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  1. Article ; Online: Single-centre experience with the treatment of high-prevalence metabolic syndrome in kidney transplant patients in Bosnia and Herzegovina.

    Dugonjić-Taletović, Maida / Tulumović, Denijal / Alečković-Halilović, Mirna / Pjanić, Mirha / Hajder, Mithad / Halilčević-Terzić, Alma / Lončar, Danijela / Jašarević, Amila

    Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

    2024  Volume 21, Issue 1, Page(s) 85–90

    Abstract: Aim To analyse prevalence of metabolic syndrome (MS) in kidney transplant recipients at the University Clinical Centre Tuzla in Bosnia and Herzegovina (B&H), and determine effects of a modern drug therapy in achieving target metabolic control in kidney ... ...

    Abstract Aim To analyse prevalence of metabolic syndrome (MS) in kidney transplant recipients at the University Clinical Centre Tuzla in Bosnia and Herzegovina (B&H), and determine effects of a modern drug therapy in achieving target metabolic control in kidney transplant patients. Methods A single-centre prospective study that included 142 kidney transplant patients over one year follow-up period was conducted. Patient data were collected during post-transplant periodical controls every 3 months including data from medical records, clinical examinations and laboratory analyses. Results Out of 142 kidney transplant patients, MS was verified in 85 (59.86%); after a pharmacologic treatment MS frequency was decreased to 75 (52.81%). After a one-year period during which patients were receiving therapy for MS, a decrease in the number of patients with hyperlipoproteinemia, decrease in average body mass index (BMI), glycemia and haemoglobin A1C (HbA1C) were observed. Hypertension did not improve during this period, which can be explained by transplant risk factors in the form of immunosuppressive drugs and chronic graft dysfunction. Conclusion A significant reduction in components of the metabolic syndrome after only one year of treatment was recorded, which should be the standard care of kidney transplant patients.
    Language English
    Publishing date 2024-02-01
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 2378942-6
    ISSN 1840-2445 ; 1840-2445
    ISSN (online) 1840-2445
    ISSN 1840-2445
    DOI 10.17392/1665-23
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  2. Article ; Online: Inflammatory bowel disease in Tuzla Canton, Bosnia-Herzegovina: A prospective 10-year follow-up.

    Tulumović, Emir / Salkić, Nermin / Tulumović, Denijal

    World journal of gastroenterology

    2021  Volume 27, Issue 20, Page(s) 2630–2642

    Abstract: Background: The incidence and prevalence of inflammatory bowel disease (IBD) vary between regions but have risen globally in recent decades. A lack of data from developing nations limits the understanding of IBD epidemiology.: Aim: To perform a ... ...

    Abstract Background: The incidence and prevalence of inflammatory bowel disease (IBD) vary between regions but have risen globally in recent decades. A lack of data from developing nations limits the understanding of IBD epidemiology.
    Aim: To perform a follow-up review of IBD epidemiology in the Tuzla Canton of Bosnia-Herzegovina during a 10-year period (2009-2019).
    Methods: We prospectively evaluated the hospital records of both IBD inpatients and outpatients residing in Tuzla Canton for the specified period of time between January 1, 2009 and December 31, 2019. Since all our patients had undergone proximal and distal endoscopic evaluations at the hospital endoscopy unit, we used the hospital's database as a primary data source, alongside an additional cross-relational search of the database. Both adult and pediatric patients were included in the study. Patients were grouped by IBD type, phenotype, age, and gender. Incidence rates were calculated with age standardization using the European standard population. Trends in incidence and prevalence were evaluated as a 3-year moving average and average annual percentage change rates.
    Results: During the 10-year follow-up period, 651 patients diagnosed with IBD were monitored (of whom 334, or 51.3%, were males, and 317, or 48.7%, were females). Of all the patients, 346 (53.1%) had been diagnosed with ulcerative colitis (UC), 292 (44.9%) with Crohn's disease (CD), and 13 (2%) with indeterminate colitis (IC). We observed 440 newly diagnosed patients with IBD: 240 (54.5%) with UC, 190 (43.2%) with CD, and 10 (2.3%) with IC. The mean annual crude incidence rates were found to be 9.01/100000 population for IBD [95% confidence interval (CI): 8.17-9.85], with 4.91/100000 (95%CI: 4.29-5.54) for UC and 3.89/100000 (95%CI: 3.34-4.44) for CD. Calculated IBD prevalence in 2019 was 146.64/100000 (95%CI: 128.09-165.19), with 77.94/100000 (95%CI: 68.08-87.70) for UC and 65.77/100000 (95%CI: 54.45-74.1) for CD. The average annual IBD percentage change was 0.79% (95%CI: 0.60-0.88), with -2.82% (95%CI: -2.67 to -2.97) for UC and 6.92% (95%CI: 6.64-7.20) for CD. During the study period, 24,509 distal endoscopic procedures were performed. The incidence of IBD was 3.16/100 examinations (95%CI: 2.86-3.45) or 1.72/100 examinations (95%CI: 1.5-1.94) for UC and 1.36/100 examinations (95%CI: 1.17-1.56) for CD.
    Conclusion: Trends in the incidence and prevalence of IBD in Tuzla Canton are similar to Eastern European averages, although there are significant epidemiological differences within geographically close and demographically similar areas.
    MeSH term(s) Adult ; Bosnia and Herzegovina/epidemiology ; Child ; Female ; Follow-Up Studies ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/epidemiology ; Male ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v27.i20.2630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Nephrology in Bosnia and Herzegovina: impact of the 1992-95 war.

    Mesic, Enisa / Aleckovic-Halilovic, Mirna / Tulumovic, Denijal / Trnacevic, Senaid

    Clinical kidney journal

    2018  Volume 11, Issue 6, Page(s) 803–809

    Abstract: It has now been more than two decades since the end of the 1992-95 war in Bosnia and Herzegovina. This may well be the proper time to provide the nephrology community with an appraisal of the care of patients with chronic kidney disease in the pre-war, ... ...

    Abstract It has now been more than two decades since the end of the 1992-95 war in Bosnia and Herzegovina. This may well be the proper time to provide the nephrology community with an appraisal of the care of patients with chronic kidney disease in the pre-war, war and post-war periods in the European transitional country. This report on nephrology in Bosnia and Herzegovina draws attention to the hurdles faced for three turbulent years on that burdensome path of providing quality care, and the chance it offered in developing a successful transplant programme while facing the dreadful chaos of war and a migrant crisis. The perception of war and natural disasters is quite different, from the victim's point of view, from the standardized and well-arranged healthcare systems in the developed world. The guidelines, written in peace, are extremely useful, but are often hard to follow during natural disasters or barbarous wars. Each of the periods described had its specificities as well as its good and bad sides. Despite the unquestionable destructive nature of the war, it was a catalyst for nephrology in Bosnia and Herzegovina to move forward.
    Language English
    Publishing date 2018-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfy098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Belching After Biliary Pancreatitis and Laparoscopic Cholecystectomy.

    Cerkezovic, Mersiha / Tulumovic, Denijal / Umihanic, Mirnesa Muminovic

    Medical archives (Sarajevo, Bosnia and Herzegovina)

    2016  Volume 70, Issue 2, Page(s) 151–153

    Abstract: Introduction: Belching is often reported symptom. It is rarely an isolated disorder and mainly occurs within various gastroduodenal diseases.: Aim: The aim is to show the great breadth of clinical symptoms of postcholecystectomy syndrome which should ...

    Abstract Introduction: Belching is often reported symptom. It is rarely an isolated disorder and mainly occurs within various gastroduodenal diseases.
    Aim: The aim is to show the great breadth of clinical symptoms of postcholecystectomy syndrome which should have a multidisciplinary therapeutic approach taking into account all aspects of patient's life.
    Case report: We report a case of excessive belching within postcholecystectomy syndrome which disturbs the general psycho-physical condition of the patient, with symptoms of depression and anxiety, and social isolation, which significantly reduces the quality of his life.
    Language English
    Publishing date 2016-04
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 128782-5
    ISSN 1986-5961 ; 0350-199X ; 0025-8083
    ISSN (online) 1986-5961
    ISSN 0350-199X ; 0025-8083
    DOI 10.5455/medarh.2016.70.151-153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Inflammatory Markers and Procoagulants in Chronic Renal Disease Stages 1-4.

    Muslimovic, Alma / Rasic, Senija / Tulumovic, Denijal / Hasanspahic, Senad / Rebic, Damir

    Medical archives (Sarajevo, Bosnia and Herzegovina)

    2015  Volume 69, Issue 5, Page(s) 307–310

    Abstract: Introduction: Starting from the point that the chronic kidney disease (CKD) is chronic, inflammatory and hypercoagulable state characterized by an increase in procoagulant and inflammatory markers high cardiovascular morbidity and mortality in these ... ...

    Abstract Introduction: Starting from the point that the chronic kidney disease (CKD) is chronic, inflammatory and hypercoagulable state characterized by an increase in procoagulant and inflammatory markers high cardiovascular morbidity and mortality in these patients could be explained.
    Aim: The aim of the research was to monitor inflammatory markers and procoagulants in various stages of kidney disease (stage 1-4).
    Materials and methods: The research included 120 subjects older than 18 years with CKD stages 1-4 examined and monitored in Clinic of Nephrology, University Clinical Centre Sarajevo over a period of 24 months. The research included determining the following laboratory parameters: serum creatinine, serum albumin, C-reactive protein, leukocytes in the blood, plasma fibrinogen, D-dimer, antithrombin III, coagulation factors VII (FC VII) and coagulation factor VIII (FC VIII).
    Results: With the progression of kidney disease (CKD stages 1-4), there was a significant increase of inflammatory and procoagulant markers: CRP, fibrinogen and coagulation factor VIII, and an increase in the average values of leukocytes and a reduction in the value of antithrombin III, but without statistical significance. Also, there were no significant differences in the values of D-dimer and coagulation factor VII.
    Conclusion: The progression of kidney disease is significantly associated with inflammation, which could in the future be useful in prognostic and therapeutic purposes. Connection of CKD with inflammation and proven connection of inflammation with cardiovascular risk indicates the potential value of some biomarkers, which could in the future identify as predictors of outcome and could have the benefit in the early diagnosis and treatment of cardiovascular disease in CKD.
    MeSH term(s) Adult ; Antithrombin III/analysis ; C-Reactive Protein/analysis ; Creatinine/blood ; Disease Progression ; Factor VII/analysis ; Factor VIII/analysis ; Fibrin Fibrinogen Degradation Products/analysis ; Fibrinogen/analysis ; Humans ; Inflammation/blood ; Leukocyte Count ; Prospective Studies ; Renal Insufficiency, Chronic/blood ; Serum Albumin/analysis ; Severity of Illness Index
    Chemical Substances Fibrin Fibrinogen Degradation Products ; Serum Albumin ; fibrin fragment D ; Antithrombin III (9000-94-6) ; Factor VII (9001-25-6) ; Factor VIII (9001-27-8) ; Fibrinogen (9001-32-5) ; C-Reactive Protein (9007-41-4) ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2015-10-04
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 128782-5
    ISSN 1986-5961 ; 0350-199X ; 0025-8083
    ISSN (online) 1986-5961
    ISSN 0350-199X ; 0025-8083
    DOI 10.5455/medarh.2015.69.307-310
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  6. Article ; Online: Influence of surgical complications on graft and patients' survival after a kidney transplantation according to donors' age.

    Jagodić, Samed / Hasukić, Sefik / Tulumović, Denijal / Tabaković, Mithat

    Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

    2013  Volume 10, Issue 1, Page(s) 139–143

    Abstract: The aim of this study was to determine a frequency and a type of early and late surgical complications in kidney transplantation, their impact on renal graft survival among 80 patients, 54 (67.5%) males and 26 (32.5%) females who had undergone a living ... ...

    Abstract The aim of this study was to determine a frequency and a type of early and late surgical complications in kidney transplantation, their impact on renal graft survival among 80 patients, 54 (67.5%) males and 26 (32.5%) females who had undergone a living and cadaveric kidney transplant at the Surgery Center in Tuzla in the period from 15.09.1999 until 31.12.2008. The subjects were divided into two groups according to donor age, younger and older than 55. A significantly higher incidence of early rather than late surgical complications was observed in an experimental group (p=0.001, and p=0.77, respectively). There was a statistically significant difference in the length of graft survival (p=0.004) and the number of deaths (p=0.038). Older age of kidney graft donor had an impact on the occurrence of early surgical complications and no influence on the occurrence of late surgical complications. Fatal outcome after kidney transplantation was significantly higher in patients who received grafts of elderly people.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Blood Loss, Surgical/statistics & numerical data ; Bosnia and Herzegovina/epidemiology ; Case-Control Studies ; Female ; Follow-Up Studies ; Graft Survival ; Humans ; Intensive Care Units ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Kidney Transplantation/statistics & numerical data ; Male ; Middle Aged ; Risk Assessment ; Risk Factors ; Survival Rate ; Thromboembolism/epidemiology ; Tissue Donors ; Treatment Outcome ; Wound Infection/epidemiology
    Language English
    Publishing date 2013-02
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 2378942-6
    ISSN 1840-2445 ; 1840-0132
    ISSN (online) 1840-2445
    ISSN 1840-0132
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  7. Article: Serum cystatin C - marker of inflammation and cardiovascular morbidity in chronic kidney disease stages 1-4.

    Muslimovic, Alma / Tulumovic, Denijal / Hasanspahic, Senad / Hamzic-Mehmedbasic, Aida / Temimovi, Ramajana

    Materia socio-medica

    2015  Volume 27, Issue 2, Page(s) 75–78

    Abstract: Aim: The aim of the research was to compare the relationship between inflammatory biomarkers and procoagulants with kidney function assessed by using cystatin C, serum creatinine, and eGFR and determine the sensitivity of cystatin C, serum creatinine ... ...

    Abstract Aim: The aim of the research was to compare the relationship between inflammatory biomarkers and procoagulants with kidney function assessed by using cystatin C, serum creatinine, and eGFR and determine the sensitivity of cystatin C, serum creatinine and eGFR to total cardiovascular morbidity in patients with CKD stages 1-4.
    Methods: The research included 120 patients older than 18 years with CKD stages 1-4 monitored over a period of 24 months.
    Results: Serum cystatin C correlates with fibrinogen (p<0.01), serum albumin (p<0.01), D-dimer (p<0.05), antithrombin III (p<0.01) strongly in relation to the evaluation of kidney function based on serum creatinine and eGFR. By following cystatin C, creatinine and eGFR with comparison of ROC to total cardiovascular morbidity, the highest sensitivity in relation to the presence of cardiovascular morbidity shows cystatin C, then eGFR and the lowest, creatinine, with a significant difference between cystatin C and serum creatinine (p<0.05).
    Conclusion: Serum cystatin C is more strongly correlated with some biomarkers (fibrinogen, serum albumin, D-dimer, antithrombin III), while simultaneously showing a stronger sensitivity in relation to total cardiovascular morbidity compared with the assessment of kidney function based on serum creatinine and eGFR.
    Language English
    Publishing date 2015-04-05
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ISSN 1512-7680
    ISSN 1512-7680
    DOI 10.5455/msm.2015.27.75-78
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  8. Article: Ultrazvucne karakteristike bubrega u djece i adolescenata s dijabetesom melitusom tipa 1.

    Hasanović, Evlijana / Tulumović, Denijal / Imamović, Goran / Trnacević, Senaid

    Lijecnicki vjesnik

    2010  Volume 132, Issue 1-2, Page(s) 13–17

    Abstract: The aim of the study was to compare ultrasound findings of morphometric measurements and registration of Doppler signs of kidneys between children and adolescents with diabetes mellitus type 1 (DMT1) with microalbuminuria, and metabolic control with ... ...

    Title translation The ultrasound characteristics of kidneys in children and adolescents with diabetes mellitus type 1.
    Abstract The aim of the study was to compare ultrasound findings of morphometric measurements and registration of Doppler signs of kidneys between children and adolescents with diabetes mellitus type 1 (DMT1) with microalbuminuria, and metabolic control with duration of the disease. Retrospective-prospective study included 80 patients, who got DMT1 in the age from 2 to 16 years. In relation to the duration of the disease, all patients were divided into two groups: the first was whose illness had lasted less than 10 years, the second group was with duration of DMT1 more than 10 years. In patients with duration of DMT1 more than 10 years, the frequency of microalbuminuria, pathological findings of the volume of right kidney, and higher HbA1C were significantly greater. The significant difference was found in the frequency of pathological findings of the resistance index (RI) in the interlobar arteries in both kidneys. Alongside microalbuminuria, monitoring the dimension and volume of the kidneys may indicate the existence of the early phases of diabetic nephropathy.
    MeSH term(s) Adolescent ; Albuminuria ; Child ; Diabetes Mellitus, Type 1/diagnostic imaging ; Diabetes Mellitus, Type 1/urine ; Female ; Humans ; Kidney/diagnostic imaging ; Male ; Ultrasonography
    Language Croatian
    Publishing date 2010-01
    Publishing country Croatia
    Document type Journal Article
    ZDB-ID 128938-x
    ISSN 1849-2177 ; 0024-3477 ; 1330-4917
    ISSN (online) 1849-2177
    ISSN 0024-3477 ; 1330-4917
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  9. Article: Mikroalbuminurija i ultrazvucne karakteristike bubrega u djece i adolescenata sa Dijabetes melitusom tip 1.

    Hasanović, Evlijana / Tulumović, Denijal / Imamović, Goran / Trnacević, Senaid

    Medicinski arhiv

    2009  Volume 63, Issue 3, Page(s) 133–136

    Abstract: The aim of the study was to compare ultrasound findings of kidneys in children and adolescents with diabetes mellitus type 1 (DMT1), establish the association with microalbuminuria, blood pressure values and metabolic control of the disease, and ... ...

    Title translation Microalbuminuria and ultrasound characteristics of kidneys in children and adolescents with diabetes mellitus type 1.
    Abstract The aim of the study was to compare ultrasound findings of kidneys in children and adolescents with diabetes mellitus type 1 (DMT1), establish the association with microalbuminuria, blood pressure values and metabolic control of the disease, and creatinine clearance. In 80 children and adolescents with DMT1, in whom illness occurred in period between 2 and 16 years of age, morphometry measurements with ultrasound were performed. Nephelometric method of three consecutive samples of urine determined microalbuminuria. In patients with microalbuminuria, creatinine clearance was also measured. Demographic data were obtained from the parents and from the patients medical records. In relation to the duration of the disease, all patients were divided into two groups: the first group of patients with illness lasting for less than 10 years, and the second were those whose illness had lasted more than 10 years. In patients with duration of DMT1 of more than 10 years, the frequency of pathological findings of the longitudinal diameter and volume of both kidneys in relation to age and anthropometric standards was statistically significantly greater. Also, the finding of microalbuminuria was more frequent. In the group of patients with DMT1 lasting for more than 10 years, the mean value of HBA1c was statistically significantly higher In patients with microalbuminuria the total mean value of creatinine clearance was within the bounds of the reference values and was statistically significantly higher in patients in whom the illness had lasted less than three years, which indicates hyperfiltration of the kidneys. Alongside microalbuminuria, monitoring of the dimension and volume of the kidneys may indicate the existence of the early phases of diabetic nephropathy and result in its prevention and prevention of illness progression.
    MeSH term(s) Adolescent ; Albuminuria ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/diagnostic imaging ; Diabetes Mellitus, Type 1/urine ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/diagnostic imaging ; Diabetic Nephropathies/urine ; Female ; Humans ; Kidney/diagnostic imaging ; Male ; Ultrasonography
    Language Bosnian
    Publishing date 2009
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ZDB-ID 128782-5
    ISSN 1986-5961 ; 0025-8083 ; 0350-199X
    ISSN (online) 1986-5961
    ISSN 0025-8083 ; 0350-199X
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  10. Article: Idiopathic retroperitoneal fibrosis: a rare onset of the illness caused by haemorrhagic fever with renal syndrome.

    Tulumović, Denijal / Mesić, Enisa / Tulumović, Ajsa

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2006  Volume 21, Issue 5, Page(s) 1450

    MeSH term(s) Acute Kidney Injury/diagnosis ; Acute Kidney Injury/therapy ; Adult ; Blood Chemical Analysis ; Combined Modality Therapy ; Drug Therapy, Combination ; Follow-Up Studies ; Hemorrhagic Fever with Renal Syndrome/complications ; Hemorrhagic Fever with Renal Syndrome/diagnosis ; Humans ; Kidney Function Tests ; Male ; Rare Diseases ; Retroperitoneal Fibrosis/etiology ; Retroperitoneal Fibrosis/pathology ; Retroperitoneal Fibrosis/therapy ; Risk Assessment ; Severity of Illness Index ; Stents ; Treatment Outcome
    Language English
    Publishing date 2006-05
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfi243
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