LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article: Calculating evidence-based renal replacement therapy - Introducing an excel-based calculator to improve prescribing and delivery in renal replacement therapy - A before and after study.

    Cottle, Daniel / Mousdale, Stephen / Waqar-Uddin, Haroon / Tully, Redmond / Taylor, Benjamin

    Journal of the Intensive Care Society

    2015  Volume 17, Issue 1, Page(s) 44–50

    Abstract: Background: Transferring the theoretical aspect of continuous renal replacement therapy to the bedside and delivering a given "dose" can be difficult. In research, the "dose" of renal replacement therapy is given as effluent flow rate in ml kg: ... ...

    Abstract Background: Transferring the theoretical aspect of continuous renal replacement therapy to the bedside and delivering a given "dose" can be difficult. In research, the "dose" of renal replacement therapy is given as effluent flow rate in ml kg
    Methods: We compared the episodes of renal replacement therapy received by a historical group of patients, by retrieving their data stored on the haemofiltration machines, to a group where the calculator was used. In the second group, the data were gathered prospectively.
    Results: The median delivered dose reduced from 41.0 ml kg
    Conclusion: Our calculator significantly reduces variation in prescriptions of continuous veno-venous haemodiafiltration and provides an evidence-based dose. It is easy to use and provides personal care for patients whilst optimizing continuous veno-venous haemodiafiltration delivery and treatment times.
    Language English
    Publishing date 2015-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2701626-2
    ISSN 1751-1437 ; 1751-1437
    ISSN (online) 1751-1437
    ISSN 1751-1437
    DOI 10.1177/1751143715603383
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: ECCO

    Combes, Alain / Auzinger, Georg / Capellier, Gilles / du Cheyron, Damien / Clement, Ian / Consales, Guglielmo / Dabrowski, Wojciech / De Bels, David / de Molina Ortiz, Francisco Javier González / Gottschalk, Antje / Hilty, Matthias P / Pestaña, David / Sousa, Eduardo / Tully, Redmond / Goldstein, Jacques / Harenski, Kai

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 490

    Abstract: Background: With recent advances in technology, patients with acute respiratory distress syndrome (ARDS) and severe acute exacerbations of chronic obstructive pulmonary disease (ae-COPD) could benefit from extracorporeal CO: Methods: A modified ... ...

    Abstract Background: With recent advances in technology, patients with acute respiratory distress syndrome (ARDS) and severe acute exacerbations of chronic obstructive pulmonary disease (ae-COPD) could benefit from extracorporeal CO
    Methods: A modified Delphi-based method was used to collate European experts' views to better understand how ECCO
    Results: Fourteen participants were selected based on known clinical expertise in critical care and in providing respiratory support with ECCO
    Conclusions: Insights from this group of experienced physicians suggest that ECCO
    MeSH term(s) Carbon Dioxide/blood ; Consensus ; Delphi Technique ; Europe ; Extracorporeal Circulation/methods ; Humans ; Intensive Care Units ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiratory Distress Syndrome, Adult/therapy
    Chemical Substances Carbon Dioxide (142M471B3J)
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03210-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial.

    McNamee, James J / Gillies, Michael A / Barrett, Nicholas A / Perkins, Gavin D / Tunnicliffe, William / Young, Duncan / Bentley, Andrew / Harrison, David A / Brodie, Daniel / Boyle, Andrew J / Millar, Jonathan E / Szakmany, Tamas / Bannard-Smith, Jonathan / Tully, Redmond P / Agus, Ashley / McDowell, Clíona / Jackson, Colette / McAuley, Daniel F

    JAMA

    2021  Volume 326, Issue 11, Page(s) 1013–1023

    Abstract: Importance: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.: Objective: To determine whether ... ...

    Abstract Importance: In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.
    Objective: To determine whether lower tidal volume mechanical ventilation using extracorporeal carbon dioxide removal improves outcomes in patients with acute hypoxemic respiratory failure.
    Design, setting, and participants: This multicenter, randomized, allocation-concealed, open-label, pragmatic clinical trial enrolled 412 adult patients receiving mechanical ventilation for acute hypoxemic respiratory failure, of a planned sample size of 1120, between May 2016 and December 2019 from 51 intensive care units in the UK. Follow-up ended on March 11, 2020.
    Interventions: Participants were randomized to receive lower tidal volume ventilation facilitated by extracorporeal carbon dioxide removal for at least 48 hours (n = 202) or standard care with conventional low tidal volume ventilation (n = 210).
    Main outcomes and measures: The primary outcome was all-cause mortality 90 days after randomization. Prespecified secondary outcomes included ventilator-free days at day 28 and adverse event rates.
    Results: Among 412 patients who were randomized (mean age, 59 years; 143 [35%] women), 405 (98%) completed the trial. The trial was stopped early because of futility and feasibility following recommendations from the data monitoring and ethics committee. The 90-day mortality rate was 41.5% in the lower tidal volume ventilation with extracorporeal carbon dioxide removal group vs 39.5% in the standard care group (risk ratio, 1.05 [95% CI, 0.83-1.33]; difference, 2.0% [95% CI, -7.6% to 11.5%]; P = .68). There were significantly fewer mean ventilator-free days in the extracorporeal carbon dioxide removal group compared with the standard care group (7.1 [95% CI, 5.9-8.3] vs 9.2 [95% CI, 7.9-10.4] days; mean difference, -2.1 [95% CI, -3.8 to -0.3]; P = .02). Serious adverse events were reported for 62 patients (31%) in the extracorporeal carbon dioxide removal group and 18 (9%) in the standard care group, including intracranial hemorrhage in 9 patients (4.5%) vs 0 (0%) and bleeding at other sites in 6 (3.0%) vs 1 (0.5%) in the extracorporeal carbon dioxide removal group vs the control group. Overall, 21 patients experienced 22 serious adverse events related to the study device.
    Conclusions and relevance: Among patients with acute hypoxemic respiratory failure, the use of extracorporeal carbon dioxide removal to facilitate lower tidal volume mechanical ventilation, compared with conventional low tidal volume mechanical ventilation, did not significantly reduce 90-day mortality. However, due to early termination, the study may have been underpowered to detect a clinically important difference.
    Trial registration: ClinicalTrials.gov Identifier: NCT02654327.
    MeSH term(s) Aged ; Carbon Dioxide/blood ; Early Termination of Clinical Trials ; Extracorporeal Circulation/adverse effects ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Respiration, Artificial/adverse effects ; Respiration, Artificial/methods ; Respiratory Distress Syndrome/therapy ; Respiratory Insufficiency/mortality ; Respiratory Insufficiency/therapy ; Tidal Volume
    Chemical Substances Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2021-09-03
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2021.13374
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial

    Horby, Peter W / Campbell, Mark / Staplin, Natalie / Spata, Enti / Emberson, Jonathan R / Pessoa-Amorim, Guilherme / Peto, Leon / Brightling, Christopher E / Sarkar, Rahuldeb / Thomas, Koshy / Jeebun, Vandana / Ashish, Abdul / Tully, Redmond / Chadwick, David / Sharafat, Muhammad / Stewart, Richard / Rudran, Banu / Baillie, J Kenneth / Buch, Maya H /
    Chappell, Lucy C / Day, Jeremy N / Furst, Saul N / Jaki, Thomas / Jeffery, Katie / Juszczak, Edmund / Lim, Wei Shen / Montgomery, Alan / Mumford, Andrew / Rowan, Kathryn / Thwaites, Guy / Mafham, Marion / Haynes, Richard / Landray, Martin J

    medRxiv

    Abstract: Findings: Between 23 April 2020 and 25 January 2021, 4116 adults were included in the assessment of tocilizumab, including 562 (14%) patients receiving invasive mechanical ventilation, 1686 (41%) receiving non-invasive respiratory support, and. 1868 (45%) ...

    Abstract Findings: Between 23 April 2020 and 25 January 2021, 4116 adults were included in the assessment of tocilizumab, including 562 (14%) patients receiving invasive mechanical ventilation, 1686 (41%) receiving non-invasive respiratory support, and. 1868 (45%) receiving no respiratory support other than oxygen. Median CRP was 143 [IQR 107-205] mg/L and 3385 (82%) patients were receiving systemic corticosteroids at randomisation. Overall, 596 (29%) of the 2022 patients allocated tocilizumab and 694 (33%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0.86; 95% confidence interval [CI] 0.77-0.96; p=0.007). Consistent results were seen in all pre-specified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital alive within 28 days (54% vs. 47%; rate ratio 1.23; 95% CI 1.12-1.34; p<0.0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (33% vs. 38%; risk ratio 0.85; 95% CI 0.78-0.93; p=0.0005). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes regardless of the level of respiratory support received and in addition to the use of systemic corticosteroids.
    Keywords covid19
    Language English
    Publishing date 2021-02-11
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.02.11.21249258
    Database COVID19

    Kategorien

  5. Article ; Online: Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial

    RECOVERY Collaborative Group / Horby, Peter W / Pessoa-Amorim, Guilherme / Peto, Leon / Brightling, Christopher E / Sarkar, Rahuldeb / Thomas, Koshy / Jeebun, Vandana / Ashish, Abdul / Tully, Redmond / Chadwick, David / Sharafat, Muhammad / Stewart, Richard / Rudran, Banu / Baillie, J Kenneth / Buch, Maya H / Chappell, Lucy C / Day, Jeremy N / Furst, Saul N /
    Jaki, Thomas / Jeffery, Katie / Juszczak, Edmund / Lim, Wei Shen / Montgomery, Alan / Mumford, Andrew / Rowan, Kathryn / Thwaites, Guy / Mafham, Marion / Haynes, Richard / Landray, Martin J

    medRxiv

    Abstract: Findings: Between 23 April 2020 and 25 January 2021, 4116 adults were included in the assessment of tocilizumab, including 562 (14%) patients receiving invasive mechanical ventilation, 1686 (41%) receiving non-invasive respiratory support, and. 1868 (45%) ...

    Abstract Findings: Between 23 April 2020 and 25 January 2021, 4116 adults were included in the assessment of tocilizumab, including 562 (14%) patients receiving invasive mechanical ventilation, 1686 (41%) receiving non-invasive respiratory support, and. 1868 (45%) receiving no respiratory support other than oxygen. Median CRP was 143 [IQR 107-205] mg/L and 3385 (82%) patients were receiving systemic corticosteroids at randomisation. Overall, 596 (29%) of the 2022 patients allocated tocilizumab and 694 (33%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0.86; 95% confidence interval [CI] 0.77-0.96; p=0.007). Consistent results were seen in all pre-specified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital alive within 28 days (54% vs. 47%; rate ratio 1.23; 95% CI 1.12-1.34; p<0.0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (33% vs. 38%; risk ratio 0.85; 95% CI 0.78-0.93; p=0.0005). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes regardless of the level of respiratory support received and in addition to the use of systemic corticosteroids.
    Keywords covid19
    Language English
    Publishing date 2021-02-11
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.02.11.21249258
    Database COVID19

    Kategorien

  6. Article ; Online: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

    Angus, Derek C / Derde, Lennie / Al-Beidh, Farah / Annane, Djillali / Arabi, Yaseen / Beane, Abigail / van Bentum-Puijk, Wilma / Berry, Lindsay / Bhimani, Zahra / Bonten, Marc / Bradbury, Charlotte / Brunkhorst, Frank / Buxton, Meredith / Buzgau, Adrian / Cheng, Allen C / de Jong, Menno / Detry, Michelle / Estcourt, Lise / Fitzgerald, Mark /
    Goossens, Herman / Green, Cameron / Haniffa, Rashan / Higgins, Alisa M / Horvat, Christopher / Hullegie, Sebastiaan J / Kruger, Peter / Lamontagne, Francois / Lawler, Patrick R / Linstrum, Kelsey / Litton, Edward / Lorenzi, Elizabeth / Marshall, John / McAuley, Daniel / McGlothin, Anna / McGuinness, Shay / McVerry, Bryan / Montgomery, Stephanie / Mouncey, Paul / Murthy, Srinivas / Nichol, Alistair / Parke, Rachael / Parker, Jane / Rowan, Kathryn / Sanil, Ashish / Santos, Marlene / Saunders, Christina / Seymour, Christopher / Turner, Anne / van de Veerdonk, Frank / Venkatesh, Balasubramanian / Zarychanski, Ryan / Berry, Scott / Lewis, Roger J / McArthur, Colin / Webb, Steven A / Gordon, Anthony C / Angus, Derek / Cheng, Allen / De Jong, Menno / Gordon, Anthony / Lawler, Patrick / Webb, Steve / Campbell, Lewis / Forbes, Andrew / Gattas, David / Heritier, Stephane / Higgins, Lisa / Peake, Sandra / Presneill, Jeffrey / Seppelt, Ian / Trapani, Tony / Young, Paul / Bagshaw, Sean / Daneman, Nick / Ferguson, Niall / Misak, Cheryl / Hullegie, Sebastiaan / Pletz, Mathias / Rohde, Gernot / Rowan, Kathy / Alexander, Brian / Basile, Kim / Girard, Timothy / Huang, David / Vates, Jennifer / Beasley, Richard / Fowler, Robert / McGloughlin, Steve / Morpeth, Susan / Paterson, David / Venkatesh, Bala / Uyeki, Tim / Baillie, Kenneth / Duffy, Eamon / Fowler, Rob / Hills, Thomas / Orr, Katrina / Patanwala, Asad / Tong, Steve / Netea, Mihai / Bihari, Shilesh / Carrier, Marc / Fergusson, Dean / Goligher, Ewan / Haidar, Ghady / Hunt, Beverley / Kumar, Anand / Laffan, Mike / Lawless, Patrick / Lother, Sylvain / McCallum, Peter / Middeldopr, Saskia / McQuilten, Zoe / Neal, Matthew / Pasi, John / Schutgens, Roger / Stanworth, Simon / Turgeon, Alexis / Weissman, Alexandra / Adhikari, Neill / Anstey, Matthew / Brant, Emily / de Man, Angelique / Lamonagne, Francois / Masse, Marie-Helene / Udy, Andrew / Arnold, Donald / Begin, Phillipe / Charlewood, Richard / Chasse, Michael / Coyne, Mark / Cooper, Jamie / Daly, James / Gosbell, Iain / Harvala-Simmonds, Heli / Hills, Tom / MacLennan, Sheila / Menon, David / McDyer, John / Pridee, Nicole / Roberts, David / Shankar-Hari, Manu / Thomas, Helen / Tinmouth, Alan / Triulzi, Darrell / Walsh, Tim / Wood, Erica / Calfee, Carolyn / O’Kane, Cecilia / Shyamsundar, Murali / Sinha, Pratik / Thompson, Taylor / Young, Ian / Bihari, Shailesh / Hodgson, Carol / Laffey, John / McAuley, Danny / Orford, Neil / Neto, Ary / Lewis, Roger / McGlothlin, Anna / Miller, Eliza / Singh, Vanessa / Zammit, Claire / van Bentum Puijk, Wilma / Bouwman, Wietske / Mangindaan, Yara / Parker, Lorraine / Peters, Svenja / Rietveld, Ilse / Raymakers, Kik / Ganpat, Radhika / Brillinger, Nicole / Markgraf, Rene / Ainscough, Kate / Brickell, Kathy / Anjum, Aisha / Lane, Janis-Best / Richards-Belle, Alvin / Saull, Michelle / Wiley, Daisy / Bion, Julian / Connor, Jason / Gates, Simon / Manax, Victoria / van der Poll, Tom / Reynolds, John / van Beurden, Marloes / Effelaar, Evelien / Schotsman, Joost / Boyd, Craig / Harland, Cain / Shearer, Audrey / Wren, Jess / Clermont, Giles / Garrard, William / Kalchthaler, Kyle / King, Andrew / Ricketts, Daniel / Malakoutis, Salim / Marroquin, Oscar / Music, Edvin / Quinn, Kevin / Cate, Heidi / Pearson, Karen / Collins, Joanne / Hanson, Jane / Williams, Penny / Jackson, Shane / Asghar, Adeeba / Dyas, Sarah / Sutu, Mihaela / Murphy, Sheenagh / Williamson, Dawn / Mguni, Nhlanhla / Potter, Alison / Porter, David / Goodwin, Jayne / Rook, Clare / Harrison, Susie / Williams, Hannah / Campbell, Hilary / Lomme, Kaatje / Williamson, James / Sheffield, Jonathan / van’t Hoff, Willian / McCracken, Phobe / Young, Meredith / Board, Jasmin / Mart, Emma / Knott, Cameron / Smith, Julie / Boschert, Catherine / Affleck, Julia / Ramanan, Mahesh / D’Souza, Ramsy / Pateman, Kelsey / Shakih, Arif / Cheung, Winston / Kol, Mark / Wong, Helen / Shah, Asim / Wagh, Atul / Simpson, Joanne / Duke, Graeme / Chan, Peter / Cartner, Brittney / Hunter, Stephanie / Laver, Russell / Shrestha, Tapaswi / Regli, Adrian / Pellicano, Annamaria / McCullough, James / Tallott, Mandy / Kumar, Nikhil / Panwar, Rakshit / Brinkerhoff, Gail / Koppen, Cassandra / Cazzola, Federica / Brain, Matthew / Mineall, Sarah / Fischer, Roy / Biradar, Vishwanath / Soar, Natalie / White, Hayden / Estensen, Kristen / Morrison, Lynette / Smith, Joanne / Cooper, Melanie / Health, Monash / Shehabi, Yahya / Al-Bassam, Wisam / Hulley, Amanda / Whitehead, Christina / Lowrey, Julie / Gresha, Rebecca / Walsham, James / Meyer, Jason / Harward, Meg / Venz, Ellen / Williams, Patricia / Kurenda, Catherine / Smith, Kirsy / Smith, Margaret / Garcia, Rebecca / Barge, Deborah / Byrne, Deborah / Byrne, Kathleen / Driscoll, Alana / Fortune, Louise / Janin, Pierre / Yarad, Elizabeth / Hammond, Naomi / Bass, Frances / Ashelford, Angela / Waterson, Sharon / Wedd, Steve / McNamara, Robert / Buhr, Heidi / Coles, Jennifer / Schweikert, Sacha / Wibrow, Bradley / Rauniyar, Rashmi / Myers, Erina / Fysh, Ed / Dawda, Ashlish / Mevavala, Bhaumik / Litton, Ed / Ferrier, Janet / Nair, Priya / Buscher, Hergen / Reynolds, Claire / Santamaria, John / Barbazza, Leanne / Homes, Jennifer / Smith, Roger / Murray, Lauren / Brailsford, Jane / Forbes, Loretta / Maguire, Teena / Mariappa, Vasanth / Smith, Judith / Simpson, Scott / Maiden, Matthew / Bone, Allsion / Horton, Michelle / Salerno, Tania / Sterba, Martin / Geng, Wenli / Depuydt, Pieter / De Waele, Jan / De Bus, Liesbet / Fierens, Jan / Bracke, Stephanie / Reeve, Brenda / Dechert, William / Chassé, Michaël / Carrier, François Martin / Boumahni, Dounia / Benettaib, Fatna / Ghamraoui, Ali / Bellemare, David / Cloutier, Ève / Francoeur, Charles / Lamontagne, François / D’Aragon, Frédérick / Carbonneau, Elaine / Leblond, Julie / Vazquez-Grande, Gloria / Marten, Nicole / Wilson, Maggie / Albert, Martin / Serri, Karim / Cavayas, Alexandros / Duplaix, Mathilde / Williams, Virginie / Rochwerg, Bram / Karachi, Tim / Oczkowski, Simon / Centofanti, John / Millen, Tina / Duan, Erick / Tsang, Jennifer / Patterson, Lisa / English, Shane / Watpool, Irene / Porteous, Rebecca / Miezitis, Sydney / McIntyre, Lauralyn / Brochard, Laurent / Burns, Karen / Sandhu, Gyan / Khalid, Imrana / Binnie, Alexandra / Powell, Elizabeth / McMillan, Alexandra / Luk, Tracy / Aref, Noah / Andric, Zdravko / Cviljevic, Sabina / Đimoti, Renata / Zapalac, Marija / Mirković, Gordan / Baršić, Bruno / Kutleša, Marko / Kotarski, Viktor / Vujaklija Brajković, Ana / Babel, Jakša / Sever, Helena / Dragija, Lidija / Kušan, Ira / Vaara, Suvi / Pettilä, Leena / Heinonen, Jonna / Kuitunen, Anne / Karlsson, Sari / Vahtera, Annukka / Kiiski, Heikki / Ristimäki, Sanna / Azaiz, Amine / Charron, Cyril / Godement, Mathieu / Geri, Guillaume / Vieillard-Baron, Antoine / Pourcine, Franck / Monchi, Mehran / Luis, David / Mercier, Romain / Sagnier, Anne / Verrier, Nathalie / Caplin, Cecile / Siami, Shidasp / Aparicio, Christelle / Vautier, Sarah / Jeblaoui, Asma / Fartoukh, Muriel / Courtin, Laura / Labbe, Vincent / Leparco, Cécile / Muller, Grégoire / Nay, Mai-Anh / Kamel, Toufik / Benzekri, Dalila / Jacquier, Sophie / Mercier, Emmanuelle / Chartier, Delphine / Salmon, Charlotte / Dequin, PierreFrançois / Schneider, Francis / Morel, Guillaume / L’Hotellier, Sylvie / Badie, Julio / Berdaguer, Fernando Daniel / Malfroy, Sylvain / Mezher, Chaouki / Bourgoin, Charlotte / Megarbane, Bruno / Voicu, Sebastian / Deye, Nicolas / Malissin, Isabelle / Sutterlin, Laetitia / Guitton, Christophe / Darreau, Cédric / Landais, Mickaël / Chudeau, Nicolas / Robert, Alain / Moine, Pierre / Heming, Nicholas / Maxime, Virginie / Bossard, Isabelle / Nicholier, Tiphaine Barbarin / Colin, Gwenhael / Zinzoni, Vanessa / Maquigneau, Natacham / Finn, André / Kreß, Gabriele / Hoff, Uwe / Friedrich Hinrichs, Carl / Nee, Jens / Hagel, Stefan / Ankert, Juliane / Kolanos, Steffi / Bloos, Frank / Petros, Sirak / Pasieka, Bastian / Kunz, Kevin / Appelt, Peter / Schütze, Bianka / Kluge, Stefan / Nierhaus, Axel / Jarczak, Dominik / Roedl, Kevin / Weismann, Dirk / Frey, Anna / Klinikum Neukölln, Vivantes / Reill, Lorenz / Distler, Michael / Maselli, Astrid / Bélteczki, János / Magyar, István / Fazekas, Ágnes / Kovács, Sándor / Szőke, Viktória / Szigligeti, Gábor / Leszkoven, János / Collins, Daniel / Breen, Patrick / Frohlich, Stephen / Whelan, Ruth / McNicholas, Bairbre / Scully, Michael / Casey, Siobhan / Kernan, Maeve / Doran, Peter / O’Dywer, Michael / Smyth, Michelle / Hayes, Leanne / Hoiting, Oscar / Peters, Marco / Rengers, Els / Evers, Mirjam / Prinssen, Anton / Bosch Ziekenhuis, Jeroen / Simons, Koen / Rozendaal, Wim / Polderman, F / de Jager, P / Moviat, M / Paling, A / Salet, A / Rademaker, Emma / Peters, Anna Linda / de Jonge, E / Wigbers, J / Guilder, E / Butler, M / Cowdrey, Keri-Anne / Newby, Lynette / Chen, Yan / Simmonds, Catherine / McConnochie, Rachael / Ritzema Carter, Jay / Henderson, Seton / Van Der Heyden, Kym / Mehrtens, Jan / Williams, Tony / Kazemi, Alex / Song, Rima / Lai, Vivian / Girijadevi, Dinu / Everitt, Robert / Russell, Robert / Hacking, Danielle / Buehner, Ulrike / Williams, Erin / Browne, Troy / Grimwade, Kate / Goodson, Jennifer / Keet, Owen / Callender, Owen / Martynoga, Robert / Trask, Kara / Butler, Amelia / Schischka, Livia / Young, Chelsea / Lesona, Eden / Olatunji, Shaanti / Robertson, Yvonne / José, Nuno / Amaro dos Santos Catorze, Teodoro / de Lima Pereira, Tiago Nuno Alfaro / Neves Pessoa, Lucilia Maria / Castro Ferreira, Ricardo Manuel / Pereira Sousa Bastos, Joana Margarida / Aysel Florescu, Simin / Stanciu, Delia / Zaharia, Miahela Florentina / Kosa, Alma Gabriela / Codreanu, Daniel / Marabi, Yaseen / Al Qasim, Eman / Moneer Hagazy, Mohamned / Al Swaidan, Lolowa / Arishi, Hatim / Muñoz-Bermúdez, Rosana / Marin-Corral, Judith / Salazar Degracia, Anna / Parrilla Gómez, Francisco / Mateo López, Maria Isabel / Rodriguez Fernandez, Jorge / Cárcel Fernández, Sheila / Carmona Flores, Rosario / León López, Rafael / de la Fuente Martos, Carmen / Allan, Angela / Polgarova, Petra / Farahi, Neda / McWilliam, Stephen / Hawcutt, Daniel / Rad, Laura / O’Malley, Laura / Whitbread, Jennifer / Kelsall, Olivia / Wild, Laura / Thrush, Jessica / Wood, Hannah / Austin, Karen / Donnelly, Adrian / Kelly, Martin / O’Kane, Sinéad / McClintock, Declan / Warnock, Majella / Johnston, Paul / Gallagher, Linda Jude / Mc Goldrick, Clare / Mc Master, Moyra / Strzelecka, Anna / Jha, Rajeev / Kalogirou, Michael / Ellis, Christine / Krishnamurthy, Vinodh / Deelchand, Vashish / Silversides, Jon / McGuigan, Peter / Ward, Kathryn / O’Neill, Aisling / Finn, Stephanie / Phillips, Barbara / Mullan, Dee / Oritz-Ruiz de Gordoa, Laura / Thomas, Matthew / Sweet, Katie / Grimmer, Lisa / Johnson, Rebekah / Pinnell, Jez / Robinson, Matt / Gledhill, Lisa / Wood, Tracy / Morgan, Matt / Cole, Jade / Hill, Helen / Davies, Michelle / Antcliffe, David / Templeton, Maie / Rojo, Roceld / Coghlan, Phoebe / Smee, Joanna / Mackay, Euan / Cort, Jon / Whileman, Amanda / Spencer, Thomas / Spittle, Nick / Kasipandian, Vidya / Patel, Amit / Allibone, Suzanne / Genetu, Roman Mary / Ramali, Mohamed / Ghosh, Alison / Bamford, Peter / London, Emily / Cawley, Kathryn / Faulkner, Maria / Jeffrey, Helen / Smith, Tim / Brewer, Chris / Gregory, Jane / Limb, James / Cowton, Amanda / O’Brien, Julie / Nikitas, Nikitas / Wells, Colin / Lankester, Liana / Pulletz, Mark / Birch, Jenny / Wiseman, Sophie / Horton, Sarah / Alegria, Ana / Turki, Salah / Elsefi, Tarek / Crisp, Nikki / Allen, Louise / McCullagh, Iain / Robinson, Philip / Hays, Carole / Babio-Galan, Maite / Stevenson, Hannah / Khare, Divya / Pinder, Meredith / Selvamoni, Selvin / Gopinath, Amitha / Pugh, Richard / Menzies, Daniel / Mackay, Callum / Allan, Elizabeth / Davies, Gwyneth / Puxty, Kathryn / McCue, Claire / Cathcart, Susanne / Hickey, Naomi / Ireland, Jane / Yusuff, Hakeem / Isgro, Graziella / Brightling, Chris / Bourne, Michelle / Craner, Michelle / Watters, Malcolm / Prout, Rachel / Davies, Louisa / Pegler, Suzannah / Kyeremeh, Lynsey / Arbane, Gill / Wilson, Karen / Gomm, Linda / Francia, Federica / Brett, Stephen / Sousa Arias, Sonia / Elin Hall, Rebecca / Budd, Joanna / Small, Charlotte / Birch, Janine / Collins, Emma / Henning, Jeremy / Bonner, Stephen / Hugill, Keith / Cirstea, Emanuel / Wilkinson, Dean / Karlikowski, Michal / Sutherland, Helen / Wilhelmsen, Elva / Woods, Jane / North, Julie / Sundaran, Dhinesh / Hollos, Laszlo / Coburn, Susan / Walsh, Joanne / Turns, Margaret / Hopkins, Phil / Smith, John / Noble, Harriet / Depante, Maria Theresa / Clarey, Emma / Laha, Shondipon / Verlander, Mark / Williams, Alexandra / Huckle, Abby / Hall, Andrew / Cooke, Jill / Gardiner-Hill, Caroline / Maloney, Carolyn / Qureshi, Hafiz / Flint, Neil / Nicholson, Sarah / Southin, Sara / Nicholson, Andrew / Borgatta, Barbara / Turner-Bone, Ian / Reddy, Amie / Wilding, Laura / Chamara Warnapura, Loku / Agno Sathianathan, Ronan / Golden, David / Hart, Ciaran / Jones, Jo / Bannard-Smith, Jonathan / Henry, Joanne / Birchall, Katie / Pomeroy, Fiona / Quayle, Rachael / Makowski, Arystarch / Misztal, Beata / Ahmed, Iram / KyereDiabour, Thyra / Naiker, Kevin / Stewart, Richard / Mwaura, Esther / Mew, Louise / Wren, Lynn / Willams, Felicity / Innes, Richard / Doble, Patricia / Hutter, Joanne / Shovelton, Charmaine / Plumb, Benjamin / Szakmany, Tamas / Hamlyn, Vincent / Hawkins, Nancy / Lewis, Sarah / Dell, Amanda / Gopal, Shameer / Ganguly, Saibal / Smallwood, Andrew / Harris, Nichola / Metherell, Stella / Lazaro, Juan Martin / Newman, Tabitha / Fletcher, Simon / Nortje, Jurgens / Fottrell-Gould, Deirdre / Randell, Georgina / Zaman, Mohsin / Elmahi, Einas / Jones, Andrea / Hall, Kathryn / Mills, Gary / Ryalls, Kim / Bowler, Helen / Sall, Jas / Bourne, Richard / Borrill, Zoe / Duncan, Tracey / Lamb, Thomas / Shaw, Joanne / Fox, Claire / Moreno Cuesta, Jeronimo / Xavier, Kugan / Purohit, Dharam / Elhassan, Munzir / Bakthavatsalam, Dhanalakshmi / Rowland, Matthew / Hutton, Paula / Bashyal, Archana / Davidson, Neil / Hird, Clare / Chhablani, Manish / Phalod, Gunjan / Kirkby, Amy / Archer, Simon / Netherton, Kimberley / Reschreiter, Henrik / Camsooksai, Julie / Patch, Sarah / Jenkins, Sarah / Pogson, David / Rose, Steve / Daly, Zoe / Brimfield, Lutece / Claridge, Helen / Parekh, Dhruv / Bergin, Colin / Bates, Michelle / Dasgin, Joanne / McGhee, Christopher / Sim, Malcolm / Hay, Sophie Kennedy / Henderson, Steven / Phull, Mandeep-Kaur / Zaidi, Abbas / Pogreban, Tatiana / Rosaroso, Lace Paulyn / Harvey, Daniel / Lowe, Benjamin / Meredith, Megan / Ryan, Lucy / Hormis, Anil / Walker, Rachel / Collier, Dawn / Kimpton, Sarah / Oakley, Susan / Rooney, Kevin / Rodden, Natalie / Hughes, Emma / Thomson, Nicola / McGlynn, Deborah / Walden, Andrew / Jacques, Nicola / Coles, Holly / Tilney, Emma / Vowell, Emma / Schuster-Bruce, Martin / Pitts, Sally / Miln, Rebecca / Purandare, Laura / Vamplew, Luke / Spivey, Michael / Bean, Sarah / Burt, Karen / Moore, Lorraine / Day, Christopher / Gibson, Charly / Gordon, Elizabeth / Zitter, Letizia / Keenan, Samantha / Baker, Evelyn / Cherian, Shiney / Cutler, Sean / Roynon-Reed, Anna / Harrington, Kate / Raithatha, Ajay / Bauchmuller, Kris / Ahmad, Norfaizan / Grecu, Irina / Trodd, Dawn / Martin, Jane / Wrey Brown, Caroline / Arias, Ana-Marie / Craven, Thomas / Hope, David / Singleton, Jo / Clark, Sarah / Rae, Nicola / Welters, Ingeborg / Hamilton, David Oliver / Williams, Karen / Waugh, Victoria / Shaw, David / Puthucheary, Zudin / Martin, Timothy / Santos, Filipa / Uddin, Ruzena / Somerville, Alastair / Tatham, Kate Colette / Jhanji, Shaman / Black, Ethel / Dela Rosa, Arnold / Howle, Ryan / Tully, Redmond / Drummond, Andrew / Dearden, Joy / Philbin, Jennifer / Munt, Sheila / Vuylsteke, Alain / Chan, Charles / Victor, Saji / Matsa, Ramprasad / Gellamucho, Minerva / Creagh-Brown, Ben / Tooley, Joe / Montague, Laura / De Beaux, Fiona / Bullman, Laetitia / Kersiake, Ian / Demetriou, Carrie / Mitchard, Sarah / Ramos, Lidia / White, Katie / Donnison, Phil / Johns, Maggie / Casey, Ruth / Mattocks, Lehentha / Salisbury, Sarah / Dark, Paul / Claxton, Andrew / McLachlan, Danielle / Slevin, Kathryn / Lee, Stephanie / Hulme, Jonathan / Joseph, Sibet / Kinney, Fiona / Senya, Ho Jan / Oborska, Aneta / Kayani, Abdul / Hadebe, Bernard / Orath Prabakaran, Rajalakshmi / Nichols, Lesley / Thomas, Matt / Worner, Ruth / Faulkner, Beverley / Gendall, Emma / Hayes, Kati / Hamilton-Davies, Colin / Chan, Carmen / Mfuko, Celina / Abbass, Hakam / Mandadapu, Vineela / Leaver, Susannah / Forton, Daniel / Patel, Kamal / Paramasivam, Elankumaran / Powell, Matthew / Gould, Richard / Wilby, Elizabeth / Howcroft, Clare / Banach, Dorota / Fernández de Pinedo Artaraz, Ziortza / Cabreros, Leilani / White, Ian / Croft, Maria / Holland, Nicky / Pereira, Rita / Zaki, Ahmed / Johnson, David / Jackson, Matthew / Garrard, Hywel / Juhaz, Vera / Roy, Alistair / Rostron, Anthony / Woods, Lindsey / Cornell, Sarah / Pillai, Suresh / Harford, Rachel / Rees, Tabitha / Ivatt, Helen / Sundara Raman, Ajay / Davey, Miriam / Lee, Kelvin / Barber, Russell / Chablani, Manish / Brohi, Farooq / Jagannathan, Vijay / Clark, Michele / Purvis, Sarah / Wetherill, Bill / Dushianthan, Ahilanandan / Cusack, Rebecca / de Courcy-Golder, Kim / Smith, Simon / Jackson, Susan / Attwood, Ben / Parsons, Penny / Page, Valerie / Zhao, Xiao Bei / Oza, Deepali / Rhodes, Jonathan / Anderson, Tom / Morris, Sheila / Xia Le Tai, Charlotte / Thomas, Amy / Keen, Alexandra / Digby, Stephen / Cowley, Nicholas / Southern, David / Reddy, Harsha / Campbell, Andy / Watkins, Claire / Smuts, Sara / Touma, Omar / Barnes, Nicky / Alexander, Peter / Felton, Tim / Ferguson, Susan / Sellers, Katharine / Bradley-Potts, Joanne / Yates, David / Birkinshaw, Isobel / Kell, Kay / Marshall, Nicola / Carr-Knott, Lisa / Summers, Charlotte

    JAMA

    2020  Volume 324, Issue 13, Page(s) 1317–1329

    Abstract: Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.: Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.: Design, setting, and participants: An ...

    Abstract Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.
    Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.
    Design, setting, and participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020.
    Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108).
    Main outcomes and measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%).
    Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively.
    Conclusions and relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions.
    Trial registration: ClinicalTrials.gov Identifier: NCT02735707.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Adult ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/adverse effects ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Early Termination of Clinical Trials ; Female ; Humans ; Hydrocortisone/administration & dosage ; Hydrocortisone/adverse effects ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Respiration, Artificial/statistics & numerical data ; SARS-CoV-2 ; Shock/drug therapy ; Shock/etiology ; Treatment Outcome ; COVID-19 Drug Treatment
    Chemical Substances Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Hydrocortisone (WI4X0X7BPJ)
    Keywords covid19
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2020.17022
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19

    Angus, Derek C / Derde, Lennie / Al-Beidh, Farah / Annane, Djillali / Arabi, Yaseen / Beane, Abigail / van Bentum-Puijk, Wilma / Berry, Lindsay / Bhimani, Zahra / Bonten, Marc / Bradbury, Charlotte / Brunkhorst, Frank / Buxton, Meredith / Buzgau, Adrian / Cheng, Allen C / de Jong, Menno / Detry, Michelle / Estcourt, Lise / Fitzgerald, Mark /
    Goossens, Herman / Green, Cameron / Haniffa, Rashan / Higgins, Alisa M / Horvat, Christopher / Hullegie, Sebastiaan J / Kruger, Peter / Lamontagne, Francois / Lawler, Patrick R / Linstrum, Kelsey / Litton, Edward / Lorenzi, Elizabeth / Marshall, John / McAuley, Daniel / McGlothin, Anna / McGuinness, Shay / McVerry, Bryan / Montgomery, Stephanie / Mouncey, Paul / Murthy, Srinivas / Nichol, Alistair / Parke, Rachael / Parker, Jane / Rowan, Kathryn / Sanil, Ashish / Santos, Marlene / Saunders, Christina / Seymour, Christopher / Turner, Anne / van de Veerdonk, Frank / Venkatesh, Balasubramanian / Zarychanski, Ryan / Berry, Scott / Lewis, Roger J / McArthur, Colin / Webb, Steven A / Gordon, Anthony C / Writing Committee for the REMAP-CAP Investigators, / Angus, Derek / Cheng, Allen / De Jong, Menno / Gordon, Anthony / Lawler, Patrick / Webb, Steve / Campbell, Lewis / Forbes, Andrew / Gattas, David / Heritier, Stephane / Higgins, Lisa / Peake, Sandra / Presneill, Jeffrey / Seppelt, Ian / Trapani, Tony / Young, Paul / Bagshaw, Sean / Daneman, Nick / Ferguson, Niall / Misak, Cheryl / Hullegie, Sebastiaan / Pletz, Mathias / Rohde, Gernot / Rowan, Kathy / Alexander, Brian / Basile, Kim / Girard, Timothy / Huang, David / Vates, Jennifer / Beasley, Richard / Fowler, Robert / McGloughlin, Steve / Morpeth, Susan / Paterson, David / Venkatesh, Bala / Uyeki, Tim / Baillie, Kenneth / Duffy, Eamon / Fowler, Rob / Hills, Thomas / Orr, Katrina / Patanwala, Asad / Tong, Steve / Netea, Mihai / Bihari, Shilesh / Carrier, Marc / Fergusson, Dean / Goligher, Ewan / Haidar, Ghady / Hunt, Beverley / Kumar, Anand / Laffan, Mike / Lawless, Patrick / Lother, Sylvain / McCallum, Peter / Middeldopr, Saskia / McQuilten, Zoe / Neal, Matthew / Pasi, John / Schutgens, Roger / Stanworth, Simon / Turgeon, Alexis / Weissman, Alexandra / Adhikari, Neill / Anstey, Matthew / Brant, Emily / de Man, Angelique / Lamonagne, Francois / Masse, Marie-Helene / Udy, Andrew / Arnold, Donald / Begin, Phillipe / Charlewood, Richard / Chasse, Michael / Coyne, Mark / Cooper, Jamie / Daly, James / Gosbell, Iain / Harvala-Simmonds, Heli / Hills, Tom / MacLennan, Sheila / Menon, David / McDyer, John / Pridee, Nicole / Roberts, David / Shankar-Hari, Manu / Thomas, Helen / Tinmouth, Alan / Triulzi, Darrell / Walsh, Tim / Wood, Erica / Calfee, Carolyn / O’Kane, Cecilia / Shyamsundar, Murali / Sinha, Pratik / Thompson, Taylor / Young, Ian / Bihari, Shailesh / Hodgson, Carol / Laffey, John / McAuley, Danny / Orford, Neil / Neto, Ary / Lewis, Roger / McGlothlin, Anna / Miller, Eliza / Singh, Vanessa / Zammit, Claire / van Bentum Puijk, Wilma / Bouwman, Wietske / Mangindaan, Yara / Parker, Lorraine / Peters, Svenja / Rietveld, Ilse / Raymakers, Kik / Ganpat, Radhika / Brillinger, Nicole / Markgraf, Rene / Ainscough, Kate / Brickell, Kathy / Anjum, Aisha / Lane, Janis-Best / Richards-Belle, Alvin / Saull, Michelle / Wiley, Daisy / Bion, Julian / Connor, Jason / Gates, Simon / Manax, Victoria / van der Poll, Tom / Reynolds, John / van Beurden, Marloes / Effelaar, Evelien / Schotsman, Joost / Boyd, Craig / Harland, Cain / Shearer, Audrey / Wren, Jess / Clermont, Giles / Garrard, William / Kalchthaler, Kyle / King, Andrew / Ricketts, Daniel / Malakoutis, Salim / Marroquin, Oscar / Music, Edvin / Quinn, Kevin / Cate, Heidi / Pearson, Karen / Collins, Joanne / Hanson, Jane / Williams, Penny / Jackson, Shane / Asghar, Adeeba / Dyas, Sarah / Sutu, Mihaela / Murphy, Sheenagh / Williamson, Dawn / Mguni, Nhlanhla / Potter, Alison / Porter, David / Goodwin, Jayne / Rook, Clare / Harrison, Susie / Williams, Hannah / Campbell, Hilary / Lomme, Kaatje / Williamson, James / Sheffield, Jonathan / van’t Hoff, Willian / McCracken, Phobe / Young, Meredith / Board, Jasmin / Mart, Emma / Knott, Cameron / Smith, Julie / Boschert, Catherine / Affleck, Julia / Ramanan, Mahesh / D’Souza, Ramsy / Pateman, Kelsey / Shakih, Arif / Cheung, Winston / Kol, Mark / Wong, Helen / Shah, Asim / Wagh, Atul / Simpson, Joanne / Duke, Graeme / Chan, Peter / Cartner, Brittney / Hunter, Stephanie / Laver, Russell / Shrestha, Tapaswi / Regli, Adrian / Pellicano, Annamaria / McCullough, James / Tallott, Mandy / Kumar, Nikhil / Panwar, Rakshit / Brinkerhoff, Gail / Koppen, Cassandra / Cazzola, Federica / Brain, Matthew / Mineall, Sarah / Fischer, Roy / Biradar, Vishwanath / Soar, Natalie / White, Hayden / Estensen, Kristen / Morrison, Lynette / Smith, Joanne / Cooper, Melanie / Health, Monash / Shehabi, Yahya / Al-Bassam, Wisam / Hulley, Amanda / Whitehead, Christina / Lowrey, Julie / Gresha, Rebecca / Walsham, James / Meyer, Jason / Harward, Meg / Venz, Ellen / Williams, Patricia / Kurenda, Catherine / Smith, Kirsy / Smith, Margaret / Garcia, Rebecca / Barge, Deborah / Byrne, Deborah / Byrne, Kathleen / Driscoll, Alana / Fortune, Louise / Janin, Pierre / Yarad, Elizabeth / Hammond, Naomi / Bass, Frances / Ashelford, Angela / Waterson, Sharon / Wedd, Steve / McNamara, Robert / Buhr, Heidi / Coles, Jennifer / Schweikert, Sacha / Wibrow, Bradley / Rauniyar, Rashmi / Myers, Erina / Fysh, Ed / Dawda, Ashlish / Mevavala, Bhaumik / Litton, Ed / Ferrier, Janet / Nair, Priya / Buscher, Hergen / Reynolds, Claire / Santamaria, John / Barbazza, Leanne / Homes, Jennifer / Smith, Roger / Murray, Lauren / Brailsford, Jane / Forbes, Loretta / Maguire, Teena / Mariappa, Vasanth / Smith, Judith / Simpson, Scott / Maiden, Matthew / Bone, Allsion / Horton, Michelle / Salerno, Tania / Sterba, Martin / Geng, Wenli / Depuydt, Pieter / De Waele, Jan / De Bus, Liesbet / Fierens, Jan / Bracke, Stephanie / Reeve, Brenda / Dechert, William / Chassé, Michaël / Carrier, François Martin / Boumahni, Dounia / Benettaib, Fatna / Ghamraoui, Ali / Bellemare, David / Cloutier, Ève / Francoeur, Charles / Lamontagne, François / D’Aragon, Frédérick / Carbonneau, Elaine / Leblond, Julie / Vazquez-Grande, Gloria / Marten, Nicole / Wilson, Maggie / Albert, Martin / Serri, Karim / Cavayas, Alexandros / Duplaix, Mathilde / Williams, Virginie / Rochwerg, Bram / Karachi, Tim / Oczkowski, Simon / Centofanti, John / Millen, Tina / Duan, Erick / Tsang, Jennifer / Patterson, Lisa / English, Shane / Watpool, Irene / Porteous, Rebecca / Miezitis, Sydney / McIntyre, Lauralyn / Brochard, Laurent / Burns, Karen / Sandhu, Gyan / Khalid, Imrana / Binnie, Alexandra / Powell, Elizabeth / McMillan, Alexandra / Luk, Tracy / Aref, Noah / Andric, Zdravko / Cviljevic, Sabina / Đimoti, Renata / Zapalac, Marija / Mirković, Gordan / Baršić, Bruno / Kutleša, Marko / Kotarski, Viktor / Vujaklija Brajković, Ana / Babel, Jakša / Sever, Helena / Dragija, Lidija / Kušan, Ira / Vaara, Suvi / Pettilä, Leena / Heinonen, Jonna / Kuitunen, Anne / Karlsson, Sari / Vahtera, Annukka / Kiiski, Heikki / Ristimäki, Sanna / Azaiz, Amine / Charron, Cyril / Godement, Mathieu / Geri, Guillaume / Vieillard-Baron, Antoine / Pourcine, Franck / Monchi, Mehran / Luis, David / Mercier, Romain / Sagnier, Anne / Verrier, Nathalie / Caplin, Cecile / Siami, Shidasp / Aparicio, Christelle / Vautier, Sarah / Jeblaoui, Asma / Fartoukh, Muriel / Courtin, Laura / Labbe, Vincent / Leparco, Cécile / Muller, Grégoire / Nay, Mai-Anh / Kamel, Toufik / Benzekri, Dalila / Jacquier, Sophie / Mercier, Emmanuelle / Chartier, Delphine / Salmon, Charlotte / Dequin, PierreFrançois / Schneider, Francis / Morel, Guillaume / L’Hotellier, Sylvie / Badie, Julio / Berdaguer, Fernando Daniel / Malfroy, Sylvain / Mezher, Chaouki / Bourgoin, Charlotte / Megarbane, Bruno / Voicu, Sebastian / Deye, Nicolas / Malissin, Isabelle / Sutterlin, Laetitia / Guitton, Christophe / Darreau, Cédric / Landais, Mickaël / Chudeau, Nicolas / Robert, Alain / Moine, Pierre / Heming, Nicholas / Maxime, Virginie / Bossard, Isabelle / Nicholier, Tiphaine Barbarin / Colin, Gwenhael / Zinzoni, Vanessa / Maquigneau, Natacham / Finn, André / Kreß, Gabriele / Hoff, Uwe / Friedrich Hinrichs, Carl / Nee, Jens / Hagel, Stefan / Ankert, Juliane / Kolanos, Steffi / Bloos, Frank / Petros, Sirak / Pasieka, Bastian / Kunz, Kevin / Appelt, Peter / Schütze, Bianka / Kluge, Stefan / Nierhaus, Axel / Jarczak, Dominik / Roedl, Kevin / Weismann, Dirk / Frey, Anna / Klinikum Neukölln, Vivantes / Reill, Lorenz / Distler, Michael / Maselli, Astrid / Bélteczki, János / Magyar, István / Fazekas, Ágnes / Kovács, Sándor / Szőke, Viktória / Szigligeti, Gábor / Leszkoven, János / Collins, Daniel / Breen, Patrick / Frohlich, Stephen / Whelan, Ruth / McNicholas, Bairbre / Scully, Michael / Casey, Siobhan / Kernan, Maeve / Doran, Peter / O’Dywer, Michael / Smyth, Michelle / Hayes, Leanne / Hoiting, Oscar / Peters, Marco / Rengers, Els / Evers, Mirjam / Prinssen, Anton / Bosch Ziekenhuis, Jeroen / Simons, Koen / Rozendaal, Wim / Polderman, F / de Jager, P / Moviat, M / Paling, A / Salet, A / Rademaker, Emma / Peters, Anna Linda / de Jonge, E / Wigbers, J / Guilder, E / Butler, M / Cowdrey, Keri-Anne / Newby, Lynette / Chen, Yan / Simmonds, Catherine / McConnochie, Rachael / Ritzema Carter, Jay / Henderson, Seton / Van Der Heyden, Kym / Mehrtens, Jan / Williams, Tony / Kazemi, Alex / Song, Rima / Lai, Vivian / Girijadevi, Dinu / Everitt, Robert / Russell, Robert / Hacking, Danielle / Buehner, Ulrike / Williams, Erin / Browne, Troy / Grimwade, Kate / Goodson, Jennifer / Keet, Owen / Callender, Owen / Martynoga, Robert / Trask, Kara / Butler, Amelia / Schischka, Livia / Young, Chelsea / Lesona, Eden / Olatunji, Shaanti / Robertson, Yvonne / José, Nuno / Amaro dos Santos Catorze, Teodoro / de Lima Pereira, Tiago Nuno Alfaro / Neves Pessoa, Lucilia Maria / Castro Ferreira, Ricardo Manuel / Pereira Sousa Bastos, Joana Margarida / Aysel Florescu, Simin / Stanciu, Delia / Zaharia, Miahela Florentina / Kosa, Alma Gabriela / Codreanu, Daniel / Marabi, Yaseen / Al Qasim, Eman / Moneer Hagazy, Mohamned / Al Swaidan, Lolowa / Arishi, Hatim / Muñoz-Bermúdez, Rosana / Marin-Corral, Judith / Salazar Degracia, Anna / Parrilla Gómez, Francisco / Mateo López, Maria Isabel / Rodriguez Fernandez, Jorge / Cárcel Fernández, Sheila / Carmona Flores, Rosario / León López, Rafael / de la Fuente Martos, Carmen / Allan, Angela / Polgarova, Petra / Farahi, Neda / McWilliam, Stephen / Hawcutt, Daniel / Rad, Laura / O’Malley, Laura / Whitbread, Jennifer / Kelsall, Olivia / Wild, Laura / Thrush, Jessica / Wood, Hannah / Austin, Karen / Donnelly, Adrian / Kelly, Martin / O’Kane, Sinéad / McClintock, Declan / Warnock, Majella / Johnston, Paul / Gallagher, Linda Jude / Mc Goldrick, Clare / Mc Master, Moyra / Strzelecka, Anna / Jha, Rajeev / Kalogirou, Michael / Ellis, Christine / Krishnamurthy, Vinodh / Deelchand, Vashish / Silversides, Jon / McGuigan, Peter / Ward, Kathryn / O’Neill, Aisling / Finn, Stephanie / Phillips, Barbara / Mullan, Dee / Oritz-Ruiz de Gordoa, Laura / Thomas, Matthew / Sweet, Katie / Grimmer, Lisa / Johnson, Rebekah / Pinnell, Jez / Robinson, Matt / Gledhill, Lisa / Wood, Tracy / Morgan, Matt / Cole, Jade / Hill, Helen / Davies, Michelle / Antcliffe, David / Templeton, Maie / Rojo, Roceld / Coghlan, Phoebe / Smee, Joanna / Mackay, Euan / Cort, Jon / Whileman, Amanda / Spencer, Thomas / Spittle, Nick / Kasipandian, Vidya / Patel, Amit / Allibone, Suzanne / Genetu, Roman Mary / Ramali, Mohamed / Ghosh, Alison / Bamford, Peter / London, Emily / Cawley, Kathryn / Faulkner, Maria / Jeffrey, Helen / Smith, Tim / Brewer, Chris / Gregory, Jane / Limb, James / Cowton, Amanda / O’Brien, Julie / Nikitas, Nikitas / Wells, Colin / Lankester, Liana / Pulletz, Mark / Birch, Jenny / Wiseman, Sophie / Horton, Sarah / Alegria, Ana / Turki, Salah / Elsefi, Tarek / Crisp, Nikki / Allen, Louise / McCullagh, Iain / Robinson, Philip / Hays, Carole / Babio-Galan, Maite / Stevenson, Hannah / Khare, Divya / Pinder, Meredith / Selvamoni, Selvin / Gopinath, Amitha / Pugh, Richard / Menzies, Daniel / Mackay, Callum / Allan, Elizabeth / Davies, Gwyneth / Puxty, Kathryn / McCue, Claire / Cathcart, Susanne / Hickey, Naomi / Ireland, Jane / Yusuff, Hakeem / Isgro, Graziella / Brightling, Chris / Bourne, Michelle / Craner, Michelle / Watters, Malcolm / Prout, Rachel / Davies, Louisa / Pegler, Suzannah / Kyeremeh, Lynsey / Arbane, Gill / Wilson, Karen / Gomm, Linda / Francia, Federica / Brett, Stephen / Sousa Arias, Sonia / Elin Hall, Rebecca / Budd, Joanna / Small, Charlotte / Birch, Janine / Collins, Emma / Henning, Jeremy / Bonner, Stephen / Hugill, Keith / Cirstea, Emanuel / Wilkinson, Dean / Karlikowski, Michal / Sutherland, Helen / Wilhelmsen, Elva / Woods, Jane / North, Julie / Sundaran, Dhinesh / Hollos, Laszlo / Coburn, Susan / Walsh, Joanne / Turns, Margaret / Hopkins, Phil / Smith, John / Noble, Harriet / Depante, Maria Theresa / Clarey, Emma / Laha, Shondipon / Verlander, Mark / Williams, Alexandra / Huckle, Abby / Hall, Andrew / Cooke, Jill / Gardiner-Hill, Caroline / Maloney, Carolyn / Qureshi, Hafiz / Flint, Neil / Nicholson, Sarah / Southin, Sara / Nicholson, Andrew / Borgatta, Barbara / Turner-Bone, Ian / Reddy, Amie / Wilding, Laura / Chamara Warnapura, Loku / Agno Sathianathan, Ronan / Golden, David / Hart, Ciaran / Jones, Jo / Bannard-Smith, Jonathan / Henry, Joanne / Birchall, Katie / Pomeroy, Fiona / Quayle, Rachael / Makowski, Arystarch / Misztal, Beata / Ahmed, Iram / KyereDiabour, Thyra / Naiker, Kevin / Stewart, Richard / Mwaura, Esther / Mew, Louise / Wren, Lynn / Willams, Felicity / Innes, Richard / Doble, Patricia / Hutter, Joanne / Shovelton, Charmaine / Plumb, Benjamin / Szakmany, Tamas / Hamlyn, Vincent / Hawkins, Nancy / Lewis, Sarah / Dell, Amanda / Gopal, Shameer / Ganguly, Saibal / Smallwood, Andrew / Harris, Nichola / Metherell, Stella / Lazaro, Juan Martin / Newman, Tabitha / Fletcher, Simon / Nortje, Jurgens / Fottrell-Gould, Deirdre / Randell, Georgina / Zaman, Mohsin / Elmahi, Einas / Jones, Andrea / Hall, Kathryn / Mills, Gary / Ryalls, Kim / Bowler, Helen / Sall, Jas / Bourne, Richard / Borrill, Zoe / Duncan, Tracey / Lamb, Thomas / Shaw, Joanne / Fox, Claire / Moreno Cuesta, Jeronimo / Xavier, Kugan / Purohit, Dharam / Elhassan, Munzir / Bakthavatsalam, Dhanalakshmi / Rowland, Matthew / Hutton, Paula / Bashyal, Archana / Davidson, Neil / Hird, Clare / Chhablani, Manish / Phalod, Gunjan / Kirkby, Amy / Archer, Simon / Netherton, Kimberley / Reschreiter, Henrik / Camsooksai, Julie / Patch, Sarah / Jenkins, Sarah / Pogson, David / Rose, Steve / Daly, Zoe / Brimfield, Lutece / Claridge, Helen / Parekh, Dhruv / Bergin, Colin / Bates, Michelle / Dasgin, Joanne / McGhee, Christopher / Sim, Malcolm / Hay, Sophie Kennedy / Henderson, Steven / Phull, Mandeep-Kaur / Zaidi, Abbas / Pogreban, Tatiana / Rosaroso, Lace Paulyn / Harvey, Daniel / Lowe, Benjamin / Meredith, Megan / Ryan, Lucy / Hormis, Anil / Walker, Rachel / Collier, Dawn / Kimpton, Sarah / Oakley, Susan / Rooney, Kevin / Rodden, Natalie / Hughes, Emma / Thomson, Nicola / McGlynn, Deborah / Walden, Andrew / Jacques, Nicola / Coles, Holly / Tilney, Emma / Vowell, Emma / Schuster-Bruce, Martin / Pitts, Sally / Miln, Rebecca / Purandare, Laura / Vamplew, Luke / Spivey, Michael / Bean, Sarah / Burt, Karen / Moore, Lorraine / Day, Christopher / Gibson, Charly / Gordon, Elizabeth / Zitter, Letizia / Keenan, Samantha / Baker, Evelyn / Cherian, Shiney / Cutler, Sean / Roynon-Reed, Anna / Harrington, Kate / Raithatha, Ajay / Bauchmuller, Kris / Ahmad, Norfaizan / Grecu, Irina / Trodd, Dawn / Martin, Jane / Wrey Brown, Caroline / Arias, Ana-Marie / Craven, Thomas / Hope, David / Singleton, Jo / Clark, Sarah / Rae, Nicola / Welters, Ingeborg / Hamilton, David Oliver / Williams, Karen / Waugh, Victoria / Shaw, David / Puthucheary, Zudin / Martin, Timothy / Santos, Filipa / Uddin, Ruzena / Somerville, Alastair / Tatham, Kate Colette / Jhanji, Shaman / Black, Ethel / Dela Rosa, Arnold / Howle, Ryan / Tully, Redmond / Drummond, Andrew / Dearden, Joy / Philbin, Jennifer / Munt, Sheila / Vuylsteke, Alain / Chan, Charles / Victor, Saji / Matsa, Ramprasad / Gellamucho, Minerva / Creagh-Brown, Ben / Tooley, Joe / Montague, Laura / De Beaux, Fiona / Bullman, Laetitia / Kersiake, Ian / Demetriou, Carrie / Mitchard, Sarah / Ramos, Lidia / White, Katie / Donnison, Phil / Johns, Maggie / Casey, Ruth / Mattocks, Lehentha / Salisbury, Sarah / Dark, Paul / Claxton, Andrew / McLachlan, Danielle / Slevin, Kathryn / Lee, Stephanie / Hulme, Jonathan / Joseph, Sibet / Kinney, Fiona / Senya, Ho Jan / Oborska, Aneta / Kayani, Abdul / Hadebe, Bernard / Orath Prabakaran, Rajalakshmi / Nichols, Lesley / Thomas, Matt / Worner, Ruth / Faulkner, Beverley / Gendall, Emma / Hayes, Kati / Hamilton-Davies, Colin / Chan, Carmen / Mfuko, Celina / Abbass, Hakam / Mandadapu, Vineela / Leaver, Susannah / Forton, Daniel / Patel, Kamal / Paramasivam, Elankumaran / Powell, Matthew / Gould, Richard / Wilby, Elizabeth / Howcroft, Clare / Banach, Dorota / Fernández de Pinedo Artaraz, Ziortza / Cabreros, Leilani / White, Ian / Croft, Maria / Holland, Nicky / Pereira, Rita / Zaki, Ahmed / Johnson, David / Jackson, Matthew / Garrard, Hywel / Juhaz, Vera / Roy, Alistair / Rostron, Anthony / Woods, Lindsey / Cornell, Sarah / Pillai, Suresh / Harford, Rachel / Rees, Tabitha / Ivatt, Helen / Sundara Raman, Ajay / Davey, Miriam / Lee, Kelvin / Barber, Russell / Chablani, Manish / Brohi, Farooq / Jagannathan, Vijay / Clark, Michele / Purvis, Sarah / Wetherill, Bill / Dushianthan, Ahilanandan / Cusack, Rebecca / de Courcy-Golder, Kim / Smith, Simon / Jackson, Susan / Attwood, Ben / Parsons, Penny / Page, Valerie / Zhao, Xiao Bei / Oza, Deepali / Rhodes, Jonathan / Anderson, Tom / Morris, Sheila / Xia Le Tai, Charlotte / Thomas, Amy / Keen, Alexandra / Digby, Stephen / Cowley, Nicholas / Southern, David / Reddy, Harsha / Campbell, Andy / Watkins, Claire / Smuts, Sara / Touma, Omar / Barnes, Nicky / Alexander, Peter / Felton, Tim / Ferguson, Susan / Sellers, Katharine / Bradley-Potts, Joanne / Yates, David / Birkinshaw, Isobel / Kell, Kay / Marshall, Nicola / Carr-Knott, Lisa

    The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.

    2020  

    Keywords Writing Committee for the REMAP-CAP Investigators ; Humans ; Pneumonia ; Viral ; Coronavirus Infections ; Shock ; Hydrocortisone ; Adrenal Cortex Hormones ; Anti-Inflammatory Agents ; Treatment Outcome ; Respiration ; Artificial ; Adult ; Middle Aged ; Intensive Care Units ; Female ; Male ; Early Termination of Clinical Trials ; Pandemics ; Betacoronavirus ; covid19
    Language English
    Publisher JAMA
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top