospital stay, higher mortality and morbidity rates in patients with gastric cancer.
    MeSH term(s) Male ; Humans ; Female ; Nutrition Assessment ; Retrospective Studies ; Prognosis ; Sarcopenia/complications ; Sarcopenia/pathology ; Stomach Neoplasms/pathology ; Muscle, Skeletal/pathology ; Morbidity ; Gastrectomy/adverse effects ; Nutritional Status
    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 210274-2
    ISSN 0001-5458
    ISSN 0001-5458
    DOI 10.1080/00015458.2021.1977462
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  3. Article ; Online: Isolated Metastasis of Pancreas due to Endometrial Carcinoma.

    Atici, Semra Demirli / Akpinar, Goksever / Sert, Ismail / Tugmen, Cem

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2021  Volume 30, Issue 12, Page(s) 1362–1363

    MeSH term(s) Endometrial Neoplasms ; Female ; Humans ; Pancreas
    Language English
    Publishing date 2021-01-04
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2020.12.1362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Investigation of Anti-HLA Antibodies of Highly Sensitized Patients by Single Antigen Bead and C1q Tests.

    Ayna, T K / Koçyİğİt, A Ö / Soypaçaci, Z / Tuğmen, C / Pirim, I

    Transplantation proceedings

    2019  Volume 51, Issue 4, Page(s) 1024–1026

    Abstract: Purpose: The single antigen bead (SAB) test contributes to conventional cellular and solid phase crossmatch tests in renal transplantation. However, the determination of anti-HLA antibodies of the patients may not reflect the pathologic features of ... ...

    Abstract Purpose: The single antigen bead (SAB) test contributes to conventional cellular and solid phase crossmatch tests in renal transplantation. However, the determination of anti-HLA antibodies of the patients may not reflect the pathologic features of these antibodies. Highly sensitized patients produce antibodies against a number of HLAs; therefore, their transplantation chance decreases. In this study, we aimed to evaluate SAB and C1q test results of highly sensitized patients.
    Method: In this study, 33 end-stage renal failure patients with >80% panel reactive antibody were included. Of the patients, 58% (n = 19) were female, and 42% (n = 14) were male. The mean age was 46.2 ± 12.4. All of the serum samples were inactivated by heat before use. SAB and C1q tests were performed according to the manufacturer's instructions.
    Results: We obtained statistically significant results between the positive bead counts and raw mean fluorescence intensity (MFI) values of 2 tests (P < .01 for class I and II). There was a statistically significant difference between the 2 tests in terms HLA-A, -C, -DR, and -DP MFI values, whereas HLA-B and -DQ MFI values were similar for the 2 tests.
    Conclusion: The difference of raw MFI values between the 2 tests may be due to the fact that the C1q test detects only IgG1 and IgG3 antibodies, whereas the SAB test can detect all IgG subtypes. We considered that anti-HLA-B and -DQ antibodies have high complement-fixing features; these antibodies should be investigated selectively due to the similarity of anti-HLA-B and -DQ antibody MFI values in the 2 tests.
    MeSH term(s) Adult ; Blood Grouping and Crossmatching/methods ; Complement C1q/immunology ; Female ; Fluorescent Antibody Technique ; HLA Antigens/immunology ; Humans ; Immunoglobulin G/analysis ; Immunoglobulin G/immunology ; Isoantibodies/analysis ; Isoantibodies/immunology ; Kidney Failure, Chronic ; Kidney Transplantation ; Male ; Middle Aged
    Chemical Substances HLA Antigens ; Immunoglobulin G ; Isoantibodies ; Complement C1q (80295-33-6)
    Language English
    Publishing date 2019-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2019.01.086
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ectopic ureter associated with Zinner's syndrome in a kidney recipient: case report and literature review.

    Tuncer, Korhan / Kilinc, Gizem / Sert, Ismail / Akpinar, Goksever / Tugmen, Cem

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 5, Page(s) 692–695

    Abstract: INTRODUCTION Zinner's Syndrome is a triad of mesonephric duct anomalies comprising unilateral renal agenesis, seminal vesicle cyst, and ejaculatory duct obstruction. In this study, we present a kidney recipient with ectopic ureter associated with Zinner' ... ...

    Abstract INTRODUCTION Zinner's Syndrome is a triad of mesonephric duct anomalies comprising unilateral renal agenesis, seminal vesicle cyst, and ejaculatory duct obstruction. In this study, we present a kidney recipient with ectopic ureter associated with Zinner's syndrome and a literature review. CASE PRESENTATION A 59-year-old male with a history of chronic kidney disease and left renal agenesis underwent deceased donor kidney transplantation. After securing optimal renal functions, the patient underwent abdominal computed tomography (CT) scan for the seroma that occurred under the incision. The final diagnosis was an ectopic distal ureter ending in the seminal vesicle cyst's wall and ipsilateral renal agenesis. The patient was discharged without any complications and the clinical follow up was uneventful. DISCUSSION AND CONCLUSION Congenital seminal vesicle disorders are usually associated with ipsilateral urinary duct anomalies stemming from the same embryonic structure. To our knowledge, this is the first case report that describes kidney transplantation in a patient with ipsilateral renal agenesis and ectopic ureter ending in the seminal vesicle cyst. In patients with renal agenesis, during the ipsilateral urinary tract anastomosis, the possibility of ectopic ureter should be kept in mind otherwise graft loss can occur with a high morbidity rate.
    MeSH term(s) Cysts ; Genital Diseases, Male ; Humans ; Kidney ; Kidney Transplantation ; Male ; Middle Aged ; Seminal Vesicles ; Ureter
    Language English
    Publishing date 2020-07-03
    Publishing country Brazil
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.5.692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Symptomatic cholelithiasis may be the first sign of sarcoidosis.

    Akalın, Murat / Atıcı, Semra Demirli / Kahraman, Dudu Solakoğlu / Tuğmen, Cem

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 8, Page(s) 1018–1020

    Abstract: Sarcoidosis is a multisystemic noncaseating granulomatous disease that rarely affects the gastrointestinal system. The initial diagnosis of sarcoidosis with gallbladder/gallbladder-associated lymph node involvement is a very rare condition in the ... ...

    Abstract Sarcoidosis is a multisystemic noncaseating granulomatous disease that rarely affects the gastrointestinal system. The initial diagnosis of sarcoidosis with gallbladder/gallbladder-associated lymph node involvement is a very rare condition in the literature. Herein, we aimed to report a case of newly diagnosed sarcoidosis with lymph node involvement associated with the gallbladder.
    MeSH term(s) Cholelithiasis/etiology ; Humans ; Rare Diseases ; Sarcoidosis/complications
    Language English
    Publishing date 2020-09-11
    Publishing country Brazil
    Document type Letter
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.8.1018
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  7. Article ; Online: Corticosteroid associated lupus pancreatitis.

    Atıcı, Semra Demirli / Engin, Ömer / Akpınar, Göksever / Tuğmen, Cem

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 10, Page(s) 1414–1416

    Abstract: The relationship between acute pancreatitis and the administration of glucocorticoids is unclear because most reported cases have been diagnosed with systemic vascular diseases, such as systemic lupus erythematosus, which may be responsible for ... ...

    Abstract The relationship between acute pancreatitis and the administration of glucocorticoids is unclear because most reported cases have been diagnosed with systemic vascular diseases, such as systemic lupus erythematosus, which may be responsible for pancreatitis. A 22-year-old woman with eye involvement of a newly diagnosed systemic lupus erythematosus was admitted to our hospital. Pulse intravenous methylprednisolone therapy was given at 1mg/kg day for 3 days, and oral prednisolone at 40 mg/day thereafter. During pulse steroid therapy, she had abdominal pain, back pain, distention, nausea, and vomiting. Her physical examination was compatible with acute abdomen and peritonitis. Abdomen Computerized Tomography scan revealed diffuse liquid perihepatic and perisplenic area with heterogeneity around the mesentery. Due to the symptoms of acute abdomen, explorative laparotomy was performed. There was diffuse free fluid in the abdomen and edematous changes were observed around the pancreas. Amylase and lipase from intraabdominal fluid were studied and found to be high. The postoperative prednol dose was reduced carefully. On the sixth postoperative day, the drain was removed, and the patient was discharged without any problem. Physicians should keep in mind that acute pancreatitis may also be a cause of differential diagnosis of newly developed abdominal pain in patients receiving pulse steroid therapy with a normal level of serum amylase and lipase.
    MeSH term(s) Acute Disease ; Adrenal Cortex Hormones ; Female ; Humans ; Lupus Erythematosus, Systemic/chemically induced ; Lupus Erythematosus, Systemic/complications ; Methylprednisolone/adverse effects ; Pancreatitis/chemically induced ; Young Adult
    Chemical Substances Adrenal Cortex Hormones ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2020-11-10
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.10.1414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Immunological Results of Long-Term Use of Mammalian Target of Rapamycin (mTOR) Inhibitors and Its Effects on Renal Graft Functions.

    Tanrısev, Mehmet / Ayna Kılıçaslan, Tülay / Çolak, Hülya / Ersan, Sibel / Yılmaz, Banu / Alp, Alper / Tuğmen, Cem / Sevgili, Bahar Engin

    Annals of transplantation

    2021  Volume 26, Page(s) e932434

    Abstract: BACKGROUND Calcineurin inhibitor drugs (CNI), which are the basis of immunosuppression in kidney transplantation, contribute to renal graft loss, with increased morbidity and mortality due to their potentially harmful effects on the renal graft, ... ...

    Abstract BACKGROUND Calcineurin inhibitor drugs (CNI), which are the basis of immunosuppression in kidney transplantation, contribute to renal graft loss, with increased morbidity and mortality due to their potentially harmful effects on the renal graft, cardiovascular system, and tumor pathology. For this reason, the mammalian target of rapamycin inhibitors (mTORi) such as sirolimus (SRL) and everolimus (EVE) has been preferred more frequently, as they are associated with fewer complications and longer graft function. MATERIAL AND METHODS We enrolled 89 adult renal transplant patients (37 patients on mTORi and 52 on CNI) who had similar age, sex, primary renal disease, dialysis type, post-transplant follow-up period, and donor type. We analyzed and compared the data between patients using mTORi for longer than 5 years and those using CNI regarding pre- and post-transplant panel reactive antibody (PRA), and donor-specific antibody (DSA), as well as post-transplantation and current graft functions. RESULTS Although those using mTORi for more than 5 years had significantly higher mismatch rates (P=0.024) than those using CNI, there was no significant change in PRA and DSA levels. Transplant time was longer in mTORi users (P=0.025). The switch time to mTORi in patients ranged from 0 to 19 years, but the average was 4 years. As expected, actual spot urine protein/creatinine was significantly higher in those using mTORi (P=0.009). Diabetes mellitus (DM) and BK virus nephropathy (BKVN) rates were significantly higher due to switching the regimen from CNI to mTORi. CONCLUSIONS Long-term use of mTORi does not appear to be an immunological problem.
    MeSH term(s) Adult ; Calcineurin Inhibitors/adverse effects ; Everolimus ; Female ; Graft Rejection/prevention & control ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation ; Male ; Middle Aged ; Sirolimus ; TOR Serine-Threonine Kinases/antagonists & inhibitors
    Chemical Substances Calcineurin Inhibitors ; Immunosuppressive Agents ; Everolimus (9HW64Q8G6G) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2021-09-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484710-3
    ISSN 2329-0358 ; 1425-9524
    ISSN (online) 2329-0358
    ISSN 1425-9524
    DOI 10.12659/AOT.932434
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  9. Article ; Online: Correlation of the Volume Control Parameters With Health Related Quality of Life in Renal Transplant Patients.

    Colak, H / Sert, I / Ekmekcı, C / Tugmen, C / Kurtulmus, Y / Kursat, S / Töz, H

    Transplantation proceedings

    2015  Volume 47, Issue 5, Page(s) 1369–1372

    Abstract: Introduction: Transplantation is the most effective treatment strategy for end-stage renal failure. We aimed to investigate the correlation of volume control parameters with health-related quality of life (HRQoL) in renal transplantation patients during ...

    Abstract Introduction: Transplantation is the most effective treatment strategy for end-stage renal failure. We aimed to investigate the correlation of volume control parameters with health-related quality of life (HRQoL) in renal transplantation patients during the pre- and post-transplantation periods.
    Material and methods: Seventy-seven patients who underwent renal transplantation from deceased donors between January 2011 and January 2013 were included in the study. The biochemical markers, complete blood count, and creatinine levels were measured during pretransplantation and at post-transplantation month 6. The Turkish version of the Short Form 36 (SF-36) health survey questionnaire was used for the assessment of HRQoL. Blood pressure (BP) and echocardiographic measurements were used to evaluate the volume status.
    Results: Significant improvements were achieved in all echocardiographic measurements, biochemical parameters except Ca(++), and SF-36 questionnaire domain scores (DSs) except vitality in the post-transplantation period. Systolic BP (SBP), the left atrium index, vena cava inferior collapsibility index (VCCI), and diastolic BP were associated with vitality (P = .02, .03, .05, and .04, respectively); SBP was associated with social functioning (P < .01) and role emotional (P < .01); and left ventricular mass index was associated with mental health (P = .05) DSs during the pretransplantation period. In the post-transplantation period, VCCI, left ventricular mass index, and SBP were associated with general health (P = .02, .05, and .05, respectively); VCCI and SBP were also associated with mental health (P = .05 and .01, respectively); and left atrium index was associated with role emotional (P = .05) DSs.
    Conclusion: Concomitant improvement in the volemic status may contribute to improvements in HRQoL after renal transplantation.
    MeSH term(s) Adult ; Cardiac Volume/physiology ; Echocardiography ; Female ; Humans ; Kidney Failure, Chronic/psychology ; Kidney Failure, Chronic/surgery ; Kidney Transplantation/psychology ; Male ; Quality of Life ; Surveys and Questionnaires ; Treatment Outcome
    Language English
    Publishing date 2015-06-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2015.04.012
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  10. Article ; Online: WITHDRAWN: Correlation of Volume Control Parameters With Health-Related Quality of Life in Renal Transplant Patients.

    Colak, H / Sert, I / Ekmekci, C / Tugmen, C / Kurtulmus, Y / Kursat, S / Töz, H

    Transplantation proceedings

    2015  

    Language English
    Publishing date 2015-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2014.11.003
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