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  1. Book ; Online ; E-Book: Drug targets in cellular processes of cancer

    Tuli, Hardeep Singh

    from nonclinical to preclinical models

    2020  

    Abstract: This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the ... ...

    Author's details Hardeep Singh Tuli, editor
    Abstract This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment. The book then discusses the regulation of various pro-apoptotic and anti-apoptotic proteins via chemotherapeutic drugs. In addition, it examines the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells. It subsequently reviews the role of reactive oxygen (ROS) species during carcinogenesis and during chemotherapy, and the potential of anti-inflammatory routes for the development of new therapeutic modulators. Lastly, it describes therapeutic strategies that target the tumor microenvironment and various angiogenic pathways for the treatment of cancer and to develop personalized medicine. Given its scope, the book is valuable resource for oncologists, cancer researchers, clinicians, and pharmaceutical industry personnel.
    Keywords Cancer/Molecular aspects
    Subject code 616.994
    Language English
    Size 1 online resource (XIII, 228 p. 28 illus., 26 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer
    Publishing place Gateway East, Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-7586-X ; 981-15-7585-1 ; 978-981-15-7586-0 ; 978-981-15-7585-3
    DOI 10.1007/978-981-15-7586-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Editorial: COVID 19: New Variants and Host Demography.

    Kaur, Ginpreet / Tuli, Hardeep Singh

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 905817

    MeSH term(s) COVID-19 ; Demography ; Humans ; SARS-CoV-2/genetics ; Vaccination
    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.905817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Phytochemical-based nanoformulations to tackle drug resistance in cancer.

    Tuli, Hardeep Singh / Kaur, Ginpreet / Yerer, Mükerrem Betül

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1165596

    Language English
    Publishing date 2023-03-16
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1165596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cancer and Nutrients.

    Tuli, Hardeep Singh / Yerer, Mukerrem Betul / Yadav, Vikas

    Cancers

    2023  Volume 15, Issue 16

    Abstract: Editorial: Over the last few decades, the scientific community has recognized the enormous potential of bioactive dietary nutrients/components in the management and prevention of cancer [ ... ]. ...

    Abstract Editorial: Over the last few decades, the scientific community has recognized the enormous potential of bioactive dietary nutrients/components in the management and prevention of cancer [...].
    Language English
    Publishing date 2023-08-17
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15164151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Patent landscape highlighting double-edged scaffold of a WNT5A-agonizing peptide, Foxy5.

    Yadav, Vikas / Islam, Rubina / Tuli, Hardeep Singh

    Pharmaceutical patent analyst

    2023  Volume 12, Issue 2, Page(s) 69–77

    Abstract: Aberrant expression of the WNT signaling pathway has been associated with cancer progression and recurrence. Research over the decades has led to development of WNT-targetable small molecules, but has faced challenges in translating to clinics. Unlike ... ...

    Abstract Aberrant expression of the WNT signaling pathway has been associated with cancer progression and recurrence. Research over the decades has led to development of WNT-targetable small molecules, but has faced challenges in translating to clinics. Unlike WNT/β-catenin inhibitors, WNT5A-mimicking peptide, Foxy5 has shown encouraging efficacy in impairing metastasis of cancers with low or absent WNT5A expression. Recent patent application US20210008149 advocates the implication of Foxy5 for treatment and prevention of cancer relapse. The inventors have demonstrated the anti-stemness activity of Foxy5 in mice xenograft model via suppressing the expression of colonic cancer stem cell markers. Foxy5 also exhibits non-toxic nature when administered alone or in synergy with standard chemotherapy thus strengthening its candidature in the field of cancer therapeutics.
    MeSH term(s) Animals ; Humans ; Mice ; Neoplasm Recurrence, Local ; Peptides ; Wnt Signaling Pathway ; Wnt-5a Protein/genetics
    Chemical Substances Peptides ; Wnt-5a Protein ; WNT5A protein, human ; Foxy-5 peptide
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Journal Article
    ISSN 2046-8962
    ISSN (online) 2046-8962
    DOI 10.4155/ppa-2022-0037
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Therapeutic potential of flavonoids in the management of obesity-induced Alzheimer's disease: an overview of preclinical and clinical studies.

    Kothawade, Sakshi M / Buttar, Harpal Singh / Tuli, Hardeep Singh / Kaur, Ginpreet

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 396, Issue 11, Page(s) 2813–2830

    Abstract: Obesity is a global epidemic that affects people of all ages, genders, and backgrounds. It can lead to a plethora of disorders, including diabetes mellitus, renal dysfunction, musculoskeletal problems, metabolic syndrome, cardiovascular, and ... ...

    Abstract Obesity is a global epidemic that affects people of all ages, genders, and backgrounds. It can lead to a plethora of disorders, including diabetes mellitus, renal dysfunction, musculoskeletal problems, metabolic syndrome, cardiovascular, and neurodegenerative abnormalities. Obesity has also been linked to neurological diseases such as cognitive decline, dementia, and Alzheimer's disease (AD), caused by oxidative stress, pro-inflammatory cytokines, and the production of reactive oxygen free radicals (ROS). Secretion of insulin hormone is impaired in obese people, leading to hyperglycaemia and increased accumulation of amyloid-β in the brain. Acetylcholine, a key neurotransmitter necessary for forming new neuronal connections in the brain, decreases in AD patients. To alleviate acetylcholine deficiency, researchers have proposed dietary interventions and adjuvant therapies that enhance the production of acetylcholine and assist in the management of AD patients. Such measures include dietary intervention with antioxidant and anti-inflammatory flavonoid-rich diets, which have been found to bind to tau receptors, reduce gliosis, and reduce neuroinflammatory markers in animal models. Furthermore, flavonoids like curcumin, resveratrol, epigallocatechin-3-gallate, morin, delphinidins, quercetin, luteolin, and oleocanthal have shown to cause significant reductions in interleukin-1β, increase BDNF levels, stimulate hippocampal neurogenesis and synapse formation, and ultimately prevent the loss of neurons in the brain. Thus, flavonoid-rich nutraceuticals can be a potential cost-effective therapeutic option for treating obesity-induced AD, but further well-designed, randomized, and placebo-controlled clinical studies are needed to assess their optimal dosages, efficacy, and long-term safety of flavonoids in humans. The main objectives of this review are to underscore the therapeutic potential of different nutraceuticals containing flavonoids that can be added in the daily diet of AD patients to enhance acetylcholine and reduce neuronal inflammation in the brain.
    MeSH term(s) Female ; Male ; Animals ; Humans ; Alzheimer Disease/drug therapy ; Alzheimer Disease/metabolism ; Flavonoids/therapeutic use ; Flavonoids/pharmacology ; Acetylcholine ; Amyloid beta-Peptides/metabolism ; Obesity/drug therapy
    Chemical Substances Flavonoids ; Acetylcholine (N9YNS0M02X) ; Amyloid beta-Peptides
    Language English
    Publishing date 2023-05-25
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02529-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: The Emergence of Mpox: Epidemiology and Current Therapeutic Options.

    Ranjan, Samriddhi / Vashishth, Kanupriya / Sak, Katrin / Tuli, Hardeep Singh

    Current pharmacology reports

    2023  Volume 9, Issue 3, Page(s) 144–153

    Abstract: The world recently witnessed the emergence of new epidemic outbreaks like COVID-19 and mpox. The 2022 outbreak of mpox amid COVID-19 presents an intricate situation and requires strategies to combat the status quo. Some of the challenges to controlling ... ...

    Abstract The world recently witnessed the emergence of new epidemic outbreaks like COVID-19 and mpox. The 2022 outbreak of mpox amid COVID-19 presents an intricate situation and requires strategies to combat the status quo. Some of the challenges to controlling an epidemic include present knowledge of the disease, available treatment options, appropriate health infrastructures facilities, current scientific methods, operations concepts, availability of technical staff, financial funds, and lastly international policies to control an epidemic state. These insufficiencies often hinder the control of disease spread and jeopardize the health of countless people. Also, disease outbreaks often put a huge burden on the developing economies. These countries are the worst affected and are immensely dependent on assistance provided from the larger economies to control such outbreaks. The first case of mpox was reported in the 1970s and several outbreaks were detected thereafter in the endemic areas eventually leading to the recent outbreak. Approximately, more than 80,000 individuals were infected, and 110 countries were affected by this outbreak. Yet, no definite vaccines and drugs are available to date. The lack of human clinical trials affected thousands of individuals in availing definite disease management. This paper focuses on the epidemiology of mpox, scientific concepts, and treatment options including future treatment modalities for mpox.
    Language English
    Publishing date 2023-05-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2198-641X
    ISSN 2198-641X
    DOI 10.1007/s40495-023-00318-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Antibiotic susceptibility profile and detection of plasmid-mediated quinolone resistant genes among extended spectrum b-lactamases (ESBL) producing uropathogens in women

    Kaur Rajanbir / Singh Drishtant / Kesavan Anup Kumar / Chauhan Abhishek / Tuli Hardeep Singh / Kaur Rajinder

    Scripta Medica, Vol 54, Iss 4, Pp 315-

    2023  Volume 328

    Abstract: Background/Aim: The most common bacterial diseases in women around the world are urinary tract infections. Aim of this study, was to evaluate the prevalence and current antibiotic resistance rate of uropathogens isolated from the female patients of a ... ...

    Abstract Background/Aim: The most common bacterial diseases in women around the world are urinary tract infections. Aim of this study, was to evaluate the prevalence and current antibiotic resistance rate of uropathogens isolated from the female patients of a tertiary care hospital in Amritsar, Punjab, India. Methods: Samples were collected from patients showing urinary tract infection (UTI) symptoms and analysed using microscopy, dipstick test and urine culturing followed by identification and characterisation of to identify the uropathogens. Antibiotic susceptibility test and MIC were performed. Results: The results revealed that E coli (35.5 %) was the most prominent uropathogen followed by Klebsiella spp (21 %), Enterobacter spp (17 %), Acinetobacter (11 %), Enterococcus spp (6 %), Pseudomonas spp (4.5 %), coagulase negative Staphylococci (4 %), coagulase-positive Staphylococci (0.5 %) and Corynebacterium aurimucosum (0.5 %). The antibiotic susceptibility profile study reported eight isolates with multi-drug resistance properties. However, gentamicin, imipenem and meropenem were found to be the most effective antibiotics against the isolated uropathogens. All the extended spectrum β-lactamase (ESBL)-positive isolates possess the quinolone-resistant gene qnrB, while qnrA was absent. Conclusion: The current study revealed that for appropriate treatment, it is crucial to be aware of the epidemiological data regarding the disease and to begin any empirical antibiotic treatment.
    Keywords urinary tract infection (uti) ; uropathogens ; antibiotic susceptibility ; β-lactamase ; quinolone resistance ; multi-drug resistant ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Editorial: Current Aspects in Chemopreventive Strategies, Volume II.

    Tuli, Hardeep Singh / Yerer, Mükerrem Betül / Sak, Katrin

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 961334

    Language English
    Publishing date 2022-07-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.961334
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Optimization and Characterization of a Novel Antioxidant Naringenin-Loaded Hydrogel for Encouraging Re-Epithelization in Chronic Diabetic Wounds: A Preclinical Study.

    Raina, Neha / Haque, Shafiul / Tuli, Hardeep Singh / Jain, Atul / Slama, Petr / Gupta, Madhu

    ACS omega

    2023  Volume 8, Issue 38, Page(s) 34995–35011

    Abstract: Nonhealed wounds are one of the most dangerous side effects of type-2 diabetes, which is linked to a high frequency of bacterial infections around the globe that eventually results in amputation of limbs. The present investigation aimed to explore the ... ...

    Abstract Nonhealed wounds are one of the most dangerous side effects of type-2 diabetes, which is linked to a high frequency of bacterial infections around the globe that eventually results in amputation of limbs. The present investigation aimed to explore the drug-loaded (naringenin) hydrogel system for chronic wound healing. The hydrogel membranes comprising Na-alginate with F-127 and poly(vinyl alcohol) were developed to treat chronic wounds using the quality-by-design (QbD) approach. The optimized formulation was tested for various parameters, such as swelling, gel fraction, water vapor transition rate (WVTR), etc.
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c04441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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